Evaluation of non-visible hematuria

References

Key articles

Barocas DA, Boorjian SA, Alvarez RD, et al. Microhematuria: AUA/SUFU Guideline. J Urol. 2020 Oct;204(4):778-86.Full text  Abstract

American College of Obstetricians and Gynecologists' Committee on Gynecologic Practice, American Urogynecologic Society. Committee opinion no. 703: asymptomatic microscopic hematuria in women. Jun 2017 [Internet publication]​.Full text

Nielsen M, Qaseem A; High Value Care Task Force of the American College of Physicians. Hematuria as a marker of occult urinary tract cancer: advice for high-value care from the American College of Physicians. Ann Intern Med. 2016;164:488-497.Full text  Abstract

Linder BJ, Bass EJ, Mostafid H, et al. Guideline of guidelines: asymptomatic microscopic haematuria. BJU Int. 2018 Feb;121(2):176-83.Full text  Abstract

American College of Radiology. ACR appropriateness criteria: hematuria. 2019 [internet publication].Full text

Reference articles

1. Barocas DA, Boorjian SA, Alvarez RD, et al. Microhematuria: AUA/SUFU Guideline. J Urol. 2020 Oct;204(4):778-86.Full text  Abstract

2. Tan WS, Feber A, Sarpong R, et al. Who should be investigated for haematuria? results of a contemporary prospective observational study of 3556 patients. Eur Urol. 2018 Jul;74(1):10-4.Full text  Abstract

3. Samson P, Waingankar N, Shah P, et al. Predictors of genitourinary malignancy in patients with asymptomatic microscopic hematuria. Urol Oncol. 2018 Jan;36(1):10.e1-10.e6.Full text  Abstract

4. Tomson C, Porter T. Asymptomatic microscopic or dipstick haematuria in adults: which investigations for which patients? A review of the evidence. BJU Int. 2002;90:185-198. Abstract

5. Wollin T, Laroche B, Psooy K. Canadian guidelines for the management of asymptomatic microscopic hematuria in adults. Can Urol Assoc J. 2009:3;77-80.Full text  Abstract

6. Hiatt RA, Ordonez JD. Dipstick urinalysis screening, asymptomatic microhematuria, and subsequent urological cancers in a population-based sample. Cancer Epidemiol Biomarkers Prev. 1994;3:439-443. [Published correction appears in Cancer Epidemiol Biomarkers Prev. 1994;3:523.]Full text  Abstract

7. Edwards TJ, Dickinson AJ, Natale S, et al. A prospective analysis of the diagnostic yield resulting from 4020 patients at a protocol-driven haematuria clinic. BJU Int. 2006;97:301-305. Abstract

8. Cohen RA, Brown RS. Microscopic hematuria. N Engl J Med. 2003;348:2330-2338. Abstract

9. Chou R, Dana T. Screening adults for bladder cancer: a review of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2010;5:153:461-468. Abstract

10. Kang M, Lee S, Jeong SJ, et al. Characteristics and significant predictors of detecting underlying diseases in adults with asymptomatic microscopic hematuria: a large case series of a Korean population. Int J Urol. 2015 Apr;22(4):389-93.Full text  Abstract

11. American College of Obstetricians and Gynecologists' Committee on Gynecologic Practice, American Urogynecologic Society. Committee opinion no. 703: asymptomatic microscopic hematuria in women. Jun 2017 [Internet publication]​.Full text

12. Escudier B, Porta C, Schmidinger M, et al. Renal cell carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2019 May 1;30(5):706-20.Full text  Abstract

13. National Institute for Health and Care Excellence. Suspected cancer: recognition and referral. Oct 2023​ [internet publication].Full text

14. Messing EM, Madeb R, Young T, et al. Long-term outcome of hematuria home screening for bladder cancer in men. Cancer. 2006;107:2173-2179.Full text  Abstract

15. Friedman GD, Carroll PR, Cattolica EV, et al. Can hematuria be a predictor as well as a symptom or sign of bladder cancer? Cancer Epidemiol Biomarkers Prev. 1996;5:993-996.Full text  Abstract

16. Sugimura K, Ikemoto S, Kawashima H, et al. Microscopic hematuria as a screening marker for urinary tract malignancies. Int J Urol. 2001;8:1-5. Abstract

17. Jones R, Latinovic R, Charlton J, et al. Alarm symptoms in early diagnosis of cancer in primary care: cohort study using general practice research database. BMJ. 2007;334:1040.Full text  Abstract

18. Nielsen M, Qaseem A; High Value Care Task Force of the American College of Physicians. Hematuria as a marker of occult urinary tract cancer: advice for high-value care from the American College of Physicians. Ann Intern Med. 2016;164:488-497.Full text  Abstract

19. Ohisa N, Kanemitsu K, Matsuki R, et al. Evaluation of hematuria using the urinary albumin-to-total-protein ratio to differentiate glomerular and nonglomerular bleeding. Clin Exp Nephrol. 2007;11:61-65. Abstract

20. Shen P, Ding X, Ten J, et al. Clinicopathological characteristics and outcome of adult patients with hematuria and/or proteinuria found during routine examination. Nephron Clin Pract. 2006;103:c149-56. Abstract

21. Cespedes RD, Peretsman SJ, Blatt SP. The significance of hematuria in patients infected with human immunodeficiency virus. J Urol. 1995;154:1455-1456. Abstract

22. Jones GR, Newhouse IJ, Jakobi JM, et al. The incidence of hematuria in middle distance track running. Can J Appl Physiol. 2001;26:336-349. Abstract

23. Worcester EM, Coe FL. Clinical practice. Calcium kidney stones. N Engl J Med. 2010 Sep 2;363(10):954-63.Full text  Abstract

24. Ricketts C, Woodward ER, Killick P, et al. Germline SDHB mutations and familial renal cell carcinoma. J Natl Cancer Inst. 2008 Sep 3;100(17):1260-2.Full text  Abstract

25. Steinberg GD, Carter BS, Beaty TH, et al. Family history and the risk of prostate cancer. Prostate. 1990;17(4):337-47. Abstract

26. Culclasure TF, Bray VJ, Hasbargen JA. The significance of hematuria in the anticoagulated patient. Arch Intern Med. 1994 Mar 28;154(6):649-52. Abstract

27. Tasian GE, Jemielita T, Goldfarb DS, et al. Oral antibiotic exposure and kidney stone disease. J Am Soc Nephrol. 2018 Jun;29(6):1731-40.Full text  Abstract

28. Gun RT, Seymour AE, Mathew TH. A cluster of haematuria cases in a pesticide-manufacturing plant. Occup Med. 1998;48:59-62.Full text

29. Alishahi S, Byrne D, Goodman CM, et al. Haematuria investigation based on a standard protocol: emphasis on the diagnosis of urological malignancy. J R Coll Surg Edinb. 2002;47:422-427. Abstract

30. Froom P, Ribak J, Benbassat J. Significance of microhaematuria in young adults. BMJ. 1984;288:20-22.Full text  Abstract

31. Topham PS, Jethwa A, Watkins M, et al. The value of urine screening in a young adult population. Fam Pract. 2004;21:18-21.Full text  Abstract

32. Paner GP, Zehnder P, Amin AM, et al. Urothelial neoplasms of the urinary bladder occurring in young adult and pediatric patients: a comprehensive review of literature with implications for patient management. Adv Anat Pathol. 2011;18:79-89. Abstract

33. Linder BJ, Bass EJ, Mostafid H, et al. Guideline of guidelines: asymptomatic microscopic haematuria. BJU Int. 2018 Feb;121(2):176-83.Full text  Abstract

34. Rodgers M, Nixon J, Hempel S, et al. Diagnostic tests and algorithms used in the investigation of haematuria: systematic reviews and economic evaluation. Health Technol Assess. 2006;10:1-259. Abstract

35. Kouri T, Malminiemi O, Penders J, et al. Limits of preservation of samples for urine strip tests and particle counting. Clin Chem Lab Med. 2008;46(5):703-13. Abstract

36. Yamagata K, Takahashi H, Tomida C, et al. Prognosis of asymptomatic hematuria and/or proteinuria in men. High prevalence of IgA nephropathy among proteinuria patients found in mass screening. Nephron. 2002;91:34-42. Abstract

37. Hall CL, Bradley R, Kerr A, et al. Clinical value of renal biopsy in patients with asymptomatic microscopic hematuria with and without low-grade proteinuria. Clin Nephrol. 2004;62:267-272. Abstract

38. McGregor DO, Lynn KL, Bailey RR, et al. Clinical audit of the use of renal biopsy in the management of isolated microscopic hematuria. Clin Nephrol. 1998;49:345-348. Abstract

39. Georgieva MV, Wheeler SB, Erim D, et al. Comparison of the harms, advantages, and costs associated with alternative guidelines for the evaluation of hematuria. JAMA Intern Med. 2019;179(10):1352-62. Abstract

40. Tan WS, Sarpong R, Khetrapal P, et al. Can renal and bladder ultrasound replace computerized tomography urogram in patients investigated for microscopic hematuria? J Urol. 2018 Nov;200(5):973-80. Abstract

41. American College of Radiology. ACR appropriateness criteria: hematuria. 2019 [internet publication].Full text

42. Blick CG, Nazir SA, Mallett S, et al. Evaluation of diagnostic strategies for bladder cancer using computed tomography (CT) urography, flexible cystoscopy and voided urine cytology: results for 778 patients from a hospital haematuria clinic. BJU Int. 2012 Jul;110(1):84-94.Full text  Abstract

43. Abrol S, Jairath A, Ganpule S, et al. Can CT virtual cystoscopy replace conventional cystoscopy in early detection of bladder cancer? Adv Urol. 2015;2015:926590.Full text  Abstract

44. Ibáñez Muñoz D, Quintana Martínez I, Fernández Militino A, et al. Virtual cystoscopy, computed tomography urography and optical cystoscopy for the detection and follow-up for bladder cancer. [in spa]. Radiologia. 2017 Sep - Oct;59(5):422-30.Full text  Abstract

45. National Institute for Health and Care Excellence. Renal and ureteric stones: assessment and management. Jan 2019 [internet publication].Full text

46. Schneider H, Ludwig M, Hossain HM, et al. The 2001 Giessen Cohort Study on patients with prostatitis syndrome--an evaluation of inflammatory status and search for microorganisms 10 years after a first analysis. Andrologia. 2003 Oct;35(5):258-62. Abstract

47. Grossfeld GD, Litwin MS, Wolf JS, et al. Evaluation of asymptomatic microscopic hematuria in adults: the American Urological Association best practice policy - part II: patient evaluation, cytology, voided markers, imaging, cystoscopy, nephrology evaluation, and follow-up. Urology. 2001 Apr;57(4):604-10. Abstract

48. Lang EK, Thomas R, Davis R, et al. Multiphasic helical computerized tomography for the assessment of microscopic hematuria: a prospective study. J Urol. 2004;171:237-243. Abstract

49. American College of Radiology. ACR appropriateness criteria: renal cell carcinoma staging. 2015 [internet publication].Full text

50. Hahn BH, McMahon M, Wilkinson A, et al. American College of Rheumatology guidelines for screening, case definition, treatment and management of lupus nephritis. Arthritis Care Res (Hoboken). 2012; 64:797-808.Full text

51. National Institute for Health and Care Excellence. Prostate cancer: diagnosis and management. Dec 2021 [internet publication].Full text

52. Drost FH, Osses DF, Nieboer D, et al. Prostate MRI, with or without MRI-targeted biopsy, and systematic biopsy for detecting prostate cancer. Cochrane Database Syst Rev. 2019 Apr 25;4:CD012663.Full text  Abstract

53. Lewinsohn DM, Leonard MK, LoBue PA, et al. Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention clinical practice guidelines: diagnosis of tuberculosis in adults and children. Clin Infect Dis. 2017 Jan 15;64(2):111-5.Full text  Abstract

54. Nataraj G, Kurup S, Pandit A, et al. Correlation of fine needle aspiration cytology, smear and culture in tuberculous lymphadenitis: a prospective study. J Postgrad Med. 2002 Apr-Jun;48(2):113-6.Full text  Abstract

55. Muneer A, Macrae B, Krishnamoorthy S, et al. Urogenital tuberculosis - epidemiology, pathogenesis and clinical features. Nat Rev Urol. 2019 Oct;16(10):573-98.Full text  Abstract

56. Geldmacher H, Taube C, Kroeger C, et al. Assessment of lymph node tuberculosis in northern Germany: a clinical review. Chest. 2002 Apr;121(4):1177-82. Abstract

57. Weir MR, Thornton GF. Extrapulmonary tuberculosis. Experience of a community hospital and review of the literature. Am J Med. 1985 Oct;79(4):467-78. Abstract

58. Baydur A. The spectrum of extrapulmonary tuberculosis. West J Med. 1977 Apr;126(4):253-62.Full text  Abstract

59. World Health Organization. WHO consolidated guidelines on tuberculosis: module 3: diagnosis: rapid diagnostics for tuberculosis detection. Mar 2024 [internet publication].Full text

60. Bjerrum S, Schiller I, Dendukuri N, et al. Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in people living with HIV. Cochrane Database Syst Rev. 2019 Oct 21;10(10):CD011420.Full text  Abstract

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