Summary
Definition
History and exam
Key diagnostic factors
- family history of HCM
- history of pre-syncope or syncope
- systolic ejection murmur
- left ventricular lift
- double apical impulse or double carotid pulsation
- family history of sudden death
Other diagnostic factors
- younger male (<50 years)
- dyspnoea
- angina
- palpitations
- irregularly irregular pulse
- older female (>50 years)
- collapse
- fourth heart sound
Diagnostic investigations
Investigations to consider
- exercise ECG
- Holter monitoring
- nuclear imaging exercise test
- CT coronary arteriography
- cardiac catheterisation
- cardiac MRI
- genetic mutation analysis
Treatment algorithm
Contributors
Authors
Monica Mukherjee, MD, MPH
Associate Professor of Medicine
Division of Cardiology
Johns Hopkins University School of Medicine
Baltimore
MD
Disclosures
MM declares that she has no competing interests.
Theodore Abraham, MD
Professor of Medicine and Radiology
Meyer Friedman Distinguished Professor of Medicine
Co-director, UCSF HCM Center of Excellence
University of California
San Francisco
CA
Disclosures
TA declares that he has no competing interests.
Acknowledgements
Dr Monica Mukherjee and Dr Theodore Abraham would like to gratefully acknowledge Dr Melanie D. Everitt and Dr Anji T. Yetman, previous contributors to this topic.
Disclosures
MDE and ATY declare that they have no competing interests.
Peer reviewers
Radhika Kuna, MD
Fellow
Division of Cardiology
University of Maryland Medical Center
Baltimore
MD
Disclosures
RK declares that she has no competing interests.
Saidi Mohiddin, BSc, MBChB
Consultant Cardiologist/Head of Unit
Heart Muscle Disease Unit
Barts and The London NHS Trust
London
UK
Disclosures
SM declares that he has no competing interests.
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