Last reviewed: 1 Sep 2020
Last updated: 19 Apr 2018



History and exam

Key diagnostic factors

  • coarsening of facial features
  • soft-tissue and skin changes
  • carpal tunnel syndrome
  • joint pain and dysfunction
  • snoring
  • alterations in sexual functioning
  • history or family history of inherited syndrome

Other diagnostic factors

  • fatigue
  • hypertension, arrhythmias
  • organomegaly
  • increased appetite, polyuria/polydipsia
  • headaches
  • visual field defects
  • signs and symptoms of hypopituitarism
  • cranial nerve palsies (e.g., ophthalmoplegia)

Risk factors

  • GPR101 over-expression
  • multiple endocrine neoplasia type 1 syndrome
  • isolated familial acromegaly
  • McCune-Albright's syndrome
  • Carney's complex

Diagnostic investigations

1st investigations to order

  • serum insulin-like growth factor 1 (IGF-1)
  • oral glucose tolerance test (OGTT)
  • random serum growth hormone (GH)
More 1st investigations to order

Investigations to consider

  • pituitary MRI or CT scan
  • GH-releasing hormone
  • chest and/or abdominal CT scanning
  • total body scintigraphy with radio-labelled somatostatin analogue (octreoscan)
  • PET scan with radio-labelled somatostatin analogue (Gallium-68 DOTATATE) 
  • plasma cortisol
  • prolactin
  • thyroid-stimulating hormone (TSH) and free T4
  • estradiol or testosterone
  • visual field testing
More investigations to consider

Treatment algorithm


Professor of Medicine (Endocrinology) and Neurological Surgery


Pituitary Center

Oregon Health & Science University




MF declares that she receives research funding (paid to Oregon Health & Science University) as well as scientific consulting fees from Chiasma, Novartis, and Pfizer; she receives scientific consulting fees from Ipsen and Ionis.

Professor Fleseriu would like to gratefully acknowledge Professor Ariel Barkan, Dr Omar Serri and Dr Sophie Vallette, previous contributors to this topic. AB has received lecturing fees and research support from Novartis and Ipsen and is an author of several references cited in this topic. OS has received lecturing and educational program fees from Novartis Canada and is an author of a reference cited in this topic. SV has received fees for lecturing and attending a symposium and is an author of a reference cited in this topic.

Peer reviewersVIEW ALL

Consultant Endocrinologist & Honorary Senior Lecturer

Department of Endocrinology

Leeds Centre for Diabetes & Endocrinology

Leeds Teaching Hospitals NHS Trust

St James’s University Hospital




RDM declares that he has no competing interests.

Senior Vice President and Dean

Cedars Sinai Medical Center

Los Angeles



SM has research grants of over 6 figures USD. SM is an author of a number of references cited in this topic.

Professor and Chief


Department of Endocrinology, Diabetes and Metabolism

Cleveland Clinic




LK declares that he has no competing interests.

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