Oral aphthous ulcers

References

Key articles

Scully C. Clinical practice: aphthous ulceration. N Engl J Med. 2006 Jul 13;355(2):165-72. Abstract

Scully C, Gorsky M, Lozada-Nur F. The diagnosis and management of recurrent aphthous stomatitis: a consensus approach. J Am Dent Assoc. 2003 Feb;134(2):200-7. Abstract

Letsinger JA, McCarty MA, Jorizzo JL. Complex aphthosis: a large case series with evaluation algorithm and therapeutic ladder from topicals to thalidomide. J Am Acad Dermatol. 2005 Mar;52(3 Pt 1):500-8. Abstract

Liu C, Zhou Z, Liu G, et al. Efficacy and safety of dexamethasone ointment on recurrent aphthous ulceration. Am J Med. 2012 Mar;125(3):292-301. Abstract

Brocklehurst P, Tickle M, Glenny AM, et al. Systemic interventions for recurrent aphthous stomatitis (mouth ulcers). Cochrane Database Syst Rev. 2012 Sep 12;(9):CD005411.Full text  Abstract

Reference articles

1. Scully C. Clinical practice: aphthous ulceration. N Engl J Med. 2006 Jul 13;355(2):165-72. Abstract

2. Scully C, Shotts R. ABC of oral health: mouth ulcers and other causes of orofacial soreness and pain. BMJ. 2000 Jul 15;321(7254):162-5.Full text  Abstract

3. Scully C, Gorsky M, Lozada-Nur F. The diagnosis and management of recurrent aphthous stomatitis: a consensus approach. J Am Dent Assoc. 2003 Feb;134(2):200-7. Abstract

4. Baccaglini L, Lalla RV, Bruce AJ, et al. Urban legends: recurrent aphthous stomatitis. Oral Dis. 2011 Nov;17(8):755-70.Full text  Abstract

5. Scully C, Felix DH. Oral medicine: update for the dental practitioner - aphthous and other common ulcers. Br Dent J. 2005 Sep 10;199(5):259-64. Abstract

6. Scully C, Porter S. Oral mucosal disease: recurrent aphthous stomatitis. Br J Oral Maxillofac Surg. 2008 Apr;46(3):198-206. Abstract

7. Kleinman DV, Swango PA, Pindborg JJ. Epidemiology of oral mucosal lesions in United States schoolchildren: 1986-87. Community Dent Oral Epidemiol. 1994 Aug;22(4):243-53. Abstract

8. Sircus W, Church R, Kelleher J. Recurrent aphthous ulceration of the mouth: a study of the natural history, aetiology, and treatment. Q J Med. 1957 Apr;26(102):235-49. Abstract

9. Shohat-Zabarski R, Kalderon S, Klein T, et al. Close association of HLA-B51 in persons with recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol. 1992 Oct;74(4):455-8. Abstract

10. Hasan A, Childerstone A, Pervin K, et al. Recognition of a unique peptide epitope of the mycobacterial and human heat shock protein 65-60 antigen by T cells of patients with recurrent oral ulcers. Clin Exp Immunol. 1995 Mar;99(3):392-7.Full text  Abstract

11. Tüzün B, Wolf R, Tuzun Y, et al. Recurrent aphthous stomatitis and smoking. Int J Dermatol. 2000 May;39(5):358-60. Abstract

12. Atkin PA, Xu X, Thornhill MH. Minor recurrent aphthous stomatitis and smoking: an epidemiological study measuring plasma cotinine. Oral Dis. 2002 May;8(3):173-6. Abstract

13. Jurge S, Kuffer R, Scully C, et al. Mucosal disease series. Number VI. Recurrent aphthous stomatitis. Oral Dis. 2006 Jan;12(1):1-21. Abstract

14. Wray D, Ferguson MM, Mason DK, et al. Recurrent aphthae: treatment with vitamin B12, folic acid, and iron. Br Med J. 1975 May 31;2(5969):490-3.Full text  Abstract

15. Olson JA, Feinberg I, Silverman S Jr, et al. Serum vitamin B12, folate, and iron levels in recurrent aphthous ulceration. Oral Surg Oral Med Oral Pathol. 1982 Nov;54(5):517-20. Abstract

16. Wray D, Graykowski EA, Notkins AL. Role of mucosal injury in initiating recurrent aphthous stomatitis. Br Med J (Clin Res Ed). 1981 Dec 12;283(6306):1569-70.Full text  Abstract

17. McCartan BE, Lamey PJ, Wallace AM. Salivary cortisol and anxiety in recurrent aphthous stomatitis. J Oral Pathol Med. 1996 Aug;25(7):357-9. Abstract

18. McCullough MJ, Abdel-Hafeth S, Scully C. Recurrent aphthous stomatitis revisited: clinical features, associations, and new association with infant feeding practices? J Oral Pathol Med. 2007 Nov;36(10):615-20. Abstract

19. Healy CM, Paterson M, Joyston-Bechal S, et al. The effect of a sodium lauryl sulfate-free dentifrice on patients with recurrent oral ulceration. Oral Dis. 1999 Jan;5(1):39-43. Abstract

20. Taylor LJ, Bagg J, Walker DM, et al. Increased production of tumour necrosis factor by peripheral blood leukocytes in patients with recurrent oral aphthous ulceration. J Oral Pathol Med. 1992 Jan;21(1):21-5. Abstract

21. Natah SS, Hayrinen-Immonen R, Hietanen J, et al. Increased density of lymphocytes bearing gamma/delta T-cell receptors in recurrent aphthous ulceration (RAU). Int J Oral Maxillofac Surg. 2000 Oct;29(5):375-80. Abstract

22. Scully C, MacFadyen E, Campbell A. Oral manifestations in cyclic neutropenia. Br J Oral Surg. 1982 Jun;20(2):96-101. Abstract

23. Yazici H, Fresko I, Yurdakul S. Behcet's syndrome: disease manifestations, management, and advances in treatment. Nat Clin Pract Rheumatol. 2007 Mar;3(3):148-55. Abstract

24. Orme RL, Nordlund JJ, Barich L, et al. The MAGIC syndrome (mouth and genital ulcers with inflamed cartilage). Arch Dermatol. 1990 Jul;126(7):940-4. Abstract

25. Femiano F, Lanza A, Buonaiuto C, et al. Oral aphthous-like lesions, PFAPA syndrome: a review. J Oral Pathol Med. 2008 Jul;37(6):319-23. Abstract

26. Scully C, Hodgson T. Recurrent oral ulceration: aphthous-like ulcers in periodic syndromes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Dec;106(6):845-52. Abstract

27. Rehberger A, Puspok A, Stallmeister T, et al. Crohn's disease masquerading as aphthous ulcers. Eur J Dermatol. 1998 Jun;8(4):274-6. Abstract

28. Shotts RH, Scully C, Avery CM, et al. Nicorandil-induced severe oral ulceration:a newly recognized drug reaction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Jun;87(6):706-7. Abstract

29. Zakrzewska JM, Robinson P, Williams IG. Severe oral ulceration in patients with HIV infection: a case series. Oral Dis. 1997 May;3(suppl 1):S194-6. Abstract

30. Femiano F, Gombos F, Scully C. Sweet's syndrome: recurrent oral ulceration, pyrexia, thrombophlebitis, and cutaneous lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Mar;95(3):324-7. Abstract

31. Femiano F, Gombos F, Nunziata M, et al. Pemphigus mimicking aphthous stomatitis. J Oral Pathol Med. 2005 Sep;34(8):508-10. Abstract

32. Letsinger JA, McCarty MA, Jorizzo JL. Complex aphthosis: a large case series with evaluation algorithm and therapeutic ladder from topicals to thalidomide. J Am Acad Dermatol. 2005 Mar;52(3 Pt 1):500-8. Abstract

33. Volkov I, Rudoy I, Freud T, et al. Effectiveness of vitamin B12 in treating recurrent aphthous stomatitis: a randomized, double-blind, placebo-controlled trial. J Am Board Fam Med. 2009 Jan-Feb;22(1):9-16.Full text  Abstract

34. Gulcan E, Toker S, Hatipoğlu H, et al. Cyanocobalamin may be beneficial in the treatment of recurrent aphthous ulcers even when vitamin B12 levels are normal. Am J Med Sci. 2008 Nov;336(5):379-82. Abstract

35. Liu HL, Chiu S, Chen KH. Effectiveness of vitamin B12 on recurrent aphthous stomatitis in long term care: a systematic review. JBI Database System Rev Implement Rep. 2013;11:281-307.

36. Liu C, Zhou Z, Liu G, et al. Efficacy and safety of dexamethasone ointment on recurrent aphthous ulceration. Am J Med. 2012 Mar;125(3):292-301. Abstract

37. Matthews RW, Scully CM, Levers BG, et al. Clinical evaluation of benzydamine, chlorhexidine, and placebo mouthwashes in the management of recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol. 1987 Feb;63(2):189-91. Abstract

38. Addy M, Tapper-Jones L, Seal M. Trial of astringent and antibacterial mouthwashes in the management of recurrent aphthous ulceration. Br Dent J. 1974 Jun 4;136(11):452-5. Abstract

39. Addy M, Carpenter R, Roberts WR. Management of recurrent aphthous ulceration: a trial of chlorhexidine gluconate gel. Br Dent J. 1976 Aug 17;141(4):118-20. Abstract

40. Addy M. Hibitane in the treatment of aphthous ulceration. J Clin Periodontol. 1977 Dec;4(5):108-16. Abstract

41. Hunter L, Addy M. Chlorhexidine gluconate mouthwash in the management of minor aphthous ulceration: a double-blind, placebo controlled cross-over trial. Br Dent J. 1987 Feb 7;162(3):106-10. Abstract

42. Graykowski EA, Kingman A. Double-blind trial of tetracycline in recurrent aphthous ulceration. J Oral Pathol. 1978;7(6):376-82. Abstract

43. Häyrinen-Immonen R, Sorsa T, Pettila J, et al. Effect of tetracyclines on collagenase activity in patients with recurrent aphthous ulcers. J Oral Pathol Med. 1994 Jul;23(6):269-72. Abstract

44. Brocklehurst P, Tickle M, Glenny AM, et al. Systemic interventions for recurrent aphthous stomatitis (mouth ulcers). Cochrane Database Syst Rev. 2012 Sep 12;(9):CD005411.Full text  Abstract

45. Hello M, Barbarot S, Bastuji-Garin S, et al. Use of thalidomide for severe recurrent aphthous stomatitis: a multicenter cohort analysis. Medicine (Baltimore). 2010 May;89(3):176-82. Abstract

46. Taylor J, Glenny AM, Walsh T, et al. Interventions for the management of oral ulcers in Behçet's disease. Cochrane Database Syst Rev. 2014 Sep 25;(9):CD011018.Full text  Abstract

47. Revuz J, Guillaume JC, Janier M, et al. Crossover study of thalidomide vs placebo in severe recurrent aphthous stomatitis. Arch Dermatol. 1990 Jul;126(7):923-7. Abstract

48. Nicolau DP, West TE. Thalidomide: treatment of severe recurrent aphthous stomatitis in patients with AIDS. DICP. 1990 Nov;24(11):1054-6. Abstract

49. O'Neill ID, Scully C. Biologics in oral medicine: principles of use and practical considerations. Oral Dis. 2012 Sep;18(6):525-36.Full text  Abstract

50. O'Neill ID, Scully C. Biologics in oral medicine: ulcerative disorders. Oral Dis. 2013 Jan;19(1):37-45. Abstract

51. Crighton AJ. Oral medicine in children. Br Dent J. 2017 Dec;223(9):706-12. Abstract

52. Robinson ND, Guitart J. Recalcitrant, recurrent aphthous stomatitis treated with etanercept. Arch Dermatol. 2003 Oct;139(10):1259-62.Full text  Abstract

53. Vujevich J, Zirwas M. Treatment of severe, recalcitrant, major aphthous stomatitis with adalimumab. Cutis. 2005 Aug;76(2):129-32. Abstract

54. O'Neill ID. Off-label use of biologicals in the management of inflammatory oral mucosal disease. J Oral Pathol Med. 2008 Nov;37(10):575-81. Abstract

55. Leao JC, Duarte A, Gueiros LA, et al. Severe oral epithelial dysplasia in a patient receiving adalimumab therapy. J Oral Pathol Med. 2005 Aug;34(7):447-8. Abstract

56. Kuehn BM. Rare neurological condition linked to newer monoclonal antibody biologics. JAMA. 2009 Apr 8;301(14):1423-4. Abstract

57. Lalla RV, Choquette LE, Feinn RS, et al. Multivitamin therapy for recurrent aphthous stomatitis: a randomized, double-masked, placebo-controlled trial. J Am Dent Assoc. 2012 Apr;143(4):370-6.Full text  Abstract

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