Evaluation of fatigue

Last reviewed: 18 Jun 2025
Last updated: 03 Jun 2025

Summary

Differentials

Common

  • Insomnia disorder
  • Depression
  • Iron-deficiency anemia
  • Iron deficiency without anemia
  • Chronic heart failure
  • Diabetes mellitus
  • Hypothyroidism
  • Hyperthyroidism
  • EBV infection
  • Influenza infection
  • Long COVID
  • Medication-induced fatigue
  • Alcohol dependence
  • Drug dependence
  • HIV infection
  • Acute myocardial ischemia
  • Atrial fibrillation
  • COPD
  • Tuberculosis
  • Toxoplasmosis
  • Stroke
Full details

Uncommon

  • Obstructive sleep apnea/hypopnea syndrome (OSAHS)
  • Obesity hypoventilation syndrome (OHS)
  • Restless legs syndrome
  • Celiac disease
  • Addison disease
  • Hypopituitarism
  • Myelodysplastic syndrome
  • Chronic myeloid leukemia
  • Non-Hodgkin lymphoma
  • Hodgkin lymphoma
  • Cytomegalovirus infection
  • Lyme disease
  • Brucellosis
  • Chronic renal disease
  • Multiple sclerosis
  • Parkinson disease
  • Fibromyalgia
  • Vitamin D deficiency (osteomalacia)
  • Systemic lupus erythematosus
  • Primary biliary cirrhosis
  • Underlying malignancy (non-lymphoma)
  • Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
  • Chronic idiopathic fatigue
  • Heavy metal toxicity
Full details

Contributors

Authors

Bernard Favrat, MD
Bernard Favrat

Associate Professor

University of Lausanne

Department of Ambulatory Care and Community Medicine

Lausanne

Switzerland

利益声明

BF has received study grants and lecture/consultant fees from Vifor Pharma and Pierre Fabre Médicament. BF is an author of a number of references cited in this topic.

Jacques Cornuz, MD, MPH
Jacques Cornuz

Associate Director

University Hospital of Lausanne

Department of Ambulatory Care and Community Medicine

Lausanne

Switzerland

利益声明

JC is an author of a reference cited in this topic.

鸣谢

Dr Bernard Favrat and Dr Jacques Cornuz would like to gratefully acknowledge Dr Idris Guessous and Dr Baptiste Pedrazzini, previous contributors to this topic.

利益声明

IG is an author of a reference cited in this topic. BP declares that he has no competing interests.

同行评议者

Chris Martin, MD

General Practitioner

Dr Moulds and Partners

Laindon Health Centre

Laindon

Essex

UK

利益声明

CM has received an NHS salary greater than 6 figures USD. CM declares that he has no competing interests.

Benjamin Natelson, MD

Professor of Neurosciences

UMDNJ

New Jersey Medical School

Newark

NJ

利益声明

BN declares that he has no competing interests.

参考文献

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关键文献

National Institute for Health and Care Excellence​. Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management. Oct 2021 [internet publication].全文

Centers for Disease Control and Prevention​. Myalgic encephalomyelitis/chronic fatigue syndrome: clinical overview of ME/CFS. May 2024 [internet publication].全文

Cornuz J, Guessous I, Favrat B. Fatigue: a practical approach to diagnosis in primary care. CMAJ. 2006 Mar 14;174(6):765-7.全文  摘要

Hamilton W, Watson J, Round A. Investigating fatigue in primary care. BMJ. 2010;341:c4259. 摘要

参考文献

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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