Brugada syndrome

References

Key articles

Krahn AD, Behr ER, Hamilton R, et al. Brugada syndrome. JACC Clin Electrophysiol. 2022 Mar;8(3):386-405.Full text  Abstract

​Cronin EM, Bogun FM, Maury P, et al. 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias. Europace. 2019 Aug 1;21(8):1143-4.Full text  Abstract

​Priori SG, Wilde AA, Horie M, et al. HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm. 2013;10(12):1932-63.Full text  Abstract

​​Zeppenfeld K, Tfelt-Hansen J, de Riva M, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. 2022 Oct 21;43(40):3997-4126.Full text  Abstract

Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Heart Rhythm. 2018 Oct;15(10):e190-e252.​Full text  Abstract

Priori SG, Wilde AA, Horie M, et al. Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Heart Rhythm. 2013;10(12):e85-108​.Full text  Abstract

Nielsen JC, Lin YJ, de Oliveira Figueiredo MJ, et al. European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population. J Arrhythm. 2020 Jun 15;36(4):553-607.Full text  Abstract

Reference articles

1. Krahn AD, Behr ER, Hamilton R, et al. Brugada syndrome. JACC Clin Electrophysiol. 2022 Mar;8(3):386-405.Full text  Abstract

2. Oe H, Takagi M, Tanaka A, et al. Prevalence and clinical course of the juveniles with Brugada-type ECG in Japanese population. Pacing Clin Electrophysiol. 2005;28(6):549-54. Abstract

3. ​Yamakawa Y, Ishikawa T, Uchino K, et al. Prevalence of right bundle-branch block and right precordial ST-segment elevation (Brugada-type electrocardiogram) in Japanese children. Circ J. 2004;68(4):275-9. Abstract

4. Bayés de Luna A, Brugada J, Baranchuk A, et al. Current electrocardiographic criteria for diagnosis of Brugada pattern: a consensus report. J Electrocardiol. 2012;45(5):433-42. Abstract

5. ​Cronin EM, Bogun FM, Maury P, et al. 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias. Europace. 2019 Aug 1;21(8):1143-4.Full text  Abstract

6. ​Priori SG, Wilde AA, Horie M, et al. HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm. 2013;10(12):1932-63.Full text  Abstract

7. ​​Zeppenfeld K, Tfelt-Hansen J, de Riva M, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. 2022 Oct 21;43(40):3997-4126.Full text  Abstract

8. Benito B, Brugada J, Brugada R, Brugada P. Brugada syndrome. Rev Esp Cardiol. 2009;62(11):1297-315​. Abstract

9. ​Antzelevitch C, Brugada P, Borggrefe M, et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation. 2005;111(5):659-70.Full text  Abstract

10. ​Jellins J, Milanovic M, Taitz DJ, Wan SH, Yam PW. Brugada syndrome. Hong Kong Med J. 2013;19(2):159-67.Full text  Abstract

11. Quan XQ, Li S, Liu R, Zheng K, Wu XF, Tang Q. A meta-analytic review of prevalence for Brugada ECG patterns and the risk for death. Medicine (Baltimore). 2016 Dec;95(50):e5643.Full text  Abstract

12. Behere SP, Weindling SN. Brugada syndrome in children - Stepping into unchartered territory. Ann Pediatr Cardiol. 2017 Sep-Dec;10(3):248-58.​Full text  Abstract

13. Mizusawa Y, Wilde AA. Brugada syndrome. Circ Arrhythm Electrophysiol. 2012;5(3):606-16.Full text  Abstract

14. Sarquella-Brugada G, Campuzano O, Arbelo E, Brugada J, Brugada R. Brugada syndrome: clinical and genetic findings. Genet Med. 2016;18(1):3-12.Full text  Abstract

15. ​Priori SG, Wilde AA, Horie M, et al. HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm. 2013;10(12):1932-63.Full text  Abstract

16. Kapplinger JD, Tester DJ, Alders M, et al. An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. Heart Rhythm. 2010 Jan;7(1):33-46. Full text  Abstract

17. Hu D, Barajas-Martínez H, Pfeiffer R, et al. Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome. J Am Coll Cardiol. 2014;64(1):66-79.Full text  Abstract

18. Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Heart Rhythm. 2018 Oct;15(10):e190-e252.​Full text  Abstract

19. Hosseini SM, Kim R, Udupa S, etal. Reappraisal of reported genes for sudden arrhythmic death: Evidence-based evaluation of gene validity for Brugada syndrome. Circulation. 2018 Sep 18;138(12):1195-205.​Full text  Abstract

20. Adler A, Topaz G, Heller K, et al. Fever-induced Brugada pattern: how common is it and what does it mean?. Heart Rhythm. 2013;10(9):1375-82.Full text  Abstract

21. Rattanawong P, Vutthikraivit W, Charoensri A, et al. Fever-induced Brugada syndrome is more common than previously suspected: A cross-sectional study from an endemic area. Ann Noninvasive Electrocardiol. 2016;21(2):136-41.​Full text  Abstract

22. ​Attard A, Stanniland C, Attard S,et al. Brugada syndrome: should we be screening patients before prescribing psychotropic medication? Ther Adv Psychopharmacol. 2022 Jan 28;12:20451253211067017.Full text  Abstract

23. ​Deschênes I, Baroudi G, Berthet M, et al. Electrophysiological characterization of SCN5A mutations causing long QT (E1784K) and Brugada (R1512W and R1432G) syndromes. Cardiovasc Res. 2000;46(1):55-65.Full text  Abstract

24. Clancy CE, Kass RS. Defective cardiac ion channels: from mutations to clinical syndromes. J Clin Invest. 2002;110(8):1075-7.Full text  Abstract

25. Behr ER, Savio-Galimberti E, Barc J, et al. Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study. Cardiovasc Res. 2015;106(3):520-9.Full text  Abstract

26. Fukuyama M, Ohno S, Makiyama T, Horie M. Novel SCN10A variants associated with Brugada syndrome. Europace. 2016;18(6):905-11.Full text  Abstract

27. Riuró H, Beltran-Alvarez P, Tarradas A, et al. A missense mutation in the sodium channel β2 subunit reveals SCN2B as a new candidate gene for Brugada syndrome. Hum Mutat. 2013;34(7):961-6. Abstract

28. ​Cerrone M, Lin X, Zhang M, et al. Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype. Circulation. 2014;129(10):1092-103.Full text  Abstract

29. Belbachir N, Portero V, Al Sayed ZR, et al. RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome. Eur Heart J. 2019 Oct 1;40(37):3081-94.Full text  Abstract

30. Giudicessi JR, Ye D, Tester DJ, et al. Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome. Heart Rhythm. 2011;8(7):1024-32.Full text  Abstract

31. ​Burashnikov E, Pfeiffer R, Barajas-Martinez H, et al. Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death. Heart Rhythm. 2010;7(12):1872-82.Full text  Abstract

32. ​Behr ER, Ben-Haim Y, Ackerman MJ, et al. Brugada syndrome and reduced right ventricular outflow tract conduction reserve: a final common pathway? Eur Heart J. 2021 Mar 14;42(11):1073-81.Full text  Abstract

33. Wilde AA, Postema PG, Di Diego JM, et al. The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization. J Mol Cell Cardiol. 2010;49(4):543-53.Full text  Abstract

34. Yan GX, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation. 1999;100(15):1660-6.Full text  Abstract

35. Iacoviello M, Forleo C, Puzzovivo A, et al. Altered two-dimensional strain measures of the right ventricle in patients with Brugada syndrome and arrhythmogenic right ventricular dysplasia/cardiomyopathy. Eur J Echocardiogr. 2011;12(10):773-81. Abstract

36. ​Bastiaenen R, Cox AT, Castelletti S, et al. Late gadolinium enhancement in Brugada syndrome: A marker for subtle underlying cardiomyopathy? Heart Rhythm. 2017 Apr;14(4):583-9. Abstract

37. ​Pieroni M, Notarstefano P, Oliva A, et al. Electroanatomic and pathologic right ventricular outflow tract abnormalities in patients with Brugada syndrome. J Am Coll Cardiol. 2018 Dec 4;72(22):2747-57.Full text  Abstract

38. Nademanee K, Veerakul G, Chandanamattha P, et al. Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium. Circulation. 2011;123(12):1270-9.Full text  Abstract

39. Milman A, Andorin A, Gourraud JB, et al. Age of first arrhythmic event in Brugada syndrome: Data from the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 patients. Circ Arrhythm Electrophysiol. 2017 Dec;10(12):e005222. Full text  Abstract

40. ​Gonzalez Corcia MC, Sieira J, Sarkozy A, et al. Brugada syndrome in the young: an assessment of risk factors predicting future events. Europace. 2017 Nov 1;19(11):1864-73.Full text  Abstract

41. Minier M, Probst V, Berthome P, et al. Age at diagnosis of Brugada syndrome: Influence on clinical characteristics and risk of arrhythmia. Heart Rhythm. 2020 May;17(5 Pt A):743-9. Abstract

42. Juang JM, Chen CY, Chen YH, et al. Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population: a nation-wide community-based study (HALST cohort). Europace. 2015 Oct;17(Suppl 2):ii54-62.Full text  Abstract

43. Kitamura T, Fukamizu S, Kawamura I, et al. Clinical characteristics and long-term prognosis of senior patients with Brugada syndrome. JACC Clin Electrophysiol. 2017 Jan;3(1):57-67.Full text  Abstract

44. Yuan M, Tian C, Li X, et al. Gender differences in prognosis and risk stratification of Brugada syndrome: A pooled analysis of 4,140 patients from 24 clinical trials. Front Physiol. 2018 Aug 22;9:1127.Full text  Abstract

45. Sieira J, Brugada P. Brugada syndrome: Defining the risk in asymptomatic patients. Arrhythm Electrophysiol Rev. 2016;5(3):164-9.Full text  Abstract

46. Berthome P, Tixier R, Briand J, et al. Clinical presentation and follow-up of women affected by Brugada syndrome. Heart Rhythm. 2019 Feb;16(2):260-7. Abstract

47. ​Probst V, Veltmann C, Eckardt L, et al. Long-term prognosis of patients diagnosed with Brugada syndrome: Results from the FINGER Brugada Syndrome Registry. Circulation. 2010;121(5):635-43.Full text  Abstract

48. Delise P, Allocca G, Marras E, et al. Risk stratification in individuals with the Brugada type 1 ECG pattern without previous cardiac arrest: usefulness of a combined clinical and electrophysiologic approach. Eur Heart J. 2011;32(2):169-76.Full text  Abstract

49. Antzelevitch C, Yan GX, Ackerman MJ, et al. J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge. Heart Rhythm. 2016 Oct;13(10):e295-324​.Full text  Abstract

50. Kamakura S, Ohe T, Nakazawa K, et al. Long-term prognosis of probands with Brugada-pattern ST-elevation in leads V1-V3. Circ Arrhythm Electrophysiol. 2009;2(5):495-503.Full text  Abstract

51. Priori SG, Wilde AA, Horie M, et al. Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Heart Rhythm. 2013;10(12):e85-108​.Full text  Abstract

52. Rodríguez-Mañero M, Sacher F, de Asmundis C, et al. Monomorphic ventricular tachycardia in patients with Brugada syndrome: A multicenter retrospective study. Heart Rhythm. 2016;13(3):669-682. Abstract

53. Eckhardt LL. Monomorphic ventricular tachycardia in Brugada syndrome: True-true but related?. Heart Rhythm. 2016;13(3):683-5. Abstract

54. Casado-Arroyo R, Berne P, Rao JY, Rodriguez-Mañero M, et al. Long-term trends in newly diagnosed Brugada syndrome: Implications for risk stratification. J Am Coll Cardiol. 2016 Aug 9;68(6):614-23.Full text  Abstract

55. Okamura H, Kamakura T, Morita H, et al. Risk stratification in patients with Brugada syndrome without previous cardiac arrest – prognostic value of combined risk factors. Circ J. 2015;79(2):310-17.Full text  Abstract

56. Kawazoe H, Nakano Y, Ochi H, et al. Risk stratification of ventricular fibrillation in Brugada syndrome using noninvasive scoring methods. Heart Rhythm. 2016 Oct;13(10):1947-54. Abstract

57. Honarbakhsh S, Providencia R, Garcia-Hernandez J, et al. A Primary prevention clinical risk score model for patients with Brugada syndrome (BRUGADA-RISK). JACC Clin Electrophysiol. 2021 Feb;7(2):210-2.Full text  Abstract

58. Olde Nordkamp LR, Vink AS, Wilde AA, et al. Syncope in Brugada syndrome: prevalence, clinical significance, and clues from history taking to distinguish arrhythmic from nonarrhythmic causes. Heart Rhythm. 2015;12(2):367-75. Abstract

59. Schimpf R, Giustetto C, Eckardt L, et al. Prevalence of supraventricular tachyarrhythmias in a cohort of 115 patients with Brugada syndrome. Ann Noninvasive Electrocardiol. 2008;13(3):266-9​.Full text  Abstract

60. ​Kusano KF, Taniyama M, Nakamura K, et al. Atrial fibrillation in patients with Brugada syndrome relationships of gene mutation, electrophysiology, and clinical backgrounds. J Am Coll Cardiol. 2008;51(12):1169-75.Full text  Abstract

61. Giustetto C, Cerrato N, Gribaudo E, et al. Atrial fibrillation in a large population with Brugada electrocardiographic pattern: prevalence, management, and correlation with prognosis. Heart Rhythm. 2014;11(2):259-65. Abstract

62. ​Holst AG, Jensen HK, Eschen O, et al. Low disease prevalence and inappropriate implantable cardioverter defibrillator shock rate in Brugada syndrome: a nationwide study. Europace. 2012;14(7):1025-9.Full text  Abstract

63. Vatta M, Dumaine R, Antzelevitch C, et al. Novel mutations in domain I of SCN5A cause Brugada syndrome. Mol Genet Metab. 2002;75(4):317-24. Abstract

64. Nielsen JC, Lin YJ, de Oliveira Figueiredo MJ, et al. European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population. J Arrhythm. 2020 Jun 15;36(4):553-607.Full text  Abstract

65. ​Veltmann C, Papavassiliu T, Konrad T, et al. Insights into the location of type I ECG in patients with Brugada syndrome: correlation of ECG and cardiovascular magnetic resonance imaging. Heart Rhythm. 2012;9(3):414-21. Abstract

66. Sangwatanaroj S, Prechawat S, Sunsaneewitayakul B, et al. New electrocardiographic leads and the procainamide test for the detection of the Brugada sign in sudden unexplained death syndrome survivors and their relatives. Eur Heart J. 2001;22(24):2290-6.Full text  Abstract

67. ​Govindan M, Batchvarov VN, Raju H, et al. Utility of high and standard right precordial leads during ajmaline testing for the diagnosis of Brugada syndrome. Heart. 2010;96(23):1904-8. Abstract

68. Arnar DO, Mairesse GH, Boriani G, et al. Management of asymptomatic arrhythmias: a European Heart Rhythm Association (EHRA) consensus document, endorsed by the Heart Failure Association (HFA), Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), Cardiac Arrhythmia Society of Southern Africa (CASSA), and Latin America Heart Rhythm Society (LAHRS). Europace. 2019 Mar 18;21(6):844–5.Full text  Abstract

69. Gollob MH, Blier L, Brugada R, et al. Recommendations for the use of genetic testing in the clinical evaluation of inherited cardiac arrhythmias associated with sudden cardiac death: Canadian Cardiovascular Society/Canadian Heart Rhythm Society joint position paper. Can J Cardiol. 2011 Mar-Apr;27(2):232-45.Full text  Abstract

70. Heermann P, Fritsch H, Koopmann M, et al. Biventricular myocardial strain analysis using cardiac magnetic resonance feature tracking (CMR-FT) in patients with distinct types of right ventricular diseases comparing arrhythmogenic right ventricular cardiomyopathy (ARVC), right ventricular outflow-tract tachycardia (RVOT-VT), and Brugada syndrome (BrS). Clin Res Cardiol. 2019 Oct;108(10):1147-62. Abstract

71. Borgquist R, Haugaa KH, Gilljam T, et al. The diagnostic performance of imaging methods in ARVC using the 2010 Task Force criteria. Eur Heart J Cardiovasc Imaging. 2014;15(11):1219-25​.Full text  Abstract

72. Peters S, Trümmel M, Denecke S, et al. Results of ajmaline testing in patients with arrhythmogenic right ventricular dysplasia-cardiomyopathy. Int J Cardiol. 2004 Jun;95(2-3):207-10.Full text  Abstract

73. ​Wilde AA, Antzelevitch C, Borggrefe M, et al. Proposed diagnostic criteria for the Brugada syndrome: consensus report. Circulation. 2002;106(19):2514-9.Full text  Abstract

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77. Anselm DD, Evans JM, Baranchuk A. Brugada phenocopy: A new electrocardiogram phenomenon. World J Cardiol. 2014;6(3):81-6.​Full text  Abstract

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79. Musunuru K, Hershberger RE, Day SM, et al. Genetic testing for inherited cardiovascular diseases: A scientific statement from the American Heart Association. Circ Genom Precis Med. 2020 Aug;13(4):e000067. Full text  Abstract

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81. ​Sieira J, Conte G, Ciconte G, et al. A score model to predict risk of events in patients with Brugada Syndrome. Eur Heart J. 2017 Jun 7;38(22):1756-63.Full text  Abstract

82. Chow JJ, Leong KMW, Yazdani M, et al. A multicenter external validation of a score model to predict risk of events in patients with Brugada syndrome. Am J Cardiol. 2021 Dec 1;160:53-9. Abstract

83. ​Probst V, Goronflot T, Anys S, et al. Robustness and relevance of predictive score in sudden cardiac death for patients with Brugada syndrome. Eur Heart J. 2021 May 1;42(17):1687-95.Full text  Abstract

84. Gonzalez Corcia MC, Sieira J, Pappaert G, de Asmundis C, Chierchia GB, Sarkozy A, Brugada P. A Clinical Score Model to Predict Lethal Events in Young Patients (≤19 Years) With the Brugada Syndrome. Am J Cardiol. 2017 Sep 1;120(5):797-802. Abstract

85. Andorin A, Behr ER, Denjoy I, et al. Impact of clinical and genetic findings on the management of young patients with Brugada syndrome. Heart Rhythm. 2016 Jun;13(6):1274-82. Abstract

86. Priori SG, Gasparini M, Napolitano C, et al. Risk stratification in Brugada syndrome: results of the PRELUDE (PRogrammed ELectrical stimUlation preDictive valuE) registry. J Am Coll Cardiol. 2012;59(1):37-45.Full text  Abstract

87. Priori SG, Napolitano C, Gasparini M, et al. Natural history of Brugada syndrome: insights for risk stratification and management. Circulation. 2002;105(11):1342-7.Full text  Abstract

88. Conte G, de Asmundis C, Sieira J, et al. Prevalence and clinical impact of early repolarization pattern and QRS-fragmentation in high-risk patients with Brugada syndrome. Circ J. 2016 Sep 23;80(10):2109-16. Abstract

89. Sroubek J, Probst V, Mazzanti A, et al. Programmed Ventricular Stimulation for Risk Stratification in the Brugada Syndrome: A Pooled Analysis. Circulation. 2016;133(7):622-30.Full text  Abstract

90. Chen C, Tan Z, Zhu W, et al. Brugada syndrome with SCN5A mutations exhibits more pronounced electrophysiological defects and more severe prognosis: A meta-analysis. Clin Genet. 2020 Jan;97(1):198-208.  Abstract

91. Papadakis M, Papatheodorou E, Mellor G, et al. The diagnostic yield of Brugada syndrome after sudden death with normal autopsy. J Am Coll Cardiol. 2018 Mar 20;71(11):1204-14.​Full text  Abstract

92. van der Werf C, Hofman N, Tan HL, et al. Diagnostic yield in sudden unexplained death and aborted cardiac arrest in the young: the experience of a tertiary referral center in The Netherlands. Heart Rhythm. 2010;7(10):1383-1389 Abstract

93. ​Sacher F, Probst V, Iesaka Y, et al. Outcome after implantation of a cardioverter-defibrillator in patients with Brugada syndrome: a multicenter study. Circulation. 2006;114(22):2317-24.Full text  Abstract

94. Kewcharoen J, Rattanawong P, Kanitsoraphan C, et al. Atrial fibrillation and risk of major arrhythmic events in Brugada syndrome: A meta-analysis. Ann Noninvasive Electrocardiol. 2019 Nov;24(6):e12676.Full text  Abstract

95. Dereci A, Yap SC, Schinkel AFL. Meta-analysis of clinical outcome after implantable cardioverter-defibrillator implantation in patients with Brugada syndrome. JACC Clin Electrophysiol. 2019 Feb;5(2):141-8.Full text  Abstract

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