Sepsis is present in many hospitalisations that culminate in death. In 2015, 23,135 people in the UK died from sepsis, where sepsis was an underlying or contributory cause of death. NHS England: Sepsis external link opens in a new window The true contribution of sepsis to these deaths is unknown. Most underlying causes of death in people with sepsis are thought to relate to severe chronic comorbidities and frailty.[5][7][8]

Multi-organ compromise is common in advanced sepsis with variable residual morbidity.[266][267]

In a cohort study of 94,748 adult sepsis survivors, age, male sex, one or more severe comorbidities, pre-hospitalisation dependency, non-surgical status, acute severity of illness, site of infection, and organ dysfunction were independently associated with long-term mortality.[268]

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