Last reviewed: September 2018
Last updated: April  2018

Summary

Definition

History and exam

Key diagnostic factors

  • family history of HCM
  • history of pre-syncope or syncope
  • systolic ejection murmur
  • left ventricular lift
  • double apical impulse or double carotid pulsation
  • family history of sudden death

Other diagnostic factors

  • younger male (<50 years)
  • dyspnoea
  • angina
  • palpitations
  • irregularly irregular pulse
  • older female (>50 years)
  • collapse
  • fourth heart sound

Risk factors

  • family history of HCM or sudden cardiac death

Diagnostic investigations

1st investigations to order

  • ECG
  • CXR
  • echocardiography
Full details

Investigations to consider

  • exercise ECG
  • Holter monitoring
  • nuclear imaging exercise test
  • CT coronary arteriography
  • cardiac catheterisation
  • cardiac MRI
  • genetic mutation analysis
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Assistant Professor of Medicine

Division of Cardiology

Johns Hopkins University School of Medicine

Baltimore

MD

Disclosures

MM declares that she has no competing interests.

Professor of Medicine and Radiology

Director

Johns Hopkins Hypertrophic Cardiomyopathy Center of Excellence

Johns Hopkins Hospital

Baltimore

MD

Disclosures

TA declares that he has no competing interests.

Dr Monica Mukherjee and Dr Theodore Abraham would like to gratefully acknowledge Dr Melanie D. Everitt and Dr Anji T. Yetman, previous contributors to this topic.

Peer reviewers VIEW ALL

Fellow

Division of Cardiology

University of Maryland Medical Center

Baltimore

MD

Disclosures

RK declares that she has no competing interests.

Consultant Cardiologist/Head of Unit

Heart Muscle Disease Unit

Barts and The London NHS Trust

London

UK

Disclosures

SM declares that he has no competing interests.

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