Criteria
Kidney Disease: Improving Global Outcomes (KDIGO) - definition criteria[1]
Any of the following:
Increase in serum creatinine by ≥26 micromol/L (≥0.3 mg/dL) within 48 hours; or
Increase in serum creatinine to ≥1.5 times baseline, which is known or presumed to have occurred within the prior 7 days; or
Urine volume <0.5 mL/kg/hour for 6 hours.
Kidney Disease: Improving Global Outcomes (KDIGO) - severity criteria[1]
Stage 1
Serum creatinine 1.5 to 1.9 times baseline; or
≥26 micromol/L (≥0.3 mg/dL) increase in serum creatinine; or
Urine output <0.5 mL/kg/hour body weight for 6 to 12 hours
Stage 2
Creatinine increased 2.0 to 2.9 times; or
Urine output <0.5 mL/kg/hour for 12 hours or longer
Stage 3
Creatinine increased ≥3.0 times; or
Increase in creatinine to ≥354 micromol/L (≥4.0 mg/dL); or
Initiation of renal replacement therapy; or
Urine output <0.3 mL/kg/hour for 24 hours OR anuria for 12 hours.
RIFLE (Risk, Injury, Failure, Loss of kidney function, and Endstage kidney disease) consensus criteria[69]
Laboratory test indicates reduced kidney clearance.
Severity groups are as follows.
Indicates risk:
Serum creatinine increased 1.5 times; or
Urine production of <0.5 mL/kg body weight for 6 hours.
Indicates injury:
Creatinine increased 2.0 times; or
Urine production of <0.5 mL/kg for 12 hours.
Indicates failure:
Creatinine increased 3.0 times; or
Urine output <0.3 mL/kg for 24 hours or anuria for 12 hours.
Indicates loss:
Persistent AKI for more than 4 weeks; complete loss of kidney function.
Indicates ESRD:
ESRD (loss >3 months).
National Institute for Health and Care Excellence: detecting acute kidney injury[3]
Detect AKI, in line with the RIFLE, Acute Kidney Injury Network (AKIN), or KDIGO definitions, by using any of the following criteria:
A rise in serum creatinine of 26 micromol/L (0.3 mg/dL) or greater within 48 hours; or
A 50% or greater rise in serum creatinine known or presumed to have occurred within the past 7 days; or
A fall in urine output to <0.5 mL/kg/hour for more than 6 hours in adults and more than 8 hours in children and young people; or
A 25% or greater fall in estimated GFR in children and young people within the past 7 days.
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