Acute asthma exacerbation in adults

References

Key articles

Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. Jul 2023 [internet publication].Full text

Cloutier MM, Baptist AP, Teach SJ, et al; Expert Panel Working Group of the National Heart, Lung, and Blood Institute (NHLBI) administered and coordinated National Asthma Education and Prevention Program Coordinating Committee (NAEPPCC). 2020 focused updates to the asthma management guidelines: a report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. J Allergy Clin Immunol. 2020 Dec;146(6):1217-70.Full text  Abstract

British Thoracic Society; Scottish Intercollegiate Guidelines Network. BTS/SIGN British guideline on the management of asthma. Jul 2019 [internet publication].Full text

Reference articles

1. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. Jul 2023 [internet publication].Full text

2. Braman SS. The global burden of asthma. Chest. 2006 Jul;130(1 Suppl):4S-12S. Abstract

3. Krishnan V, Diette GB, Rand CS, et al. Mortality in patients hospitalized for asthma exacerbations in the United States. Am J Respir Crit Care Med. 2006 Sep 15;174(6):633-8. Abstract

4. Johnston NW, Sears MR. Asthma exacerbations. 1: epidemiology. Thorax. 2006 Aug;61(8):722-8.Full text  Abstract

5. Dulek DE, Peebles RS Jr. Viruses and asthma. Biochim Biophys Acta. 2011 Nov;1810(11):1080-90. Abstract

6. Qibin L, Yacan L, Minli J, et al. The impact of PM2.5 on lung function in adults with asthma. Int J Tuberc Lung Dis. 2020 Jun 1;24(6):570-576.Full text  Abstract

7. Nicholson PJ, Cullinan P, Burge PS, et al. Occupational asthma: prevention, identification & management: systematic review & recommendations. Mar 2010 [internet publication].Full text

8. Singh AM, Busse WW. Asthma exacerbations. 2: aetiology. Thorax. 2006 Sep;61(9):809-16.Full text  Abstract

9. Wark PA, Gibson PG. Asthma exacerbations. 3: pathogenesis. Thorax. 2006 Oct;61(10):909-15.Full text  Abstract

10. Carroll NG, Mutavdzic S, James AL. Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma. Thorax. 2002 Aug;57(8):677-82. Abstract

11. Wood LG, Garg ML, Blake RJ, et al. Airway and circulating levels of carotenoids in asthma and healthy controls. J Am Coll Nutr. 2005 Dec;24(6):448-55. Abstract

12. Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbations of asthma in adults. BMJ. 1993 Oct 16;307(6910):982-6. Abstract

13. Haselkorn T, Fish JE, Zeiger RS, et al; TENOR Study Group. Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. J Allergy Clin Immunol. 2009 Nov;124(5):895-902;e1-4.Full text  Abstract

14. Patel M, Pilcher J, Reddel HK, et al. Metrics of salbutamol use as predictors of future adverse outcomes in asthma. Clin Exp Allergy. 2013 Oct;43(10):1144-51. Abstract

15. Suissa S, Ernst P, Boivin JF, et al. A cohort analysis of excess mortality in asthma and the use of inhaled beta-agonists. Am J Respir Crit Care Med. 1994 Mar;149(3 pt 1):604-10. Abstract

16. Melani AS, Bonavia M, Cilenti V, et al. Inhaler mishandling remains common in real life and is associated with reduced disease control. Respir Med. 2011 Jun;105(6):930-8.Full text  Abstract

17. Osborne ML, Pedula KL, O'Hollaren M, et al. Assessing future need for acute care in adult asthmatics. The Profile of Asthma Risk Study: a prospective health maintenance organization-based study. Chest. 2007 Oct;132(4):1151-61. Abstract

18. Denlinger LC, Phillips BR, Ramratnam S, et al; National Heart, Lung, and Blood Institute's Severe Asthma Research Program-3 Investigators. Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations. Am J Respir Crit Care Med. 2017 Feb 1;195(3):302-13.Full text  Abstract

19. Thomson NC, Chaudhuri R, Livingston E. Asthma and cigarette smoking. Eur Respir J. 2004 Nov;24(5):822-33. Abstract

20. Wills TA, Soneji SS, Choi K, et al. E-cigarette use and respiratory disorders: an integrative review of converging evidence from epidemiological and laboratory studies. Eur Respir J. 2021 Jan 21;57(1):1901815.Full text  Abstract

21. Cho JH, Paik SY. Association between electronic cigarette use and asthma among high school students in South Korea. PLoS One. 2016;11(3):e0151022.Full text  Abstract

22. Bernstein JA, Alexis N, Barnes C, et al. Health effects of air pollution. J Allergy Clin Immunol. 2004 Nov;114(5):1116-23. Abstract

23. Orellano P, Quaranta N, Reynoso J, et al. Effect of outdoor air pollution on asthma exacerbations in children and adults: systematic review and multilevel meta-analysis. PLoS One. 2017 Mar 20;12(3):e0174050.Full text  Abstract

24. Zheng XY, Ding H, Jiang LN, et al. Association between air pollutants and asthma emergency room visits and hospital admissions in time series studies: a systematic review and meta-analysis. PLoS One. 2015;10(9):e0138146.Full text  Abstract

25. Mazenq J, Dubus JC, Gaudart J, et al. City housing atmospheric pollutant impact on emergency visit for asthma: a classification and regression tree approach. Respir Med. 2017 Nov;132:1-8.Full text  Abstract

26. World Health Organization. WHO guidelines for indoor air quality: dampness and mould. 2009 [internet publication].Full text

27. Park HJ, Lee HY, Suh CH, et al. The effect of particulate matter reduction by indoor air filter use on respiratory symptoms and lung function: a systematic review and meta-analysis. Allergy Asthma Immunol Res. 2021 Sep;13(5):719-32.Full text  Abstract

28. Peters U, Dixon AE, Forno E. Obesity and asthma. J Allergy Clin Immunol. 2018 Apr;141(4):1169-79.Full text  Abstract

29. Martinez FD, Wright AL, Taussig LM, et al; The Group Health Medical Associates. Asthma and wheezing in the first six years of life. N Engl J Med. 1995 Jan 19;332(3):133-8.Full text  Abstract

30. Miller MK, Lee JH, Miller DP, et al. Recent asthma exacerbations: a key predictor of future exacerbations. Respir Med. 2007 Mar;101(3):481-9.Full text  Abstract

31. Murphy VE, Clifton VL, Gibson PG. Asthma exacerbations during pregnancy: incidence and association with adverse pregnancy outcomes. Thorax. 2006 Feb;61(2):169-76.Full text  Abstract

32. Sturdy PM, Victor CR, Anderson HR, et al. Psychological, social and health behaviour risk factors for deaths certified as asthma: a national case-control study. Thorax. 2002 Dec;57(12):1034-9.Full text  Abstract

33. Biscardi S, Lorrot M, Marc E, et al. Mycoplasma pneumoniae and asthma in children. Clin Infect Dis. 2004 May 15;38(10):1341-6.Full text  Abstract

34. Cunningham AF, Johnston SL, Julious SA, et al. Chronic Chlamydia pneumoniae infection and asthma exacerbations in children. Eur Respir J. 1998 Feb;11(2):345-9. Abstract

35. Miyashita N, Kubota Y, Nakajima M, et al. Chlamydia pneumoniae and exacerbations of asthma in adults. Ann Allergy Asthma Immunol. 1998 May;80(5):405-9. Abstract

36. Emre U, Sokolovskaya N, Roblin PM, et al. Detection of anti-Chlamydia pneumoniae IgE in children with reactive airway disease. J Infect Dis. 1995 Jul;172(1):265-7. Abstract

37. Chauhan BF, Jeyaraman MM, Singh Mann A, et al. Addition of anti-leukotriene agents to inhaled corticosteroids for adults and adolescents with persistent asthma. Cochrane Database Syst Rev. 2017 Mar 16;(3):CD010347.Full text  Abstract

38. FitzGerald J M, Gibson PG. Asthma exacerbations. 4: prevention. Thorax. 2006 Nov;61(11):992-9.Full text  Abstract

39. Cloutier MM, Baptist AP, Teach SJ, et al; Expert Panel Working Group of the National Heart, Lung, and Blood Institute (NHLBI) administered and coordinated National Asthma Education and Prevention Program Coordinating Committee (NAEPPCC). 2020 focused updates to the asthma management guidelines: a report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. J Allergy Clin Immunol. 2020 Dec;146(6):1217-70.Full text  Abstract

40. Ring N, Malcolm C, Wyke S, et al. Promoting the use of personal asthma action plans: a systematic review. Prim Care Respir J. 2007 Oct;16(5):271-83.Full text  Abstract

41. Cassim R, Russell MA, Lodge CJ, et al. The role of circulating 25 hydroxyvitamin D in asthma: a systematic review. Allergy. 2015 Apr;70(4):339-54.Full text  Abstract

42. Jolliffe DA, Greenberg L, Hooper RL, et al. Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data. Lancet Respir Med. 2017 Nov;5(11):881-90. Abstract

43. Martineau AR, Cates CJ, Urashima M, et al. Vitamin D for the management of asthma. Cochrane Database Syst Rev. 2016 Sep 5;(9):CD011511.Full text  Abstract

44. Ford ES, Mannino DM, Williams SG. Asthma and influenza vaccination: findings from the 1999-2001 National Health Interview Surveys. Chest. 2003 Sep;124(3):783-9. Abstract

45. Moreira A, Bonini M, Garcia-Larsen V, et al. Weight loss interventions in asthma: EAACI evidence-based clinical practice guideline (part I). Allergy. 2013 Apr;68(4):425-39. Abstract

46. British Thoracic Society; Scottish Intercollegiate Guidelines Network. BTS/SIGN British guideline on the management of asthma. Jul 2019 [internet publication].Full text

47. British Thoracic Society and Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. July 2019 [internet publication].Full text

48. McFadden ER Jr, Gilbert IA. Exercise-induced asthma. N Engl J Med. 1994 May 12;330(19):1362-7. Abstract

49. Parsons JP, Mastronarde JG. Exercise-induced bronchoconstriction in athletes. Chest. 2005 Dec;128(6):3966-74. Abstract

50. McCullough PA, Nowak RM, McCord J, et al. B-type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure: analysis from Breathing Not Properly (BNP) Multinational Study. Circulation. 2002 Jul 23;106(4):416-22. Abstract

51. Greenberger PA. Clinical aspects of allergic bronchopulmonary aspergillosis. Front Biosci. 2003 Jan 1;8:s119-27. Abstract

52. Jolly AT, Klees JE, Pacheco KA, et al. Work-related asthma. J Occup Environ Med. 2015 Oct;57(10):e121-9.Full text  Abstract

53. National Heart, Lung, and Blood Institute. National Asthma Education and Prevention Program expert panel report 3: guidelines for the diagnosis and management of asthma. Jul 2007 [internet publication].Full text

54. Holguin F, Cardet JC, Chung KF, et al. Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2020 Jan;55(1):1900588.Full text  Abstract

55. Nakamura Y, Tamaoki J, Nagase H, et al; Japanese Society of Allergology. Japanese guidelines for adult asthma 2020. Allergol Int. 2020 Oct;69(4):519-48.Full text  Abstract

56. Hasegawa K, Craig SS, Teach SJ, et al. Management of asthma exacerbations in the emergency department. J Allergy Clin Immunol Pract. 2021 Jul;9(7):2599-610. Abstract

57. Zaidan MF, Ameredes BT, Calhoun WJ. Management of acute asthma in adults in 2020. JAMA. 2020 Feb 11;323(6):563-4. Abstract

58. Cates CJ, Welsh EJ, Rowe BH. Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma. Cochrane Database Syst Rev. 2013 Sep 13;(9):CD000052.Full text  Abstract

59. Centers for Disease Control and Prevention. Clinical questions about COVID-19: questions and answers - patients with asthma. Sept 2022 [internet publication].Full text

60. Goldstein KM, Ghadimi K, Mystakelis H, et al. Risk of transmitting coronavirus disease 2019 during nebulizer treatment: a systematic review. J Aerosol Med Pulm Drug Deliv. 2021 Jun;34(3):155-70.Full text  Abstract

61. Colebourn CL, Barber V, Young JD. Use of helium-oxygen mixture in adult patients presenting with exacerbations of asthma and chronic obstructive pulmonary disease: a systematic review. Anaesthesia. 2007 Jan;62(1):34-42. Abstract

62. Rodrigo G, Pollack C, Rodrigo C, et al. Heliox for nonintubated acute asthma patients. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD002884.Full text  Abstract

63. Soar J, Böttiger BW, Carli P, et al. European Resuscitation Council guidelines 2021: adult advanced life support. Resuscitation. 2021 Apr;161:115-51.Full text  Abstract

64. Colquhoun MC, Handley AJ, Evans TR. ABC of resuscitation. 5th ed. London: BMJ Publishing Group; 2004.

65. Chrimes N, Higgs A, Hagberg CA, et al. Preventing unrecognised oesophageal intubation: a consensus guideline from the Project for Universal Management of Airways and international airway societies. Anaesthesia. 2022 Dec;77(12):1395-415.Full text  Abstract

66. Rodrigo GJ, Nannini LJ. Comparison between nebulized adrenaline and beta2 agonists for the treatment of acute asthma: a meta-analysis of randomized trials. Am J Emerg Med. 2006 Mar;24(2):217-22. Abstract

67. Kirkland SW, Vandenberghe C, Voaklander B, et al. Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma. Cochrane Database Syst Rev. 2017 Jan 11;(1):CD001284.Full text  Abstract

68. Rowe BH, Bretzlaff JA, Bourdon C, et al. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database Syst Rev. 2000 Jan 24;(2):CD001490.Full text  Abstract

69. Skobeloff EM, Spivey WH, McNamara RM, et al. Intravenous magnesium sulfate for the treatment of acute asthma in the emergency department. JAMA. 1989 Sep 1;262(9):1210-3. Abstract

70. Kew KM, Kirtchuk L, Michell CI. Intravenous magnesium sulfate for treating adults with acute asthma in the emergency department. Cochrane Database Syst Rev. 2014 May 28;(5):CD010909.Full text  Abstract

71. Edmonds ML, Milan SJ, Camargo CA Jr, et al. Early use of inhaled corticosteroids in the emergency department treatment of acute asthma. Cochrane Database Syst Rev. 2012 Dec 12;(12):CD002308.Full text  Abstract

72. Kravitz J, Dominici P, Ufberg J, et al. Two days of dexamethasone versus 5 days of prednisone in the treatment of acute asthma: a randomized controlled trial. Ann Emerg Med. 2011 Aug;58(2):200-4. Abstract

73. Normansell R, Sayer B, Waterson S, et al. Antibiotics for exacerbations of asthma. Cochrane Database Syst Rev. 2018 Jun 25;(6):CD002741.Full text  Abstract

74. Stefan MS, Shieh MS, Spitzer KA, et al. Association of antibiotic treatment with outcomes in patients hospitalized for an asthma exacerbation treated with systemic corticosteroids. JAMA Intern Med. 2019 Mar 1;179(3):333-9.Full text  Abstract

75. Petsky HL, Li A, Chang AB. Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults. Cochrane Database Syst Rev. 2017 Aug 24;(8):CD005603.Full text  Abstract

76. Petsky HL, Kew KM, Turner C, Chang AB. Exhaled nitric oxide levels to guide treatment for adults with asthma. Cochrane Database Syst Rev. 2016 Sep 1;(9):CD011440.Full text  Abstract

77. Rodrigo G, Rodrigo C, Burschtin O. A meta-analysis of the effects of ipratropium bromide in adults with acute asthma. Am J Med. 1999 Oct;107(4):363-70. Abstract

78. Rodrigo GJ, Rodrigo C. First-line therapy for adult patients with acute asthma receiving a multiple-dose protocol of ipratropium bromide plus albuterol in the emergency department. Am J Respir Crit Care Med. 2000 Jun;161(6):1862-8. Abstract

79. Lanes SF, Garrett JE, Wentworth CE 3rd, et al. The effect of adding ipratropium bromide to salbutamol in the treatment of acute asthma: a pooled analysis of three trials. Chest. 1998 Aug;114(2):365-72. Abstract

80. Plotnick LH, Ducharme FM. Should inhaled anticholinergics be added to beta2 agonists for treating acute childhood and adolescent asthma? A systematic review. BMJ. 1998 Oct 10;317(7164):971-7. Abstract

81. Currie GP, Devereux GS, Lee DK, et al. Recent developments in asthma management. BMJ. 2005 Mar 12;330(7491):585-9. Abstract

82. Rodrigo GJ. Rapid effects of inhaled corticosteroids in acute asthma: an evidence-based evaluation. Chest. 2006 Nov;130(5):1301-11. Abstract

83. Rodrigo GJ, Castro-Rodriguez JA. Safety of long-acting beta agonists for the treatment of asthma: clearing the air. Thorax. 2012 Apr;67(4):342-9. Abstract

84. Papi A, Mansur AH, Pertseva T, et al. Long-term fluticasone propionate/formoterol fumarate combination therapy is associated with a low incidence of severe asthma exacerbations. J Aerosol Med Pulm Drug Deliv. 2016 Aug;29(4):346-61.Full text  Abstract

85. Balanag VM, Yunus F, Yang PC, et al. Efficacy and safety of budesonide/formoterol compared with salbutamol in the treatment of acute asthma. Pulm Pharmacol Ther. 2006;19(2):139-47. Abstract

86. Rodrigo GJ, Neffen H, Colodenco FD, et al. Formoterol for acute asthma in the emergency department: a systematic review with meta-analysis. Ann Allergy Asthma Immunol. 2010 Mar;104(3):247-52. Abstract

87. Watts K, Chavasse RJ. Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children. Cochrane Database Syst Rev. 2012 May 16;(5):CD006100. Abstract

88. Camargo CA Jr, Smithline HA, Malice MP, et al. A randomized controlled trial of intravenous montelukast in acute asthma. Am J Respir Crit Care Med. 2003 Feb 15;167(4):528-33.Full text  Abstract

89. Chan WW, Chiou E, Obstein KL, et al. The efficacy of proton pump inhibitors for the treatment of asthma in adults: a meta-analysis. Arch Intern Med. 2011 Apr 11;171(7):620-9.Full text  Abstract

90. Panchal AR, Bartos JA, Cabañas JG, et al. Part 3: adult basic and advanced life support: 2020 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2020 Oct 20;142(16_suppl_2):S366-468.Full text  Abstract

91. American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 90: asthma in pregnancy. Feb 2008 [internet publication].Full text

92. FitzGerald JM, Lemiere C, Lougheed MD, et al. Recognition and management of severe asthma: a Canadian Thoracic Society position statement. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 2017;1(4):199-221.Full text

93. Reddel HK, Taylor DR, Bateman ED, et al. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med. 2009 Jul 1;180(1):59-99.Full text  Abstract

94. Lalloo UG, Ainslie GM, Abdool-Gaffar MS, et al; South African Thoracic Society. Guideline for the management of acute asthma in adults: 2013 update. S Afr Med J. 2013 Mar;103(3):189-98.Full text  Abstract

95. Custovic A, Johnston SL, Pavord I, et al. EAACI position statement on asthma exacerbations and severe asthma. Allergy. 2013 Dec;68(12):1520-31.Full text  Abstract

96. National Asthma Council Australia. Australian asthma handbook version 2.2. Apr 2022 [internet publication].Full text

97. O'Byrne PM, Barnes PJ, Rodriguez-Roisin R, et al. Low dose inhaled budesonide and formoterol in mild persistent asthma: the OPTIMA randomized trial. Am J Respir Crit Care Med. 2001 Oct 15;164(8 Pt 1):1392-7. Abstract

98. Suissa S, Ernst, P, Benayoun S, et al. Low-dose inhaled corticosteroids and the prevention of death from asthma. N Engl J Med. 2000 Aug 3;343(5):332-6. Abstract

99. Findley LJ, Sahn SA. The value of chest roentgenograms in acute asthma in adults. Chest. 1981 Nov;80(5):535-6. Abstract

100. McKeever T, Mortimer K, Wilson A, et al. Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations. N Engl J Med. 2018 Mar 8;378(10):902-10.Full text  Abstract

101. Villa-Roel C, Nikel T, Ospina M, et al. Effectiveness of educational interventions to increase primary care follow-up for adults seen in the emergency department for acute asthma: a systematic review and meta-analysis. Acad Emerg Med. 2016 Jan;23(1):5-13. Abstract

102. Tapp S, Lasserson TJ, Rowe B. Education interventions for adults who attend the emergency room for acute asthma. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD003000.Full text  Abstract

103. Loymans RJ, Honkoop PJ, Termeer EH, et al. Identifying patients at risk for severe exacerbations of asthma: development and external validation of a multivariable prediction model. Thorax. 2016 Sep;71(9):838-46. Abstract

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