The exact diagnosis of uveitis can be extremely challenging given the vast array of presentations and aetiologies. While clinical examination and laboratory testing are important for the diagnosis of uveitis, making a sound differential diagnosis of the underlying aetiology also requires careful attention to the patient's presentation and history, and to demographic information. Bilaterality is more commonly seen in systemic conditions, whereas idiopathic and herpetic uveitis is more commonly unilateral. The non-granulomatous versus granulomatous nature of the presentation will also help to narrow further the differential diagnosis. Early referral to an ophthalmologist with experience in uveitis is essential.

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