The annual incidence of infectious keratitis in the developed world has been increasing due to higher rates of contact lens use, and is now 2 to 11 per 100,000 per year. A study from Hong Kong found an annual incidence of 0.63 per 10,000 in non-contact lens wearers and 3.4 per 10,000 in contact lens wearers.Acanthamoeba keratitis, unknown prior to 1973, now accounts for approximately 1% of all cases, with contact lens use acting as a major risk factor. Among contact lens wearers, most patients present between 20 to 29 years of age, reflecting the age distribution of contact lens users, although contact lens-related infections are also encountered in younger and older patients. No clear sex differences are borne out in epidemiological studies. The incidence of infectious keratitis in the developing world is considerably higher. In Nepal, for example, the rate is estimated to be 799 per 100,000 per year. Fungi cause keratitis in about 6% of patients in temperate climates, but figure more prominently in tropical regions. In South India, 35% of corneal ulcers were due to bacteria and 32% were due to fungi. Another study in eastern India found that 62% of the corneal ulcers were due to fungi.
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