References
Key articles
Carvalho M, Carmo H, Costa VM, et al. Toxicity of amphetamines: an update. Arch Toxicol. 2012 Aug;86(8):1167-231. Abstract
Glasner-Edwards S, Mooney LJ. Methamphetamine psychosis: epidemiology and management. CNS Drugs. 2014 Dec;28(12):1115-26.Full text Abstract
Richards JR, Albertson TE, Derlet RW, et al. Treatment of toxicity from amphetamines, related derivatives, and analogues: a systematic clinical review. Drug Alcohol Depend. 2015 May 1;150:1-13. Abstract
Reference articles
1. Ely EW, Truman B, Shintani A, et al. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA. 2003 Jun 11;289(22):2983-91.Full text Abstract
2. Moon K, Albuquerque FC, Mitkov M, et al. Methamphetamine use is an independent predictor of poor outcome after aneurysmal subarachnoid hemorrhage. J Neurointerv Surg. 2015 May;7(5):346-50. Abstract
3. Gledhill JA, Moore DF, Bell D, et al. Subarachnoid haemorrhage associated with MDMA abuse. J Neurol Neurosurg Psychiatry. 1993 Sep;56(9):1036-7. Abstract
4. Bowyer JF, Hanig JP. Amphetamine- and methamphetamine-induced hyperthermia: implications of the effects produced in brain vasculature and peripheral organs to forebrain neurotoxicity. Temperature (Austin). 2014 Nov 14;1(3):172-82.Full text Abstract
5. Matsumoto RR, Seminerio MJ, Turner RC, et al. Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia. Pharmacol Ther. 2014 Oct;144(1):28-40.Full text Abstract
6. Kalant H. The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs. CMAJ. 2001 Oct 2;165(7):917-28.Full text Abstract
7. Hall AP, Henry JA. Acute toxic effects of 'Ecstasy' (MDMA) and related compounds: overview of pathophysiology and clinical management. Br J Anaesth. 2006 Jun;96(6):678-85.Full text Abstract
8. Carvalho M, Carmo H, Costa VM, et al. Toxicity of amphetamines: an update. Arch Toxicol. 2012 Aug;86(8):1167-231. Abstract
9. Harro J. Neuropsychiatric adverse effects of amphetamine and methamphetamine. Int Rev Neurobiol. 2015;120:179-204. Abstract
10. United Nations Office on Drugs and Crime. World Drug Report 2016. May 2016 [internet publication].Full text
11. United Nations Office on Drugs and Crime. 2014 global synthetic drugs assessment: amphetamine-type stimulants and new psychoactive substances. May 2014 [internet publication].Full text
12. Substance Abuse and Mental Health Services Administration. Key substance use and mental health indicators in the United States: results from the 2019 National Survey on Drug Use and Health. Sep 2020 [internet publication].Full text
13. Kariisa M, Scholl L, Wilson N, et al. Drug Overdose Deaths Involving Cocaine and Psychostimulants with Abuse Potential - United States, 2003-2017. MMWR Morb Mortal Wkly Rep. 2019 May 3;68(17):388-95.Full text Abstract
14. Fleckenstein AE, Volz TJ, Riddle EL, et al. New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007 Feb 10;47:681-98. Abstract
15. Courtney KE, Ray LA. Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature. Drug Alcohol Depend. 2014 Oct 1;143:11-21.Full text Abstract
16. Yamamoto T, Malavasi E, Archer JR, et al. Management of body stuffers presenting to the emergency department. Eur J Emerg Med. 2016 Dec;23(6):425-9. Abstract
17. Liechti ME, Kunz I, Kupferschmidt H. Acute medical problems due to Ecstasy use: case-series of emergency department visits. Swiss Med Wkly. 2005 Oct 29;135(43-44):652-7.Full text Abstract
18. Tossmann P, Boldt S, Tensil MD. The use of drugs within the techno party scene in European metropolitan cities. Eur Addict Res. 2001 Mar;7(1):2-23. Abstract
19. Barrett SP, Darredeau C, Pihl RO. Patterns of simultaneous polysubstance use in drug using university students. Hum Psychopharmacol. 2006 Jun;21(4):255-63. Abstract
20. Liechti M. Novel psychoactive substances (designer drugs): overview and pharmacology of modulators of monoamine signaling. Swiss Med Wkly. 2015 Jan 14;145:w14043.Full text Abstract
21. Schep LJ, Slaughter RJ, Beasley DM. The clinical toxicology of metamfetamine. Clin Toxicol (Phila). 2010 Aug;48(7):675-94. Abstract
22. Hutson PH, Tarazi FI, Madhoo M, et al. Preclinical pharmacology of amphetamine: implications for the treatment of neuropsychiatric disorders. Pharmacol Ther. 2014 Sep;143(3):253-64. Abstract
23. Richards JR, Johnson EB, Stark RW, et al. Methamphetamine abuse and rhabdomyolysis in the ED: a 5-year study. Am J Emerg Med. 1999 Nov;17(7):681-5. Abstract
24. Kaye S, Darke S, Duflou J, et al. Methamphetamine-related fatalities in Australia: demographics, circumstances, toxicology and major organ pathology. Addiction. 2008 Aug;103(8):1353-60. Abstract
25. Schifano F, Corkery J, Naidoo V, et al. Overview of amphetamine-type stimulant mortality data - UK, 1997-2007. Neuropsychobiology. 2010 Mar;61(3):122-30. Abstract
26. Bordo DJ, Dorfman MA. Ecstasy overdose: rapid cooling leads to successful outcome. Am J Emerg Med. 2004 Jul;22(4):326-7. Abstract
27. Dobry Y, Rice T, Sher L. Ecstasy use and serotonin syndrome: a neglected danger to adolescents and young adults prescribed selective serotonin reuptake inhibitors. Int J Adolesc Med Health. 2013 Sep 4;25(3):193-9. Abstract
28. Poikolainen K. Ecstasy and the antecedents of illicit drug use. BMJ. 2006 Apr 8;332(7545):803-4. Abstract
29. Russell K, Dryden DM, Liang Y, et al. Risk factors for methamphetamine use in youth: a systematic review. BMC Pediatr. 2008 Oct 28;8:48.Full text Abstract
30. Faraone SV, Wilens TE. Effect of stimulant medications for attention-deficit/hyperactivity disorder on later substance use and the potential for stimulant misuse, abuse, and diversion. J Clin Psychiatry. 2007;68(suppl 11):15-22. Abstract
31. Cumming C, Troeung L, Young JT, et al. Barriers to accessing methamphetamine treatment: a systematic review and meta-analysis. Drug Alcohol Depend. 2016 Nov 1;168:263-73. Abstract
32. Tucker GT, Lennard MS, Ellis SW, et al. The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6). Biochem Pharmacol. 1994 Mar 29;47(7):1151-6. Abstract
33. Maurer HH, Kraemer T, Springer D, et al. Chemistry pharmacology, toxicology, and hepatic metabolism of designer drugs of the amphetamine (ecstasy), piperazine, and pyrrolidinophenone types: a synopsis. Ther Drug Monit. 2004 Apr;26(2):127-31. Abstract
34. Kraemer T, Maurer HH. Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives. Ther Drug Monit. 2002 Apr;24(2):277-89. Abstract
35. Sutter ME, Gaedigk A, Albertson TE, et al. Polymorphisms in CYP2D6 may predict methamphetamine related heart failure. Clin Toxicol (Phila). 2013 Aug;51(7):540-4. Abstract
36. Glasner-Edwards S, Mooney LJ. Methamphetamine psychosis: epidemiology and management. CNS Drugs. 2014 Dec;28(12):1115-26.Full text Abstract
37. Richards JR, Albertson TE, Derlet RW, et al. Treatment of toxicity from amphetamines, related derivatives, and analogues: a systematic clinical review. Drug Alcohol Depend. 2015 May 1;150:1-13. Abstract
38. Armenian P, Mamantov TM, Tsutaoka BT, et al. Multiple MDMA (Ecstasy) overdoses at a rave event: a case series. J Intensive Care Med. 2013 Jul-Aug;28(4):252-8. Abstract
39. Yacoubian GS Jr, Peters RJ. An exploration of recent club drug use among rave attendees. J Drug Educ. 2007;37(2):145-61. Abstract
40. Fendrich M, Wislar JS, Johnson TP, et al. A contextual profile of club drug use among adults in Chicago. Addiction. 2003 Dec;98(12):1693-703. Abstract
41. De-Carolis C, Boyd GA, Mancinelli L, et al. Methamphetamine abuse and "meth mouth" in Europe. Med Oral Patol Oral Cir Bucal. 2015 Mar 1;20(2):e205-10.Full text Abstract
42. Richards JR, Brofeldt BT. Patterns of tooth wear associated with methamphetamine use. J Periodontol. 2000 Aug;71(8):1371-4. Abstract
43. Degenhardt L, Coffey C, Carlin JB, et al. Who are the new amphetamine users? A 10-year prospective study of young Australians. Addiction. 2007 Aug;102(8):1269-79. Abstract
44. Sterk CE, Theall KP, Elifson KW. Getting into ecstasy: comparing moderate and heavy young adult users. J Psychoactive Drugs. 2007 Jun;39(2):103-13. Abstract
45. Dunkley EJ, Isbister GK, Sibbritt D, et al. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM. 2003 Sep;96(9):635-42.Full text Abstract
46. Suarez RV, Riemersma R. "Ecstasy" and sudden cardiac death. Am J Forensic Med Pathol. 1988 Dec;9(4):339-41. Abstract
47. Turnipseed SD, Richards JR, Kirk JD, et al. Frequency of acute coronary syndrome in patients presenting to the emergency department with chest pain after methamphetamine use. J Emerg Med. 2003 May;24(4):369-73. Abstract
48. Johnson TD, Berenson MM. Methamphetamine-induced ischemic colitis. J Clin Gastroenterol. 1991 Dec;13(6):687-9. Abstract
49. Baggott MJ. Preventing problems in Ecstasy users: reduce use to reduce harm. J Psychoactive Drugs. 2002 Apr-Jun;34(2):145-62. Abstract
50. Jafari Giv M. Exposure to amphetamines leads to development of amphetamine type stimulants associated cardiomyopathy (ATSAC). Cardiovasc Toxicol. 2017 Jan;17(1):13-24. Abstract
51. Sliman S, Waalen J, Shaw D. Methamphetamine-associated congestive heart failure: increasing prevalence and relationship of clinical outcomes to continued use or abstinence. Cardiovasc Toxicol. 2016 Oct;16(4):381-9. Abstract
52. Won S, Hong RA, Shohet RV, et al. Methamphetamine-associated cardiomyopathy. Clin Cardiol. 2013 Dec;36(12):737-42.Full text Abstract
53. Akhgari M, Mobaraki H, Etemadi-Aleagha A. Histopathological study of cardiac lesions in methamphetamine poisoning-related deaths. Daru. 2017 Feb 17;25(1):5.Full text Abstract
54. Jones AL, Dargan PI. Churchill's textbook of toxicology. Edinburgh, UK: Churchill-Livingstone; 2001.
55. Clinical Guidelines on Drug Misuse and Dependence Update 2017 Independent Expert Working Group (2017) Drug misuse and dependence: UK guidelines on clinical management. London: Department of HealthFull text
56. Royal College of Emergency Medicine. Management of suspected internal drug trafficker. Dec 2020 [internet publication].Full text
57. Shoptaw, SJ, Kao U, Ling W. Treatment for amphetamine psychosis. Cochrane Database Syst Rev. 2009 Jan 21;2009(1):CD003026. Abstract
58. London JA, Utter GH, Battistella F, et al. Methamphetamine use is associated with increased hospital resource consumption among minimally injured trauma patients. J Trauma. 2009 Feb;66(2):485-90. Abstract
59. Richards JR, Derlet RW, Albertson TE, et al. Methamphetamine, "bath salts," and other amphetamine-related derivatives: progressive treatment update. August 2014 [internet publication].Full text
60. Radfar SR, Rawson RA. Current research on methamphetamine: epidemiology, medical and psychiatric effects, treatment, and harm reduction efforts. Addict Health. Summer-Autumn 2014;6(3-4):146-54.Full text Abstract
61. Asser A, Taba P. Psychostimulants and movement disorders. Front Neurol. 2015 Apr 20;6:75.Full text Abstract
62. Cassel JC, Hamida SB, Jones BC. Ethanol and MDMA: a comment on the paper by Dumont et al. Psychopharmacology (Berl). 2008 Oct;200(2):305-6. Abstract
63. U.S. Preventive Services Task Force. Drug Use, Illicit: Screening. Jan 2008 [internet publication]Full text
64. Canadian Agency for Drugs and Technologies in Health. Use of antipsychotics and/or benzodiazepines as rapid tranquilization in in-patients of mental facilities and emergency departments: a review of the clinical effectiveness and guidelines. October 2015 [internet publication]Full text
65. Calver L, Drinkwater V, Gupta R, et al. Droperidol v. haloperidol for sedation of aggressive behaviour in acute mental health: randomised controlled trial. Br J Psychiatry. 2015 Mar;206(3):223-8.Full text
66. Canadian Agency for Drugs and Technologies in Health. Management of Acute Withdrawal and Detoxification for Adults who Misuse Methamphetamine: A Review of the Clinical Evidence and Guidelines. Feb 2019 [internet publication].Full text
67. Yap CY, Taylor DM, Knott JC, et al. Intravenous midazolam-droperidol combination, droperidol or olanzapine monotherapy for methamphetamine-related acute agitation: subgroup analysis of a randomized controlled trial. Addiction. 2017 Jul;112(7):1262-9. Abstract
68. Taylor DM, Yap CY, Knott JC, et al. Midazolam-droperidol, droperidol, or olanzapine for acute agitation: a randomized clinical trial. Ann Emerg Med. 2017 Mar;69(3):318-26.e1. Abstract
69. Chan EW, Taylor DM, Knott JC, et al. Intravenous droperidol or olanzapine as an adjunct to midazolam for the acutely agitated patient: a multicenter, randomized, double-blind, placebo-controlled clinical trial. Ann Emerg Med. 2013 Jan;61(1):72-81. Abstract
70. Richards JR, Schneir AB. Droperidol in the emergency department: is it safe? J Emerg Med. 2003 May;24(4):441-7. Abstract
71. Perkins J, Ho JD, Vilke GM, et al. American Academy of Emergency Medicine position statement: safety of droperidol use in the emergency department. J Emerg Med. 2015 Jul;49(1):91-7. Abstract
72. O'Connor AD, Padilla-Jones A, Gerkin RD, et al. Prevalence of rhabdomyolysis in sympathomimetic toxicity: a comparison of stimulants. J Med Toxicol. 2015 Jun;11(2):195-200.Full text Abstract
73. Hall AP, Lyburn ID, Spears FD, et al. An unusual case of ecstasy poisoning. Intensive Care Med. 1996 Jul;22(7):670-1.Full text Abstract
74. Richards JR, Colby DK. Stimulant-induced hyperthermia and ice-water submersion: practical considerations. Clin Toxicol (Phila). 2016;54(1):69-70. Abstract
75. Li J, Li J, Chen Y, et al. Methamphetamine use associated with monomorphic ventricular tachycardia. J Addict Med. 2014 Nov-Dec;8(6):470-3. Abstract
76. Haning W, Goebert D. Electrocardiographic abnormalities in methamphetamine abusers. Addiction. 2007 Apr;102 Suppl 1:70-5. Abstract
77. Etminan N, Macdonald RL. Management of aneurysmal subarachnoid hemorrhage. Handb Clin Neurol. 2017;140:195-228. Abstract
78. Cobb A, Thornton L. Sodium nitroprusside as a hyperinflation drug and therapeutic alternatives. J Pharm Pract. 2018 Aug;31(4):374-81.Full text Abstract
79. Grunau BE, Wiens MO, Brubacher JR. Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review. CJEM. 2010 Sep;12(5):435-42. Abstract
80. Kram B, Kram SJ, Sharpe ML, et al. Analgesia and sedation requirements in mechanically ventilated trauma patients with acute, preinjury use of cocaine and/or amphetamines. Anesth Analg. 2017 Mar;124(3):782-8. Abstract
81. Chhabra N, Gimbar RP, Walla LM, et al. Emergency department patient burden from an electronic dance music festival. J Emerg Med. 2018 Apr;54(4):435-39.Full text Abstract
82. Klega AE, Keehbauch JT. Stimulant and designer drug use: primary care management. Am Fam Physician. 2018 Jul 15;98(2):85-92. Abstract
83. Kleber HD, Weiss RD, Anton RF Jr, et al. Treatment of patients with substance use disorders, second edition. American Psychiatric Association. Am J Psychiatry. 2007 Apr;164(4 suppl):5-123. Abstract
84. Verheyden SL, Henry JA, Curran HV. Acute, sub-acute and long-term subjective consequences of 'ecstasy' (MDMA) consumption in 430 regular users. Hum Psychopharmacol. 2003 Oct;18(7):507-17. Abstract
85. Rogers G, Elston J, Garside R, et al. The harmful health effects of recreational ecstasy: a systematic review of observational evidence. Health Technol Assess. 2009 Jan;13(6):iii-iv, ix-xii, Abstract
86. Jones AL, Simpson KJ. Review article: mechanisms and management of hepatotoxicity in ecstasy (MDMA) and amphetamine intoxications. Aliment Pharmacol Ther. 1999 Feb;13(2):129-33.Full text Abstract
87. Onitilo AA, Kio E, Doi SA. Tumor-related hyponatremia. Clin Med Res. 2007 Dec;5(4):228-37.Full text Abstract
88. Mizia-Stec K, Gasior Z, Wojnicz R, et al. Severe dilated cardiomyopathy as a consequence of Ecstasy intake. Cardiovasc Pathol. 2008 Jul-Aug;17(4):250-3. Abstract
89. Marsh JC, Abboudi ZH, Gibson FM, et al. Aplastic anaemia following exposure to 3,4-methylendioxymethamphetamine ('Ecstasy'). Br J Haematol. 1994 Oct;88(2):281-5. Abstract
90. Whitlock EP, Orleans CT, Pender N, et al. Evaluating primary care behavioral counseling interventions: an evidence-based approach. Am J Prev Med. 2002 May;22(4):267-84. Abstract
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