Approach

Patient presentation can be very helpful in determining if symptoms are consistent with Creutzfeldt-Jakob disease (CJD) or if they can be attributed to another condition. An exclusionary approach should be used when diagnosing patients, although brain diffusion-weighted imaging (DWI) and attenuated diffusion coefficient map (ADC) MRI findings have high diagnostic utility.[63][64][65] Real-time quaking-induced conversion (RT-QuIC) of the CSF also has high diagnostic value.[66]

com.bmj.content.model.Caption@5b80f8f0[Figure caption and citation for the preceding image starts]: Outline of evaluation for non-Creutzfeldt-Jakob rapidly progressive dementias work-upMemory and Aging Center, University of California, San Francisco, CA [Citation ends].

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