Acute otitis media

References

Key articles

Uhari M, Mantysaari K, Niemela M. A meta-analytic review of the risk factors for acute otitis media. Clin Infect Dis. 1996;22:1079-1083. Abstract

Uhari M, Mantysaari K, Niemela M. A meta-analytic review of the risk factors for acute otitis media. Clin Infect Dis. 1996 Jun;22(6):1079-83.Full text  Abstract

Lieberthal AS, Carroll AE, Chonmaitree T, et al. The diagnosis and management of acute otitis media. Pediatrics. 2013 Mar;131(3):e964-99. [Erratum in Pediatrics. 2014 Feb;133(2):346.]Full text  Abstract

Vouloumanou EK, Karageorgopoulos DE, Kazantzi MS, et al. Antibiotics versus placebo or watchful waiting for acute otitis media: a meta-analysis of randomized controlled trials. J Antimicrob Chemother. 2009 Jul;64(1):16-24. Abstract

Lieberthal AS, Carroll AE, Chonmaitree T, et al. The diagnosis and management of acute otitis media. Pediatrics. 2013 Mar;131(3):e964-99. [Erratum in: Pediatrics. 2014 Feb;133(2):346.]Full text  Abstract

Spiro DM, Tay KY, Arnold DH, et al. Wait-and-see prescription for the treatment of acute otitis media: a randomized controlled trial. JAMA. 2006 Sep 13;296(10):1235-41.Full text  Abstract

Reference articles

1. Teele DW, Klein JO, Rosner B. Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study. J Infect Dis. 1989;160:83-94. Abstract

2. Paradise JL, Rockette HE, Colborn DK, et al. Otitis media in 2253 Pittsburgh-area infants: prevalence and risk factors during the first two years of life. Pediatrics. 1997;99:318-333. Abstract

3. Uhari M, Mantysaari K, Niemela M. A meta-analytic review of the risk factors for acute otitis media. Clin Infect Dis. 1996;22:1079-1083. Abstract

4. Heikkinen T, Thint M, Chonmaitree T. Prevalence of various respiratory viruses in the middle ear during acute otitis media. N Engl J Med. 1999;340:260-264. Abstract

5. Pitkaranta A, Virolainen A, Jero J, et al. Detection of rhinovirus, respiratory syncytial virus, and coronavirus infections in acute otitis media by reverse transcriptase polymerase chain reaction. Pediatrics. 1998;102:291-295. Abstract

6. Sanyal MA, Henderson FW, Stempel EC, et al. Effect of upper respiratory tract infection on eustachian tube ventilatory function in the preschool child. J Pediatr. 1980;97:11-15. Abstract

7. Winther B, Hayden FG, Arruda E, et al. Viral respiratory infection in schoolchildren: effects on middle ear pressure. Pediatrics. 2002;109:826-832. Abstract

8. Gehanno P, Lenoir G, Barry B, et al. Evaluation of nasopharyngeal cultures for bacteriologic assessment of acute otitis media in children. Pediatr Infect Dis J. 1996;15:329-332. Abstract

9. Paradise JL, Rockette HE, Colborn DK, et al. Otitis media in 2253 Pittsburgh-area infants: prevalence and risk factors during the first two years of life. Pediatrics. 1997 Mar;99(3):318-33. Abstract

10. Kero P, Piekkala P. Factors affecting the occurrence of acute otitis media during the first year of life. Acta Paediatr Scand. 1987 Jul;76(4):618-23. Abstract

11. Uhari M, Mantysaari K, Niemela M. A meta-analytic review of the risk factors for acute otitis media. Clin Infect Dis. 1996 Jun;22(6):1079-83.Full text  Abstract

12. Teele DW, Klein JO, Rosner B. Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study. J Infect Dis. 1989 Jul;160(1):83-94. Abstract

13. Sanyal MA, Henderson FW, Stempel EC, et al. Effect of upper respiratory tract infection on eustachian tube ventilatory function in the preschool child. J Pediatr. 1980 Jul;97(1):11-5. Abstract

14. Casselbrant ML, Mandel EM, Kurs-Lasky M, et al. Otitis media in a population of black American and white American infants, 0-2 years of age. Int J Pediatr Otorhinolaryngol. 1995 Aug;33(1):1-16. Abstract

15. van Ingen G, le Clercq CMP, Touw CE, et al. Environmental determinants associated with acute otitis media in children: a longitudinal study. Pediatr Res. 2020 Jan;87(1):163-8.Full text  Abstract

16. Casselbrant ML, Mandel EM, Fall PA, et al. The heritability of otitis media: a twin and triplet study. JAMA. 1999 Dec 8;282(22):2125-30.Full text  Abstract

17. Curns AT, Holman RC, Shay DK, et al. Outpatient and hospital visits associated with otitis media among American Indian and Alaska Native children younger than 5 years. Pediatrics. 2002 Mar;109(3):E41-1.Full text  Abstract

18. Niemela M, Pihakari O, Pokka T, et al. Pacifier as a risk factor for acute otitis media: a randomized, controlled trial of parental counseling. Pediatrics. 2000 Sep;106(3):483-8. Abstract

19. Culpepper L, Froom J, Bartelds AI, et al. Acute otitis media in adults: a report from the International Primary Care Network. J Am Board Fam Pract. 1993 Jul-Aug;6(4):333-9. Abstract

20. Halsted C, Lepow ML, Balassanian H, et al. Otitis media. Clinical observations, microbiology, and evaluation of therapy. Am J Dis Child. 1968 May;115(5):542-51. Abstract

21. Shaikh N, Hoberman A, Rockette HE, et al. Development of an algorithm for the diagnosis of otitis media. Acad Pediatr. 2012 May-Jun;12(3):214-8. Abstract

22. Schwartz RH, Stool SE, Rodriguez WJ, et al. Acute otitis media: toward a more precise definition. Clin Pediatr (Phila). 1981 Sep;20(9):549-54. Abstract

23. Lieberthal AS, Carroll AE, Chonmaitree T, et al. The diagnosis and management of acute otitis media. Pediatrics. 2013 Mar;131(3):e964-99. [Erratum in Pediatrics. 2014 Feb;133(2):346.]Full text  Abstract

24. Arguedas A, Soley C, Kamicker BJ, et al. Single-dose extended-release azithromycin versus a 10-day regimen of amoxicillin/clavulanate for the treatment of children with acute otitis media. Int J Infect Dis. 2011 Apr;15(4):e240-8. Abstract

25. Sjoukes A, Venekamp RP, van de Pol AC, et al. Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. Cochrane Database Syst Rev. 2016 Dec 15;(12):CD011534.Full text  Abstract

26. Chonmaitree T, Saeed K, Uchida T, et al. A randomized, placebo-controlled trial of the effect of antihistamine or corticosteroid treatment in acute otitis media. J Pediatr. 2003 Sep;143(3):377-85. Abstract

27. Hum SW, Shaikh KJ, Musa SS, et al. Adverse events of antibiotics used to treat acute otitis media in children: a systematic meta-analysis. J Pediatr. 2019 Dec;215:139-43;e7. Abstract

28. Mather MW, Drinnan M, Perry JD, et al. A systematic review and meta-analysis of antimicrobial resistance in paediatric acute otitis media. Int J Pediatr Otorhinolaryngol. 2019 Aug;123:102-9. Abstract

29. Vouloumanou EK, Karageorgopoulos DE, Kazantzi MS, et al. Antibiotics versus placebo or watchful waiting for acute otitis media: a meta-analysis of randomized controlled trials. J Antimicrob Chemother. 2009 Jul;64(1):16-24. Abstract

30. Tähtinen PA, Laine MK, Huovinen P, et al. A placebo-controlled trial of antimicrobial treatment for acute otitis media. N Engl J Med. 2011 Jan 13;364(2):116-26.Full text  Abstract

31. Hoberman A, Paradise JL, Rockette HE, et al. Treatment of acute otitis media in children under 2 years of age. N Engl J Med. 2011 Jan 13;364(2):105-15.Full text  Abstract

32. Venekamp RP, Sanders SL, Glasziou PP, et al. Antibiotics for acute otitis media in children. Cochrane Database Syst Rev. 2015 Jun 23;(6):CD000219.Full text  Abstract

33. Lieberthal AS, Carroll AE, Chonmaitree T, et al. The diagnosis and management of acute otitis media. Pediatrics. 2013 Mar;131(3):e964-99. [Erratum in: Pediatrics. 2014 Feb;133(2):346.]Full text  Abstract

34. Rosenfeld RM, Vertrees JE, Carr J, et al. Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials. J Pediatr. 1994 Mar;124(3):355-67. Abstract

35. Courter JD, Baker WL, Nowak KS, et al. Increased clinical failures when treating acute otitis media with macrolides: a meta-analysis. Ann Pharmacother. 2010 Mar;44(3):471-8. Abstract

36. Casey JR, Block SL, Hedrick J, et al. Comparison of amoxicillin/clavulanic acid high dose with cefdinir in the treatment of acute otitis media. Drugs. 2012 Oct 22;72(15):1991-7.Full text  Abstract

37. Cohen R, Levy C, Boucherat M, et al. A multicenter, randomized, double-blind trial of 5 versus 10 days of antibiotic therapy for acute otitis media in young children. J Pediatr. 1998 Nov;133(5):634-9. Abstract

38. Hoberman A, Paradise JL, Rockette HE, et al. Shortened antimicrobial treatment for acute otitis media in young children. N Engl J Med. 2016 Dec 22;375(25):2446-56.Full text  Abstract

39. Little P, Gould C, Williamson I, et al. Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media. BMJ. 2001 Feb 10;322(7282):336-42.Full text  Abstract

40. Spiro DM, Tay KY, Arnold DH, et al. Wait-and-see prescription for the treatment of acute otitis media: a randomized controlled trial. JAMA. 2006 Sep 13;296(10):1235-41.Full text  Abstract

41. Siegel RM, Kiely M, Bien JP, et al. Treatment of otitis media with observation and a safety-net antibiotic prescription. Pediatrics. 2003 Sep;112(3 pt 1):527-31. Abstract

42. Rovers MM, Glasziou P, Appelman CL, et al. Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: a meta-analysis of individual patient data. Pediatrics. 2007 Mar;119(3):579-85. Abstract

43. Tähtinen PA, Laine MK, Ruohola A. Prognostic factors for treatment failure in acute otitis media. Pediatrics. 2017 Sep;140(3):e20170072. Abstract

44. Sun D, McCarthy TJ, Liberman DB. Cost-effectiveness of watchful waiting in acute otitis media. Pediatrics. 2017 Apr;139(4):e20163086.Full text  Abstract

45. Bluestone CD. Role of surgery for otitis media in the era of resistant bacteria. Pediatr Infect Dis J. 1998 Nov;17(11):1090-8. Abstract

46. Block SL. Tympanocentesis: why, when and how. Contemp Pediatr. 1999;16:103-27.

47. Bertin L, Pons G, d'Athis P, et al. A randomized, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children. Fundam Clin Pharmacol. 1996;10(4):387-92. Abstract

48. US Food and Drug Administration. FDA news release: FDA takes action against unapproved prescription ear drop products. July 2015 [internet publication].Full text

49. Scott AM, Clark J, Julien B, et al. Probiotics for preventing acute otitis media in children. Cochrane Database Syst Rev. 2019 Jun 18;6:CD012941.Full text  Abstract

50. Marchisio P, Santagati M, Scillato M, et al. Streptococcus salivarius 24SMB administered by nasal spray for the prevention of acute otitis media in otitis-prone children. Eur J Clin Microbiol Infect Dis. 2015 Dec;34(12):2377-83. Abstract

51. Bluestone CD. Clinical course, complications and sequelae of acute otitis media. Pediatr Infect Dis J. 2000 May;19(5 suppl):S37-46. Abstract

52. Koopman L, Hoes AW, Glasziou PP, et al. Antibiotic therapy to prevent the development of asymptomatic middle ear effusion in children with acute otitis media: a meta-analysis of individual patient data. Arch Otolaryngol Head Neck Surg. 2008 Feb;134(2):128-32.Full text  Abstract

53. American Academy of Family Physicians, American Academy of Otolaryngology-Head and Neck Surgery, and American Academy of Pediatrics Subcommittee on Otitis Media With Effusion. Otitis media with effusion. Pediatrics. 2004 May;113(5):1412-29.Full text  Abstract

54. Rault P, Chabrier A, Roy H, et al. Assessment of adherence to at-home oral anti-infective therapy among paediatric patients discharged from a Quebec hospital. Eur J Hosp Pharm. 2021 Apr 29;ejhpharm-2020-002656.Full text  Abstract

55. Bowatte G, Tham R, Allen KJ, et al. Breastfeeding and childhood acute otitis media: a systematic review and meta-analysis. Acta Paediatr. 2015 Dec;104(467):85-95.Full text  Abstract

56. van Ingen G, le Clercq CMP, Touw CE, et al. Environmental determinants associated with acute otitis media in children: a longitudinal study. Pediatr Res. 2020 Jan;87(1):163-168.Full text  Abstract

57. Marchisio P, Bortone B, Ciarcià M, et al. Updated Guidelines for the Management of Acute Otitis Media in Children by the Italian Society of Pediatrics: Prevention. Pediatr Infect Dis J. 2019 Dec;38(12s suppl):S22-S36.Full text  Abstract

58. de Sévaux JL, Venekamp RP, Lutje V, et al. Pneumococcal conjugate vaccines for preventing acute otitis media in children. Cochrane Database Syst Rev. 2020 Nov 24;11:CD001480.Full text  Abstract

59. Pichichero M, Kaur R, Scott DA, et al. Effectiveness of 13-valent pneumococcal conjugate vaccination for protection against acute otitis media caused by Streptococcus pneumoniae in healthy young children: a prospective observational study. Lancet Child Adolesc Health. 2018 Aug;2(8):561-8. Abstract

60. Norhayati MN, Ho JJ, Azman MY. Influenza vaccines for preventing acute otitis media in infants and children. Cochrane Database Syst Rev. 2017 Oct 17;(10):CD010089.Full text  Abstract

61. Winther BB. Impact of oseltamivir treatment on the incidence and course of acute otitis media in children with influenza. Int J Pediatr Otorhinolaryngol. 2010 Jun;74(6):684-8. Abstract

62. Gibbs D. Oseltamivir effective for reducing influenza duration in children. Am Fam Physician. 2010 Nov 1;82(9):1140-1.Full text

63. Tapiainen T, Luotonen L, Kontiokari T, et al. Xylitol administered only during respiratory infections failed to prevent acute otitis media. Pediatrics. 2002 Feb;109(2):E19.Full text  Abstract

64. Hautalahti O, Renko M, Tapiainen T, et al. Failure of xylitol given three times a day for preventing acute otitis media. Pediatr Infect Dis J. 2007 May;26(5):423-7. Abstract

65. Azarpazhooh A, Lawrence HP, Shah PS, et al. Xylitol for preventing acute otitis media in children up to 12 years of age. Cochrane Database Syst Rev. 2016 Aug 3;(8):CD007095.Full text  Abstract

66. Danhauer JL, Johnson CE, Corbin NE, et al. Xylitol as a prophylaxis for acute otitis media: systematic review. Int J Audiol. 2010 Oct;49(10):754-61. Abstract

67. Leach AJ, Morris PS. Antibiotics for the prevention of acute and chronic suppurative otitis media in children. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD004401.Full text  Abstract

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