Diagnosis is based on the presence of upper motor neuron (UMN) and lower motor neuron (LMN) signs, disease progression, and absence of any other explanation for the presentation. Diagnosis of ALS is primarily based on clinical criteria. A thorough history and physical examination are central to the diagnostic process, followed by electrodiagnostic testing when required for additional evidence of occult LMN involvement.

BMJ Best Practice is an evidence-based point of care tool for healthcare practitioners.

To continue reading and access all of BMJ Best Practice's pages you'll need to log in or start a free trial.

You can access through your institution if your hospital, university, trust or other institution provides access to BMJ Best Practice through either OpenAthens or Shibboleth.

Use of this content is subject to our disclaimer