Across all patients with epilepsy, generalised tonic-clonic seizures (GTCSs) represent a significant percentage of the total seizure burden, with over half of all patients reporting at least one GTCS. Additionally, multiple epidemiological studies have found that GTCSs represent around 25% of all seizure types reported by epilepsy patients. This incidence does not seem to differ based on age, sex, or ethnicity. However, there are differences in the frequency of GTCSs when factoring in the epilepsy syndrome. GTCSs are likely to occur more frequently in patients with generalised-onset epilepsies and in those patients who experience only one seizure type.
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