Last reviewed: 29 Oct 2020
Last updated: 29 May 2020

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • diarrhoea

Other diagnostic factors

  • generalised abdominal pain
  • right upper quadrant abdominal pain
  • weight loss
  • cough
  • fever
  • altered mental status or limb weakness
  • dyspnoea
  • guarding and rebound tenderness of the abdomen
  • jaundice
  • right lung decreased air entry and percussion note

Risk factors

  • exposure in endemic areas
  • institutionalisation of intellectually disabled people
  • men who have sex with men
  • oral-anal sexual contact
  • HIV infection, past or current syphilis infection
  • male sex

Diagnostic investigations

1st investigations to order

  • stool antigen detection
  • PCR or qPCR of stool or liver abscess pus for E histolytica DNA
  • serum antibody test
More 1st investigations to order

Investigations to consider

  • stool microscopy
  • colonoscopy
  • liver ultrasound
  • CXR
  • CT liver/chest/head
  • MRI brain
More investigations to consider

Treatment algorithm

Contributors

Attending physician

AIDS Clinical Center

National Center for Global health and Medicine

Tokyo

Japan

Disclosures

KW is an author of a number of references cited in this topic.

Dr Koji Watanabe would like to gratefully acknowledge Dr William A. Petri, a previous contributor to this topic. WAP is a consultant for TechLab, Inc. which manufactures diagnostic tests for amoebiasis and is also the author of a number of references cited in this topic.

Peer reviewersVIEW ALL

Senior Lecturer in Microbiology and Medicine

Department of Clinical Microbiology and Infectious Diseases

Hadassah-Hebrew University Medical Center

Jerusalem

Israel

Disclosures

RNP declares that he has no competing interests.

Assistant Professor of Medicine

Division of Infectious Diseases

University of Vermont College of Medicine

Burlington

VT

Disclosures

CH declares that he has no competing interests.

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