Emerging treatments

Early corticosteroid administration

An open-label randomised controlled study of patients with moderate-to-severe ARDS found that early dexamethasone resulted in a substantial increase in ventilator-free days (4.8 days), and a 15% reduction in mortality, compared with placebo.[116] These findings need to be validated and must be considered cautiously given serious concerns about the safety of high-dose glucocorticoids in critically ill patients, including risk of nosocomial infections and critical illness polyneuropathy/myopathy.

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