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Traveller's diarrhoea

Last reviewed: 25 Mar 2025
Last updated: 03 Sep 2024

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • diarrhoea (with or without tenesmus), cramping, nausea, and vomiting
  • dysentery (blood and fever)
  • persistent diarrhoea >14 days
Full details

Other diagnostic factors

  • diarrhoea without illness
Full details

Risk factors

  • travel to a high-risk destination
  • age <30 years
  • proton-pump inhibitor use
  • travellers with prior residence in higher-risk destination visiting friends and relatives
  • travel during hot and wet seasons
  • deployed military populations
  • lack of caution in food and water selection
Full details

Diagnostic investigations

1st investigations to order

  • stool culture and sensitivity
  • multi-pathogen molecular diagnostic (polymerase chain reaction)
  • protozoal stool antigens
Full details

Investigations to consider

  • stool ova and parasite examination
  • Clostridioides difficile stool toxin
  • colonoscopy, endoscopy, and biopsy
  • haematology, blood chemistries, serology
Full details

Treatment algorithm

INITIAL

pre-travel prophylaxis

ACUTE

non-pregnant adults: mild diarrhoea

non-pregnant adults: moderate diarrhoea

non-pregnant adults: severe diarrhoea

pregnant

children

Contributors

Authors

Daniel T. Leung, MD, MSc

Associate Professor

Division of Infectious Diseases

University of Utah School of Medicine

Salt Lake City

UT

Disclosures

DTL receives authorship royalties from UpToDate, Inc, for a chapter on travel medicine. DTL is an author of upcoming chapters on traveller's diarrhoea for the US CDC Yellow Book. DTL is the president-elect of the American Committee on Clinical Tropical Medicine and Travelers' Health - Clinical Group within the American Society of Tropical Medicine and Hygiene. DTL is an author of some of the references cited in this topic.

Jakrapun Pupaibool, MD, MS

Associate Professor

Division of Infectious Diseases

University of Utah School of Medicine

Salt Lake City

UT

Disclosures

JP declares that he has no competing interests.

Acknowledgements

Dr Daniel T. Leung and Dr Jakrapun Pupaibool would like to gratefully acknowledge Dr Mark Riddle and Professor Gregory Juckett, the previous contributor to this topic.

Disclosures

MR has given talks on the management of traveller's diarrhoea for the International Society of Travel Medicine (ISTM), the CDC Foundation, the American College of Gastroenterology (ACG), and the American College of Preventive Medicine. MR has led the development of guidelines for traveller's diarrhea for the ISTM, the ACG, and the Department of Defense. This work has been unpaid but support for travel has been accepted. MR is employed with Pfizer Inc., and is working on their Lyme disease vaccine programme. While this is not in conflict with traveller’s diarrhoea, Pfizer also makes azithromycin, which is an antibiotic recommended for the treatment of traveller’s diarrhoea. MR does not work in the area of Pfizer that develops, markets, or distributes azithromycin. MR is an author of several references cited in this topic. GJ declares that he has no competing interests.

Peer reviewers

Andrea Summer, MD

Assistant Professor of Pediatrics

Medical University of South Carolina

Charleston

SC

Disclosures

AS declares that she has no competing interests.

Phil Fischer, MD

Professor of Pediatrics

Department of Pediatric and Adolescent Medicine

Mayo Clinic

Rochester

MN

Disclosures

PF is an author of a reference cited in this topic.

  • Differentials

    • Food poisoning
    • Irritable bowel syndrome
    • Secondary disaccharidase (or other dietary) deficiency
    More Differentials
  • Guidelines

    • CDC Yellow Book 2024: travelers' diarrhea
    • 2017 Infectious Diseases Society of America clinical practice guidelines for the diagnosis and management of infectious diarrhea
    More Guidelines
  • Patient information

    Diarrhoea in adults

    More Patient information
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