Pediatric acute-onset neuropsychiatric syndrome

Pfeiffer HCV, Wickstrom R, Skov L, et al. Clinical guidance for diagnosis and management of suspected pediatric acute-onset neuropsychiatric syndrome in the Nordic countries. Acta Paediatr. 2021 Dec;110(12):3153-60.Full text  Abstract

Chang K, Frankovich J, Cooperstock M, et al. Clinical evaluation of youth with pediatric acute-onset neuropsychiatric syndrome (PANS): recommendations from the 2013 PANS Consensus Conference. J Child Adolesc Psychopharmacol. 2015 Feb;25(1):3-13.Full text  Abstract

Cooperstock MS, Swedo SE, Pasternack MS, et al. Clinical management of pediatric acute-onset neuropsychiatric syndrome: part III-treatment and prevention of infections. J Child Adolesc Psychopharmacol. 2017 Sep;27(7):594-606.Full text  Abstract

Frankovich J, Swedo S, Murphy T, et al. Clinical management of pediatric acute-onset neuropsychiatric syndrome: part II-use of immunomodulatory therapies. J Child Adolesc Psychopharmacol. 2017 Sep;27(7):574-93.Full text  Abstract

Thienemann M, Murphy T, Leckman J, et al. Clinical management of pediatric acute-onset neuropsychiatric syndrome: part I-psychiatric and behavioral interventions. J Child Adolesc Psychopharmacol. 2017 Sep;27(7):566-73.Full text  Abstract

1. Swedo SE, Leckman JF, Rose NR. From research subgroup to clinical syndrome: modifying the PANDAS criteria to describe PANS (pediatric acute-onset neuropsychiatric syndrome). Pediatr Ther. 2012;2(2):1000113.Full text

2. Pfeiffer HCV, Wickstrom R, Skov L, et al. Clinical guidance for diagnosis and management of suspected pediatric acute-onset neuropsychiatric syndrome in the Nordic countries. Acta Paediatr. 2021 Dec;110(12):3153-60.Full text  Abstract

3. Frankovich J, Thienemann M, Pearlstein J, et al. Multidisciplinary clinic dedicated to treating youth with pediatric acute-onset neuropsychiatric syndrome: presenting characteristics of the first 47 consecutive patients. J Child Adolesc Psychopharmacol. 2015 Feb;25(1):38-47. Abstract

4. Gromark C, Harris RA, Wickström R, et al. Establishing a pediatric acute-onset neuropsychiatric syndrome clinic: baseline clinical features of the pediatric acute-onset neuropsychiatric syndrome cohort at Karolinska Institutet. J Child Adolesc Psychopharmacol. 2019 Oct;29(8):625-33.Full text  Abstract

5. Gromark C, Hesselmark E, Djupedal IG, et al. A two-to-five year follow-up of a pediatric acute-onset neuropsychiatric syndrome cohort. Child Psychiatry Hum Dev. 2022 Apr;53(2):354-64.Full text  Abstract

6. Swedo SE, Leonard HL, Garvey M, et al. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry. 1998 Feb;155(2):264-71.Full text  Abstract

7. Murphy TK, Patel PD, McGuire JF, et al. Characterization of the pediatric acute-onset neuropsychiatric syndrome phenotype. J Child Adolesc Psychopharmacol. 2015 Feb;25(1):14-25. Abstract

8. Swedo SE, Seidlitz J, Kovacevic M, et al. Clinical presentation of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections in research and community settings. J Child Adolesc Psychopharmacol. 2015 Feb;25(1):26-30.Full text  Abstract

9. Johnson M, Fernell E, Preda I, et al. Paediatric acute-onset neuropsychiatric syndrome in children and adolescents: an observational cohort study. Lancet Child Adolesc Health. 2019 Mar;3(3):175-80. Abstract

10. Frankovich J, Leibold CM, Farmer C, et al. The burden of caring for a child or adolescent with pediatric acute-onset neuropsychiatric syndrome (PANS): an observational longitudinal study. J Clin Psychiatry. 2018 Dec 11;80(1):17m12091. Abstract

11. Farmer C, Thienemann M, Leibold C, et al. Psychometric evaluation of the caregiver burden inventory in children and adolescents with PANS. J Pediatr Psychol. 2018 Aug 1;43(7):749-57.Full text  Abstract

12. World Health Organization. International statistical classification of diseases and related health problems. 11th revision. Jan 2022 [internet publication].Full text

13. Wald E, Eickhoff J, Flood GE. Estimate of the incidence of PANDAS and PANS in 3 primary care populations. Front Pediatr. 2023 Sep 21;11:1170379.Full text

14. Flament MF, Whitaker A, Rapoport JL, et al. Obsessive compulsive disorder in adolescence: an epidemiological study. J Am Acad Child Adolesc Psychiatry. 1988 Nov;27(6):764-71. Abstract

15. Valleni-Basile LA, Garrison CZ, Jackson KL, et al. Frequency of obsessive-compulsive disorder in a community sample of young adolescents. J Am Acad Child Adolesc Psychiatry. 1994 Jul-Aug;33(6):782-91. Abstract

16. Jaspers-Fayer F, Han SHJ, Chan E, et al. Prevalence of acute-onset subtypes in pediatric obsessive-compulsive disorder. J Child Adolesc Psychopharmacol. 2017 May;27(4):332-41. Abstract

17. Aman M, Coelho JS, Lin B, et al. Prevalence of pediatric acute-onset neuropsychiatric syndrome (PANS) in children and adolescents with eating disorders. J Eat Disord. 2022 Dec 13;10(1):194.Full text  Abstract

18. Singer HS, Giuliano JD, Zimmerman AM, et al. Infection: a stimulus for tic disorders. Pediatr Neurol. 2000 May;22(5):380-3. Abstract

19. Garvey MA, Giedd J, Swedo SE. PANDAS: the search for environmental triggers of pediatric neuropsychiatric disorders. Lessons from rheumatic fever. J Child Neurol. 1998 Sep;13(9):413-23. Abstract

20. Chang K, Frankovich J, Cooperstock M, et al. Clinical evaluation of youth with pediatric acute-onset neuropsychiatric syndrome (PANS): recommendations from the 2013 PANS Consensus Conference. J Child Adolesc Psychopharmacol. 2015 Feb;25(1):3-13.Full text  Abstract

21. Lepri G, Rigante D, Bellando Randone S, et al. Clinical-serological characterization and treatment outcome of a large cohort of Italian children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection and pediatric acute neuropsychiatric syndrome. J Child Adolesc Psychopharmacol. 2019 Oct;29(8):608-14. Abstract

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23. Brown KD, Farmer C, Freeman GM Jr, et al. Effect of early and prophylactic nonsteroidal anti-inflammatory drugs on flare duration in pediatric acute-onset neuropsychiatric syndrome: an observational study of patients followed by an academic community-based pediatric acute-onset neuropsychiatric syndrome clinic. J Child Adolesc Psychopharmacol. 2017 Sep;27(7):619-28. Abstract

24. Spartz EJ, Freeman GM Jr, Brown K, et al. Course of neuropsychiatric symptoms after introduction and removal of nonsteroidal anti-inflammatory drugs: a pediatric observational study. J Child Adolesc Psychopharmacol. 2017 Sep;27(7):652-9. Abstract

25. Brown K, Farmer C, Farhadian B, et al. Pediatric acute-onset neuropsychiatric syndrome response to oral corticosteroid bursts: an observational study of patients in an academic community-based PANS clinic. J Child Adolesc Psychopharmacol. 2017 Sep;27(7):629-39. Abstract

26. Perlmutter SJ, Leitman SF, Garvey MA, et al. Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood. Lancet. 1999 Oct 2;354(9185):1153-8. Abstract

27. Latimer ME, L'Etoile N, Seidlitz J, et al. Therapeutic plasma apheresis as a treatment for 35 severely ill children and adolescents with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. J Child Adolesc Psychopharmacol. 2015 Feb;25(1):70-5. Abstract

28. Melamed I, Kobayashi RH, O'Connor M, et al. Evaluation of intravenous immunoglobulin in pediatric acute-onset neuropsychiatric syndrome. J Child Adolesc Psychopharmacol. 2021 Mar;31(2):118-28.Full text  Abstract

29. Kovacevic M, Grant P, Swedo SE. Use of intravenous immunoglobulin in the treatment of twelve youths with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. J Child Adolesc Psychopharmacol. 2015 Feb;25(1):65-9.Full text  Abstract

30. Mell LK, Davis RL, Owens D. Association between streptococcal infection and obsessive-compulsive disorder, Tourette's syndrome, and tic disorder. Pediatrics. 2005 Jul;116(1):56-60. Abstract

31. Leslie DL, Kozma L, Martin A, et al. Neuropsychiatric disorders associated with streptococcal infection: a case-control study among privately insured children. J Am Acad Child Adolesc Psychiatry. 2008 Oct;47(10):1166-72.Full text  Abstract

32. Orlovska S, Vestergaard CH, Bech BH, et al. Association of streptococcal throat infection with mental disorders: testing key aspects of the PANDAS hypothesis in a nationwide study. JAMA Psychiatry. 2017 Jul 1;74(7):740-6.Full text  Abstract

33. Cooperstock MS, Swedo SE, Pasternack MS, et al. Clinical management of pediatric acute-onset neuropsychiatric syndrome: part III-treatment and prevention of infections. J Child Adolesc Psychopharmacol. 2017 Sep;27(7):594-606.Full text  Abstract

34. Murphy TK, Snider LA, Mutch PJ, et al. Relationship of movements and behaviors to group A streptococcus infections in elementary school children. Biol Psychiatry. 2007 Feb 1;61(3):279-84.Full text  Abstract

35. Chan A, Frankovich J. Infections, antibiotics, and mental health deteriorations. J Child Adolesc Psychopharmacol. 2019 Oct;29(8):647-8. Abstract

36. Cutforth T, DeMille MM, Agalliu I, et al. CNS autoimmune disease after Streptococcus pyogenes infections: animal models, cellular mechanisms and genetic factors. Future Neurol. 2016 Dec;11(1):63-76.Full text  Abstract

37. Zheng J, Frankovich J, McKenna ES, et al. Association of pediatric acute-onset neuropsychiatric syndrome with microstructural differences in brain regions detected via diffusion-weighted magnetic resonance imaging. JAMA Netw Open. 2020 May 1;3(5):e204063.Full text  Abstract

38. Cabrera B, Romero-Rebollar C, Jiménez-Ángeles L, et al. Neuroanatomical features and its usefulness in classification of patients with PANDAS. CNS Spectr. 2019 Oct;24(5):533-43. Abstract

39. Kumar A, Williams MT, Chugani HT. Evaluation of basal ganglia and thalamic inflammation in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection and tourette syndrome: a positron emission tomographic (PET) study using 11C-[R]-PK11195. J Child Neurol. 2015 May;30(6):749-56. Abstract

40. Giedd JN, Rapoport JL, Garvey MA, et al. MRI assessment of children with obsessive-compulsive disorder or tics associated with streptococcal infection. Am J Psychiatry. 2000 Feb;157(2):281-3.Full text  Abstract

41. Rahman S, Gaertner F, Houghton J, et al. Pediatric acute-onset neuropsychiatric syndrome (PANS) is characterized by a novel subset of monocytes with markers associated with crossing the blood brain barrier (BBB) [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 4).Full text

42. Frick LR, Rapanelli M, Jindachomthong K, et al. Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum. Brain Behav Immun. 2018 Mar;69:304-11.Full text  Abstract

43. Xu J, Liu RJ, Fahey S, et al. Antibodies from children with PANDAS bind specifically to striatal cholinergic interneurons and alter their activity. Am J Psychiatry. 2021 Jan 1;178(1):48-64.Full text  Abstract

44. Chain JL, Alvarez K, Mascaro-Blanco A, et al. Autoantibody biomarkers for basal ganglia encephalitis in Sydenham chorea and pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections. Front Psychiatry. 2020 Jun 24:11:564.Full text  Abstract

45. Hoffman KL, Hornig M, Yaddanapudi K, et al. A murine model for neuropsychiatric disorders associated with group A beta-hemolytic streptococcal infection. J Neurosci. 2004 Feb 18;24(7):1780-91.Full text  Abstract

46. Brimberg L, Benhar I, Mascaro-Blanco A, et al. Behavioral, pharmacological, and immunological abnormalities after streptococcal exposure: a novel rat model of Sydenham chorea and related neuropsychiatric disorders. Neuropsychopharmacology. 2012 Aug;37(9):2076-87.Full text  Abstract

47. Dileepan T, Smith ED, Knowland D, et al. Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells. J Clin Invest. 2016 Jan;126(1):303-17.Full text  Abstract

48. Gagliano A, Galati C, Ingrassia M, et al. Pediatric acute-onset neuropsychiatric syndrome: a data mining approach to a very specific constellation of clinical variables. J Child Adolesc Psychopharmacol. 2020 Oct;30(8):495-511. Abstract

49. Chan A, Phu T, Farhadian B, et al. Familial clustering of immune-mediated diseases in children with abrupt-onset obsessive compulsive disorder. J Child Adolesc Psychopharmacol. 2020 Jun;30(5):345-6. Abstract

50. Calaprice D, Tona J, Parker-Athill EC, et al. A survey of pediatric acute-onset neuropsychiatric syndrome characteristics and course. J Child Adolesc Psychopharmacol. 2017 Sep;27(7):607-18.Full text  Abstract

51. Frankovich J, Swedo S, Murphy T, et al. Clinical management of pediatric acute-onset neuropsychiatric syndrome: part II-use of immunomodulatory therapies. J Child Adolesc Psychopharmacol. 2017 Sep;27(7):574-93.Full text  Abstract

52. Swedo SE, Leonard HL, Mittleman BB, et al. Identification of children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections by a marker associated with rheumatic fever. Am J Psychiatry. 1997 Jan;154(1):110-2. Abstract

53. Ma M, Sandberg J, Farhadian B, et al. Arthritis in children with psychiatric deteriorations: a case series. Dev Neurosci. 2023 May 12 [Epub ahead of print].Full text  Abstract

54. Swedo SE, Leonard HL, Rapoport JL. The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) subgroup: separating fact from fiction. Pediatrics. 2004 Apr;113(4):907-11. Abstract

55. Murphy TK, Storch EA, Lewin AB, et al. Clinical factors associated with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. J Pediatr. 2012 Feb;160(2):314-9.Full text  Abstract

56. Bernstein GA, Victor AM, Pipal AJ, et al. Comparison of clinical characteristics of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and childhood obsessive-compulsive disorder. J Child Adolesc Psychopharmacol. 2010 Aug;20(4):333-40. Abstract

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58. Frankovich J, Thienemann M, Rana S, et al. Five youth with pediatric acute-onset neuropsychiatric syndrome of differing etiologies. J Child Adolesc Psychopharmacol. 2015 Feb;25(1):31-7.Full text  Abstract

59. Silverman M, Frankovich J, Nguyen E, et al. Psychotic symptoms in youth with pediatric acute-onset neuropsychiatric syndrome (PANS) may reflect syndrome severity and heterogeneity. J Psychiatr Res. 2019 Mar;110:93-102. Abstract

60. Johnson M, Ehlers S, Fernell E, et al. Anti-inflammatory, antibacterial and immunomodulatory treatment in children with symptoms corresponding to the research condition PANS (Pediatric Acute-onset Neuropsychiatric Syndrome): a systematic review. PLoS One. 2021 Jul 1;16(7):e0253844.Full text  Abstract

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62. Mahony T, Sidell D, Gans H, et al. Palatal petechiae in the absence of group A streptococcus in pediatric patients with acute-onset neuropsychiatric deterioration: a cohort study. J Child Adolesc Psychopharmacol. 2017 Sep;27(7):660-6. Abstract

63. Toufexis MD, Hommer R, Gerardi DM, et al. Disordered eating and food restrictions in children with PANDAS/PANS. J Child Adolesc Psychopharmacol. 2015 Feb;25(1):48-56.Full text  Abstract

64. Shulman ST, Bisno AL, Clegg HW, et al. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. 2012 Nov 15;55(10):e86-102.Full text  Abstract

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68. Santoro JD, Frankovich J, Bhargava S. Continued presence of period limb movements during REM sleep in patients with chronic static pediatric acute-onset neuropsychiatric syndrome (PANS). J Clin Sleep Med. 2018 Jul 15;14(7):1187-92.Full text  Abstract

69. Gaughan T, Buckley A, Hommer R, et al. Rapid eye movement sleep abnormalities in children with pediatric acute-onset neuropsychiatric syndrome (PANS). J Clin Sleep Med. 2016 Jul 15;12(7):1027-32.Full text  Abstract

70. Swedo SE. Sydenham's chorea. A model for childhood autoimmune neuropsychiatric disorders. JAMA. 1994 Dec 14;272(22):1788-91. Abstract

71. Chan A, Karpel H, Spartz E, et al. Hypoferritinemia and iron deficiency in youth with pediatric acute-onset neuropsychiatric syndrome. Pediatr Res. 2021 May;89(6):1477-84.Full text  Abstract

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85. Swedo SE, Frankovich J, Murphy TK. Overview of treatment of pediatric acute-onset neuropsychiatric syndrome. J Child Adolesc Psychopharmacol. 2017 Sep;27(7):562-5.Full text  Abstract

86. Thienemann M, Murphy T, Leckman J, et al. Clinical management of pediatric acute-onset neuropsychiatric syndrome: part I-psychiatric and behavioral interventions. J Child Adolesc Psychopharmacol. 2017 Sep;27(7):566-73.Full text  Abstract

87. Thienemann M, Park M, Chan A, et al. Patients with abrupt early-onset OCD due to PANS tolerate lower doses of antidepressants and antipsychotics. J Psychiatr Res. 2021 Mar;135:270-8. Abstract

88. Williams KA, Swedo SE, Farmer CA, et al. Randomized, controlled trial of intravenous immunoglobulin for pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. J Am Acad Child Adolesc Psychiatry. 2016 Oct;55(10):860-7.e2. Abstract

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90. Ellerkamp H, Thienemann M, Tinero J, et al. Group psychotherapy for parents of youth with pediatric acute-onset neuropsychiatric syndrome. J Clin Psychol Med Settings. 2023 Sep;30(3):660-72. Abstract