Assessment of fatigue

Last reviewed: 9 Nov 2022
Last updated: 13 May 2022

Summary

Differentials

Common

  • Insomnia disorder
  • Depression
  • Iron-deficiency anaemia
  • Iron deficiency without anaemia
  • Chronic heart failure
  • Diabetes mellitus
  • Hypothyroidism
  • Hyperthyroidism
  • EBV infection
  • Influenza infection
  • Coronavirus disease 2019 (COVID-19)
  • Long COVID
  • Medicine-induced fatigue
  • Alcohol dependence
  • Drug dependence
  • HIV infection
  • Acute myocardial ischaemia
  • Atrial fibrillation
  • COPD
  • Tuberculosis
  • Toxoplasmosis
  • Stroke
Full details

Uncommon

  • Obstructive sleep apnoea/hypopnoea syndrome (OSAHS)
  • Obesity hypoventilation syndrome (OHS)
  • Restless legs syndrome
  • Coeliac disease
  • Addison's disease
  • Hypopituitarism
  • Myelodysplastic syndrome
  • Chronic myeloid leukaemia
  • Non-Hodgkin's lymphoma
  • Hodgkin's lymphoma
  • Cytomegalovirus infection
  • Lyme disease
  • Brucellosis
  • Chronic renal disease
  • Multiple sclerosis
  • Parkinson's disease
  • Fibromyalgia
  • Vitamin D deficiency (osteomalacia)
  • Systemic lupus erythematosus
  • Primary biliary cirrhosis
  • Underlying malignancy (non-lymphoma)
  • Chronic fatigue syndrome (myalgic encephalomyelitis)/systemic exertion intolerance disease
  • Chronic idiopathic fatigue
  • Heavy metal toxicity
Full details

Contributors

Authors

Bernard Favrat, MD
Bernard Favrat

Associate Professor

University of Lausanne

Department of Ambulatory Care and Community Medicine

Lausanne

Switzerland

Disclosures

BF has received study grants and lecture/consultant fees from Vifor Pharma and Pierre Fabre Médicament. BF is an author of a number of references cited in this topic.

Jacques Cornuz, MD, MPH
Jacques Cornuz

Associate Director

University Hospital of Lausanne

Department of Ambulatory Care and Community Medicine

Lausanne

Switzerland

Disclosures

JC is an author of a reference cited in this topic.

Acknowledgements

Dr Bernard Favrat and Dr Jacques Cornuz would like to gratefully acknowledge Dr Idris Guessous and Dr Baptiste Pedrazzini, previous contributors to this topic.

Disclosures

IG is an author of a reference cited in this topic. BP declares that he has no competing interests.

Peer reviewers

Chris Martin, MD

General Practitioner

Dr Moulds and Partners

Laindon Health Centre

Laindon

Essex

UK

Disclosures

CM has received an NHS salary greater than 6 figures USD. CM declares that he has no competing interests.

Benjamin Natelson, MD

Professor of Neurosciences

UMDNJ

New Jersey Medical School

Newark

NJ

Disclosures

BN declares that he has no competing interests.

  • Guidelines

    • Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16s
    • Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management
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