Kidney Disease: Improving Global Outcomes (KDIGO) - definition criteria
Any of the following:
Increase in serum creatinine by ≥26 micromol/L (≥0.3 mg/dL) within 48 hours; or
Increase in serum creatinine to ≥1.5 times baseline, which is known or presumed to have occurred within the prior 7 days; or
Urine volume <0.5 mL/kg/hour for 6 hours.
Kidney Disease: Improving Global Outcomes (KDIGO) - severity criteria
Serum creatinine 1.5 to 1.9 times baseline; or
≥26 micromol/L (≥0.3 mg/dL) increase in serum creatinine; or
Urine output <0.5 mL/kg/hour body weight for 6 to 12 hours
Creatinine increased 2.0 to 2.9 times; or
Urine output <0.5 mL/kg/hour for 12 hours or longer
Creatinine increased ≥3.0 times; or
Increase in creatinine to ≥354 micromol/L (≥4.0 mg/dL); or
Initiation of renal replacement therapy; or
Urine output <0.3 mL/kg/hour for 24 hours OR anuria for 12 hours.
RIFLE (Risk, Injury, Failure, Loss of kidney function, and Endstage kidney disease) consensus criteria
Laboratory test indicates reduced kidney clearance.
Severity groups are as follows.
Serum creatinine increased 1.5 times; or
Urine production of <0.5 mL/kg body weight for 6 hours.
Creatinine increased 2.0 times; or
Urine production of <0.5 mL/kg for 12 hours.
Creatinine increased 3.0 times; or
Urine output <0.3 mL/kg for 24 hours or anuria for 12 hours.
Persistent AKI for more than 4 weeks; complete loss of kidney function.
ESRD (loss >3 months).
National Institute for Health and Care Excellence: detecting acute kidney injury
Detect AKI, in line with the RIFLE, Acute Kidney Injury Network (AKIN), or KDIGO definitions, by using any of the following criteria:
A rise in serum creatinine of 26 micromol/L (0.3 mg/dL) or greater within 48 hours; or
A 50% or greater rise in serum creatinine known or presumed to have occurred within the past 7 days; or
A fall in urine output to <0.5 mL/kg/hour for more than 6 hours in adults and more than 8 hours in children and young people; or
A 25% or greater fall in estimated GFR in children and young people within the past 7 days.
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