Patient presentation can be very helpful in determining if symptoms are consistent with Creutzfeldt-Jakob disease (CJD) or if they can be attributed to another condition. An exclusionary approach should be used when diagnosing patients, although brain diffusion-weighted imaging (DWI) and attenuated diffusion coefficient map (ADC) MRI findings have high diagnostic utility. Real-time quaking-induced conversion (RT-QuIC) of the CSF also has high diagnostic value.
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