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Anterior cruciate ligament injury

Last reviewed: 20 Jul 2025
Last updated: 19 Aug 2025

Summary

Definition

History and exam

Key diagnostic factors

  • audible pop
  • rapid knee swelling/effusion
  • inability to return to the ongoing sporting activity
  • sensation of knee instability or buckling
  • pain
  • positive anterior drawer test
  • positive Lachman test
  • positive pivot shift maneuver
Full details

Other diagnostic factors

  • tenderness at lateral femoral condyle, lateral tibial plateau
Full details

Risk factors

  • acute trauma
  • female sex (after puberty)
  • biomechanics
  • history of previous anterior cruciate ligament injury
  • use of cleats or spikes
  • rough or uneven playing surface
  • ground condition/weather
  • fatigue
  • adolescent, young adults, and middle-aged athletes
Full details

Diagnostic tests

1st tests to order

  • x-rays
  • MRI
Full details

Tests to avoid

  • CT
Full details

Treatment algorithm

ACUTE

all patients

Contributors

Authors

Philip H. Cohen, MD
Philip H. Cohen

Clinical Assistant Professor of Medicine

Robert Wood Johnson Medical School

University of Medicine and Dentistry of New Jersey

Piscataway

NJ

Disclosures

PHC has been reimbursed for travel/lodging costs and has been given a stipend for medical education lectures for MCE Conferences.

Peer reviewers

Richard Ma, MD

Gregory L. and Ann L. Hummel Distinguished Professor

Director - Division of Sports Medicine

University of Missouri School of Medicine

Columbia

MO

Disclosures

RM declares that he has no competing interests.

​Matthew A. Tao, MD

Associate Professor

Sports Medicine and Arthroscopic Surgery

University of Nebraska Medical Center

Omaha

NE

Disclosures

MAT has provided consulting services to Vericel and NewClip.

Nicholas A. Trasolini, MD

Assistant Professor of Orthopaedic Surgery

Wake Forest University School of Medicine

Winston-Salem

MO

Disclosures

NAT declares that he has no competing interests.

Jason M. Scopp, MD

Director

Joint Preservation and Sports Medicine Institute

Peninsula Orthopaedic Associates

Salisbury

MD

Disclosures

JMS declares that he has no competing interests.

Jung-Ro Yoon, MD

Director

Department of Orthopedic Surgery

Seoul Veterans Hospital

Seoul

South Korea

Disclosures

JRY declares that she has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Arundale AJH, Bizzini M, Dix C, et al. Exercise-based knee and anterior cruciate ligament injury prevention. J Orthop Sports Phys Ther. 2023 Jan;53(1):CPG1-34.Full text  Abstract

American Academy of Orthopaedic Surgeons. Management of anterior cruciate ligament injuries​: evidence-based clinical practice guideline. Aug 2022 [internet publication].Full text

Padua DA, DiStefano LJ, Hewett TE, et al. National Athletic Trainers' Association Position Statement: Prevention of Anterior Cruciate Ligament Injury. J Athl Train. 2018 Jan;53(1):5-19.Full text  Abstract

van Melick N, van Cingel RE, Brooijmans F, et al. Evidence-based clinical practice update: practice guidelines for anterior cruciate ligament rehabilitation based on a systematic review and multidisciplinary consensus. Br J Sports Med. 2016 Dec;50(24):1506-15.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
  • Anterior cruciate ligament injury images
  • Differentials

    • Medial collateral ligament (MCL) sprain
    • Posterior collateral ligament (PCL) sprain
    • Lateral collateral ligament (LCL) sprain
    More Differentials
  • Guidelines

    • AAOS anterior cruciate ligament injury prevention programs: appropriate use criteria
    • Exercise-based knee and anterior cruciate ligament injury prevention
    More Guidelines
  • Patient information

    Anterior cruciate ligament injury

    More Patient information
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