Resumo
Definição
História e exame físico
Principais fatores diagnósticos
- increased predisposition in certain ethnic/geographic groups
- oral ulcers
- genital ulcers
- uveitis
- acne lesions
- erythema nodosum
- limited duration of symptoms
- superficial thrombophlebitis
- hypopyon
- stroke
- eye pain, blurry vision, photophobia, or photosensitivity
- memory loss
- headache, confusion, or fever
- hemoptysis, cough, shortness of breath, or chest pain
- eye redness or tearing
- impaired speech, balance, or movement
Outros fatores diagnósticos
- cramping abdominal pain, diarrhea, or gastrointestinal ulceration
Fatores de risco
- age 20-40 years
- family history of Behcet syndrome
- genetic predisposition
Investigações diagnósticas
Investigações a serem consideradas
- pathergy testing
- rheumatoid factor
- antinuclear antibodies
- antineutrophil cytoplasmic antibodies
- HLA-B51
- lumbar puncture
- MRI, magnetic resonance angiography brain with contrast
- colonoscopy
- upper gastrointestinal endoscopy
- high-resolution chest CT
- CT angiography of chest
- pulmonary angiography
Novos exames
- anti-Saccharomyces cerevisiae antibodies
Algoritmo de tratamento
mucocutaneous ulcers
eye involvement
gastrointestinal involvement
central nervous system involvement
major vascular involvement
Colaboradores
Autores
Yusuf Yazici, MD
Clinical Associate Professor of Medicine
New York University School of Medicine
Director
Behcet's Syndrome Center
New York University School of Medicine
NY
Declarações
YY has received research support from Amgen, Genentech, and Bristol-Myers Squibb. YY is a consultant for Bristol-Myers Squibb Chugai, Hemay, and Amgen. He is an author of some of the references cited in this topic.
Revisores
Izzet Fresko, MD
Associate Professor of Medicine
Department of Rheumatology
Cerrahpasa Medical Faculty
Istanbul
Turkey
Declarações
IF declares that he has no competing interests.
Megan E.B. Clowse, MD, MPH
Assistant Professor of Medicine
Division of Rheumatology and Immunology
Duke University Medical Center
Durham
NC
Declarações
MEBC has received speaking fees from Abbott Pharmaceuticals.
Philip Seo, MD, MHS
Assistant Professor of Medicine
Division of Rheumatology
Johns Hopkins University School of Medicine
Co-Director
Johns Hopkins Vasculitis Center
Baltimore
MD
Declarações
PS declares that he has no competing interests.
Créditos aos pareceristas
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Declarações
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Referências
Principais artigos
Kural-Seyahi E, Fresko I, Seyahi N, et al. The long-term mortality and morbidity of Behcet's syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center. Medicine (Baltimore). 2003 Jan;82(1):60-76. Resumo
International Study Group for Behcet's Disease. Criteria for diagnosis of Behcet's disease. Lancet. 1990 May 5;335(8697):1078-80. Resumo
Hatemi G, Christensen R, Bang D, et al. 2018 update of the EULAR recommendations for the management of Behçet's syndrome. Ann Rheum Dis. 2018 Jun;77(6):808-18.Texto completo Resumo
Artigos de referência
Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
Differentials
- Aphthous stomatitis (recurrent)
- Crohn disease
- Ulcerative colitis
Mais Diagnósticos diferenciaisGuidelines
- 2018 update of the EULAR recommendations for the management of Behçet's syndrome
- Criteria for diagnosis of Behcet's disease
Mais Guidelines
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