References
Key articles
Hwang JH, Fisher DA, Ben-Menachem T, et al. The role of endoscopy in the management of acute non-variceal upper GI bleeding. Gastrointest Endosc. 2012 Jun;75(6):1132-8.Full text Abstract
Barkun AN, Almadi M, Kuipers EJ, et al. Management of nonvariceal upper gastrointestinal bleeding: guideline recommendations from the International Consensus Group. Ann Intern Med. 2019 Dec 3;171(11):805-22.Full text Abstract
Gralnek IM, Stanley AJ, Morris AJ, et al. Endoscopic diagnosis and management of nonvariceal upper gastrointestinal hemorrhage (NVUGIH): European Society of Gastrointestinal Endoscopy (ESGE) guideline - update 2021. Endoscopy. 2021 Mar;53(3):300-32.Full text Abstract
Laine L, Barkun AN, Saltzman JR, et al. ACG clinical guideline: upper gastrointestinal and ulcer bleeding. Am J Gastroenterol. 2021 May 1;116(5):899-917.Full text Abstract
American College of Radiology. ACR appropriateness criteria®: nonvariceal upper gastrointestinal bleeding. 2024 [internet publication].Full text
Reference articles
1. Wilcox CM, Alexander LN, Cotsonis G. A prospective characterization of upper gastrointestinal hemorrhage presenting with hematochezia. Am J Gastroenterol. 1997 Feb;92(2):231-5. Abstract
2. Hwang JH, Fisher DA, Ben-Menachem T, et al. The role of endoscopy in the management of acute non-variceal upper GI bleeding. Gastrointest Endosc. 2012 Jun;75(6):1132-8.Full text Abstract
3. Abougergi MS, Travis AC, Saltzman JR. The in-hospital mortality rate for upper GI hemorrhage has decreased over 2 decades in the United States: a nationwide analysis. Gastrointest Endosc. 2014 Dec 5;81(4):882-8.e1. Abstract
4. Rosenstock SJ, Møller MH, Larsson H, et al. Improving quality of care in peptic ulcer bleeding: nationwide cohort study of 13,498 consecutive patients in the Danish Clinical Register of Emergency Surgery. Am J Gastroenterol. 2013 Sep;108(9):1449-57. Abstract
5. Jairath V, Desborough MJ. Modern-day management of upper gastrointestinal haemorrhage. Transfus Med. 2015 Dec 28;25(6):351-7. Abstract
6. Siau K, Chapman W, Sharma N, et al. Management of acute upper gastrointestinal bleeding: an update for the general physician. J R Coll Physicians Edinb. 2017 Sep;47(3):218-30.Full text Abstract
7. Hearnshaw SA, Logan RF, Lowe D, et al. Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit. Gut. 2011 Oct;60(10):1327-35. Abstract
8. Barkun AN, Almadi M, Kuipers EJ, et al. Management of nonvariceal upper gastrointestinal bleeding: guideline recommendations from the International Consensus Group. Ann Intern Med. 2019 Dec 3;171(11):805-22.Full text Abstract
9. National Institute for Health and Care Excellence. Acute upper gastrointestinal bleeding in over 16s: management. Aug 2016 [internet publication].Full text
10. Gralnek IM, Stanley AJ, Morris AJ, et al. Endoscopic diagnosis and management of nonvariceal upper gastrointestinal hemorrhage (NVUGIH): European Society of Gastrointestinal Endoscopy (ESGE) guideline - update 2021. Endoscopy. 2021 Mar;53(3):300-32.Full text Abstract
11. Fujishiro M, Iguchi M, Kakushima N, et al; Japan Gastroenterological Endoscopy Society (JGES). Guidelines for endoscopic management of non-variceal upper gastrointestinal bleeding. Dig Endosc. 2016 May;28(4):363-78.Full text Abstract
12. Bai Y, Li ZS. Guidelines for the diagnosis and treatment of acute non-variceal upper gastrointestinal bleeding (2015, Nanchang, China). J Dig Dis. 2016 Feb;17(2):79-87. Abstract
13. Rockall TA, Logan RF, Devlin HB, et al. Risk assessment after acute upper gastrointestinal haemorrhage. Gut. 1996 Mar;38(3):316-21.Full text Abstract
14. Tham TC, James C, Kelly M. Predicting outcome of acute non-variceal upper gastrointestinal haemorrhage without endoscopy using the clinical Rockall Score. Postgrad Med J. 2006 Nov;82(973):757-9.Full text Abstract
15. Srirajaskanthan R, Conn R, Bulwer C, et al. The Glasgow Blatchford scoring system enables accurate risk stratification of patients with upper gastrointestinal haemorrhage. Int J Clin Pract. 2010 Jun;64(7):868-74. Abstract
16. Masaoka T, Suzuki H, Hori S, et al. Blatchford scoring system is a useful scoring system for detecting patients with upper gastrointestinal bleeding who do not need endoscopic intervention. J Gastroenterol Hepatol. 2007 Sep;22(9):1404-8. Abstract
17. Sung JJ, Chiu PW, Chan FKL, et al. Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: an update 2018. Gut. 2018 Apr 24;67(10):1757-68. [Erratum in: Gut. 2019 Feb;68(2):380.]Full text Abstract
18. Yaka E, Yılmaz S, Doğan NÖ, et al. Comparison of the Glasgow-Blatchford and AIMS65 scoring systems for risk stratification in upper gastrointestinal bleeding in the emergency department. Acad Emerg Med. 2015 Jan;22(1):22-30.Full text Abstract
19. Laursen SB, Oakland K, Laine L, et al. ABC score: a new risk score that accurately predicts mortality in acute upper and lower gastrointestinal bleeding: an international multicentre study. Gut. 2021 Apr;70(4):707-16. Abstract
20. Gralnek IM, Camus Duboc M, Garcia-Pagan JC, et al. Endoscopic diagnosis and management of esophagogastric variceal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) guideline. Endoscopy. 2022 Nov;54(11):1094-120.Full text Abstract
21. Semler MW, Self WH, Wanderer JP, et al. Balanced crystalloids versus saline in critically ill adults. N Engl J Med. 2018 Mar 1;378(9):829-39.Full text Abstract
22. Simundic AM, Bölenius K, Cadamuro J, et al. Joint EFLM-COLABIOCLI recommendation for venous blood sampling. Clin Chem Lab Med 2018;56(12):2015-38. Abstract
23. Stanworth SJ, Dowling K, Curry N, et al. Haematological management of major haemorrhage: a British Society for Haematology Guideline. Br J Haematol. 2022 Aug;198(4):654-67.Full text Abstract
24. Carson JL, Stanworth SJ, Dennis JA, et al. Transfusion thresholds for guiding red blood cell transfusion. Cochrane Database Syst Rev. 2021 Dec 21;12(12):CD002042.Full text Abstract
25. Razzaghi A, Barkun AN. Platelet transfusion threshold in patients with upper gastrointestinal bleeding: a systematic review. J Clin Gastroenterol. 2012 Jul;46(6):482-6. Abstract
26. Afdhal N, McHutchison J, Brown R, et al. Thrombocytopenia associated with chronic liver disease. J Hepatol. 2008 Jun;48(6):1000-7.Full text Abstract
27. Laine L, Barkun AN, Saltzman JR, et al. ACG clinical guideline: upper gastrointestinal and ulcer bleeding. Am J Gastroenterol. 2021 May 1;116(5):899-917.Full text Abstract
28. Kanno T, Yuan Y, Tse F, et al. Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding. Cochrane Database Syst Rev. 2022 Jan 7;(1):CD005415.Full text Abstract
29. Sung JJ, Chan FK, Lau JY, et al. The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with nonbleeding visible vessels or adherent clots: a randomized comparison. Ann Intern Med. 2003 Aug 19;139(4):237-43. Abstract
30. Khuroo MS, Yattoo GN, Javid G, et al. A comparison of omeprazole and placebo for bleeding peptic ulcer. N Engl J Med. 1997 Apr 10;336(15):1054-8.Full text Abstract
31. Milling TJ, Refaai MA, Sengupta N. Anticoagulant reversal in gastrointestinal bleeding: review of treatment guidelines. Dig Dis Sci. 2021 Nov;66(11):3698-714.Full text Abstract
32. Abraham NS, Barkun AN, Sauer BG, et al. American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of anticoagulants and antiplatelets during acute gastrointestinal bleeding and the periendoscopic period. J Can Assoc Gastroenterol. 2022 Apr;5(2):100-1.Full text Abstract
33. Veitch AM, Radaelli F, Alikhan R, et al. Endoscopy in patients on antiplatelet or anticoagulant therapy: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guideline update. Endoscopy. 2021 Sep;53(9):947-69.Full text Abstract
34. Lee JG, Turnipseed S, Romano PS, et al. Endoscopy-based triage significantly reduces hospitalization rates and costs of treating upper GI bleeding: a randomized controlled trial. Gastrointest Endosc. 1999 Dec;50(6):755-61. Abstract
35. Cipolletta L, Bianco MA, Rotondano G, et al. Outpatient management for low-risk nonvariceal upper GI bleeding: a randomized controlled trial. Gastrointest Endosc. 2002 Jan;55(1):1-5. Abstract
36. Henry Z, Patel K, Patton H, et al. AGA clinical practice update on management of bleeding gastric varices: expert review. Clin Gastroenterol Hepatol. 2021 Jun;19(6):1098-107.e1.Full text Abstract
37. Lau JYW, Yu Y, Tang RSY, et al. Timing of endoscopy for acute upper gastrointestinal bleeding. N Engl J Med. 2020 Apr 2;382(14):1299-308.Full text Abstract
38. Guo CLT, Wong SH, Lau LHS, et al. Timing of endoscopy for acute upper gastrointestinal bleeding: a territory-wide cohort study. Gut. 2022 Aug;71(8):1544-50.Full text Abstract
39. Tarasconi A, Coccolini F, Biffl WL, et al. Perforated and bleeding peptic ulcer: WSES guidelines. World J Emerg Surg. 2020 Jan 7:15:3.Full text Abstract
40. Zhang W, Huang Y, Xiang H, et al. Timing of endoscopy for acute variceal bleeding in patients with cirrhosis (CHESS1905): a nationwide cohort study. Hepatol Commun. 2023 May 4;7(5):e0152.Full text Abstract
41. Mullady DK, Wang AY, Waschke KA. AGA clinical practice update on endoscopic therapies for non-variceal upper gastrointestinal bleeding: expert review. Gastroenterology. 2020 Sep;159(3):1120-8.Full text Abstract
42. Ibrahim M, El-Mikkawy A, Abdel Hamid M, et al. Early application of haemostatic powder added to standard management for oesophagogastric variceal bleeding: a randomised trial. Gut. 2018 May 5;68(5):844-53.Full text Abstract
43. Sinha R, Lockman KA, Church NI, et al. The use of hemostatic spray as an adjunct to conventional hemostatic measures in high-risk nonvariceal upper GI bleeding (with video). Gastrointest Endosc. 2016 Apr 21;84(6):900-6.e3.Full text Abstract
44. Hu ML, Wu KL, Chiu KW, et al. Predictors of rebleeding after initial hemostasis with epinephrine injection in high-risk ulcers. World J Gastroenterol. 2010 Nov 21;16(43):5490-5.Full text Abstract
45. Chan SM, Chiu PW, Teoh AY, et al. Use of the over-the-scope clip for treatment of refractory upper gastrointestinal bleeding: a case series. Endoscopy. 2014 May;46(5):428-31. Abstract
46. Sulz MC, Frei R, Meyenberger C, et al. Routine use of hemospray for gastrointestinal bleeding: prospective two-center experience in Switzerland. Endoscopy. 2014 Jul;46(7):619-24. Abstract
47. Babiuc RD, Purcarea M, Sadagurschi R, et al. Use of Hemospray in the treatment of patients with acute UGIB - short review. J Med Life. 2013 Jun 15;6(2):117-9.Full text Abstract
48. Hussein M, Alzoubaidi D, Lopez MF, et al. Hemostatic spray powder TC-325 in the primary endoscopic treatment of peptic ulcer-related bleeding: multicenter international registry. Endoscopy. 2021 Jan;53(1):36-43. Abstract
49. Hwang JH, Shergill AK, Acosta RD, et al. The role of endoscopy in the management of variceal hemorrhage. Gastrointest Endosc. 2014 Aug;80(2):221-7.Full text Abstract
50. Tripathi D, Stanley AJ, Hayes PC, et al. UK guidelines on the management of variceal haemorrhage in cirrhotic patients. Gut. 2015 Nov;64(11):1680-704.Full text Abstract
51. Eikelboom JW, Connolly SJ, Bosch J, et al. Bleeding and new cancer diagnosis in patients with atherosclerosis. Circulation. 2019 Oct 29;140(18):1451-9.Full text Abstract
52. Jung DH, Huh CW, Kim NJ, et al. Optimal endoscopy timing in patients with acute variceal bleeding: a systematic review and meta-analysis. Sci Rep. 2020 Mar 4;10(1):4046.Full text Abstract
53. Garcia-Tsao G, Abraldes JG, Berzigotti A, et al. Portal hypertensive bleeding in cirrhosis: risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the Study of Liver Diseases. Hepatology. 2017 Jan;65(1):310-35. [Erratum in: Hepatology. 2017 Jul;66(1):304.]Full text Abstract
54. Kaplan DE, Ripoll C, Thiele M, et al. AASLD practice guidance on risk stratification and management of portal hypertension and varices in cirrhosis. Hepatology. 2024 May 1;79(5):1180-211.Full text Abstract
55. Laine L, Jensen DM. Management of patients with ulcer bleeding. Am J Gastroenterol. 2012 Mar;107(3):345-60. Abstract
56. Adão D, Gois AF, Pacheco RL, et al. Erythromycin prior to endoscopy for acute upper gastrointestinal haemorrhage. Cochrane Database Syst Rev. 2023 Feb 1;2(2):CD013176. Abstract
57. Witting MD, Magder L, Heins AE, et al. ED predictors of upper gastrointestinal tract bleeding in patients without hematemesis. Am J Emerg Med. 2006 May;24(3):280-5. Abstract
58. Saers SJ, Scheltinga MR. Primary aortoenteric fistula. Br J Surg. 2005 Feb;92(2):143-52.Full text Abstract
59. Hughes FM, Kavanagh D, Barry M, et al. Aortoenteric fistula: a diagnostic dilemma. Abdom Imaging. 2007 May-Jun;32(3):398-402. Abstract
60. Just KS, Dormann H, Schurig M, et al. The phenotype of adverse drug effects: do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study. Br J Clin Pharmacol. 2020 Nov;86(11):2144-54.Full text Abstract
61. Dore MP, Soro S, Niolu C, et al. Clinical features and natural history of idiopathic peptic ulcers: a retrospective case-control study. Scand J Gastroenterol. 2019 Nov;54(11):1315-21. Abstract
62. Yao TC, Huang YW, Chang SM, et al. Association between oral corticosteroid bursts and severe adverse events: a nationwide population-based cohort study. Ann Intern Med. 2020 Sep 1;173(5):325-30. Abstract
63. Sverdén E, Markar SR, Agreus L, et al. Acute upper gastrointestinal bleeding. BMJ. 2018 Oct 25;363:k4023. Abstract
64. Longstreth GF, Feitelberg SP. Successful outpatient management of acute upper gastrointestinal hemorrhage: use of practice guidelines in a large patient series. Gastrointest Endosc. 1998 Mar;47(3):219-22. Abstract
65. Chak A, Cooper GS, Lloyd LE, et al. Effectiveness of endoscopy in patients admitted to the intensive care unit with upper GI hemorrhage. Gastrointest Endosc. 2001 Jan;53(1):6-13. Abstract
66. American College of Radiology. ACR appropriateness criteria®: nonvariceal upper gastrointestinal bleeding. 2024 [internet publication].Full text
67. Sengupta N, Kastenberg DM, Bruining DH, et al. The role of imaging for GI bleeding: ACG and SAR consensus recommendations. Radiology. 2024 Mar;310(3):e232298.Full text Abstract
68. Junquera F, Quiroga S, Saperas E, et al. Accuracy of helical computed tomographic angiography for the diagnosis of colonic angiodysplasia. Gastroenterology. 2000 Aug;119(2):293-9.Full text Abstract
69. Squillace SJ, Johnson DA, Sanowski RA. The endosonographic appearance of a Dieulafoy's lesion. Am J Gastroenterol. 1994 Feb;89(2):276-7. Abstract
70. Savides TJ, Jensen DM, Cohen J, et al. Severe upper gastrointestinal tumor bleeding: endoscopic findings, treatment, and outcome. Endoscopy. 1996 Feb;28(2):244-8. Abstract
71. Voorhoeve R, Moll FL, de Letter JA, et al. Primary aortoenteric fistula: report of eight new cases and review of the literature. Ann Vasc Surg. 1996 Jan;10(1):40-8. Abstract
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