Approach

Acromegaly is an insidious chronic disease. Early physical changes may be unnoticed by patients, their family members and other close contacts, and their physicians. The diagnosis is often delayed up to 10 years after the appearance of the initial symptoms and signs (by retrospective analysis).[11] By the time the diagnosis is made, the patient's physical appearance has been changed, and the metabolic, cardiovascular, and osteoarticular complications have significantly affected their quality of life. Early symptom recognition is very important for improvement of prognosis and quality of life. Diagnosis is based on biochemical confirmation of growth hormone (GH)/insulin-like growth factor 1 (IGF-1) hypersecretion.

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