Acute appendicitis


Key articles

Di Saverio S, Podda M, de Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020 Apr 15;15(1):27.Full text  Abstract

Gorter RR, Eker HH, Gorter-Stam MA, et al. Diagnosis and management of acute appendicitis: EAES consensus development conference 2015. Surg Endosc. 2016 Nov;30(11):4668-90.Full text  Abstract

Association of Surgeons of Great Britain and Ireland; Royal College of Surgeons of England. Commissioning guide: emergency general surgery (acute abdominal pain). April 2014 [internet publication].Full text

Reference articles

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41. de Castro SM, Ünlü C, Steller EP, et al. Evaluation of the appendicitis inflammatory response score for patients with acute appendicitis. World J Surg. 2012 Jul;36(7):1540-5.Full text  Abstract

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45. Kulik DM, Uleryk EM, Maguire JL. Does this child have appendicitis? A systematic review of clinical prediction rules for children with acute abdominal pain. J Clin Epidemiol. 2013 Jan;66(1):95-104.Full text  Abstract

46. Song CW, Kang JW, Kim JY. Different clinical features and lower scores in clinical scoring systems for appendicitis in preschool children: comparison with school age onset. Pediatr Gastroenterol Hepatol Nutr. 2018 Jan;21(1):51-8.Full text  Abstract

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48. Macco S, Vrouenraets BC, de Castro SM. Evaluation of scoring systems in predicting acute appendicitis in children. Surgery. 2016 Dec;160(6):1599-604. Abstract

49. Benito J, Fernandez S, Gendive M, et al. A new clinical score to identify children at low risk for appendicitis. Am J Emerg Med. 2020 Mar;38(3):554-61. Abstract

50. van Tol RR, Breukink SO, Lahaye MJ, et al. Inclusion of C-reactive protein and white blood cell count in diagnostic workup of patients with clinically suspected appendicitis stratifies for imaging. J Med Diagn Meth 2016;5:2.Full text

51. Andersson RE. Meta-analysis of the clinical and laboratory diagnosis of acute appendicitis. Br J Surg. 2004 Jan;91(1):28-37. Abstract

52. Bendeck SE, Nino-Murcia M, Berry GJ, et al. Imaging for suspected appendicitis: negative appendectomy and perforation rates. Radiology. 2002 Oct;225(1):131-6.Full text  Abstract

53. Bachur RG, Callahan MJ, Monuteaux MC, et al. Integration of ultrasound findings and a clinical score in the diagnostic evaluation of pediatric appendicitis. J Pediatr. 2015 May;166(5):1134-9. Abstract

54. Dahabreh IJ, Adam GP, Halladay CW, et al. Diagnosis of right lower quadrant pain and suspected acute appendicitis. In: Agency for Healthcare Research and Quality (US). AHRQ Comparative effectiveness reviews report no. 15(16)-EHC025-EF. 2015. Rockville, MD: Agency for Healthcare Research and Quality (US).Full text  Abstract

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56. Basaran A, Basaran M. Diagnosis of acute appendicitis during pregnancy: a systematic review. Obstet Gynecol Surv. 2009 Jul;64(7):481-8. Abstract

57. Choi D, Park H, Lee YR, et al. The most useful finding for the diagnosing acute appendicitis on contrast-enhanced helical CT. Acta Radiol. 2003 Nov;44(6):574-82. Abstract

58. Terasawa T, Blackmore CC, Bent S, et al. Systematic review: computed tomography and ultrasonography to detect acute appendicitis in adults and adolescents. Ann Intern Med. 2004 Oct 5;141(7):537-46. Abstract

59. Rud B, Vejborg TS, Rappeport ED, et al. Computed tomography for diagnosis of acute appendicitis in adults. Cochrane Database Syst Rev. 2019 Nov 19;2019(11):CD009977.Full text  Abstract

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61. Wei B, Qi CL, Chen TF, et al. Laparoscopic versus open appendectomy for acute appendicitis: a metaanalysis. Surg Endosc. 2011 Apr;25(4):1199-208. Abstract

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73. Andersen BR, Kallehave FL, Andersen HK. Antibiotics versus placebo for prevention of postoperative infection after appendicectomy. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD001439.Full text  Abstract

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75. United Kingdom National Surgical Research Collaborative; Bhangu A. Safety of short, in-hospital delays before surgery for acute appendicitis: multicentre cohort study, systematic review, and meta-analysis. Ann Surg. 2014 May;259(5):894-903. Abstract

76. Salminen P, Paajanen H, Rautio T, et al. Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial. JAMA. 2015 Jun 16;313(23):2340-8. Abstract

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78. Flum DR. Clinical practice: a cute appendicitis – appendectomy or the "antibiotics first" strategy. N Engl J Med. 2015 May 14;372(20):1937-43. Abstract

79. Mahida JB, Lodwick DL, Nacion KM, et al. High failure rate of nonoperative management of acute appendicitis with an appendicolith in children. J Pediatr Surg. 2016 Jun;51(6):908-11. Abstract

80. Ventham NT, Dungworth JC, Benzoni C. Transition towards laparoscopic appendicectomy at a UK center over a 7-year period. Surg Laparosc Endosc Percutan Tech. 2015 Feb;25(1):59-63. Abstract

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83. Kasatpibal N, Nørgaard M, Sørensen HT, et al. Risk of surgical site infection and efficacy of antibiotic prophylaxis: a cohort study of appendectomy patients in Thailand. BMC Infect Dis. 2006 Jul 12;6:111.Full text  Abstract

84. Daskalakis K, Juhlin C, Påhlman L. The use of pre- or postoperative antibiotics in surgery for appendicitis: a systematic review. Scand J Surg. 2014 Mar;103(1):14-20.Full text  Abstract

85. Mui LM, Ng CS, Wong SK, et al. Optimum duration of prophylactic antibiotics in acute non-perforated appendicitis. ANZ J Surg. 2005 Jun;75(6):425-8. Abstract

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88. Coakley BA, Sussman ES, Wolfson TS, et al. Postoperative antibiotics correlate with worse outcomes after appendectomy for nonperforated appendicitis. J Am Coll Surg. 2011 Dec;213(6):778-83. Abstract

89. van Rossem CC, Schreinemacher MH, Treskes K, et al. Duration of antibiotic treatment after appendicectomy for acute complicated appendicitis. Br J Surg. 2014 May;101(6):715-9. Abstract

90. Liu Z, Zhang P, Ma Y, et al. Laparoscopy or not: a meta-analysis of the surgical effects of laparoscopic versus open appendicectomy. Surg Laparosc Endosc Percutan Tech. 2010 Dec;20(6):362-70. Abstract

91. Jaschinski T, Mosch CG, Eikermann M, et al. Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev. 2018 Nov 28;(11):CD001546.Full text  Abstract

92. Kraemer M, Ohmann C, Leppert R, et al. Macroscopic assessment of the appendix at diagnostic laparoscopy is reliable. Surg Endosc. 2000 Jul;14(7):625-33. Abstract

93. van den Broek WT, Bijnen AB, de Ruiter P, et al. A normal appendix found during diagnostic laparoscopy should not be removed. Br J Surg. 2001 Feb;88(2):251-4. Abstract

94. Jaschinski T, Mosch C, Eikermann M, et al. Laparoscopic versus open appendectomy in patients with suspected appendicitis: a systematic review of meta-analyses of randomised controlled trials. BMC Gastroenterol. 2015 Apr 15;15:48.Full text  Abstract

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101. Busch M, Gutzwiller FS, Aellig S, et al. In-hospital delay increases the risk of perforation in adults with appendicitis. World J Surg. 2011 Jul;35(7):1626-33. Abstract

102. Teo AT, Lefter LP, Zarrouk AJ, et al. Institutional review of patients presenting with suspected appendicitis. ANZ J Surg. 2015 Jun;85(6):420-4. Abstract

103. Stahlfeld K, Hower J, Homitsky S, et al. Is acute appendicitis a surgical emergency? Am Surg. 2007 Jun;73(6):626-9. Abstract

104. Livingston EH, Woodward WA, Sarosi GA, et al. Disconnect between incidence of nonperforated and perforated appendicitis: implications for pathophysiology and management. Ann Surg. 2007 Jun;245(6):886-92.Full text  Abstract

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107. Andersson RE. The natural history and traditional management of appendicitis revisited: spontaneous resolution and predominance of prehospital perforations imply that a correct diagnosis is more important than an early diagnosis. World J Surg. 2007 Jan;31(1):86-92. Abstract

108. Go DY, Boo YJ, Lee JS, et al. Transumbilical laparoscopic-assisted appendectomy is a useful surgical option for pediatric uncomplicated appendicitis: a comparison with conventional 3-port laparoscopic appendectomy. Ann Surg Treat Res. 2016 Aug;91(2):80-4.Full text  Abstract

109. Andersson RE, Hugander A, Ravn H, et al. Repeated clinical and laboratory examinations in patients with an equivocal diagnosis of appendicitis. World J Surg. 2000 Apr;24(4):479-85. Abstract

110. Salminen P, Tuominen R, Paajanen H, et al. Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial. JAMA. 2018 Sep 25;320(12):1259-65.Full text  Abstract

111. Zhang S, Du T, Jiang X, et al. Laparoscopic appendectomy in children with perforated appendicitis: a meta-analysis. Surg Laparosc Endosc Percutan Tech. 2017 Aug;27(4):262-6. Abstract

112. Yu MC, Feng YJ, Wang W, et al. Is laparoscopic appendectomy feasible for complicated appendicitis? A systematic review and meta-analysis. Int J Surg. 2017 Apr;40:187-97.Full text  Abstract

113. Low ZX, Bonney GK, So JBY, et al. Laparoscopic versus open appendectomy in pediatric patients with complicated appendicitis: a meta-analysis. Surg Endosc. 2019 Dec;33(12):4066-77. Abstract

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116. Teixeira PG, Sivrikoz E, Inaba K, et al. Appendectomy timing: waiting until the next morning increases the risk of surgical site infections. Ann Surg. 2012 Sep;256(3):538-43. Abstract

117. Dimitriou I, Reckmann B, Nephuth O, et al. Single institution's experience in laparoscopic appendectomy as a suitable therapy for complicated appendicitis. Langenbecks Arch Surg. 2013 Jan;398(1):147-52. Abstract

118. Thomson JE, Kruger D, Jann-Kruger C, et al. Laparoscopic versus open surgery for complicated appendicitis: a randomized controlled trial to prove safety. Surg Endosc. 2015 Jul;29(7):2027-32. Abstract

119. Tuggle KR, Ortega G, Bolorunduro OB, et al. Laparoscopic versus open appendectomy in complicated appendicitis: a review of the NSQIP database. J Surg Res. 2010 Oct;163(2):225-8. Abstract

120. Athanasiou C, Lockwood S, Markides GA. Systematic review and meta-analysis of laparoscopic versus open appendicectomy in adults with complicated appendicitis: an update of the literature. World J Surg. 2017 Dec;41(12):3083-99. Abstract

121. Simillis C, Symeonides P, Shorthouse AJ, et al. A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon). Surgery. 2010 Jun;147(6):818-29. Abstract

122. Andersson RE, Petzold MG. Nonsurgical treatment of appendiceal abscess or phlegmon: a systematic review and meta-analysis. Ann Surg. 2007 Nov;246(5):741-8. Abstract

123. Horn CB, Coleoglou Centeno AA, Guerra JJ, et al. Drain failure in intra-abdominal abscesses associated with appendicitis. Surg Infect (Larchmt). 2018 Apr;19(3):321-5. Abstract

124. Gavriilidis P, de'Angelis N, Katsanos K, et al. Acute appendicectomy or conservative treatment for complicated appendicitis (phlegmon or abscess)? A systematic review by updated traditional and cumulative meta-analysis. J Clin Med Res. 2019 Jan;11(1):56-64. Abstract

125. Mentula P, Sammalkorpi H, Leppäniemi A. Laparoscopic surgery or conservative treatment for appendiceal abscess in adults? A randomized controlled trial. Ann Surg. 2015;262:237-42. Abstract

126. Mällinen J, Rautio T, Grönroos J, et al. Risk of appendiceal neoplasm in periappendicular abscess in patients treated with interval appendectomy vs follow-up with magnetic resonance imaging: 1-year outcomes of the Peri-Appendicitis Acuta randomized clinical trial. JAMA Surg. 2019 Mar 1;154(3):200-7.Full text  Abstract

127. Renteria O, Shahid Z, Huerta S. Outcomes of appendectomy in elderly veteran patients. Surgery. 2018 Sep;164(3):460-5.Full text  Abstract

128. Rushing A, Bugaev N, Jones C, et al. Management of acute appendicitis in adults: a practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2019 Jul;87(1):214-24. Abstract

129. Song CW, Kang JW, Kim JY. Different clinical features and lower scores in clinical scoring systems for appendicitis in preschool children: comparison with school age onset. Pediatr Gastroenterol Hepatol Nutr. 2018 Jan;21(1):51-8.Full text  Abstract

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131. Howell EC, Dubina ED, Lee SL. Perforation risk in pediatric appendicitis: assessment and management. Pediatric Health Med Ther. 2018 Oct 26;9:135-45.Full text  Abstract

132. Fugazzola P, Coccolini F, Tomasoni M, et al. Early appendectomy vs. conservative management in complicated acute appendicitis in children: a meta-analysis. J Pediatr Surg. 2019 Nov;54(11):2234-41. Abstract

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