小结
定义
Анамнез и осмотр
Ключевые диагностические факторы
- fluctuations
- visual hallucinations
- motor symptoms
- rapid eye movement (REM) sleep behavioral disturbance
Другие диагностические факторы
- severe antipsychotic sensitivity
- depression
- anxiety
- repeated falls and syncope
- orthostatic hypotension
- urinary symptoms
- constipation
- attentional and visual processing abnormalities
- delusions
- hypersomnia
- hyposmia
- auditory hallucinations
Факторы риска
- older age
- familial occurrence
Диагностические исследования
Исследования, которые показаны в первую очередь
- serum thyroid-stimulating hormone (TSH)
- serum vitamin B12
- CT head
- MRI head
Исследования, проведение которых нужно рассмотреть
- CBC
- metabolic panel
- serum folate
- serum Venereal Disease Research Laboratory
- urine drug screen
- urinalysis
- HIV testing
- single-photon emission CT (SPECT)/positron emission tomography (PET)
- quantitative EEG
- polysomnography
- cerebrospinal fluid (CSF) analysis
- neuropsychological testing
- MIBG myocardial scintigraphy
Алгоритм лечения
all patients
Составители
Авторы
Alan J. Lerner, MD
Professor of Neurology
Department of Neurology
University Hospitals Cleveland Medical Center
Case Western Reserve University
Cleveland
OH
Раскрытие информации
AJL declares that he has no competing interests.
Mohamed I. Elkasaby, MD
Fellow in Behavioral Neurology and Neuropsychiatry
Department of Neurology
University Hospitals Cleveland Medical Center
Case Western Reserve University
Cleveland
OH
Раскрытие информации
MIE declares that he has no competing interests.
Выражение благодарностей
Dr Alan J. Lerner and Dr Mohamed I. Elkasaby would like to gratefully acknowledge Dr Brian S. Appleby, Dr Ethan Gore, Dr Rajeet Shrestha, Dr Timothy Wuerz, Dr Julie Schneider, Dr Viola Fahmy, and Dr Sube Banerjee, previous contributors to this topic.
Раскрытие информации
BSA, EG, RS, TW, JS, VF, and SB declare that they have no competing interests.
Рецензенты
Bryan Bernard, PhD
Assistant Professor and Clinical Neuropsychologist
Department of Neurological Sciences
Rush University Medical Center
Chicago
IL
Раскрытие информации
BB declares that he has no competing interests.
James E. Galvin, MD, MPH
Associate Professor
Neurology, Psychiatry and Neurobiology
Director
Memory Diagnostic Center and Alzheimer Treatment Unit
Director
Education and Community Outreach
Alzheimer Disease Research Center
Washington University School of Medicine
St Louis
MO
Раскрытие информации
JEG declares that he has no competing interests.
Ian McKeith, MBBS
Professor of Old Age Psychiatry
Clinical Director
Institute for Ageing and Health
Newcastle University
Newcastle
UK
Раскрытие информации
IM is the author of several references cited in this topic.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
Список литературы
Основные статьи
McKeith IG, Boeve BF, Dickson DW, et al. Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium. Neurology. 2017 Jul 4;89(1):88-100.Полный текст Аннотация
Expert Panel on Neurological Imaging, Soderlund KA, Austin MJ, et al. ACR appropriateness criteria® Dementia: 2024 update. J Am Coll Radiol. 2025 May;22(5s):S202-33.Полный текст Аннотация
Taylor JP, McKeith IG, Burn DJ, et al. New evidence on the management of Lewy body dementia. Lancet Neurol. 2020 Feb;19(2):157-69.Полный текст Аннотация
O'Brien JT, Holmes C, Jones M, et al. Clinical practice with anti-dementia drugs: a revised (third) consensus statement from the British Association for Psychopharmacology. J Psychopharmacol. 2017 Feb;31(2):147-68. Аннотация
Reus VI, Fochtmann LJ, Eyler AE, et al. The American Psychiatric Association practice guideline on the use of antipsychotics to treat agitation or psychosis in patients with dementia. Am J Psychiatry. 2016 May 1;173(5):543-6.Полный текст Аннотация
Статьи, указанные как источники
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Отличия
- Alzheimer disease
- Parkinson disease
- Frontotemporal dementia
Больше ОтличияРекомендации
- ACR appropriateness criteria: dementia
- Management of REM sleep behavior disorder
Больше РекомендацииЛифлеты для пациента
Alzheimer disease and other kinds of dementia
Caring for someone with dementia
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