Associated with acute liver failure including cirrhosis.
Diagnosed by excluding other causes of renal failure.
Liver transplantation is the only definitive treatment.
Dialysis and transjugular intrahepatic portosystemic shunts are temporising measures while awaiting liver transplantation.
The vasopressin analogue terlipressin is very effective at reversing the condition in some patients.
General prognosis is poor.
Hepatorenal syndrome (HRS) is the development of renal failure in patients with severe liver disease (acute or chronic) in the absence of any other identifiable cause of renal pathology. 
Associate Professor of Surgery
Michigan State University
JK declares that he has no competing interests.
Professor of Medicine and Cell Biology
Columbia University College of Physicians and Surgeons
HJW declares that he has no competing interests.
Professor of Medicine
University of Connecticut Health Center
GYW is on the medical advisory boards of the following: Gilead Sciences, Bristol-Myers Squibb, AbbVie, and Intercept.
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