Approach

A presumptive diagnosis of GS is made when a patient exhibits the following findings:

  • Repeated unconjugated hyperbilirubinaemia

  • No evidence of haemolysis, with normal findings on complete blood count, reticulocyte count, Coombs' test, and blood smear

  • Normal LFTs except for the bilirubin

  • Exclusion of other disease processes.

If the above findings continue to be present, a definitive diagnosis may be reported after 3 to 12 months of follow-up. Confirmatory tests may be performed in the case of any diagnostic doubt.[2]

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