Acromegaly is a rare, chronic disease caused by excessive secretion of growth hormone (GH), usually due to a pituitary somatotroph adenoma. It is associated with increased morbidity and premature mortality if not appropriately treated.
The diagnosis is often delayed. Early recognition and appropriate treatment are crucial for reducing the potentially debilitating complications of the disease.
Must be screened for in the presence of pituitary adenoma, profuse sweating, acral growth, coarsening of facial features, and when suspected in conjunction with commonly associated conditions, such as carpal tunnel syndrome, arthralgia, glucose intolerance or diabetes mellitus, amenorrhoea, hypertension, and sleep apnoea.
Modern surgical and pharmacological modalities are associated with improved outcomes. Normalisation of plasma insulin-like growth factor 1 (IGF-1) and a decrease of plasma GH to below 1 microgram/L (1 nanogram/mL) bring the mortality rate to normal.
Monitoring and treatment of the comorbidities associated with acromegaly are essential for improving patient quality of life.
The term acromegaly is derived from the Greek akros (meaning extremity) and megas (large). It refers to the characteristic growth of extremities, which describes one aspect of the disease. Acromegaly is a chronic, progressive, multi-systemic disease associated with significant morbidity and increased mortality. It is caused by excessive secretion of growth hormone, usually due to a pituitary somatotroph adenoma. Gigantism occurs with disease onset in childhood (prior to epiphyseal closure).
History and exam
- pituitary MRI or CT scan
- GH-releasing hormone
- chest and/or abdominal CT scanning
- total body scintigraphy with radio-labelled somatostatin analogue (octreoscan)
- PET scan with radio-labelled somatostatin analogue (Gallium-68 DOTATATE)
- plasma cortisol
- thyroid-stimulating hormone (TSH) and free thyroxine
- estradiol or testosterone
- visual field testing
Maria Fleseriu, MD, FACE
Professor of Medicine (Endocrinology) and Neurological Surgery
Oregon Health & Science University
MF declares that she receives research funding (paid to Oregon Health & Science University) as well as scientific consulting fees from Chiasma, Crinetics, Ionis and Recordati; she receives scientific consulting fees from Ipsen and Pfizer. MF is an author of a number of references cited in this topic.
Professor Fleseriu would like to gratefully acknowledge Professor Ariel Barkan, Dr Omar Serri and Dr Sophie Vallette, previous contributors to this topic.
AB has received lecturing fees and research support from Novartis and Ipsen and is an author of several references cited in this topic. OS has received lecturing and educational program fees from Novartis Canada and is an author of a reference cited in this topic. SV has received fees for lecturing and attending a symposium and is an author of a reference cited in this topic.
Robert D. Murray, MBBS, BSc, FRCP, MD
Consultant Endocrinologist & Honorary Senior Lecturer
Department of Endocrinology
Leeds Centre for Diabetes & Endocrinology
Leeds Teaching Hospitals NHS Trust
St James’s University Hospital
RDM declares that he has no competing interests.
Shlomo Melmed, MD
Senior Vice President and Dean
Cedars Sinai Medical Center
SM has research grants of over 6 figures USD. SM is an author of a number of references cited in this topic.
Laurence Kennedy, MD, FRCP
Professor and Chief
Department of Endocrinology, Diabetes and Metabolism
LK declares that he has no competing interests.
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