Erythema nodosum predominantly affects women aged 20 to 40 years. Diagnosis is clinical, but may be confirmed by biopsy, and should be accompanied by a search for the underlying cause. Initial tests are performed to identify the most common and important causes, in particular streptococcal infections, sarcoidosis, and tuberculosis, plus any additional conditions prevalent in the geographical area. However, no cause is found in 60% of patients with erythema nodosum.

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