Toxic thyroid adenoma
Summary
Definition
History and exam
Key diagnostic factors
- presence of risk factors
- palpable thyroid nodule
- younger age
Other diagnostic factors
- hyperphagia
- weight loss
- sweating/heat intolerance
- nervousness
- palpitations
- oligomenorrhoea
- hyperdefecation
- dyspnoea
- stare or lid lag
- tachycardia
- tremor
- warm moist skin
- muscle weakness
- hoarseness
- dysphagia
- choking
- mood change
Risk factors
- young adult age
- iodine deficiency
- head and neck irradiation
- family history of thyroid nodules
- female sex
Diagnostic investigations
1st investigations to order
- thyroid stimulating hormone (TSH)
- thyroid ultrasound
Investigations to consider
- free thyroxine (T4; or total T4 with a measure of binding)
- total T3 with a measure of binding (or free T3)
- thyroid scan and uptake
- metabolic panel
- FBC
- TSH receptor antibodies
- thyroid peroxidase antibodies
- ECG
- CT neck (non-contrast)
Treatment algorithm
non-pregnant non-lactating adults without mass effect
non-pregnant non-lactating adults with mass effect
pregnant or lactating
Contributors
Authors
Elizabeth N. Pearce, MD
Professor of Medicine
Boston University Medical Center
Boston
MA
Disclosures
ENP is a member of the Management Council of the Iodine Global Network. She was the 2018-2019 President of the American Thyroid Association (ATA) and served on its board and executive committee until 2020. She is a current member of the ATA's thyroid in pregnancy guidelines writing task force. She is currently a Deputy Editor at the Journal of Clinical Endocrinology and Metabolism and has previously served as an Associated Editor for the journals Thyroid, Endocrine Practice, and Clinical Thyroidology. She is an author of a number of references cited in this topic.
Acknowledgements
Dr Elizabeth N. Pearce would like to gratefully acknowledge Dr Sheila Feit, the previous contributor to this topic.
Peer reviewers
John C. Morris, MD
Professor of Medicine
Mayo Clinic
Rochester
MN
Disclosures
JCM declares that he has no competing interests.
Petros Perros, BSc, MBBS, MD, FRCP
Consultant Endocrinologist
Freeman Hospital
Newcastle-Upon-Tyne
UK
Disclosures
PP declares that he has no competing interests.
Differentials
- Graves' disease
- Toxic multinodular goitre
- Thyrotoxic phase of painless lymphocytic thyroiditis
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