Summary
Definition
History and exam
Key diagnostic factors
- child or adolescent age
- winter or spring season (in bacterial pharyngitis)
- summer/fall season (in enteroviral pharyngitis)
- rhinorrhea, nasal congestion, hoarseness, oral ulcers, and cough (in viral infection)
- sore throat
- pharyngeal exudate
- cervical adenopathy
- fever
- headache
- nausea, vomiting, and abdominal pain
- conjunctivitis
- maculopapular rash (in measles)
- Koplik spots (in measles)
- scarlatiniform rash (in group A Streptococcus [GAS] pharyngitis)
Other diagnostic factors
- sexual activity or abuse (in HIV, gonorrheal, or chlamydial infection)
- treatment failure of penicillin
- pharyngeal ulceration (in tularemia)
- pharyngeal gray membrane (in diphtheria)
Risk factors
- nasal colonization with group A Streptococcus (GAS)
- GAS-infected contact
- sexual activity or abuse
- ingestion of nondomestic meats
- immunocompromised host
- use of inhaled corticosteroids
- lack of immunization or vaccine failure
Diagnostic tests
1st tests to order
- rapid antigen test for group A Streptococcus (GAS)
- nucleic acid amplification (via polymerase chain reaction) for group A Streptococcus (GAS)
Tests to avoid
- broad viral testing
- serum Monospot for Epstein-Barr virus infection
Tests to consider
- culture of throat swab for group A Streptococcus (GAS)
- culture or PCR of throat swab for gonococcus or chlamydia
Treatment algorithm
all patients
Contributors
Authors
Jeffrey R. Donowitz, MD
Pediatrician
Pediatric Infectious Diseases
University of Virginia
Charlottesville
VA
Disclosures
JRD declares that he has no competing interests.
Acknowledgements
Dr Jeffrey R. Donowitz would like to gratefully acknowledge Dr William A. Petri, Jr, a previous contributor to this topic.
Disclosures
WAP declares that he has no competing interests.
Peer reviewers
Richard Roberts, MD, JD, FAAFP, FCLM
Professor of Family Medicine
University of Wisconsin School of Medicine and Public Health
Madison
WI
Disclosures
RR declares that he has no competing interests.
Remco de Bree, MD, PhD
Otolaryngologist
Head and Neck Surgeon
VU University Medical Center
Amsterdam
The Netherlands
Disclosures
RdB declares that he has no competing interests.
References
Key articles
Shulman ST, Bisno AL, Clegg HW, et al. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America (Archived). Clin Infect Dis. 2012 Nov 15;55(10):e86-102.Full text Abstract
Centers for Disease Control and Prevention. Pharyngitis (strep throat). Jun 2022 [internet publication].Full text
Centers for Disease Control and Prevention. Antibiotic prescribing and use - adult outpatient treatment recommendations: pharyngitis. Oct 2017 [internet publication].Full text
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Differentials
- Epiglottitis
- Retropharyngeal, peritonsillar, and lateral abscess
- Infectious mononucleosis
More DifferentialsGuidelines
- Guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2024 update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM)
- Pharyngitis (strep throat)
More GuidelinesPatient information
Sore throat
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