It is the second most common chronic bone-remodelling disorder after osteoporosis. The majority of cases are sporadic, but between 5% and 40% of patients report a first-degree relative with Paget's disease of bone. The incidence has been decreasing in the US and the UK. The prevalence in the UK is about 2.5% among men and 1.6% among women aged 55 years and older. Age-adjusted prevalence rates declined steeply between 1974 and 1994. Prevalence appears to be similar throughout Europe. In the US, it is now considered to affect about 3.5% of people aged over 45 years. The mean age of onset is 55 years, with equal distribution among men and women (although there is a slight male predominance in the 45- to 74-years age group). The prevalence is equal in white and black people.
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