Cellulitis and erysipelas


Key articles

Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014 Jul 15;59(2):e10-52.Full text  Abstract

National Institute for Health and Care Excellence. Cellulitis and erysipelas: antimicrobial prescribing. September 2019 [internet publication].Full text

Clinical Resource Efficiency Support Team. Guidelines on the management of cellulitis in adults. June 2005 [internet publication].Full text

Reference articles

1. McCormick A, Fleming D, Charlton J; Office of Population Censuses and Surveys. Morbidity statistics from general practice: fourth national study 1991-1992. London: HMSO; 1995.

2. NHS Digital. Hospital admitted patient care activity 2018-19. September 2019 [internet publication].Full text

3. Sigurdsson AF, Gudmundsson S. The etiology of bacterial cellulitis as determined by fine-needle aspiration. Scand J Infect Dis. 1989;21(5):537-42. Abstract

4. Bernard P, Bedane C, Mounier M, et al. Streptococcal cause of erysipelas and cellulitis in adults. A microbiologic study using a direct immunofluorescence technique. Arch Dermatol. 1989 Jun;125(6):779-82. Abstract

5. Eriksson B, Jorup-Ronstrom C, Karkkonen K, et al. Erysipelas: clinical and bacteriologic spectrum and serological aspects. Clin Infect Dis. 1996 Nov;23(5):1091-8. Abstract

6. Lutomski DM, Trott AT, Runyon JM, et al. Microbiology of adult cellulitis. J Fam Pract. 1988 Jan;26(1):45-8. Abstract

7. Leppard BJ, Seal DV, Colman G, et al. The value of bacteriology and serology in the diagnosis of cellulitis and erysipelas. Br J Dermatol. 1985 May;112(5):559-67. Abstract

8. Kielhofner MA, Brown B, Dall L. Influence of underlying disease process on the utility of cellulitis needle aspirates. Arch Intern Med. 1988 Nov;148(11):2451-2. Abstract

9. Bernard P, Toty L, Mounier M, et al. Early detection of streptococcal group antigens in skin samples by latex particle agglutination. Arch Dermatol. 1987 Apr;123(4):468-70. Abstract

10. Sachs MK. The optimum use of needle aspiration in the bacteriologic diagnosis of cellulitis in adults. Arch Intern Med. 1990 Sep;150(9):1907-12. Abstract

11. Duvanel T, Auckenthaler R, Rohner P, et al. Quantitative cultures of biopsy specimens from cutaneous cellulitis. Arch Intern Med. 1989 Feb;149(2):293-6. Abstract

12. Howe PM, Fajardo JE, Orcutt MA. Etiologic diagnosis of cellulitis: comparison of aspirates obtained from the leading edge and the point of maximal inflammation. Pediatr Infect Dis J. 1987 Jul;6(7):685-6. Abstract

13. Gunderson CG, Martinello RA. A systematic review of bacteremias in cellulitis and erysipelas. J Infect. 2012 Feb;64(2):148-55. Abstract

14. Chira S, Miller LG. Staphylococcus aureus is the most common identified cause of cellulitis: a systematic review. Epidemiol Infect. 2010 Mar;138(3):313-7. Abstract

15. Hook EW 3rd, Hooton TM, Horton CA, et al. Microbiologic evaluation of cutaneous cellulitis in adults. Arch Intern Med. 1986 Feb;146(2):295-7. Abstract

16. Baddour LM, Bisno AL. Recurrent cellulitis after coronary bypass surgery. JAMA. 1984 Feb 24;251(8):1049-52. Abstract

17. Kupper TS. Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations. J Clin Invest. 1990 Dec;86(6):1783-9.Full text  Abstract

18. Okada N, Pentland AP, Falk P, et al. M Protein and protein F act as important determinants of cell-specific tropism of Streptococcus pyogenes in skin tissue. J Clin Invest. 1994 Sep;94(3):965-77.Full text  Abstract

19. Semel JD, Goldin H. Association of athlete's foot with cellulitis of the lower extremities: diagnostic value of bacterial cultures of ipsilateral interdigital space samples. Clin Infect Dis. 1996 Nov;23(5):1162-4. Abstract

20. Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014 Jul 15;59(2):e10-52.Full text  Abstract

21. National Institute for Health and Care Excellence. Cellulitis and erysipelas: antimicrobial prescribing. September 2019 [internet publication].Full text

22. Edwards G, Freeman K, Llewelyn MJ, et al. What diagnostic strategies can help differentiate cellulitis from other causes of red legs in primary care? BMJ. 2020 Feb 12;368:m54. Abstract

23. Clinical Resource Efficiency Support Team. Guidelines on the management of cellulitis in adults. June 2005 [internet publication].Full text

24. Morris A. Cellulitis and erysipelas. Clin Evid. 2004 Dec;(12):2271-7. Abstract

25. Phoenix G, Das S, Joshi M. Diagnosis and management of cellulitis. BMJ. 2012 Aug 7;345:e4955. Abstract

26. Morris AD. Cellulitis and erysipelas. BMJ Clin Evid. 2008 Jan 2;2008:1708.Full text  Abstract

27. National Institute for Health and Care Excellence. Sepsis: recognition, diagnosis and early management. September 2017 [internet publication].Full text

28. NHS England. Sepsis guidance implementation advice for adults. September 2017 [internet publication].Full text

29. Royal College of Physicians. National early warning score (NEWS) 2: standardising the assessment of acute-illness severity in the NHS. December 2017 [internet publication].Full text

30. Sullivan T, de Barra E. Diagnosis and management of cellulitis. Clin Med (Lond). 2018 Mar;18(2):160-3.Full text  Abstract

31. Miller JM, Binnicker MJ, Campbell S, et al. A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the American Society for Microbiology. Clin Infect Dis. 2018 Aug 31;67(6):e1-94.Full text  Abstract

32. Cross HH. Obtaining a wound swab culture specimen. Nursing. 2014 Jul;44(7):68-9.Full text  Abstract

33. Public Health England. UK standards for microbiology investigations: investigation of swabs from skin and superficial soft tissue infections. December 2018 [internet publication].Full text

34. Inada-Kim M. Introducing the suspicion of sepsis insights dashboard. Royal College of Pathologists Bulletin. 2019 Apr;186;109.

35. Rhodes A, Evans LE, Alhazzani W, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med. 2017 Mar;43(3):304-77.Full text  Abstract

36. Nutbeam T, Daniels R; The UK Sepsis Trust. Professional resources: clinical [internet publication].Full text

37. Quirke M, Ayoub F, McCabe A, et al. Risk factors for nonpurulent leg cellulitis: a systematic review and meta-analysis. Br J Dermatol. 2017 Aug;177(2):382-94. Abstract

38. Kloek CE, Rubin PA. Role of inflammation in orbital cellulitis. Int Ophthalmol Clin. 2006 Spring;46(2):57-68. Abstract

39. Rumelt S, Rubin PA. Potential sources for orbital cellulitis. Int Ophthalmol Clin. 1996 Summer;36(3):207-21. Abstract

40. Swift AC, Charlton G. Sinusitis and the acute orbit in children. J Laryngol Otol. 1990 Mar;104(3):213-6. Abstract

41. Eron LJ, Lipsky BA, Low DE, et al. Managing skin and soft tissue infections: expert panel recommendations on key decision points. J Antimicrob Chemother. 2003 Nov;52 Suppl 1:i3-17.Full text  Abstract

42. Al Ghazal P, Körber A, Klode J, et al. Evaluation of the Essen Rotary as a new technique for bacterial swabs: results of a prospective controlled clinical investigation in 50 patients with chronic leg ulcers. Int Wound J. 2014 Feb;11(1):44-9. Abstract

43. Perl B, Gottehrer NP, Raveh D. Cost-effectiveness of blood cultures for adult patients with cellulitis. Clin Infect Dis. 1999 Dec;29(6):1483-8. Abstract

44. Newell PM, Norden CW. Value of needle aspiration in bacteriologic diagnosis of cellulitis in adults. J Clin Microbiol. 1998 Mar;26(3):401-4.Full text  Abstract

45. Lebre C, Girard-Pipau F, Roujeau JC, et al. Value of fine-needle aspiration in infectious cellulitis. Arch Dermatol. 1996 Jul;132(7):842-3. Abstract

46. Schmid MR, Kossmann T, Duewell S. Differentiation of necrotizing fasciitis and cellulitis using MR imaging. Am J Roentgenol. 1998 Mar;170(3):615-20.Full text  Abstract

47. McHenry CR, Piotrowski JJ, Petrinic D. Determinants of mortality for necrotizing soft-tissue infections. Ann Surg. 1995 May;221(5):558-63.Full text  Abstract

48. National Institute for Health and Care Excellence. Lyme disease. October 2018 [internet publication].Full text

49. Falagas ME, Vergidis PI. Narrative review: diseases that masquerade as infectious cellulitis. Ann Intern Med. 2005 Jan 4;142(1):47-55. Abstract

50. Fitzpatrick TB, Johnson RA, Wolff K. Color atlas & synopsis of clinical dermatology: common and serious diseases. 4th ed. New York, NY: The McGraw-Hill Companies; 2001.

51. Aberer W, Konrad K, Wolff K. Wells' syndrome is a distinctive disease entity and not a histologic diagnosis. J Am Acad Dermatol. 1988 Jan;18(1 Pt 1):105-14. Abstract

52. Callen JP. Neutrophilic dermatoses. Dermatol Clin. 2002 Jul;20(3):409-19. Abstract

53. Rapini RP, Warner NB. Relapsing polychondritis. Clin Dermatol. 2006 Nov-Dec;24(6):482-5. Abstract

54. Fine A, Zacharias J. Calciphylaxis is usually non-ulcerating: risk factors, outcome and therapy. Kidney Int. 2002 Jun;61(6):2210-7.Full text  Abstract

55. Kirsner RS, Pardes JB, Eaglstein WH, et al. The clinical spectrum of lipodermatosclerosis. J Am Acad Dermatol. 1993 Apr;28(4):623-7. Abstract

56. Bruun T, Oppegaard O, Hufthammer KO, et al. Early response in cellulitis: a prospective study of dynamics and predictors. Clin Infect Dis. 2016 Oct 15;63(8):1034-41.Full text  Abstract

57. Brindle R, Williams OM, Barton E, et al. Assessment of antibiotic treatment of cellulitis and erysipelas: a systematic review and meta-analysis. JAMA Dermatol. 2019 Jun 12;155(9):1033-40.Full text  Abstract

58. Public Health England. Antimicrobial stewardship: start smart – then focus. March 2015 [internet publication].Full text

59. National Institute for Health and Care Excellence. Evidence review for cellulitis and erysipelas – antimicrobial prescribing. NICE guideline NG414 evidence review. September 2019 [internet publication].Full text

60. National Institute for Health and Care Excellence. Antimicrobial stewardship: systems and processes for effective antimicrobial medicine use. August 2015 [internet publication].Full text

61. Department of Health and Social Care. Chief Medical Officer annual report 2011: antimicrobial resistance. March 2013 [internet publication].Full text

62. European Medicines Agency. Quinolone- and fluoroquinolone-containing medicinal products. March 2019 [internet publication].Full text

63. Medicines and Healthcare products Regulatory Agency. Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects. March 2019 [internet publication].Full text

64. Lee RA, Centor RM, Humphrey LL, et al. Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians. Ann Intern Med. 2021 Jun;174(6):822-7.Full text  Abstract

65. Webb E, Neeman T, Bowden FJ, et al. Compression Therapy to Prevent Recurrent Cellulitis of the Leg. N Engl J Med. 2020 Aug 13;383(7):630-9.Full text  Abstract

66. Clinical Resource Efficiency Support Team. Guidelines on the management of cellulitis in adults. June 2005 [internet publication]Full text

67. Eron LJ, Lipsky BA, Low DE, et al. Managing skin and soft tissue infections: expert panel recommendations on key decision points. J Antimicrob Chemother. 2003 Nov;52 Suppl 1:i3-17Full text  Abstract

68. National Institute for Health and Care Excellence. Intravenous fluid therapy in adults in hospital. Clinical guideline CG174. May 2017 [internet publication]Full text

69. Verbrugge FH, Grieten L, Mullens W. Management of the cardiorenal syndrome in decompensated heart failure. Cardiorenal Med. 2014 Dec;4(3-4):176-88Full text  Abstract

70. National Institute for Health and Care Excellence. Acute kidney injury: prevention, detection and management. December 2019 [internet publication]Full text

71. Hsu CY, Ordoñez JD, Chertow GM, et al. The risk of acute renal failure in patients with chronic kidney disease. Kidney Int. 2008 Apr 2;74(1):101-7Full text  Abstract

72. Law JP, Pickup L, Townend JN, et al. Anticoagulant strategies for the patient with chronic kidney disease. Clin Med (Lond). 2020 Mar;20(2):151-5Full text  Abstract

73. National Institute for Health and Care Excellence. Cellulitis and erysipelas: antimicrobial prescribing. September 2019 [internet publication]Full text

74. Davison SN. Clinical pharmacology considerations in pain management in patients with advanced kidney failure. Clin J Am Soc Nephrol. 2019 Jun 7;14(6):917-31Full text  Abstract

75. Global Initiative for Asthma. Global strategy for asthma management and prevention. 2022 [internet publication]Full text

76. Joint British Diabetes Societies for inpatient care. The management of diabetic ketoacidosis in adults. June 2021 [internet publication]Full text

77. Joint British Diabetes Societies for inpatient care. The management of the hyperosmolar hyperglycaemic state (HHS) in adults. February 2022 [internet publication]Full text

78. Chowdhury TA, Cheston H, Claydon A. Managing adults with diabetes in hospital during an acute illness. BMJ. 2017 Jun 22;357:j2551 Abstract

79. Joint British Diabetes Societies for inpatient care. Self-management of diabetes in hospital. August 2021 [internet publication]Full text

80. Joint British Diabetes Societies for inpatient care. Glycaemic management during the inpatient enteral feeding of stroke patients with diabetes. November 2019 [internet publication]Full text

81. Joint British Diabetes Societies for inpatient care. The use of variable rate intravenous insulin infusion (VRIII) in medical inpatients. October 2014 [internet publication]Full text

82. Joint British Diabetes Societies for inpatient care. A good inpatient diabetes service. July 2019 [internet publication]Full text

83. Centre for Perioperative Care. Guideline for perioperative care for people with diabetes mellitus undergoing elective and emergency surgery. March 2021 [internet publication]Full text

84. Pasquel FJ, Lansang MC, Dhatariya K, et al. Management of diabetes and hyperglycaemia in the hospital. Lancet Diabetes Endocrinol. 2021 Mar;9(3):174-88Full text  Abstract

85. Medicines and Healthcare products Regulatory Agency. SGLT2 inhibitors: monitor ketones in blood during treatment interruption for surgical procedures or acute serious medical illness. March 2020 [internet publication]Full text

86. Peters AL, Buschur EO, Buse JB, et al. Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition. Diabetes Care. 2015 Jun 15;38(9):1687-93 Abstract

87. Grau AJ, Urbanek C, Palm F. Common infections and the risk of stroke. Nat Rev Neurol. 2010 Nov 9;6(12):681-94 Abstract

88. Eigenbrodt ML, Rose KM, Couper DJ, et al. Orthostatic hypotension as a risk factor for stroke: the atherosclerosis risk in communities (ARIC) study, 1987-1996. Stroke. 2000 Oct;31(10):2307-13 Abstract

89. Winstein CJ, Stein J, Arena R, et al. Guidelines for adult stroke rehabilitation and recovery: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016 May 4;47(6):e98-e169Full text  Abstract

90. Pendlebury ST, Klaus SP, Mather M, et al. Routine cognitive screening in older patients admitted to acute medicine: abbreviated mental test score (AMTS) and subjective memory complaint versus Montreal Cognitive Assessment and IQCODE. Age Ageing. 2015 Oct 13;44(6):1000-5Full text  Abstract

91. Hodkinson HM. Evaluation of a mental test score for assessment of mental impairment in the elderly. Age Ageing. 1972 Nov;1(4):233-8 Abstract

92. National Institute for Health and Care Excellence. Delirium: diagnosis, prevention and management. March 2019 [internet publication]Full text

93. National Institute for Health and Care Excellence. Dementia: assessment, management and support for people living with dementia and their carers. June 2018 [internet publication]Full text

94. Scottish Intercollegiate Guidelines Network. Risk reduction and management of delirium. March 2019 [internet publication]Full text

95. Nova Scotia Health Authority. This is not my Mom. 2012 [internet publication]Full text

96. Inouye SK, Schlesinger MJ, Lydon TJ. Delirium: a symptom of how hospital care is failing older persons and a window to improve quality of hospital care. Am J Med. 1999 May;106(5):565-73 Abstract

97. Bellelli G, Morandi A, Davis DH, et al. Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people. Age Ageing. 2014 Mar 2;43(4):496-502Full text  Abstract

98. MacLullich AM, Shenkin SD, Goodacre S, et al. The 4 'A's test for detecting delirium in acute medical patients: a diagnostic accuracy study. Health Technol Assess. 2019 Aug;23(40):1-194Full text  Abstract

99. White S, Griffiths R, Baxter M, et al. Guidelines for the peri-operative care of people with dementia: guidelines from the Association of Anaesthetists. Anaesthesia. 2019 Jan 11;74(3):357-72Full text  Abstract

100. Siddiqi N, Harrison JK, Clegg A, et al. Interventions for preventing delirium in hospitalised non-ICU patients. Cochrane Database Syst Rev. 2016 Mar 11;3:CD005563Full text  Abstract

101. Martinez F, Tobar C, Hill N. Preventing delirium: should non-pharmacological, multicomponent interventions be used? A systematic review and meta-analysis of the literature. Age Ageing. 2014 Nov 25;44(2):196-204Full text  Abstract

102. Public Health England. Urinary tract infection: diagnostic tools for primary care. October 2020 [internet publication]Full text

103. Medicines and Healthcare products Regulatory Agency. Haloperidol (haldol): reminder of risks when used in elderly patients for the acute treatment of delirium. 2021 [internet publication]Full text

104. Ma H, Huang Y, Cong Z, et al. The efficacy and safety of atypical antipsychotics for the treatment of dementia: a meta-analysis of randomized placebo-controlled trials. J Alzheimers Dis. 2014;42(3):915-37 Abstract

105. Huybrechts KF, Gerhard T, Crystal S, et al. Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study. BMJ. 2012 Feb 23;344:e977Full text  Abstract

106. Van Leeuwen E, Petrovic M, van Driel ML, et al. Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia. Cochrane Database Syst Rev. 2018 Mar 30;3:CD007726Full text  Abstract

107. Fritz Z, Slowther AM, Perkins GD. Resuscitation policy should focus on the patient, not the decision. BMJ. 2017 Feb 28;356:j813Full text  Abstract

108. National Institute for Health and Care Excellence. Decision making and mental capacity. October 2018 [internet publication]Full text

109. Department of Health. Mental Capacity Act 2005 [internet publication]Full text

110. Social Care Institute for Excellence. Independent mental capacity advocate (IMCA). 2011 [internet publication]Full text

111. American Diabetes Association. 16. Diabetes care in the hospital: standards of medical care in diabetes - 2022. Diabetes Care. 2022 Jan 1;45(suppl 1):S244-S253.Full text  Abstract

112. Joint British Diabetes Societies for inpatient care. A good inpatient diabetes service. July 2019 [internet publication]Full text

113. National Institute for Health and Care Excellence. Type 1 diabetes in adults: diagnosis and management. March 2022 [internet publication]Full text

114. Joint British Diabetes Societies for inpatient care. Inpatient care of the frail older adult with diabetes. 2019 [internet publication]Full text

115. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001 Nov 8;345(19):1359-67Full text  Abstract

116. NICE-SUGAR Study Investigators; Finfer S, Chittock DR, Su SY, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009 Mar 26;360(13):1283-97.Full text  Abstract

117. Marik PE, Preiser JC. Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest. 2010 Mar;137(3):544-51Full text  Abstract

118. Rehman A, Setter SM, Vue MH. Drug-induced glucose alterations part 2: drug-Induced hyperglycemia. Diabetes Spect. 2011 Nov;24(4):234-8Full text

119. NHS Digital. National Diabetes Inpatient Audit (NaDIA) - 2019. Nov 2020 [internet publication]Full text

120. Joint British Diabetes Societies for inpatient care. The hospital management of hypoglycaemia in adults with diabetes mellitus. March 2022 [internet publication]Full text

121. TREND Diabetes. End of life guidance for diabetes care. November 2021 [internet publication]Full text

122. National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. October 2019 [internet publication]Full text

123. Rayman G, Vas PR, Baker N, et al. The Ipswich Touch Test: a simple and novel method to identify inpatients with diabetes at risk of foot ulceration. Diabetes Care. 2011 May 18;34(7):1517-8Full text  Abstract

124. British Thoracic Society; Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma: a national clinical guideline. July 2019 [internet publication].Full text

125. Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis. Chest. 2004 Jun;125(6):2309-21Full text  Abstract

126. Au DH, Curtis JR, Every NR, et al. Association between inhaled beta-agonists and the risk of unstable angina and myocardial infarction. Chest. 2002 Mar;121(3):846-51Full text  Abstract

127. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. 2020 [internet publication]Full text

128. Walters JA, Tan DJ, White CJ, et al. Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2018 Mar 19;3:CD006897Full text  Abstract

129. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13 Abstract

130. Boden JM, Fergusson DM. Alcohol and depression. Addiction. 2011 Mar 7;106(5):906-14Full text  Abstract

131. Cleare A, Pariante CM, Young AH, et al. Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines. J Psychopharmacol. 2015 May 12;29(5):459-525Full text  Abstract

132. National Institute for Health and Care Excellence. Depression in adults with a chronic physical health problem: recognition and management. October 2009 [internet publication]Full text

133. Taylor DM, Barnes TRE, Young AH. The Maudsley prescribing guidelines in psychiatry. 13th edition. Chichester: Wiley-Blackwell; 2018

134. Flowers L. Nicotine replacement therapy. Am J Psychiatry Resid. 2016 Jun;11(6)4-7Full text

135. Desai HD, Seabolt J, Jann MW. Smoking in patients receiving psychotropic medications: a pharmacokinetic perspective. CNS Drugs. 2001;15(6):469-94

136. Oliveira P, Ribeiro J, Donato H, Madeira N. Smoking and antidepressants pharmacokinetics: a systematic review. Ann Gen Psychiatry. 2017;16:17Full text  Abstract

137. National Centre for Smoking Cessation and Training. Smoking cessation and mental health. 2014 [internet publication]Full text

138. Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005 Mar 17;352(11):1112-20 Abstract

139. Auerbach AD, Vittinghoff E, Maselli J, et al. Perioperative use of selective serotonin reuptake inhibitors and risks for adverse outcomes of surgery. JAMA Intern Med. 2013 Jun 24;173(12):1075-81Full text  Abstract

140. National Institute for Health and Care Excellence. Liaison psychiatry. In: Emergency acute medical care in over 16s: service delivery and organisation. March 2018 [internet publication]Full text

141. National Confidential Enquiry into Patient Outcome and Death (NCEPOD). Treat as one. Bridging the gap between mental and physical healthcare in general hospitals. 2017 [internet publication]Full text

142. DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000 Jul 24;160(14):2101-7 Abstract

143. Clarke DM, Currie KC. Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence. Med J Aust. 2009 Apr 6;190(7 suppl):S54-60 Abstract

144. Prina AM, Cosco TD, Dening T, et al. The association between depressive symptoms in the community, non-psychiatric hospital admission and hospital outcomes: a systematic review. J Psychosom Res. 2014 Nov 8;78(1):25-33Full text  Abstract

145. World Health Organization. Excess mortality in persons with severe mental disorders. 2016 [internet publication]Full text

146. National Institute for Health and Care Excellence. Tobacco: preventing uptake, promoting quitting and treating dependence. Nov 2021 [internet publication]Full text

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