Primary adrenal insufficiency

References

Key articles

Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and treatment of primary adrenal insufficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2016 Feb;101(2):364-89.Full text  Abstract

Husebye ES, Pearce SH, Krone NP, et al. Adrenal insufficiency. Lancet. 2021 Feb 13;397(10274):613-29. Abstract

Betterle C, Presotto F, Furmaniak J. Epidemiology, pathogenesis, and diagnosis of Addison's disease in adults. J Endocrinol Invest. 2019 Dec;42(12):1407-33. Abstract

Arlt W; Society for Endocrinology Clinical Committee. Society For Endocrinology endocrine emergency guidance: emergency management of acute adrenal insufficiency (adrenal crisis) in adult patients. Endocr Connect. 2016 Sep;5(5):G1-3.Full text  Abstract

Reference articles

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2. Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and treatment of primary adrenal insufficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2016 Feb;101(2):364-89.Full text  Abstract

3. Husebye ES, Pearce SH, Krone NP, et al. Adrenal insufficiency. Lancet. 2021 Feb 13;397(10274):613-29. Abstract

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26. Arlt W; Society for Endocrinology Clinical Committee. Society For Endocrinology endocrine emergency guidance: emergency management of acute adrenal insufficiency (adrenal crisis) in adult patients. Endocr Connect. 2016 Sep;5(5):G1-3.Full text  Abstract

27. Karaca Z, Grossman A, Kelestimur F. Investigation of the hypothalamo-pituitary-adrenal (HPA) axis: a contemporary synthesis. Rev Endocr Metab Disord. 2021 Jun;22(2):179-204. Abstract

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29. Javorsky BR, Raff H, Carroll TB, et al. New cutoffs for the biochemical diagnosis of adrenal insufficiency after ACTH stimulation using specific cortisol assays. J Endocr Soc. 2021 Apr 1;5(4):bvab022.Full text  Abstract

30. Cho HY, Kim JH, Kim SW, et al. Different cut-off values of the insulin tolerance test, the high-dose short Synacthen test (250 μg) and the low-dose short Synacthen test (1 μg) in assessing central adrenal insufficiency. Clin Endocrinol (Oxf). 2014 Jul;81(1):77-84. Abstract

31. Gonzalez-Gonzalez JG, De la Garza-Hernandez NE, Mancillas-Adame LG, et al. A high-sensitivity test in the assessment of adrenocortical insufficiency: 10 microg vs 250 microg cosyntropin dose assessment of adrenocortical insufficiency. J Endocrinol. 1998 Nov;159(2):275-80.Full text  Abstract

32. Ospina NS, Al Nofal A, Bancos I, et al. ACTH stimulation tests for the diagnosis of adrenal insufficiency: systematic review and meta-analysis. J Clin Endocrinol Metab. 2016 Feb;101(2):427-34.Full text  Abstract

33. Nasrallah MP, Arafah BM. The value of dehydroepiandrosterone sulfate measurements in the assessment of adrenal function. J Clin Endocrinol Metab. 2003 Nov;88(11):5293-8.Full text  Abstract

34. Sayyed Kassem L, El Sibai K, Chaiban J, et al. Measurements of serum DHEA and DHEA sulphate levels improve the accuracy of the low-dose cosyntropin test in the diagnosis of central adrenal insufficiency. J Clin Endocrinol Metab. 2012 Oct;97(10):3655-62.Full text  Abstract

35. Betterle C, Dal Pra C, Mantero F, et al. Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr Rev. 2002 Jun;23(3):327-64.Full text  Abstract

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40. Arambewela M, Ross R, Pirzada O, et al. Tuberculosis as a differential for bilateral adrenal masses in the UK. BMJ Case Rep. 2019 May 28;12(5):e228532. Abstract

41. National Institute of Diabetes and Digestive and Kidney Diseases. Adrenal insufficiency & Addison’s disease. 2018 [internet publication].Full text

42. Dineen R, Thompson CJ, Sherlock M. Adrenal crisis: prevention and management in adult patients. Ther Adv Endocrinol Metab. 2019 Jun 13;10:2042018819848218.Full text  Abstract

43. Nowotny H, Ahmed SF, Bensing S, et al. Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis. Endocrine. 2021 Mar;71(3):586-94.Full text  Abstract

44. Flad TM, Conway JD, Cunningham SK, et al. The role of plasma renin activity in evaluating the adequacy of mineralocorticoid replacement in primary adrenal insufficiency. Clin Endocrinol (Oxf). 1996 Nov;45(5):529-34. Abstract

45. Prete A, Taylor AE, Bancos I, et al. Prevention of adrenal crisis: cortisol responses to major stress compared to stress dose hydrocortisone delivery. J Clin Endocrinol Metab. 2020 Jul 1;105(7):2262-74.Full text  Abstract

46. Woodcock T, Barker P, Daniel S, et al. Guidelines for the management of glucocorticoids during the peri-operative period for patients with adrenal insufficiency: guidelines from the Association of Anaesthetists, the Royal College of Physicians and the Society for Endocrinology UK. Anaesthesia. 2020 May;75(5):654-63.Full text  Abstract

47. Liu MM, Reidy AB, Saatee S, et al. Perioperative steroid management: approaches based on current evidence. Anesthesiology. 2017 Jul;127(1):166-72.Full text  Abstract

48. Yong SL, Coulthard P, Wrzosek A. Supplemental perioperative steroids for surgical patients with adrenal insufficiency. Cochrane Database Syst Rev. 2012 Dec 12;12:CD005367.Full text  Abstract

49. Arafah BM. Perioperative glucocorticoid therapy for patients with adrenal insufficiency: dosing based on pharmacokinetic data. J Clin Endocrinol Metab. 2020 Mar 1;105(3):dgaa042. Abstract

50. Bothou C, Anand G, Li D, et al. Current management and outcome of pregnancies in women with adrenal insufficiency: experience from a multicenter survey. J Clin Endocrinol Metab. 2020 Aug 1;105(8):dgaa266. Abstract

51. Alkatib AA, Cosma M, Elamin MB, et al. A systematic review and meta-analysis of randomized placebo-controlled trials of DHEA treatment effects on quality of life in women with adrenal insufficiency. J Clin Endocrinol Metab. 2009 Oct;94(10):3676-81.Full text  Abstract

52. Arlt W, Callies F, van Vlijmen JC, et al. Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med. 1999 Sep 30;341(14):1013-20. Abstract

53. Gebre-Medhin G, Husebye ES, Mallmin H, et al. Oral dehydroepiandrosterone (DHEA) replacement therapy in women with Addison's disease. Clin Endocrinol (Oxf). 2000 Jun;52(6):775-80. Abstract

54. Løvås K, Gebre-Medhin G, Trovik TS, et al. Replacement of dehydroepiandrosterone in adrenal failure: no benefit for subjective health status and sexuality in a 9-month, randomized, parallel group clinical trial. J Clin Endocrinol Metab. 2003 Mar;88(3):1112-8.Full text  Abstract

55. Isidori AM, Venneri MA, Graziadio C, et al. Effect of once-daily, modified-release hydrocortisone versus standard glucocorticoid therapy on metabolism and innate immunity in patients with adrenal insufficiency (DREAM): a single-blind, randomised controlled trial. Lancet Diabetes Endocrinol. 2018 Mar;6(3):173-85. Abstract

56. Giordano R, Guaraldi F, Marinazzo E, et al. Improvement of anthropometric and metabolic parameters, and quality of life following treatment with dual-release hydrocortisone in patients with Addison's disease. Endocrine. 2016 Feb;51(2):360-8. Abstract

57. Oksnes M, Björnsdottir S, Isaksson M, et al. Continuous subcutaneous hydrocortisone infusion versus oral hydrocortisone replacement for treatment of addison's disease: a randomized clinical trial. J Clin Endocrinol Metab. 2014 May;99(5):1665-74.Full text  Abstract

58. Pearce SHS, Gan EH, Napier C. Management of endocrine disease: residual adrenal function in Addison's disease. Eur J Endocrinol. 2021 Feb;184(2):R61-7.Full text  Abstract

59. Napier C, Gan EH, Mitchell AL, et al. Residual adrenal function in autoimmune addison's disease-effect of dual therapy with rituximab and depot tetracosactide. J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgz287.Full text  Abstract

60. Repping-Wuts HJ, Stikkelbroeck NM, Noordzij A, et al. A glucocorticoid education group meeting: an effective strategy for improving self-management to prevent adrenal crisis. Eur J Endocrinol. 2013 Jul;169(1):17-22.Full text  Abstract

61. Burger-Stritt S, Eff A, Quinkler M, et al. Standardised patient education in adrenal insufficiency: a prospective multi-centre evaluation. Eur J Endocrinol. 2020 Aug;183(2):119-27.Full text  Abstract

62. Keil MF, Van Ryzin C. The key to adrenal insufficiency education: repetition, repetition, repetition. Pediatr Endocrinol Rev. 2017 Jun;14(suppl 2):448-53. Abstract

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