Hypopituitarism is relatively rare, with a prevalence of 45 cases per 100,000 and an incidence of about 4 cases per 100,000 per year in the normal population. In contrast, the prevalence of pituitary adenomas/incidentalomas found at autopsy or on imaging studies is relatively high - up to 27% of post-mortem studies and 10% of magnetic resonance imaging studies. There are no specific sex, ethnic, geographical, or age group trends in the incidence or prevalence of the most frequent aetiologies of hypopituitarism. Hypopituitarism has been associated with a 1.8-fold higher mortality compared with an age- and sex-matched population. Cardiovascular and cerebrovascular death rates are higher in patients with hypopituitarism compared with the normal population. Growth hormone deficiency is most probably responsible for this increased mortality from cardiovascular disease. Hypopituitarism as a consequence of traumatic brain injury is increasingly being recognised.
BMJ Best Practice is an evidence-based point of care tool for healthcare practitioners.
To continue reading and access all of BMJ Best Practice's pages you'll need to log in or start a free trial.
You can access through your institution if your hospital, university, trust or other institution provides access to BMJ Best Practice through either OpenAthens or Shibboleth.
Use of this content is subject to our disclaimer