Autism spectrum disorder

References

Key articles

Levy SE, Mandell DS, Schultz RT. Autism. Lancet. 2009 Nov 7;374(9701):1627-38.Full text  Abstract

Baird G, Simonoff E, Pickles A, et al. Prevalence of disorders of the autistic spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet. 2006 Jul 15;368(9531):210-5. Abstract

Hyman SL, Levy SE, Myers SM, et al. Identification, evaluation, and management of children with autism spectrum disorder. Pediatrics. 2020 Jan;145(1):e20193447.Full text  Abstract

Anagnostou E, Zwaigenbaum L, Szatmari P, et al. Autism spectrum disorder: advances in evidence-based practice. CMAJ. 2014 Apr 15;186(7):509-19. Abstract

National Institute for Health and Care Excellence. Autism spectrum disorder in adults: diagnosis and management. June 2021 [internet publication].Full text

Baird G, Cass H, Slonims V. Diagnosis of autism. BMJ. 2003 Aug 30;327(7413):488-93.Full text  Abstract

Le Couteur A, Haden G, Hammal D, et al. Diagnosing autistic spectrum disorders in pre-school children using two standardised assessment instruments: the ADI-R and the ADOS. J Autism Dev Disord. 2008 Feb;38(2):362-72. Abstract

Parr J. Autism. BMJ Clin Evid. 2010 Jan 7;2010:0322.Full text

National Institute for Health and Care Excellence. Autism spectrum disorder in under 19s: support and management. June 2021 [internet publication].Full text

Reference articles

1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed., text revision (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022.

2. World Health Organization. International Classification of Diseases 11th revision (ICD-11). Chapter 6: mental, behavioural or neurodevelopmental disorders. Jan 2022 [internet publication].Full text

3. Rogers SJ. Developmental regression in autistic spectrum disorders. Ment Retard Dev Disabil Res Rev. 2004;10(2):139-43. Abstract

4. Parr JR, Le Couteur A, Baird G, et al. Early developmental regression in autism spectrum disorder: evidence from an international multiplex sample. J Autism Dev Disord. 2011 Mar;41(3):332-40. Abstract

5. Volkmar FR, Nelson DS. Seizure disorders in autism. J Am Acad Child Adolesc Psychiatry. 1990 Jan;29(1):127-9. Abstract

6. Levy SE, Mandell DS, Schultz RT. Autism. Lancet. 2009 Nov 7;374(9701):1627-38.Full text  Abstract

7. Baird G, Simonoff E, Pickles A, et al. Prevalence of disorders of the autistic spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet. 2006 Jul 15;368(9531):210-5. Abstract

8. Woolfenden S, Sarkozy V, Ridley G, et al. A systematic review of two outcomes in autism spectrum disorder - epilepsy and mortality. Dev Med Child Neurol. 2012 Apr;54(4):306-12.Full text  Abstract

9. Besag FM. Epilepsy in patients with autism: links, risks and treatment challenges. Neuropsychiatr Dis Treat. 2017 Dec 18;14:1-10.Full text  Abstract

10. Maenner MJ, Shaw KA, Bakian AV, et al. Prevalence and characteristics of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 Sites, United States, 2018. MMWR Surveill Summ. 2021 Dec 3;70(11):1-16.Full text  Abstract

11. Maskey M, Warnell F, Parr JR, et al. Emotional and behavioural problems in children with autism spectrum disorder. J Autism Dev Disord. 2013 Apr;43(4):851-9. Abstract

12. National Institute for Health and Care Excellence. Autism spectrum disorder in under 19s: recognition, referral and diagnosis. September 2017 [internet publication].Full text

13. Posar A, Visconti P. Sensory abnormalities in children with autism spectrum disorder. J Pediatr (Rio J). 2018 Jul - Aug;94(4):342-50.Full text  Abstract

14. Ghirardi L, Brikell I, Kuja-Halkola R, et al. The familial co-aggregation of ASD and ADHD: a register-based cohort study. Mol Psychiatry. 2017 Feb;23(2):257-62.Full text  Abstract

15. Lee DO, Ousley OY. Attention-deficit hyperactivity disorder symptoms in a clinic sample of children and adolescents with pervasive developmental disorders. J Child Adolesc Psychopharmacol. 2006 Dec;16(6):737-46. Abstract

16. Goldstein S, Schwebach AJ. The comorbidity of pervasive developmental disorder and attention deficit hyperactivity disorder: results of a retrospective chart review. J Autism Dev Disord. 2004 Jun;34(3):329-39. Abstract

17. Gadow KD, DeVincent CJ, Pomeroy J. ADHD symptom subtypes in children with pervasive developmental disorder. J Autism Dev Disord. 2006 Feb;36(2):271-83. Abstract

18. Baxter AJ, Brugha TS, Erskine HE, et al. The epidemiology and global burden of autism spectrum disorders. Psychol Med. 2015 Feb;45(3):601-13. Abstract

19. Fombonne E. The prevalence of autism. JAMA. 2003 Jan 1;289(1):87-9. Abstract

20. Autism and Developmental Disabilities Monitoring Network. Prevalence of autistic spectrum disorders: autism and developmental disabilities monitoring network, 14 sites, United States, 2002. MMWR Surveill Summ. 2007 Feb 9;56(1):12-28.Full text  Abstract

21. Blumberg SJ, Bramlett MD, Kogan MD, et al. Changes in prevalence of parent-reported autism spectrum disorder in school-aged U.S. children: 2007 to 2011-2012. Natl Health Stat Report. 2013 Mar 20;(65):1-11, 1 p following 11.Full text  Abstract

22. Elsabbagh M, Divan G, Koh YJ, et al. Global prevalence of autism and other pervasive developmental disorders. Autism Res. 2012 Jun;5(3):160-79.Full text  Abstract

23. Xu G, Strathearn L, Liu B, et al. Prevalence of autism spectrum disorder among US children and adolescents, 2014-2016. JAMA. 2018 Jan 2;319(1):81-2.Full text  Abstract

24. Baio J, Wiggins L, Christensen DL, et al. Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 Sites, United States, 2014. MMWR Surveill Summ. 2018 Apr 27;67(6):1-23.Full text  Abstract

25. Shattuck PT. Diagnostic substitution and changing autism prevalence. Pediatrics. 2006 Apr;117(4):1438-9. Abstract

26. Hansen SN, Schendel DE, Parner ET. Explaining the increase in the prevalence of autism spectrum disorders: the proportion attributable to changes in reporting practices. JAMA Pediatr. 2015 Jan;169(1):56-62.Full text  Abstract

27. Kim YS, Leventhal BL, Koh YJ, et al. Prevalence of autism spectrum disorders in a total population sample. Am J Psychiatry. 2011 Sep;168(9):904-12.Full text  Abstract

28. Christensen DL, Bilder DA, Zahorodny W, et al. Prevalence and characteristics of autism spectrum disorder among 4-year-old children in the Autism and Developmental Disabilities Monitoring Network. J Dev Behav Pediatr. 2016 Jan;37(1):1-8.Full text  Abstract

29. Hyman SL, Levy SE, Myers SM, et al. Identification, evaluation, and management of children with autism spectrum disorder. Pediatrics. 2020 Jan;145(1):e20193447.Full text  Abstract

30. Tomlinson M, Yasamy MT, Emerson E, et al. Setting global research priorities for developmental disabilities, including intellectual disabilities and autism. J Intellect Disabil Res. 2014 Dec;58(12):1121-30.Full text  Abstract

31. Mayes SD, Calhoun SL, Murray MJ, et al. Anxiety, depression, and irritability in children with autism relative to other neuropsychiatric disorders and typical development. Res Autism Spectr Disord. 2010 Jul;5:474–85.

32. de Bruin EI, Ferdinand RF, Meester S, et al. High rates of psychiatric co-morbidity in PDD-NOS. J Autism Dev Disord. 2007 May;37(5):877-86. Abstract

33. Simonoff E, Pickles A, Charman T, et al. Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. J Am Acad Child Adolesc Psychiatry. 2008 Aug;47(8):921-9. Abstract

34. Richdale AL, Schreck KA. Sleep problems in autism spectrum disorders: prevalence, nature, & possible biopsychosocial aetiologies. Sleep Med Rev. 2009 Dec;13(6):403-11. Abstract

35. Croen LA, Zerbo O, Qian Y, et al. The health status of adults on the autism spectrum. Autism. 2015 Oct;19(7):814-23. Abstract

36. Lever AG, Geurts HM. Psychiatric co-occurring symptoms and disorders in young, middle-aged, and older adults with autism spectrum disorder. J Autism Dev Disord. 2016 Jun;46(6):1916-30.Full text  Abstract

37. Joshi G, Wozniak J, Petty C, et al. Psychiatric comorbidity and functioning in a clinically referred population of adults with autism spectrum disorders: a comparative study. J Autism Dev Disord. 2013 Jun;43(6):1314-25. Abstract

38. Hofvander B, Delorme R, Chaste P, et al. Psychiatric and psychosocial problems in adults with normal-intelligence autism spectrum disorders. BMC Psychiatry. 2009 Jun 10;9:35.Full text  Abstract

39. Elsabbagh M. Linking risk factors and outcomes in autism spectrum disorder: is there evidence for resilience? BMJ. 2020 Jan 28;368:l6880. Abstract

40. Bai D, Yip BHK, Windham GC, et al. Association of genetic and environmental factors with autism in a 5-country cohort. JAMA Psychiatry. 2019 Oct 1;76(10):1035-43.Full text  Abstract

41. Lichtenstein P, Carlström E, Råstam M, et al. The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood. Am J Psychiatry. 2010 Nov;167(11):1357-63.Full text  Abstract

42. Ronald A, Hoekstra RA. Autism spectrum disorders and autistic traits: a decade of new twin studies. Am J Med Genet B Neuropsychiatr Genet. 2011 Apr;156B(3):255-74. Abstract

43. Sandin S, Lichtenstein P, Kuja-Halkola R, et al. The familial risk of autism. JAMA. 2014 May 7;311(17):1770-7.Full text  Abstract

44. Woodbury-Smith M, Scherer SW. Progress in the genetics of autism spectrum disorder. Dev Med Child Neurol. 2018 May;60(5):445-51.Full text  Abstract

45. Wood CL, Warnell F, Johnson M, et al. Evidence for ASD recurrence rates and reproductive stoppage from large UK ASD research family databases. Autism Res. 2015 Feb;8(1):73-81. Abstract

46. Ozonoff S, Young GS, Carter A, et al. Recurrence risk for autism spectrum disorders: a Baby Siblings Research Consortium study. Pediatrics. 2011 Sep;128(3):e488-95.Full text  Abstract

47. Hallmayer J, Cleveland S, Torres A, et al. Genetic heritability and shared environmental factors among twin pairs with autism. Arch Gen Psychiatry. 2011 Nov;68(1):1095-102.Full text  Abstract

48. Carter MT, Scherer SW. Autism spectrum disorder in the genetics clinic: a review. Clin Genet. 2013 May;83(5):399-407. Abstract

49. Pinto D, Delaby E, Merico D, et al. Convergence of genes and cellular pathways dysregulated in autism spectrum disorders. Am J Hum Genet. 2014 May 1;94(5):677-94.Full text  Abstract

50. O'Roak BJ, Vives L, Girirajan S, et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature. 2012 Apr 4;485(7397):246-50.Full text  Abstract

51. Sanders SJ, Murtha MT, Gupta AR, et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature. 2012 Apr 4;485(7397):237-41.Full text  Abstract

52. Jiang YH, Yuen RK, Jin X, et al. Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing. Am J Hum Genet. 2013 Aug 8;93(2):249-63.Full text  Abstract

53. Yuen RK, Thiruvahindrapuram B, Merico D, et al. Whole-genome sequencing of quartet families with autism spectrum disorder. Nat Med. 2015 Feb;21(2):185-91. Abstract

54. Yoo H. Genetics of autism spectrum disorder: current status and possible clinical applications. Exp Neurobiol. 2015 Dec;24(4):257-72.Full text  Abstract

55. Bailey A, Palferman S, Heavey L, et al. Autism: the phenotype in relatives. J Autism Dev Disord. 1998 Oct;28(5):369-92. Abstract

56. Abrahams BS, Geschwind DH. Advances in autism genetics: on the threshold of a new neurobiology. Nat Rev Genet. 2008 May;9(5):341-55.Full text  Abstract

57. Rubenstein E, Chawla D. Broader autism phenotype in parents of children with autism: a systematic review of percentage estimates. J Child Fam Stud. 2018 Jun;27(6):1705-20.Full text  Abstract

58. Ruparelia K, Manji K, Abubakar A, et al. Investigating the evidence of behavioral, cognitive, and psychiatric endophenotypes in autism: a systematic review. Autism Res Treat. 2017;2017:6346912.Full text  Abstract

59. Gentile S. Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions. CNS Spectr. 2014 Aug;19(4):305-15. Abstract

60. Christensen J, Grønborg TK, Sørensen MJ, et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA. 2013 Apr 24;309(16):1696-703.Full text  Abstract

61. Modabbernia A, Velthorst E, Reichenberg A. Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses. Mol Autism. 2017 Mar 17;8:13Full text  Abstract

62. Muhle RA, Reed HE, Stratigos KA, et al. The emerging clinical neuroscience of autism spectrum disorder: a review. JAMA Psychiatry. 2018 May 1;75(5):514-23. Abstract

63. Emerson RW, Adams C, Nishino T, et al. Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age. Sci Transl Med. 2017 Jun 7;9(393):eaag2882.Full text  Abstract

64. Wolff JJ, Jacob S, Elison JT. The journey to autism: insights from neuroimaging studies of infants and toddlers. Dev Psychopathol. 2018 May;30(2):479-95.Full text  Abstract

65. Lewis JD, Evans AC, Pruett JR Jr, et al. The emergence of network inefficiencies in infants with autism spectrum disorder. Biol Psychiatry. 2017 Aug 1;82(3):176-85.Full text  Abstract

66. Shen MD, Nordahl CW, Young GS, et al. Early brain enlargement and elevated extra-axial fluid in infants who develop autism spectrum disorder. Brain. 2013 Sep;136(pt 9):2825-35.Full text  Abstract

67. Courchesne E, Campbell K, Solso S. Brain growth across the life span in autism: age-specific changes in anatomical pathology. Brain Res. 2011 Mar 22;1380:138-45.Full text  Abstract

68. Redcay E, Courchesne E. When is the brain enlarged in autism? A meta-analysis of all brain size reports. Biol Psychiatry. 2005 Jul 1;58(1):1-9. Abstract

69. Ozonoff S. Components of executive function deficits in autism and other disorders. In: Russel J, ed. Autism as an executive disorder. Oxford, UK: Oxford University Press; 1997:179-211.

70. Frith U. Autism: explaining the enigma. Oxford, UK: Blackwell; 1989.

71. Baron-Cohen S. Mind blindness. Cambridge, MA: MIT Press; 1995.

72. Dworzynski K, Ronald A, Bolton P, et al. How different are girls and boys above and below the diagnostic threshold for autism spectrum disorders? J Am Acad Child Adolesc Psychiatry. 2012 Aug;51(8):788-97. Abstract

73. Lai MC, Lombardo MV, Auyeung B, et al. Sex/gender differences and autism: setting the scene for future research. J Am Acad Child Adolesc Psychiatry. 2015 Jan;54(1):11-24.Full text  Abstract

74. Scottish Intercollegiate Guidelines Network. Assessment, diagnosis and interventions for autism spectrum disorders. June 2016 [internet publication].Full text

75. Folstein SE, Rutter M. Infantile autism: a genetic study of 21 twin pairs. J Child Psychol Psychiatry. 1977 Sep;18(4):297-321. Abstract

76. Bailey A, Le Couteur A, Gottesman I, et al. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol Med. 1995 Jan;25(1):63-77. Abstract

77. European Medicines Agency. New measures to avoid valproate exposure in pregnancy endorsed. March 2018 [internet publication].Full text

78. Cook EH Jr, Lindgren V, Leventhal BL, et al. Autism or atypical autism in maternally but not paternally derived proximal 15q duplication. Am J Hum Genet. 1997 Apr;60(4):928-34.Full text  Abstract

79. Vignoli A, La Briola F, Peron A, et al. Autism spectrum disorder in tuberous sclerosis complex: searching for risk markers. Orphanet J Rare Dis. 2015 Dec 2;10:154.Full text  Abstract

80. Numis AL, Major P, Montenegro MA, et al. Identification of risk factors for autism spectrum disorders in tuberous sclerosis complex. Neurology. 2011 Mar 15;76(11):981-7.Full text  Abstract

81. Garg S, Green J, Leadbitter K, et al. Neurofibromatosis type 1 and autism spectrum disorder. Pediatrics. 2013 Dec;132(6):e1642-8.Full text  Abstract

82. Warner G, Moss J, Smith P, et al. Autism characteristics and behavioural disturbances in ~ 500 children with Down's syndrome in England and Wales. Autism Res. 2014 Aug;7(4):433-41. Abstract

83. Harris SW, Hessl D, Goodlin-Jones B, et al. Autism profiles of males with fragile X syndrome. Am J Ment Retard. 2008 Nov;113(6):427-38.Full text  Abstract

84. Percy AK. Rett syndrome: exploring the autism link. Arch Neurol. 2011 Aug;68(8):985-9.Full text  Abstract

85. Guy A, Seaton SE, Boyle EM, et al. Infants born late/moderately preterm are at increased risk for a positive autism screen at 2 years of age. J Pediatr. 2015 Feb;166(2):269-75.e3.Full text  Abstract

86. Agrawal S, Rao SC, Bulsara MK, et al. Prevalence of autism spectrum disorder in preterm infants: a meta-analysis. Pediatrics. 2018 Sep;142(3):e20180134.Full text  Abstract

87. Lai MC, Lombardo MV, Pasco G, et al. A behavioral comparison of male and female adults with high functioning autism spectrum conditions. PLoS One. 2011;6(6):e20835.Full text  Abstract

88. Anagnostou E, Zwaigenbaum L, Szatmari P, et al. Autism spectrum disorder: advances in evidence-based practice. CMAJ. 2014 Apr 15;186(7):509-19. Abstract

89. Milner V, McIntosh H, Colvert E, et al. A qualitative exploration of the female experience of autism spectrum disorder (ASD). J Autism Dev Disord. 2019 Jun;49(6):2389-2402.Full text  Abstract

90. Russell G, Steer C, Golding J. Social and demographic factors that influence the diagnosis of autistic spectrum disorders. Soc Psychiatry Psychiatr Epidemiol. 2011 Dec;46(12):1283-93. Abstract

91. Geelhand P, Bernard P, Klein O, et al. The role of gender in the perception of autism symptom severity and future behavioral development. Mol Autism. 2019;10:16.Full text  Abstract

92. Mandell DS, Listerud J, Levy SE, et al. Race differences in the age at diagnosis among medicaid-eligible children with autism. J Am Acad Child Adolesc Psychiatry. 2002 Dec;41(12):1447-53. Abstract

93. Bailey A, Parr J. Implications of the broader phenotype for concepts of autism. Novartis Found Symp. 2003 Feb;251:26-35. Abstract

94. Chawarska K, Paul R, Klin A, et al. Parental recognition of developmental problems in toddlers with autism spectrum disorders. J Autism Dev Disord. 2007 Jan;37(1):62-72. Abstract

95. Pijl MKJ, Bussu G, Charman T, et al. Temperament as an early risk marker for autism spectrum disorders? A longitudinal study of high-risk and low-risk infants. J Autism Dev Disord. 2019 May;49(5):1825-36. Abstract

96. Garon N, Zwaigenbaum L, Bryson S, et al. Temperament and its association with autism symptoms in a high-risk population. J Abnorm Child Psychol. 2016 May;44(4):757-69. Abstract

97. Cermak SA, Curtin C, Bandini LG. Food selectivity and sensory sensitivity in children with autism spectrum disorders. J Am Diet Assoc. 2010 Feb;110(2):238-46.Full text  Abstract

98. Stone WL, Ousley OY, Yoder PJ, et al. Nonverbal communication in two- and three-year-old children with autism. J Autism Dev Disord. 1997 Dec;27(6):677-96. Abstract

99. Howlin P. Outcome in high-functioning adults with autism with and without early language delays: implications for the differentiation between autism and Asperger syndrome. J Autism Dev Disord. 2003 Feb;33(1):3-13. Abstract

100. Pickles A, Anderson DK, Lord C. Heterogeneity and plasticity in the development of language: a 17-year follow-up of children referred early for possible autism. J Child Psychol Psychiatry. 2014 Dec;55(12):1354-62.Full text  Abstract

101. Miodovnik A, Harstad E, Sideridis G, et al. Timing of the diagnosis of attention-deficit/hyperactivity disorder and autism spectrum disorder. Pediatrics. 2015 Oct;136(4):e830-7. Abstract

102. Bradley CC, Boan AD, Cohen AP, et al. Reported history of developmental regression and restricted, repetitive behaviors in children with autism spectrum disorders. J Dev Behav Pediatr. 2016 Jul-Aug;37(6):451-6. Abstract

103. Howes OD, Rogdaki M, Findon JL, et al. Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology. J Psychopharmacol. 2018 Jan;32(1):3-29.Full text  Abstract

104. National Institute for Health and Care Excellence. Autism spectrum disorder in adults: diagnosis and management. June 2021 [internet publication].Full text

105. Dean M, Harwood R, Kasari C. The art of camouflage: Gender differences in the social behaviors of girls and boys with autism spectrum disorder. Autism. 2017 Aug;21(6):678-89. Abstract

106. Lai MC, Lombardo MV, Pasco G, et al. A behavioral comparison of male and female adults with high functioning autism spectrum conditions. PLoS One. 2011;6(6):e20835.Full text  Abstract

107. Wigham S, Rodgers J, Berney T, et al. Psychometric properties of questionnaires and diagnostic measures for autism spectrum disorders in adults: A systematic review. Autism. 2019 Feb;23(2):287-305. Abstract

108. Lai MC, Baron-Cohen S. Identifying the lost generation of adults with autism spectrum conditions. Lancet Psychiatry. 2015 Nov;2(11):1013-27. Abstract

109. Kirkovski M, Enticott PG, Fitzgerald PB. A review of the role of female gender in autism spectrum disorders. J Autism Dev Disord. 2013 Nov;43(11):2584-603. Abstract

110. Van Wijngaarden-Cremers PJ, van Eeten E, Groen WB, et al. Gender and age differences in the core triad of impairments in autism spectrum disorders: a systematic review and meta-analysis. J Autism Dev Disord. 2014 Mar;44(3):627-35. Abstract

111. Volkmar F, Siegel M, Woodbury-Smith M, et al. Practice parameter for the assessment and treatment of children and adolescents with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 2014 Feb;53(2):237-57.Full text  Abstract

112. Randall M, Egberts KJ, Samtani A, et al. Diagnostic tests for autism spectrum disorder (ASD) in preschool children. Cochrane Database Syst Rev. 2018 Jul 24;(7):CD009044.Full text  Abstract

113. Lord C, Risi S, Lambrecht L, et al. The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord. 2000 Jun;30(3):205-23. Abstract

114. Le Couteur A, Lord C Rutter M. The Autism Diagnostic Interview-Revised (AD I-R). Los Angeles, CA: Western Psychological Services;. 2003.

115. Hirota T, So R, Kim YS, et al. A systematic review of screening tools in non-young children and adults for autism spectrum disorder. Res Dev Disabil. 2018 Sep;80:1-12. Abstract

116. Ashwood KL, Gillan N, Horder J, et al. Predicting the diagnosis of autism in adults using the Autism-Spectrum Quotient (AQ) questionnaire. Psychol Med. 2016 Sep;46(12):2595-604.Full text  Abstract

117. Lugnegård T, Hallerbäck MU, Gillberg C. Asperger syndrome and schizophrenia: Overlap of self-reported autistic traits using the Autism-spectrum Quotient (AQ). Nord J Psychiatry. 2015 May;69(4):268-74. Abstract

118. Hus V, Lord C. The autism diagnostic observation schedule, module 4: revised algorithm and standardized severity scores. J Autism Dev Disord. 2014 Aug;44(8):1996-2012.Full text  Abstract

119. de Bildt A, Sytema S, Meffert H, et al. The autism diagnostic observation achedule, module 4: application of the revised algorithms in an independent, well-defined, Dutch sample (n = 93). J Autism Dev Disord. 2016 Jan;46(1):21-30.Full text  Abstract

120. Maddox BB, Brodkin ES, Calkins ME, et al. The accuracy of the ADOS-2 in identifying autism among adults with complex psychiatric conditions. J Autism Dev Disord. 2017 Sep;47(9):2703-09.Full text  Abstract

121. Langmann A, Becker J, Poustka L, et al. Diagnostic utility of the autism diagnostic observation schedule in a clinical sample of adolescents and adults. Research in Autism Spectrum Disorders. 2017 Feb;34:34-43.

122. Mutsaerts CG, Heinrich M, Sterkenburg PS, et al. Screening for ASD in adults with ID-moving toward a standard using the DiBAS-R and the ACL. J Intellect Disabil Res. 2016 May;60(5):512-22. Abstract

123. Baird G, Cass H, Slonims V. Diagnosis of autism. BMJ. 2003 Aug 30;327(7413):488-93.Full text  Abstract

124. Fombonne E. The epidemiology of autism: a review. Psychol Med. 1999 Jul;29(4):769-86. Abstract

125. Tammimies K, Marshall CR, Walker S, et al. Molecular diagnostic yield of chromosomal microarray analysis and whole-exome sequencing in children with autism spectrum disorder. JAMA. 2015 Sep 1;314(9):895-903.Full text  Abstract

126. Miller DT, Adam MP, Aradhya S, et al. Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. Am J Hum Genet. 2010 May 14;86(5):749-64.Full text  Abstract

127. American College of Medical Genetics and Genomics. Five things physicians and patients should question. Choosing Wisely, an initiative of the ABIM Foundation. 2021​ [internet publication].Full text

128. American Academy of Pediatrics Council on Environmental Health. Five things physicians and patients should question. Choosing Wisely, an initiative of the ABIM Foundation. 2022 [internet publication].Full text

129. World Health Organization. The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research. 1993 [internet publication].Full text

130. Rutter M, Bailey A, Bolton P, et al. Autism and known medical conditions: myth and substance. J Child Psychol Psychiatry. 1994 Feb;35(2):311-22. Abstract

131. Bigler ED, Bocian M, et al. Head circumference and height in autism: a study by the Collaborative Program of Excellence in Autism. Am J Med Genet A. 2006 Nov 1;140(21):2257-74. Abstract

132. Berument SK, Rutter M, Lord C, et al. Autism screening questionnaire: diagnostic validity. Br J Psych. 1999 Nov;175:444-51. Abstract

133. Chandler S, Charman T, Baird G, et al. Validation of the social communication questionnaire in a population cohort of children with autistic spectrum disorders. J Am Acad Child Adolesc Psychiatry. 2007 Oct;46(10):1324-32. Abstract

134. Schopler E, Reichler RJ, DeVellis RF, et al. Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). J Autism Dev Disord. 1980 Mar;10(1):91-103. Abstract

135. Dumont-Mathieu T, Fein D. Screening for autism in young children: The Modified Checklist for Autism in Toddlers (M-CHAT) and other measures. Ment Retard Dev Disabil Res Rev. 2005;11(3):253-62. Abstract

136. Scott FJ, Baron-Cohen S, Bolton P, et al. The CAST (Childhood Asperger Syndrome Test): preliminary development of a UK screen for mainstream primary-school-age children. Autism. 2002 Mar;6(1):9-31. Abstract

137. Le Couteur A, Haden G, Hammal D, et al. Diagnosing autistic spectrum disorders in pre-school children using two standardised assessment instruments: the ADI-R and the ADOS. J Autism Dev Disord. 2008 Feb;38(2):362-72. Abstract

138. McPheeters ML, Weitlauf A, Vehorn A, et al.; US Preventive Services Task Force. Screening for autism spectrum disorder in young children: a systematic evidence review for the US Preventive Services Task Force: evidence synthesis no. 129. February 2016 [internet publication].Full text

139. Yuen T, Penner M, Carter MT, et al. Assessing the accuracy of the modified checklist for autism in toddlers: a systematic review and meta-analysis. Dev Med Child Neurol. 2018 Nov;60(11):1093-1100.Full text  Abstract

140. Charman T, Gotham K. Measurement Issues: Screening and diagnostic instruments for autism spectrum disorders - lessons from research and practise. Child Adolesc Ment Health. 2013 Feb;18(1):52-63.Full text  Abstract

141. Zwaigenbaum L, Bauman ML, Choueiri R, et al. Early intervention for children with autism spectrum disorder under 3 years of age: recommendations for practice and research. Pediatrics. 2015 Oct;136 Suppl 1:S60-81. Abstract

142. Filipek P, Accardo PG, Ashwal S, et al. Practice parameter: screening and diagnosis of autism: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Child Neurology Society. Neurology. 2000 Aug 22;55(4):468-79.Full text  Abstract

143. Schaefer GB, Mendelsohn NJ; Professional Practice and Guidelines Committee. Clinical genetics evaluation in identifying the etiology of autism spectrum disorders: 2013 guideline revisions. Genet Med. 2013 May;15(5):399-407.Full text  Abstract

144. National Autistic Society. Position statement: strategies and interventions. Aug 2020 [internet publication].Full text

145. Ayres M, Parr JR, Rodgers J, et al. A systematic review of quality of life of adults on the autism spectrum. Autism. 2018 Oct;22(7):774-83. Abstract

146. Lai MC, Anagnostou E, Wiznitzer M, et al. Evidence-based support for autistic people across the lifespan: maximising potential, minimising barriers, and optimising the person-environment fit. Lancet Neurol. 2020 May;19(5):434-51. Abstract

147. Parsons D, Cordier R, Vaz S, et al. Parent-mediated intervention training delivered remotely for children with autism spectrum disorder living outside of urban areas: systematic review. J Med Internet Res. 2017 Aug 14;19(8):e198.Full text  Abstract

148. Kasari C, Gulsrud AC, Wong C, et al. Randomized controlled caregiver mediated joint engagement intervention for toddlers with autism. J Autism Dev Disord. 2010 Sep;40(9):1045-56.Full text  Abstract

149. Green J, Charman T, McConachie H, et al; PACT Consortium. Parent-mediated communication-focused treatment in children with autism (PACT): a randomised controlled trial. Lancet. 2010 Jun 19;375(9732):2152-60.Full text  Abstract

150. Oono IP, Honey EJ, McConachie H. Parent-mediated early intervention for young children with autism spectrum disorders (ASD). Cochrane Database Syst Rev. 2013 Apr 30;(4):CD009774.Full text  Abstract

151. Althoff CE, Dammann CP, Hope SJ, et al. Parent-mediated interventions for children with autism spectrum disorder: a systematic review. Am J Occup Ther. 2019 May/Jun;73(3):7303205010p1-7303205010p13. Abstract

152. Nevill RE, Lecavalier L, Stratis EA. Meta-analysis of parent-mediated interventions for young children with autism spectrum disorder. Autism. 2018 Feb;22(2):84-98. Abstract

153. Pickles A, Le Couteur A, Leadbitter K, et al. Parent-mediated social communication therapy for young children with autism (PACT): long-term follow-up of a randomised controlled trial. Lancet. 2016 Nov 19;388(10059):2501-09.Full text  Abstract

154. Estes A, Munson J, Rogers SJ, et al. Long-term outcomes of early intervention in 6-year-old children with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 2015 Jul;54(7):580-7.Full text  Abstract

155. Green J, Pickles A, Pasco G, et al. Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years. J Child Psychol Psychiatry. 2017 Dec;58(12):1330-40.Full text  Abstract

156. Bearss K, Johnson C, Smith T, et al. Effect of parent training vs parent education on behavioral problems in children with autism spectrum disorder: a randomized clinical trial. JAMA. 2015 Apr 21;313(15):1524-33.Full text  Abstract

157. Howlin P, Magiati I, Charman T. Systematic review of early intensive behavioral interventions for children with autism. Am J Intellect Dev Disabil. 2009 Jan;114(1):23-41. Abstract

158. Warren Z, McPheeters ML, Sathe N, et al. A systematic review of early intensive intervention for autism spectrum disorders. Pediatrics. 2011 May;127(5):e1303-11. Abstract

159. French L, Kennedy EMM. Annual Research Review: Early intervention for infants and young children with, or at-risk of, autism spectrum disorder: a systematic review. J Child Psychol Psychiatry. 2018 Apr;59(4):444-56.Full text  Abstract

160. Green J, Garg S. Annual Research Review: The state of autism intervention science: progress, target psychological and biological mechanisms and future prospects. J Child Psychol Psychiatry. 2018 Apr;59(4):424-43.Full text  Abstract

161. Parr J. Autism. BMJ Clin Evid. 2010 Jan 7;2010:0322.Full text

162. Charman T, Howlin P, Aldred C, et al. Research into early intervention for children with autism and related disorders: methodological and design issues. Report on a workshop funded by the Wellcome Trust, Institute of Child Health, London, UK, November 2001. Autism. 2003 Jun;7(2):217-25. Abstract

163. Weitlauf AS, McPheeters ML, Peters B, et al. Therapies for children with autism spectrum disorder: behavioral interventions update [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2014.Full text  Abstract

164. Waddington H, van der Meer L, Sigafoos J, et al. Effectiveness of the Early Start Denver Model: a systematic review. Rev J of Autism and Dev Disord. 2016 Jan;3(2):93-106.

165. Baril EM, Humphreys BP. An evaluation of the research evidence on the Early Start Denver Model. 2017 Jul;39(4):321-38.

166. Fuller EA, Oliver K, Vejnoska SF, et al. The effects of the Early Start Denver Model for children with autism spectrum disorder: a meta-analysis. Brain Sci. 2020 Jun; 10(6): 368. Abstract

167. Rogers SJ, Estes A, Lord C, et al. Effects of a brief Early Start Denver Model (ESDM)-based parent intervention on toddlers at risk for autism spectrum disorders: a randomized controlled trial. J Am Acad Child Adolesc Psychiatry. 2012 Oct;51(10):1052-65.Full text  Abstract

168. McConachie H, Randle V, Hammal D, et al. A controlled trial of a training course for parents of children with suspected autistic spectrum disorder. J Pediatr. 2005 Sep;147(3):335-40. Abstract

169. Carter AS, Messinger DS, Stone WL, et al. A randomized controlled trial of Hanen's 'More Than Words' in toddlers with early autism symptoms. J Child Psychol Psychiatry. 2011 Jul;52(7):741-52.Full text  Abstract

170. Eikeseth S, Smith T, Jahr E, et al. Intensive behavioral treatment at school for 4- to 7-year-old children with autism. A 1-year comparison controlled study. Behav Modif. 2002 Jan;26(1):49-68. Abstract

171. Smith T, Iadarola S. Evidence base update for autism spectrum disorder. J Clin Child Adolesc Psychol. 2015;44(6):897-922. Abstract

172. Reichow B, Hume K, Barton EE, et al. Early intensive behavioral intervention (EIBI) for young children with autism spectrum disorders (ASD). Cochrane Database Syst Rev. 2018 May 9;(5):CD009260.Full text  Abstract

173. Linstead E, Dixon DR, French R, et al. Intensity and learning outcomes in the treatment of children with autism spectrum disorder. Behav Modif. 2017 Mar;41(2):229-52. Abstract

174. Orinstein AJ, Helt M, Troyb E, et al. Intervention for optimal outcome in children and adolescents with a history of autism. J Dev Behav Pediatr. 2014 May;35(4):247-56.Full text  Abstract

175. Eldevik S, Hastings RP, Hughes JC, et al. Meta-analysis of Early Intensive Behavioral Intervention for children with autism. J Clin Child Adolesc Psychol. 2009 May;38(3):439-50. Abstract

176. Kasari C, Freeman S, Paparella T. Joint attention and symbolic play in young children with autism: a randomized controlled intervention study. J Child Psychol Psychiatry. 2006 Jun;47(6):611-20. Abstract

177. Kaale A, Smith L, Sponheim E. A randomized controlled trial of preschool-based joint attention intervention for children with autism. J Child Psychol Psychiatry. 2012 Jan;53(1):97-105. Abstract

178. Kasari C, Lawton K, Shih W, et al. Caregiver-mediated intervention for low-resourced preschoolers with autism: an RCT. Pediatrics. 2014 Jul;134(1):e72-9.Full text  Abstract

179. Kasari C, Gulsrud A, Paparella T, et al. Randomized comparative efficacy study of parent-mediated interventions for toddlers with autism. J Consult Clin Psychol. 2015 Jun;83(3):554-63.Full text  Abstract

180. Shire SY, Chang YC, Shih W, et al. Hybrid implementation model of community-partnered early intervention for toddlers with autism: a randomized trial. J Child Psychol Psychiatry. 2017 May;58(5):612-22. Abstract

181. Strain PS, Bovey EH II. Randomized, controlled trial of the LEAP model of early intervention for young children with autism spectrum disorders. Topics Early Child Spec Educ. 2011;31(3):133–54.

182. Strain PS, Hoyson M. The need for longitudinal, intensive social skill intervention: LEAP follow up outcomes for children with autism. Apr 2000;20(2):116–22.

183. Wolstencroft J, Robinson L, Srinivasan R, et al. A systematic review of group social skills interventions, and meta-analysis of outcomes, for children with high functioning ASD. J Autism Dev Disord. 2018 Jul;48(7):2293-2307.Full text  Abstract

184. Gates JA, Kang E, Lerner MD. Efficacy of group social skills interventions for youth with autism spectrum disorder: A systematic review and meta-analysis. Clin Psychol Rev. 2017 Mar;52:164-81.Full text  Abstract

185. Frankel F, Myatt R, Sugar C, et al. A randomized controlled study of parent-assisted Children's Friendship Training with children having autism spectrum disorders. J Autism Dev Disord. 2010 Jul;40(7):827-42.Full text  Abstract

186. Laugeson EA, Frankel F, Mogil C, et al. Parent-assisted social skills training to improve friendships in teens with autism spectrum disorders. J Autism Dev Disord. 2009 Apr;39(4):596-606. Abstract

187. Sutton BM, Webster AA, Westerveld MF. A systematic review of school-based interventions targeting social communication behaviors for students with autism. Autism. 2019 Feb;23(2):274-86. Abstract

188. Chang YC, Locke J. A systematic review of peer-mediated interventions for children with autism spectrum disorder. Res Autism Spectr Disord. 2016 Jul;27:1-10.Full text  Abstract

189. Ozonoff S, Cathcart K. Effectiveness of a home program intervention for young children with autism. J Autism Dev Disord. 1998 Feb;28(1):25-32. Abstract

190. Virues-Ortega J, Julio FM, Pastor-Barriuso R. The TEACCH program for children and adults with autism: a meta-analysis of intervention studies. Clin Psychol Rev. 2013 Dec;33(8):940-53.Full text  Abstract

191. Boyd BA, Hume K, McBee MT, et al. Comparative efficacy of LEAP, TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders. J Autism Dev Disord. 2014 Feb;44(2):366-80. Abstract

192. National Institute for Health and Care Excellence. Autism spectrum disorder in under 19s: support and management. June 2021 [internet publication].Full text

193. Lorenc T, Rodgers M, Marshall D, et al. Support for adults with autism spectrum disorder without intellectual impairment: systematic review. Autism. 2018 Aug;22(6):654-68.Full text  Abstract

194. Rao PA, Beidel DC, Murray MJ. Social skills interventions for children with Asperger's syndrome or high-functioning autism: a review and recommendations. J Autism Dev Disord. 2008 Feb;38(2):353-61.Full text  Abstract

195. Spain D, Blainey SH. Group social skills interventions for adults with high-functioning autism spectrum disorders: A systematic review. Autism. 2015 Oct;19(7):874-86. Abstract

196. Hillier A, Fish T, Cloppert P, et al. Outcomes of a social and vocational skills support group for adolescents and young adults on the autism spectrum. Focus Autism Other Dev Disabl. 2007 May;22(2):107–15.

197. Howlin P, Yates P. The potential effectiveness of social skills groups for adults with autism. Autism. 1999 Sep;3(3):299-307.

198. Laugeson EA, Gantman A, Kapp SK, et al. A randomized controlled trial to improve social skills in young adults with autism spectrum disorder: The UCLA PEERS(®) Program. J Autism Dev Disord. 2015 Dec;45(12):3978-89. Abstract

199. Gantman A, Kapp SK, Orenski K, et al. Social skills training for young adults with high-functioning autism spectrum disorders: a randomized controlled pilot study. J Autism Dev Disord. 2012 Jun;42(6):1094-103. Abstract

200. Wolf JM, Tanaka JW, Klaiman C, et al. Specific impairment of face-processing abilities in children with autism spectrum disorder using the Let's Face It! skills battery. Autism Res. 2008;1:329-340. Abstract

201. Human Emotions, Cambridge University. Mind reading: the interactive guide to emotions. Cambridge: Human Emotions; 2002.

202. Tanaka JW, Wolf JM, Klaiman C, et al. Using computerized games to teach face recognition skills to children with autism spectrum disorder: the Let's Face It! program. J Child Psychol Psychiatry. 2010 Aug;51(8):944-52. Abstract

203. Khemka I, Hickson L, Reynolds G. Evaluation of a decision-making curriculum designed to empower women with mental retardation to resist abuse. Am J Ment Retard. 2005 May;110(3):193-204. Abstract

204. Khemka I. Increasing independent decision-making skills of women with mental retardation in simulated interpersonal situations of abuse. Am J Ment Retard. 2000 Sep;105(5):387-401. Abstract

205. Prior D, Win S, Hassiotis A, et al. Behavioural and cognitive-behavioural interventions for outwardly directed aggressive behaviour in people with intellectual disabilities. Cochrane Database Syst Rev. 2023 Feb 6;2(2):CD003406.Full text  Abstract

206. Green L, McNeil K, Korossy M, et al. HELP for behaviours that challenge in adults with intellectual and developmental disabilities. Can Fam Physician. 2018 Apr;64(suppl 2):S23-31.Full text  Abstract

207. Reynhout GC. Evaluation of the efficacy of Social Stories™ using three single subject metrics. Res Autism Spectrum Disord. 2011 Apr;5(2):885-900.

208. Karkhaneh M, Clark B, Ospina MB, et al. Social Stories™ to improve social skills in children with autism spectrum disorder: a systematic review. Autism. 2010 Nov;14(6):641-62. Abstract

209. National Institute for Health and Care Excellence. Psychotropic medicines in people with learning disabilities whose behaviour challenges. January 2017 [internet publicaton].Full text

210. National Institute for Health and Care Excellence. Challenging behaviour and learning disabilities: prevention and interventions for people with learning disabilities whose behaviour challenges. May 2015 [internet publication].Full text

211. Alfageh BH, Wang Z, Mongkhon P, et al. Safety and tolerability of antipsychotic medication in individuals with autism spectrum disorder: a systematic review and meta-analysis. Paediatr Drugs. 2019 Jun;21(3):153-67. Abstract

212. Ray WA, Stein CM, Murray KT, et al. Association of antipsychotic treatment with risk of unexpected death among children and youths. JAMA Psychiatry. 2019 Feb 1;76(2):162-171.Full text  Abstract

213. De Hert M, Dobbelaere M, Sheridan EM, et al. Metabolic and endocrine adverse effects of second-generation antipsychotics in children and adolescents: a systematic review of randomized, placebo controlled trials and guidelines for clinical practice. Eur Psychiatry. 2011 Apr;26(3):144-53. Abstract

214. McPheeters ML, Warren Z, Sathe N, et al. A systematic review of medical treatments for children with autism spectrum disorders. Pediatrics. 2011 May;127(5):1312-21. Abstract

215. McCracken JT, McGough J, Shah B, et al. Risperidone in children with autism and serious behavioral problems. N Engl J Med. 2002 Aug 1;347(5):314-21.Full text  Abstract

216. Shea S, Turgay A, Carroll A, et al. Risperidone in the treatment of disruptive behavioral symptoms in children with autistic and other pervasive developmental disorders. Pediatrics. 2004 Nov;114(5):e634-41. Abstract

217. Research Units on Pediatric Psychopharmacology Autism Network. Risperidone treatment of autistic disorder: longer-term benefits and blinded discontinuation after 6 months. Am J Psychiatry. 2005 Jul;162(7):1361-9. Abstract

218. McDougle CJ, Scahil L, Aman MG, et al. Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacology. Am J Psychiatry. 2005 Jun;162(6):1142-8.Full text  Abstract

219. Aman MG, Arnold LE, McDougle CJ, et al. Acute and long-term safety and tolerability of risperidone in children with autism. J Child Adolesc Psychopharmacol. 2005 Dec;15(6):869-84. Abstract

220. Hirsch LE, Pringsheim T. Aripiprazole for autism spectrum disorders (ASD). Cochrane Database Syst Rev. 2016 Jun 26;(6):CD009043.Full text  Abstract

221. Douglas-Hall P, Curran S, Bird V, et al. Aripiprazole: a review of its use in the treatment of irritability associated with autistic disorder patients aged 6-17. J Cent Nerv Syst Dis. 2011;3:143-53.Full text  Abstract

222. McDougle CJ, Holmes JP, Carlson DC, et al. A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders. Arch Gen Psychiatry. 1998 Jul;55(7):633-41.Full text  Abstract

223. Anderson LT, Campbell M, Adams P, et al. The effects of haloperidol on discrimination learning and behavioral symptoms in autistic children. J Autism Dev Disord. 1989 Jun;19(2):227-39. Abstract

224. Williams K, Brignell A, Randall M, et al. Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). Cochrane Database Syst Rev. 2013 Aug 20;(8):CD004677.Full text  Abstract

225. Kolevzon A, Mathewson KA, Hollander E. Selective serotonin reuptake inhibitors in autism: a review of efficacy and tolerability. J Clin Psychiatry. 2006 Mar;67(3):407-14. Abstract

226. King BH, Hollander E, Sikich L, et al. Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: citalopram ineffective in children with autism. Arch Gen Psychiatry. 2009 Jun;66(6):583-90.Full text  Abstract

227. Solmi M, Fornaro M, Ostinelli EG, et al. Safety of 80 antidepressants, antipsychotics, anti-attention-deficit/hyperactivity medications and mood stabilizers in children and adolescents with psychiatric disorders: a large scale systematic meta-review of 78 adverse effects. World Psychiatry. 2020 Jun;19(2):214-232.Full text  Abstract

228. McGillivray JA, Evert HT. Group cognitive behavioural therapy program shows potential in reducing symptoms of depression and stress among young people with ASD. J Autism Dev Disord. 2014 Aug;44(8):2041-51. Abstract

229. Danial JT, Wood JJ. Cognitive behavioral therapy for children with autism: review and considerations for future research. J Dev Behav Pediatr. 2013 Nov-Dec;34(9):702-15. Abstract

230. Russell A, Gaunt DM, Cooper K, et al. The feasibility of low-intensity psychological therapy for depression co-occurring with autism in adults: The Autism Depression Trial (ADEPT) - a pilot randomised controlled trial. Autism. 2020 Aug;24(6):1360-72.Full text  Abstract

231. Spek AA, van Ham NC, Nyklíček I. Mindfulness-based therapy in adults with an autism spectrum disorder: a randomized controlled trial. Res Dev Disabil. 2013 Jan;34(1):246-53. Abstract

232. Hillier AJ, Fish T, Siegel JH, et al. Social and vocational skills training reduces self-reported anxiety and depression among young adults on the autism spectrum. J Dev Phys Disabil. 2011 Jan;23:267-76.

233. Vasa RA, Carroll LM, Nozzolillo AA, et al. A systematic review of treatments for anxiety in youth with autism spectrum disorders. J Autism Dev Disord. 2014 Dec;44(12):3215-29. Abstract

234. Kreslins A, Robertson AE, Melville C. The effectiveness of psychosocial interventions for anxiety in children and adolescents with autism spectrum disorder: a systematic review and meta-analysis. Child Adolesc Psychiatry Ment Health. 2015;9:22.Full text  Abstract

235. Ung D, Selles R, Small BJ, et al. A systematic review and meta-analysis of cognitive-behavioral therapy for anxiety in youth with high-functioning autism spectrum disorders. Child Psychiatry Hum Dev. 2015 Aug;46(4):533-47. Abstract

236. James AC, Reardon T, Soler A, et al. Cognitive behavioural therapy for anxiety disorders in children and adolescents. Cochrane Database Syst Rev. 2020 Nov 16;11(11):CD013162.Full text  Abstract

237. Clarke C, Hill V, Charman T. School based cognitive behavioural therapy targeting anxiety in children with autistic spectrum disorder: a quasi-experimental randomised controlled trail incorporating a mixed methods approach. J Autism Dev Disord. 2017 Dec;47(12):3883-95. Abstract

238. Reaven J, Blakeley-Smith A, Leuthe E, et al. Facing your fears in adolescence: cognitive-behavioral therapy for high-functioning autism spectrum disorders and anxiety. Autism Res Treat. 2012;2012:423905.Full text  Abstract

239. Wigham S, Rodgers J, South M, et al. The interplay between sensory processing abnormalities, intolerance of uncertainty, anxiety and restricted and repetitive behaviours in autism spectrum disorder. J Autism Dev Disord. 2015 Apr;45(4):943-52. Abstract

240. Maskey M, Rodgers J, Grahame V, et al. A randomised controlled feasibility trial of immersive virtual reality treatment with cognitive behaviour therapy for specific phobias in young people with autism spectrum disorder. J Autism Dev Disord. 2019 May;49(5):1912-27.Full text  Abstract

241. Weston L, Hodgekins J, Langdon PE. Effectiveness of cognitive behavioural therapy with people who have autistic spectrum disorders: A systematic review and meta-analysis. Clin Psychol Rev. 2016 Nov;49:41-54.Full text  Abstract

242. Lang R, Regester A, Lauderdale S, et al. Treatment of anxiety in autism spectrum disorders using cognitive behaviour therapy: a systematic review. Dev Neurorehabil. 2010 Feb;13(1):53-63. Abstract

243. Ooi YP, Lam CM, Sung M, et al. Effects of cognitive-behavioural therapy on anxiety for children with high-functioning autistic spectrum disorders. Singapore Med J. 2008 Mar;49(3):215-20.Full text  Abstract

244. Wood JJ, Drahota A, Sze K, et al. Cognitive behavioral therapy for anxiety in children with autism spectrum disorders: a randomized, controlled trial. J Child Psychol Psychiatry. 2009 Mar;50(3):224-34.Full text  Abstract

245. Rodgers J, Ofield A. Understanding, recognising and treating co-occurring anxiety in autism. Curr Dev Disord Rep. 2018;5(1):58-64.Full text  Abstract

246. Maskey M, Rodgers J, Ingham B, et al. Using virtual reality environments to augment cognitive behavioral therapy for fears and phobias in autistic adults. Autism Adulthood. 2019 Jun 1;1(2):134-45.Full text  Abstract

247. Buchsbaum MS, Hollander E, Haznedar MM, et al. Effect of fluoxetine on regional cerebral metabolism in autistic spectrum disorders: a pilot study. Int J Neuropsychopharmacol. 2001 Jun;4(2):119-25.Full text  Abstract

248. Hollander E, Soorya L, Chaplin W, et al. A double-blind placebo-controlled trial of fluoxetine for repetitive behaviors and global severity in adult autism spectrum disorders. Am J Psychiatry. 2012 Mar;169(3):292-9.Full text  Abstract

249. Murray K, Jassi A, Mataix-Cols D, et al. Outcomes of cognitive behaviour therapy for obsessive-compulsive disorder in young people with and without autism spectrum disorders: A case controlled study. Psychiatry Res. 2015 Jul 30;228(1):8-13. Abstract

250. Elliott SJ, Marshall D, Morley K, et al. Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD). Cochrane Database Syst Rev. 2021 Sep 3;9(9):CD013173.Full text  Abstract

251. Reddihough DS, Marraffa C, Mouti A, et al. Effect of fluoxetine on obsessive-compulsive behaviors in children and adolescents with autism spectrum disorders: a randomized clinical trial. JAMA. 2019 Oct 22;322(16):1561-69.Full text  Abstract

252. Chugani DC, Chugani HT, Wiznitzer M, et al; Autism Center of Excellence Network. Efficacy of low-dose buspirone for restricted and repetitive behavior in young children with autism spectrum disorder: a randomized trial. J Pediatr. 2016 Mar;170:45-53.e1-4.Full text  Abstract

253. Hollander E, Phillips A, Chaplin W, et al. A placebo controlled crossover trial of liquid fluoxetine on repetitive behaviors in childhood and adolescent autism. Neuropsychopharmacology. 2005 Mar;30(3):582-9.Full text  Abstract

254. McDougle CJ, Naylor ST, Cohen DJ, et al. A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Arch Gen Psychiatry. 1996 Nov;53(11):1001-8. Abstract

255. Woodbury-Smith MR, Volkmar FR. Asperger syndrome. Eur Child Adolesc Psychiatry. 2009 Jan;18(1):2-11. Abstract

256. Malow BA, Byars K, Johnson K, et al. A practice pathway for the identification, evaluation, and management of insomnia in children and adolescents with autism spectrum disorders. Pediatrics. 2012 Nov;130 Suppl 2:S106-24. Abstract

257. Malow BA, Adkins KW, Reynolds A, et al. Parent-based sleep education for children with autism spectrum disorders. J Autism Dev Disord. 2014 Jan;44(1):216-28.Full text  Abstract

258. Rossignol DA, Frye RE. Melatonin in autism spectrum disorders: a systematic review and meta-analysis. Dev Med Child Neurol. 2011 Sep;53(9):783-92.Full text  Abstract

259. Gringras P, Gamble C, Jones AP, et al. Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial. BMJ. 2012 Nov 5;345:e6664.Full text  Abstract

260. Appleton RE, Jones AP, Gamble C, et al. The use of melatonin in children with neurodevelopmental disorders and impaired sleep: a randomised, double-blind, placebo-controlled, parallel study (MENDS). Health Technol Assess. 2012;16(40):i-239.Full text  Abstract

261. Cortesi F, Giannotti F, Sebastiani T, et al. Controlled-release melatonin, singly and combined with cognitive behavioural therapy, for persistent insomnia in children with autism spectrum disorders: a randomized placebo-controlled trial. J Sleep Res. 2012 Dec;21(6):700-9. Abstract

262. Williams Buckley A, Hirtz D, Oskoui M, et al. Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2020 Mar 3;94(9):392-404.Full text  Abstract

263. Relia S, Ekambaram V. Pharmacological approach to sleep disturbances in autism spectrum disorders with psychiatric comorbidities: a literature review. Med Sci (Basel). 2018 Oct;6(4):95.Full text  Abstract

264. Wilson S, Anderson K, Baldwin D, et al. British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update. J Psychopharmacol. 2019 Aug;33(8):923-47. Abstract

265. Cheng SK, Dizon J. Computerised cognitive behavioural therapy for insomnia: a systematic review and meta-analysis. Psychother Psychosom. 2012;81(4):206-16. Abstract

266. Seyffert M, Lagisetty P, Landgraf J, et al. Internet-delivered cognitive behavioral therapy to treat insomnia: a systematic review and meta-analysis. PLoS One. 2016;11(2):e0149139.Full text  Abstract

267. van Straten A, van der Zweerde T, Kleiboer A, et al. Cognitive and behavioral therapies in the treatment of insomnia: A meta-analysis. Sleep Med Rev. 2018 Apr;38:3-16. Abstract

268. Zachariae R, Lyby MS, Ritterband LM, et al. Efficacy of internet-delivered cognitive-behavioral therapy for insomnia - a systematic review and meta-analysis of randomized controlled trials. Sleep Med Rev. 2016 Dec;30:1-10. Abstract

269. Galli-Carminati G, Deriaz N, Bertschy G. Melatonin in treatment of chronic sleep disorders in adults with autism: a retrospective study. Swiss Med Wkly. 2009 May 16;139(19-20):293-6. Abstract

270. Bolea-Alamañac B, Nutt DJ, Adamou M, et al. Evidence-based guidelines for the pharmacological management of attention deficit hyperactivity disorder: update on recommendations from the British Association for Psychopharmacology. J Psychopharmacol. 2014 Mar;28(3):179-203. Abstract

271. National Institute for Health and Care Excellence. Attention deficit hyperactivity disorder: diagnosis and management. March 2018 [internet publication].Full text

272. The MTA Cooperative Group. A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group Multimodal Treatment Study of Children with ADHD. Arch Gen Psychiatry. 1999 Dec;56(12):1073-86.Full text  Abstract

273. Research Units on Pediatric Psychopharmacology Autism Network. Randomized, controlled, crossover trial of methylphenidate in pervasive developmental disorders with hyperactivity. Arch Gen Psychiatry. 2005 Nov;62(11):1266-74.Full text  Abstract

274. Sturman N, Deckx L, van Driel ML. Methylphenidate for children and adolescents with autism spectrum disorder. Cochrane Database Syst Rev. 2017 Nov 21;(11):CD011144.Full text  Abstract

275. Harfterkamp M, van de Loo-Neus G, Minderaa RB, et al. A randomized double-blind study of atomoxetine versus placebo for attention-deficit/hyperactivity disorder symptoms in children with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 2012 Jul;51(7):733-41. Abstract

276. Arnold LE, Aman MG, Cook AM, et al. Atomoxetine for hyperactivity in autism spectrum disorders: placebo-controlled crossover pilot trial. J Am Acad Child Adolesc Psychiatry. 2006 Oct;45(10):1196-205. Abstract

277. Patra S, Nebhinani N, Viswanathan A, et al. Atomoxetine for attention deficit hyperactivity disorder in children and adolescents with autism: A systematic review and meta-analysis. Autism Res. 2019 Apr;12(4):542-52. Abstract

278. Handen BL, Aman MG, Arnold LE, et al. Atomoxetine, parent training, and their combination in children with autism spectrum disorder and attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2015 Nov;54(11):905-15.Full text  Abstract

279. Smith T, Aman MG, Arnold LE, et al. Atomoxetine and parent training for children with autism and attention-deficit/hyperactivity disorder: a 24-week extension study. J Am Acad Child Adolesc Psychiatry. 2016 Oct;55(10):868-76.e2.Full text  Abstract

280. Fankhauser MP, Karumanchi VC, German ML, et al. A double-blind, placebo-controlled study of the efficacy of transdermal clonidine in autism. J Clin Psychiatry. 1992 Mar;53(3):77-82. Abstract

281. Jaselskis CA, Cook EH Jr, Fletcher KE, et al. Clonidine treatment of hyperactive and impulsive children with autistic disorder. J Clin Psychopharmacol. 1992 Oct;12(5):322-7. Abstract

282. Scahill L, McCracken JT, King BH, et al.; Research Units on Pediatric Psychopharmacology Autism Network. Extended-release guanfacine for hyperactivity in children with autism spectrum disorder. Am J Psychiatry. 2015 Dec;172(12):1197-206.Full text  Abstract

283. Cortese S, Castelnau P, Morcillo C, et al. Psychostimulants for ADHD-like symptoms in individuals with autism spectrum disorders. Expert Rev Neurother. 2012 Apr;12(4):461-73. Abstract

284. Posey DJ, Aman MG, McCracken JT, et al. Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures. Biol Psychiatry. 2007 Feb 15;61(4):538-44. Abstract

285. Yoder P, Stone WL. A randomized comparison of the effect of two prelinguistic communication interventions on the acquisition of spoken communication in preschoolers with ASD. J Speech Lang Hear Res. 2006 Aug;49(4):698-711. Abstract

286. Yoder P, Stone WL. Randomized comparison of two communication interventions for preschoolers with autistic spectrum disorders. J Consult Clin Psychol. 2006 Jun;74(3):426-35. Abstract

287. Howlin P, Gordon RK, Pasco G, et al. The effectiveness of Picture Exchange Communication System (PECS) training for teachers of children with autism: a pragmatic, group randomised controlled trial. J Child Psychol Psychiatry. 2007 May;48(5):473-81. Abstract

288. Brignell A, Chenausky KV, Song H, et al. Communication interventions for autism spectrum disorder in minimally verbal children. Cochrane Database Syst Rev. 2018 Nov 5;(11):CD012324.Full text  Abstract

289. Preston D, Carter M. A review of the efficacy of the picture exchange communication system intervention. J Autism Dev Disord. 2009 Oct;39(10):1471-86. Abstract

290. Flippin M, Reszka S, Watson LR. Effectiveness of the Picture Exchange Communication System (PECS) on communication and speech for children with autism spectrum disorders: a meta-analysis. Am J Speech Lang Pathol. 2010 May;19(2):178-95. Abstract

291. Lorah ER, Parnell A, Whitby PS, et al. A systematic review of tablet computers and portable media players as speech generating devices for individuals with autism spectrum disorder. J Autism Dev Disord. 2015 Dec;45(12):3792-804. Abstract

292. Green VA, Pituch KA, Itchon J, et al. Internet survey of treatments used by parents of children with autism. Res Dev Disabil. 2006 Jan-Feb;27(1):70-84. Abstract

293. DeThorne L, Johnson CJ, Walder L, et al. When "Simon says" doesn't work: alternatives to imitation for facilitating early speech development. Am J Speech Lang Pathol. 2009 May;18(2):133-45. Abstract

294. Anderson DK, Lord C, Risi S, et al. Patterns of growth in verbal abilities among children with autism spectrum disorder. J Consult Clin Psychol. 2007 Aug;75(4):594-604. Abstract

295. Wodka EL, Mathy P, Kalb L. Predictors of phrase and fluent speech in children with autism and severe language delay. Pediatrics. 2013 Apr;131(4):e1128-34. Abstract

296. Bilaver LA, Cushing LS, Cutler AT. Prevalence and correlates of educational intervention utilization among children with autism spectrum disorder. J Autism Dev Disord. 2016 Feb;46(2):561-71. Abstract

297. Barton EE, Reichow B, Schnitz A, et al. A systematic review of sensory-based treatments for children with disabilities. Res Dev Disabil. 2015 Feb;37:64-80. Abstract

298. Case-Smith J, Weaver LL, Fristad MA. A systematic review of sensory processing interventions for children with autism spectrum disorders. Autism. 2015 Feb;19(2):133-48. Abstract

299. Weitlauf AS, Sathe N, McPheeters ML, et al. Interventions targeting sensory challenges in autism spectrum disorder: a systematic review. Pediatrics. 2017 Jun;139(6):e20170347. Abstract

300. Uljarević M, Baranek G, Vivanti G, et al. Heterogeneity of sensory features in autism spectrum disorder: Challenges and perspectives for future research. Autism Res. 2017 May;10(5):703-10. Abstract

301. Volkmar F, Cook EH Jr, Pomeroy J, et al. Practice parameters for the assessment and treatment of children, adolescents, and adults with autism and other pervasive developmental disorders: American Academy of Child and Adolescent Psychiatry Working Group on Quality Issues. J Am Acad Child Adolesc Psychiatry. 1999 Dec;38(12 Suppl):32S-54. Abstract

302. Millward C, Ferriter M, Calver S, et al. Gluten- and casein-free diets for autistic spectrum disorder. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD003498.Full text  Abstract

303. Singer A, Ravi R. Complementary and alternative treatments for autism part 2: identifying and avoiding non-evidence-based treatments. AMA J Ethics. 2015 Apr 1;17(4):375-80.Full text  Abstract

304. Williams K, Wray JA, Wheeler DM. Intravenous secretin for autism spectrum disorders (ASD). Cochrane Database Syst Rev. 2012 Apr 18;(4):CD003495.Full text  Abstract

305. Krishnaswami S, McPheeters ML, Veenstra-Vanderweela J. A systematic review of secretin for children with autism sprectrum disorders. Pediatrics. 2011 May;127(5):1322-5.Full text  Abstract

306. Piwowarczyk A, Horvath A, Łukasik J, et al. Gluten- and casein-free diet and autism spectrum disorders in children: a systematic review. Eur J Nutr. 2018 Mar;57(2):433-40. Abstract

307. Taylor JL, McPheeters ML, Sathe NA, et al. A systematic review of vocational interventions for young adults with autism spectrum disorders. Pediatrics. 2012 Sep;130(3):531-8.Full text  Abstract

308. Geretsegger M, Fusar-Poli L, Elefant C, et al. Music therapy for autistic people. Cochrane Database Syst Rev. 2022 May 9;5(5):CD004381.Full text  Abstract

309. Bieleninik L, Geretsegger M, Mössler K, et al. Effects of improvisational music therapy vs enhanced standard care on symptom severity among children with autism spectrum disorder: The TIME-a randomized clinical trial. JAMA. 2017 Aug 8;318(6):525-35.Full text  Abstract

310. Scahill L, Hallett V, Aman MG, et al. Brief Report: social disability in autism spectrum disorder: results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network trials. J Autism Dev Disord. 2013 Mar;43(3):739-46.Full text  Abstract

311. Marcus RN, Owen R, Kamen L, et al. A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder. J Am Acad Child Adolesc Psychiatry. 2009 Nov;48(11):1110-119. Abstract

312. Aman MG, Kasper W, Manos G, et al. Line-item analysis of the Aberrant Behavior Checklist: results from two studies of aripiprazole in the treatment of irritability associated with autistic disorder. J Child Adolesc Psychopharmacol. 2010 Oct;20(5):415-22. Abstract

313. Anagnostou E, Soorya L, Chaplin W, et al. Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial. Mol Autism. 2012 Dec 5;3(1):16.Full text  Abstract

314. Watanabe T, Kuroda M, Kuwabara H, et al. Clinical and neural effects of six-week administration of oxytocin on core symptoms of autism. Brain. 2015 Nov;138(pt 11):3400-12.Full text  Abstract

315. Yatawara CJ, Einfeld SL, Hickie IB, et al. The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: a randomized clinical crossover trial. Mol Psychiatry. 2016 Sep;21(9):1225-31.Full text  Abstract

316. Ooi YP, Weng SJ, Kossowsky J, et al. Oxytocin and autism spectrum disorders: a systematic review and meta-analysis of randomized controlled trials. Pharmacopsychiatry. 2017 Jan;50(1):5-13. Abstract

317. Okamoto Y, Ishitobi M, Wada Y, et al. The potential of nasal oxytocin administration for remediation of autism spectrum disorders. CNS Neurol Disord Drug Targets. 2016;15(5):564-77.Full text  Abstract

318. Cai Q, Feng L, Yap KZ. Systematic review and meta-analysis of reported adverse events of long-term intranasal oxytocin treatment for autism spectrum disorder. Psychiatry Clin Neurosci. 2018 Mar;72(3):140-51.Full text  Abstract

319. Sikich L, Kolevzon A, King BH, et al. Intranasal oxytocin in children and adolescents with autism spectrum disorder. N Engl J Med. 2021 Oct 14;385(16):1462-73.Full text  Abstract

320. Magiati I, Tay XW, Howlin P. Cognitive, language, social and behavioural outcomes in adults with autism spectrum disorders: a systematic review of longitudinal follow-up studies in adulthood. Clin Psychol Rev. 2014 Feb;34(1):73-86. Abstract

321. Renty JO, Roeyers H. Quality of life in high-functioning adults with autism spectrum disorder: The predictive value of disability and support characteristics. Autism. 2006 Sep;10(5):511-24. Abstract

322. Brignell A, Harwood RC, May T, et al. Overall prognosis of preschool autism spectrum disorder diagnoses. Cochrane Database Syst Rev. 2022 Sep 28;9(9):CD012749.Full text  Abstract

323. Anderson DK, Liang JW, Lord C. Predicting young adult outcome among more and less cognitively able individuals with autism spectrum disorders. J Child Psychol Psychiatry. 2014 May;55(5):485-94.Full text  Abstract

324. Zwaigenbaum L, Bauman ML, Fein D, et al. Early screening of autism spectrum disorder: recommendations for practice and research. Pediatrics. 2015 Oct;136 Suppl 1:S41-59. Abstract

325. Steinhausen HC, Mohr Jensen C, Lauritsen MB. A systematic review and meta-analysis of the long-term overall outcome of autism spectrum disorders in adolescence and adulthood. Acta Psychiatr Scand. 2016 Jun;133(6):445-52. Abstract

326. Schendel DE, Overgaard M, Christensen J, et al. Association of psychiatric and neurologic comorbidity with mortality among persons with autism spectrum disorder in a Danish population. JAMA Pediatr. 2016 Mar;170(3):243-50. Abstract

327. Hollocks MJ, Lerh JW, Magiati I, et al. Anxiety and depression in adults with autism spectrum disorder: a systematic review and meta-analysis. Psychol Med. 2019 Mar;49(4):559-72.Full text  Abstract

328. Legg H, Tickle A. UK parents' experiences of their child receiving a diagnosis of autism spectrum disorder: A systematic review of the qualitative evidence. Autism. 2019 Nov;23(8):1897-1910. Abstract

329. Bolton P, Macdonald H, Pickles A, et al. A case-control family history study of autism. J Child Psychol Psychiatry. 1994 Jul;35(5):877-900. Abstract

330. Di Pietrantonj C, Rivetti A, Marchione P, et al. Vaccines for measles, mumps, rubella, and varicella in children. Cochrane Database Syst Rev. 2020 Apr 20;(4):CD004407.Full text  Abstract

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