Last reviewed:December 2019
Last updated:October  2019

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • history of recurrent or severe bleeding
  • bleeding into muscles
  • prolonged bleeding following heel prick or circumcision
  • mucocutaneous bleeding
  • haemarthrosis
  • intracranial bleeding

Other diagnostic factors

  • excessive bruising/haematoma
  • fatigue
  • menorrhagia and bleeding following surgical procedures or childbirth (female carriers)
  • extensive cutaneous purpura (acquired haemophilia)
  • gastrointestinal bleeding and haematuria
  • distended and painful abdomen
  • pallor, tachycardia, tachypnoea, or hypotension

Risk factors

  • family history of haemophilia (congenital haemophilia)
  • male sex (congenital haemophilia)
  • age >60 years (acquired haemophilia)
  • autoimmune disorders, inflammatory bowel disease, diabetes, hepatitis, pregnancy, postnatal, or malignancy (acquired haemophilia)

Diagnostic investigations

Treatment algorithm

Contributors

Clinical Professor

Departments of Medicine, Pediatrics and Oncology

Cumming School of Medicine

University of Calgary

Calgary

Canada

Disclosures

M-CP has been an ad hoc speaker for Bayer, Novo Nordisk, and Pfizer; attended advisory board meetings of Biogen Idec, Baxalta/Shire, CSL Behring, Novo Nordisk, Octapharma, Pfizer, and Roche; received grant funding from CSL Behring and Bayer; and undertaken contract research for Novo Nordisk.

Clinical Assistant Professor

Department of Medicine

Cumming School of Medicine

University of Calgary

Calgary

Canada

Disclosures

AL declares that she has no competing interests.

Professor Poon and Dr Lee would like to gratefully acknowledge Dr Nigel S. Key, Dr Paul Giangrande, Dr Nidra I. Rodriguez, and Dr W. Keith Hoots, the previous contributors to this topic.

Peer reviewersVIEW ALL

The Mary Weinfeld Professor of Clinical Research in Hemophilia

Mount Sinai School of Medicine

New York

NY

Disclosures

LA declares that he has no competing interests.

Associate Professor of Medicine

Innsbruck Medical University

Innsbruck

Austria

Disclosures

CP declares that he has no competing interests.

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