Last reviewed: September 2018
Last updated: July  2018

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • acral and periorificial depigmentation
  • perianal and genital depigmentation
  • recent cutaneous trauma
  • localised sunburn pain
  • enhancement and fluorescence with UV-A exposure
  • halo naevus
  • universal depigmentation
  • lip depigmentation
  • erythema, oedema, or blistering
  • retinal depigmentation

Risk factors

  • age <30 years
  • FHx of vitiligo
  • auto-immune disease
  • chemical contact

Diagnostic investigations

Treatment algorithm

Contributors

Authors VIEW ALL

Associate Professor

Department of Dermatology

University of Massachusetts Medical School

Worcester

MA

Disclosures

JEH has received consulting fees and/or research grants from the following: Pfizer, AbbVie, Combe, Concert Pharmaceuticals, Stiefel/GSK, Mitsubishi Tanabe Pharma, Novartis, Aclaris Therapeutics, The Expert Institute, Celgene, Biologics MD, Gliknik, Janssen, TeVido BioDevices, EMD Serono, 3rd Rock Ventures, Sun Pharmaceuticals and Dermira. JEH is an author of a number of references cited in this topic.

Physician Resident

Department of Dermatology

University of Massachusetts Medical School

Worcester

MA

Disclosures

MR is an author of a number of references cited in this topic.

Dr John E. Harris and Dr Mehdi Rashighi would like to gratefully acknowledge Dr Bernhard Ortel, a previous contributor to this topic. BO declares that he has no competing interests.

Peer reviewers VIEW ALL

Senior Staff Physician

Multicultural Dermatology Center

Henry Ford Hospital

Detroit

MI

Disclosures

IH is an author of a number of references cited in this topic.

Chair

Dermatology Department

University of Brescia

Brescia

Italy

Disclosures

PC-P is an author of a number of references cited in this topic.

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