References

Key articles

Di Saverio S, Podda M, de Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020 Apr 15;15(1):27.Full text  Abstract

Gorter RR, Eker HH, Gorter-Stam MA, et al. Diagnosis and management of acute appendicitis: EAES consensus development conference 2015. Surg Endosc. 2016 Nov;30(11):4668-90.Full text  Abstract

Association of Surgeons of Great Britain and Ireland; Royal College of Surgeons of England. Commissioning guide: emergency general surgery (acute abdominal pain). April 2014 [internet publication].Full text

Reference articles

1. Fitz RH. Perforating inflammation of the vermiform appendix with special reference to its early diagnosis and treatment. Am J Med Sci. 1886;92:321-46.

2. Moris D, Paulson EK, Pappas TN. Diagnosis and management of acute appendicitis in adults: a review. JAMA. 2021 Dec 14;326(22):2299-311. Abstract

3. Lapsa S, Ozolins A, Strumfa I, et al. Acute appendicitis in the elderly: a literature review on an increasingly frequent surgical problem. Geriatrics (Basel). 2021 Sep 18;6(3):93.Full text  Abstract

4. Antoniou SA, Mavridis D, Kontouli KM, et al. EAES rapid guideline: appendicitis in the elderly. Surg Endosc. 2021 Jul;35(7):3233-43. Abstract

5. Fugazzola P, Ceresoli M, Agnoletti V, et al. The SIFIPAC/WSES/SICG/SIMEU guidelines for diagnosis and treatment of acute appendicitis in the elderly (2019 edition). World J Emerg Surg. 2020 Mar 10;15(1):19.Full text  Abstract

6. Andersen B, Nielsen TF. Appendicitis in pregnancy: diagnosis, management and complications. Acta Obstet Gynecol Scand. 1999 Oct;78(9):758-62. Abstract

7. Di Saverio S, Podda M, de Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020 Apr 15;15(1):27.Texto completo  Resumo

8. Davenport M. Acute abdominal pain in children. BMJ. 1996 Feb 24;312(7029):498-501.Texto completo  Resumo

9. Benabbas R, Hanna M, Shah J, et al. Diagnostic accuracy of history, physical examination, laboratory tests, and point-of-care ultrasound for pediatric acute appendicitis in the emergency department: a systematic review and meta-analysis. Acad Emerg Med. 2017 May;24(5):523-51.Texto completo  Resumo

10. NHS England. Hospital admitted patient care activity, 2021-22. Sep 2022 [internet publication].Texto completo

11. Ferris M, Quan S, Kaplan BS, et al. The global incidence of appendicitis: a systematic review of population-based studies. Ann Surg. 2017 Aug;266(2):237-41. Resumo

12. Snyder MJ, Guthrie M, Cagle S. Acute appendicitis: efficient diagnosis and management. Am Fam Physician. 2018 Jul 1;98(1):25-33.Texto completo  Resumo

13. Gorter RR, Eker HH, Gorter-Stam MA, et al. Diagnosis and management of acute appendicitis: EAES consensus development conference 2015. Surg Endosc. 2016 Nov;30(11):4668-90.Texto completo  Resumo

14. Eslahi AV, Olfatifar M, Houshmand E, et al. Parasites in surgically removed appendices as a neglected public health concern: a systematic review and meta-analysis. Pathog Glob Health. 2022 Sep;116(6):341-55.Texto completo  Resumo

15. Zacarias M, Pizzol D, de Miranda H, et al. Schistosomal appendicitis: Case series and systematic literature review. PLoS Negl Trop Dis. 2021 Jun;15(6):e0009478.Texto completo  Resumo

16. Di Sebastiano P, Fink T, di Mola FF, et al. Neuroimmune appendicitis. Lancet. 1999 Aug 7;354(9177):461-6. Resumo

17. Peisl S, Burckhardt O, Egger B. Neurogenic appendicopathy: an underestimated disease-systematic review of the literature. Int J Colorectal Dis. 2021 Sep;36(9):1995-2005. Resumo

18. Soffer D, Zait S, Klausner J, et al. Peritoneal cultures and antibiotic treatment in patients with perforated appendicitis. Eur J Surg. 2001 Mar;167(3):214-6. Resumo

19. Brunicardi FC, Andersen DK, Billiar TR, et al, eds. Schwartz's principles of surgery. 8th ed. New York, NY: McGraw-Hill; 2005.

20. Huis in 't Veld JH. Gastrointestinal flora and health in man and animal [in Dutch]. Tijdschr Diergeneeskd. 1991 Mar 1;116(5):232-9. Resumo

21. Walker AR, Segal I. What causes appendicitis? J Clin Gastroenterol. 1990 Apr;12(2):127-9. Resumo

22. Montgomery SM, Pounder RE, Wakefield AJ. Smoking in adults and passive smoking in children are associated with acute appendicitis. Lancet. 1999 Jan 30;353(9150):379. Resumo

23. Oldmeadow C, Wood I, Mengersen K, et al. Investigation of the relationship between smoking and appendicitis in Australian twins. Ann Epidemiol. 2008 Aug;18(8):631-6. Resumo

24. Lee SL, Walsh AJ, Ho HS. Computed tomography and ultrasonography do not improve and may delay the diagnosis and treatment of acute appendicitis. Arch Surg. 2001 May;136(5):556-62.Texto completo  Resumo

25. Lewis SR, Mahony PJ, Simpson J. Appendicitis. BMJ. 2011 Oct 6;343:d5976. Resumo

26. National Institute for Health and Care Excellence. Sepsis: recognition, diagnosis and early management. September 2017 [internet publication].Texto completo

27. Association of Surgeons of Great Britain and Ireland; Royal College of Surgeons of England. Commissioning guide: emergency general surgery (acute abdominal pain). April 2014 [internet publication].Texto completo

28. Carstens AK, Fensby L, Penninga L. Nonoperative treatment of appendicitis during pregnancy in a remote area. AJP Rep. 2018 Jan;8(1):e37-8.Texto completo  Resumo

29. Humes DJ, Simpson J. Acute appendicitis. BMJ. 2006 Sep 9;333(7567):530-4.Texto completo  Resumo

30. American College of Emergency Physicians Clinical Policies Subcommittee (Writing Committee) on Appendicitis, Diercks DB, Adkins EJ, et al. Clinical policy: critical issues in the evaluation and management of emergency department patients with suspected appendicitis: approved by ACEP Board of Directors February 1, 2023. Ann Emerg Med. 2023 Jun;81(6):e115-52.Texto completo  Resumo

31. Bhangu A; RIFT Study Group on behalf of the West Midlands Research Collaborative. Evaluation of appendicitis risk prediction models in adults with suspected appendicitis. Br J Surg. 2020 Jan;107(1):73-86.Texto completo  Resumo

32. National Institute for Health and Care Excellence. Suspected cancer: recognition and referral. 2025 [internet publication].Texto completo

33. Makama JG, Kache SA, Ajah LJ, et al. Intestinal obstruction caused by appendicitis: a systematic review. J West Afr Coll Surg. 2017 Jul-Sep;7(3):94-115.Texto completo  Resumo

34. Brown JJ, Wilson C, Coleman S, Joypaul BV. Appendicitis in pregnancy: an ongoing diagnostic dilemma. Colorectal Dis. 2009 Feb;11(2):116-22. Resumo

35. Baird DLH, Simillis C, Kontovounisios C, et al. Acute appendicitis. BMJ. 2017 Apr 19;357:j1703. Resumo

36. Takada T, Nishiwaki H, Yamamoto Y, et al. The role of digital rectal examination for diagnosis of acute appendicitis: a systematic review and meta-analysis. PLoS One. 2015 Sep 2;10(9):e0136996.Texto completo  Resumo

37. Manterola C, Vial M, Moraga J, et al. Analgesia in patients with acute abdominal pain. Cochrane Database Syst Rev. 2011 Jan 19;(1):CD005660.Texto completo  Resumo

38. Green R, Bulloch B, Kabani A, et al. Early analgesia for children with acute abdominal pain. Pediatrics. 2005 Oct;116(4):978-83. Resumo

39. Chong CF, Adi MI, Thien A, et al. Development of the RIPASA score: a new appendicitis scoring system for the diagnosis of acute appendicitis. Singapore Med J. 2010 Mar;51(3):220-5.Texto completo  Resumo

40. de Castro SM, Ünlü C, Steller EP, et al. Evaluation of the appendicitis inflammatory response score for patients with acute appendicitis. World J Surg. 2012 Jul;36(7):1540-5.Texto completo  Resumo

41. Sammalkorpi HE, Mentula P, Savolainen H, et al. The introduction of Adult Appendicitis Score reduced negative appendectomy rate. Scand J Surg. 2017 Sep;106(3):196-201.Texto completo  Resumo

42. Tan WJ, Acharyya S, Goh YC, et al. Prospective comparison of the Alvarado score and CT scan in the evaluation of suspected appendicitis: a proposed algorithm to guide CT use. J Am Coll Surg. 2015 Feb;220(2):218-24. Resumo

43. Samuel M. Pediatric appendicitis score. J Pediatr Surg. 2002 Jun;37(6):877-81. Resumo

44. Kulik DM, Uleryk EM, Maguire JL. Does this child have appendicitis? A systematic review of clinical prediction rules for children with acute abdominal pain. J Clin Epidemiol. 2013 Jan;66(1):95-104.Texto completo  Resumo

45. Song CW, Kang JW, Kim JY. Different clinical features and lower scores in clinical scoring systems for appendicitis in preschool children: comparison with school age onset. Pediatr Gastroenterol Hepatol Nutr. 2018 Jan;21(1):51-8.Texto completo  Resumo

46. Chung PHY, Dai K, Yang Z, et al. Validity of Alvarado Score in predicting disease severity and postoperative complication in pediatric acute appendicitis. World J Pediatr Surg. 2019 Feb 12;2:e000003.Texto completo

47. Macco S, Vrouenraets BC, de Castro SM. Evaluation of scoring systems in predicting acute appendicitis in children. Surgery. 2016 Dec;160(6):1599-604. Resumo

48. Benito J, Fernandez S, Gendive M, et al. A new clinical score to identify children at low risk for appendicitis. Am J Emerg Med. 2020 Mar;38(3):554-61. Resumo

49. Simundic AM, Bölenius K, Cadamuro J, et al. Joint EFLM-COLABIOCLI recommendation for venous blood sampling. Clin Chem Lab Med 2018;56(12):2015-38. Resumo

50. van Tol RR, Breukink SO, Lahaye MJ, et al. Inclusion of C-reactive protein and white blood cell count in diagnostic workup of patients with clinically suspected appendicitis stratifies for imaging. J Med Diagn Meth 2016;5:2.Texto completo

51. Andersson RE. Meta-analysis of the clinical and laboratory diagnosis of acute appendicitis. Br J Surg. 2004 Jan;91(1):28-37. Resumo

52. Bendeck SE, Nino-Murcia M, Berry GJ, et al. Imaging for suspected appendicitis: negative appendectomy and perforation rates. Radiology. 2002 Oct;225(1):131-6. Resumo

53. Bachur RG, Callahan MJ, Monuteaux MC, et al. Integration of ultrasound findings and a clinical score in the diagnostic evaluation of pediatric appendicitis. J Pediatr. 2015 May;166(5):1134-9. Resumo

54. Basaran A, Basaran M. Diagnosis of acute appendicitis during pregnancy: a systematic review. Obstet Gynecol Surv. 2009 Jul;64(7):481-8. Resumo

55. D'Souza N, Hicks G, Beable R, et al. Magnetic resonance imaging (MRI) for diagnosis of acute appendicitis. Cochrane Database Syst Rev. 2021 Dec 14;12(12):CD012028.Texto completo  Resumo

56. Choi D, Park H, Lee YR, et al. The most useful finding for the diagnosing acute appendicitis on contrast-enhanced helical CT. Acta Radiol. 2003 Nov;44(6):574-82. Resumo

57. Dahabreh IJ, Adam GP, Halladay CW, et al. Diagnosis of right lower quadrant pain and suspected acute appendicitis. In: Agency for Healthcare Research and Quality (US). AHRQ Comparative effectiveness reviews report no. 15(16)-EHC025-EF. 2015. Rockville, MD: Agency for Healthcare Research and Quality (US).Texto completo  Resumo

58. Terasawa T, Blackmore CC, Bent S, et al. Systematic review: computed tomography and ultrasonography to detect acute appendicitis in adults and adolescents. Ann Intern Med. 2004 Oct 5;141(7):537-46. Resumo

59. Fu J, Zhou X, Chen L, et al. Abdominal ultrasound and its diagnostic accuracy in diagnosing acute appendicitis: a meta-analysis. Front Surg. 2021;8:707160.Texto completo  Resumo

60. Rud B, Vejborg TS, Rappeport ED, et al. Computed tomography for diagnosis of acute appendicitis in adults. Cochrane Database Syst Rev. 2019 Nov 19;2019(11):CD009977.Texto completo  Resumo

61. Hlibczuk V, Dattaro JA, Jin Z, et al. Diagnostic accuracy of noncontrast computed tomography for appendicitis in adults: a systematic review. Ann Emerg Med. 2010 Jan;55(1):51-9. Resumo

62. Wei B, Qi CL, Chen TF, et al. Laparoscopic versus open appendectomy for acute appendicitis: a metaanalysis. Surg Endosc. 2011 Apr;25(4):1199-208. Resumo

63. Arruzza E, Milanese S, Li LSK, et al. Diagnostic accuracy of computed tomography and ultrasound for the diagnosis of acute appendicitis: a systematic review and meta-analysis. Radiography (Lond). 2022 Nov;28(4):1127-41. Resumo

64. Anderson BA, Salem L, Flum DR. A systematic review of whether oral contrast is necessary for the computed tomography diagnosis of appendicitis in adults. Am J Surg. 2005 Sep;190(3):474-8. Resumo

65. Yamamoto M, Ando T, Kanai S, et al. Abnormal urinalysis in acute appendicitis. Hinyokika Kiyo. 1985 Oct;31(10):1723-5.Texto completo  Resumo

66. Gray J, Wardrope J, Fothergill DJ. 7 Abdominal pain, abdominal pain in women, complications of pregnancy and labour. Emerg Med J. 2004 Sep;21(5):606-13. Resumo

67. Eun S, Ho IG, Bae GE, et al. Neutrophil-to-lymphocyte ratio for the diagnosis of pediatric acute appendicitis: a systematic review and meta-analysis. Eur Rev Med Pharmacol Sci. 2021 Nov;25(22):7097-7107.Texto completo  Resumo

68. Giannis D, Matenoglou E, Moris D. Hyponatremia as a marker of complicated appendicitis: a systematic review. Surgeon. 2020 Oct;18(5):295-304. Resumo

69. Zhan W, Deng W, Liu Y, et al. Hyponatremia as a predictor of complicated appendicitis in children: a systematic review and meta-analysis. Asian J Surg. 2022 Oct;45(10):2009-11.Texto completo  Resumo

70. Anand S, Pakkasjärvi N, Bajpai M, et al. Utility of Pentraxin-3 as a biomarker for diagnosis of acute appendicitis: a systematic review and meta-analysis. Pediatr Surg Int. 2022 Aug;38(8):1105-12.Texto completo  Resumo

71. Shi W, Wu Y, Zhong L, et al. Diagnostic accuracy of serum amyloid A in acute appendicitis: a systematic review and meta-analysis. Surg Infect (Larchmt). 2022 May;23(4):380-7. Resumo

72. Tullavardhana T, Sanguanlosit S, Chartkitchareon A. Role of platelet indices as a biomarker for the diagnosis of acute appendicitis and as a predictor of complicated appendicitis: a meta-analysis. Ann Med Surg (Lond). 2021 Jun;66:102448.Texto completo  Resumo

73. Shen G, Li S, Shao Z, et al. Platelet indices in patients with acute appendicitis: a systematic review with meta-analysis. Updates Surg. 2021 Aug;73(4):1327-41. Resumo

74. Chiu YH, Chen JD, Wang SH, et al. Whether intravenous contrast is necessary for CT diagnosis of acute appendicitis in adult ED patients? Acad Radiol. 2013 Jan;20(1):73-8.Texto completo  Resumo

75. Hajibandeh S, Hajibandeh S, Hobbs N, et al. Neutrophil-to-lymphocyte ratio predicts acute appendicitis and distinguishes between complicated and uncomplicated appendicitis: a systematic review and meta-analysis. Am J Surg. 2020 Jan;219(1):154-63. Resumo

76. Sabiston D. The biliary system. In: Sabiston D, Lyerly HK, eds. Textbook of surgery: the biological basis of modern surgical practice. 15th ed. Philadelphia, PA: W.B. Saunders Company; 1997:1127.

77. Vincelette J, Schirm J, Bogard M, et al. Multicenter evaluation of the fully automated COBAS AMPLICATOR PCR test for detection of Chlamydia trachomatis in urogenital specimens. J Clin Microbiol. 1999 Jan;37(1):74-80.Texto completo  Resumo

78. Uhe I, Meyer J, Viviano M, et al. Caecal diverticulitis can be misdiagnosed as acute appendicitis: a systematic review of the literature. Colorectal Dis. 2021 Oct;23(10):2515-26.Texto completo  Resumo

79. National Institute for Health and Care Excellence. Intravenous fluid therapy in adults in hospital. May 2017 [internet publication].Texto completo

80. NHS England. Sepsis guidance implementation advice for adults. September 2017 [internet publication].Texto completo

81. Royal College of Physicians. National early warning score (NEWS) 2: standardising the assessment of acute-illness severity in the NHS. December 2017 [internet publication].Texto completo

82. Nutbeam T, Daniels R; The UK Sepsis Trust. Professional resources: clinical [internet publication].Texto completo

83. Bion J, Barton G, Boyle A, et al. Academy of Medical Royal Colleges statement on the initial antimicrobial treatment of sepsis V2.0. Oct 2022 [internet publication].Texto completo

84. Weston P, Moroz P. Appendicitis in pregnancy: how to manage and whether to deliver. Obstet Gynecol. 2015 Apr;17(2):105-10.

85. United Kingdom National Surgical Research Collaborative; Bhangu A. Safety of short, in-hospital delays before surgery for acute appendicitis: multicentre cohort study, systematic review, and meta-analysis. Ann Surg. 2014 May;259(5):894-903. Resumo

86. Andersen BR, Kallehave FL, Andersen HK. Antibiotics versus placebo for prevention of postoperative infection after appendicectomy. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD001439.Texto completo  Resumo

87. Salminen P, Paajanen H, Rautio T, et al. Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial. JAMA. 2015 Jun 16;313(23):2340-8. Resumo

88. Bhangu A, Søreide K, Di Saverio S, et al. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet. 2015 Sep 26;386(10000):1278-87. Resumo

89. Flum DR. Clinical practice: acute appendicitis – appendectomy or the "antibiotics first" strategy. N Engl J Med. 2015 May 14;372(20):1937-43. Resumo

90. de Almeida Leite RM, Seo DJ, Gomez-Eslava B, et al. Nonoperative vs operative management of uncomplicated acute appendicitis: a systematic review and meta-analysis. JAMA Surg. 2022 Sep 1;157(9):828-34.Texto completo  Resumo

91. Emile SH, Sakr A, Shalaby M, et al. Efficacy and safety of non-operative management of uncomplicated acute appendicitis compared to appendectomy: an umbrella review of systematic reviews and meta-Analyses. World J Surg. 2022 May;46(5):1022-38.Texto completo  Resumo

92. Herrod PJJ, Kwok AT, Lobo DN. Randomized clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis. BJS Open. 2022 Jul 7;6(4):zrac100.Texto completo  Resumo

93. Meier J, Stevens A, Bhat A, et al. Outcomes of nonoperative vs operative management of acute appendicitis in older adults in the US. JAMA Surg. 2023 Jun 1;158(6):625-32. Resumo

94. Mahida JB, Lodwick DL, Nacion KM, et al. High failure rate of nonoperative management of acute appendicitis with an appendicolith in children. J Pediatr Surg. 2016 Jun;51(6):908-11. Resumo

95. Ventham NT, Dungworth JC, Benzoni C. Transition towards laparoscopic appendicectomy at a UK center over a 7-year period. Surg Laparosc Endosc Percutan Tech. 2015 Feb;25(1):59-63. Resumo

96. Markar SR, Penna M, Harris A. Laparoscopic approach to appendectomy reduces the incidence of short- and long-term post-operative bowel obstruction: systematic review and pooled analysis. J Gastrointest Surg. 2014 Sep;18(9):1683-92. Resumo

97. Webster J, Osborne S, Rickard CM, et al. Clinically-indicated replacement versus routine replacement of peripheral venous catheters. Cochrane Database Syst Rev. 2019 Jan 23;1(1):CD007798.Texto completo  Resumo

98. Kasatpibal N, Nørgaard M, Sørensen HT, et al. Risk of surgical site infection and efficacy of antibiotic prophylaxis: a cohort study of appendectomy patients in Thailand. BMC Infect Dis. 2006 Jul 12;6:111.Texto completo  Resumo

99. Daskalakis K, Juhlin C, Påhlman L. The use of pre- or postoperative antibiotics in surgery for appendicitis: a systematic review. Scand J Surg. 2014 Mar;103(1):14-20.Texto completo  Resumo

100. Mui LM, Ng CS, Wong SK, et al. Optimum duration of prophylactic antibiotics in acute non-perforated appendicitis. ANZ J Surg. 2005 Jun;75(6):425-8. Resumo

101. Pinto DJ, Sanderson PJ. Rational use of antibiotic therapy after appendicectomy. Br Med J. 1980 Feb 2;280(6210):275-7.Texto completo  Resumo

102. Ambrose NS, Donovan IA, Wise R, et al. Metronidazole and ticarcillin in the prevention of sepsis after appendicectomy. Am J Surg. 1983 Sep;146(3):346-8. Resumo

103. Coakley BA, Sussman ES, Wolfson TS, et al. Postoperative antibiotics correlate with worse outcomes after appendectomy for nonperforated appendicitis. J Am Coll Surg. 2011 Dec;213(6):778-83. Resumo

104. van Rossem CC, Schreinemacher MH, Treskes K, et al. Duration of antibiotic treatment after appendicectomy for acute complicated appendicitis. Br J Surg. 2014 May;101(6):715-9. Resumo

105. Liew AN, Lim KY, Quach D, et al. Laparoscopic versus open appendicectomy in pregnancy: experience from a single institution and meta-analysis. ANZ J Surg. 2022 May;92(5):1071-8. Resumo

106. Zeng Q, Aierken A, Gu SS, et al. Laparoscopic versus open appendectomy for appendicitis in pregnancy: systematic review and meta-analysis. Surg Laparosc Endosc Percutan Tech. 2021 May 3;31(5):637-44. Resumo

107. de Wijkerslooth EML, Bakas JM, van Rosmalen J, et al. Same-day discharge after appendectomy for acute appendicitis: a systematic review and meta-analysis. Int J Colorectal Dis. 2021 Jun;36(6):1297-309.Texto completo  Resumo

108. Liu Z, Zhang P, Ma Y, et al. Laparoscopy or not: a meta-analysis of the surgical effects of laparoscopic versus open appendicectomy. Surg Laparosc Endosc Percutan Tech. 2010 Dec;20(6):362-70. Resumo

109. Jaschinski T, Mosch CG, Eikermann M, et al. Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev. 2018 Nov 28;(11):CD001546.Texto completo  Resumo

110. Zhang G, Wu B. Meta-analysis of the clinical efficacy of laparoscopic appendectomy in the treatment of acute appendicitis. World J Emerg Surg. 2022 May 26;17(1):26.Texto completo  Resumo

111. Alganabi M, Biouss G, Pierro A. Surgical site infection after open and laparoscopic surgery in children: a systematic review and meta-analysis. Pediatr Surg Int. 2021 Aug;37(8):973-81. Resumo

112. Kraemer M, Ohmann C, Leppert R, et al. Macroscopic assessment of the appendix at diagnostic laparoscopy is reliable. Surg Endosc. 2000 Jul;14(7):625-33. Resumo

113. van den Broek WT, Bijnen AB, de Ruiter P, et al. A normal appendix found during diagnostic laparoscopy should not be removed. Br J Surg. 2001 Feb;88(2):251-4. Resumo

114. Jaschinski T, Mosch C, Eikermann M, et al. Laparoscopic versus open appendectomy in patients with suspected appendicitis: a systematic review of meta-analyses of randomised controlled trials. BMC Gastroenterol. 2015 Apr 15;15:48.Texto completo  Resumo

115. Zhang J, Wang M, Xin Z, et al. Updated evaluation of laparoscopic vs. open appendicectomy during pregnancy: a systematic review and meta-analysis. Front Surg. 2021;8:720351.Texto completo  Resumo

116. Lee SH, Lee JY, Choi YY, et al. Laparoscopic appendectomy versus open appendectomy for suspected appendicitis during pregnancy: a systematic review and updated meta-analysis. BMC Surg. 2019 Apr 25;19(1):41.Texto completo  Resumo

117. Wang YC, Yang HR, Chung PK, et al. Laparoscopic appendectomy in the elderly. Surg Endosc. 2006 Jun;20(6):887-9. Resumo

118. Kim MJ, Fleming FJ, Gunzler DD, et al. Laparoscopic appendectomy is safe and efficacious for the elderly: an analysis using the National Surgical Quality Improvement Project database. Surg Endosc. 2011 Jun;25(6):1802-7. Resumo

119. Yeh CC, Wu SC, Liao CC, et al. Laparoscopic appendectomy for acute appendicitis is more favorable for patients with comorbidities, the elderly, and those with complicated appendicitis: a nationwide population-based study. Surg Endosc. 2011 Sep;25(9):2932-42. Resumo

120. Masoomi H, Mills S, Dolich MO, et al. Does laparoscopic appendectomy impart an advantage over open appendectomy in elderly patients? World J Surg. 2012 Jul;36(7):1534-9. Resumo

121. Southgate E, Vousden N, Karthikesalingam A, et al. Laparoscopic vs open appendectomy in older patients. Arch Surg. 2012 Jun;147(6):557-62.Texto completo  Resumo

122. Busch M, Gutzwiller FS, Aellig S, et al. In-hospital delay increases the risk of perforation in adults with appendicitis. World J Surg. 2011 Jul;35(7):1626-33. Resumo

123. Teo AT, Lefter LP, Zarrouk AJ, et al. Institutional review of patients presenting with suspected appendicitis. ANZ J Surg. 2015 Jun;85(6):420-4. Resumo

124. Stahlfeld K, Hower J, Homitsky S, et al. Is acute appendicitis a surgical emergency? Am Surg. 2007 Jun;73(6):626-9. Resumo

125. Livingston EH, Woodward WA, Sarosi GA, et al. Disconnect between incidence of nonperforated and perforated appendicitis: implications for pathophysiology and management. Ann Surg. 2007 Jun;245(6):886-92.Texto completo  Resumo

126. CODA Collaborative; Flum DR, Davidson GH, Monsell SE, et al. A randomized trial comparing antibiotics with appendectomy for appendicitis. N Engl J Med. 2020 Nov 12;383(20):1907-19.Texto completo  Resumo

127. Supreme Court (UK). Judgment: Montgomery (appellant) v Lanarkshire Health Board (respondent) (Scotland). March 2015 [internet publication].Texto completo

128. Andersson RE. The natural history and traditional management of appendicitis revisited: spontaneous resolution and predominance of prehospital perforations imply that a correct diagnosis is more important than an early diagnosis. World J Surg. 2007 Jan;31(1):86-92. Resumo

129. Andersson RE, Hugander A, Ravn H, et al. Repeated clinical and laboratory examinations in patients with an equivocal diagnosis of appendicitis. World J Surg. 2000 Apr;24(4):479-85. Resumo

130. Salminen P, Tuominen R, Paajanen H, et al. Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial. JAMA. 2018 Sep 25;320(12):1259-65.Texto completo  Resumo

131. Kiblawi R, Zoeller C, Zanini A, et al. Laparoscopic versus open pediatric surgery: three decades of comparative studies. Eur J Pediatr Surg. 2022 Feb;32(1):9-25. Resumo

132. Zhang S, Du T, Jiang X, et al. Laparoscopic appendectomy in children with perforated appendicitis: a meta-analysis. Surg Laparosc Endosc Percutan Tech. 2017 Aug;27(4):262-6. Resumo

133. Yu MC, Feng YJ, Wang W, et al. Is laparoscopic appendectomy feasible for complicated appendicitis? A systematic review and meta-analysis. Int J Surg. 2017 Apr;40:187-97.Texto completo  Resumo

134. Low ZX, Bonney GK, So JBY, et al. Laparoscopic versus open appendectomy in pediatric patients with complicated appendicitis: a meta-analysis. Surg Endosc. 2019 Dec;33(12):4066-77. Resumo

135. Temple CL, Shirley AH, Temple WJ. The natural history of appendicitis in adults: a prospective study. Ann Surg. 1995 Mar;221(3):278-81.Texto completo  Resumo

136. Franz MG, Norman J, Fabri PJ. Increased morbidity of appendicitis with advancing age. Am Surg. 1995 Jan;61(1):40-4. Resumo

137. Teixeira PG, Sivrikoz E, Inaba K, et al. Appendectomy timing: waiting until the next morning increases the risk of surgical site infections. Ann Surg. 2012 Sep;256(3):538-43. Resumo

138. Ahmed A, Feroz SH, Dominic JL, et al. Is emergency appendicectomy better than elective appendicectomy for the treatment of appendiceal phlegmon?: A Review. Cureus. 2020 Dec 12;12(12):e12045.Texto completo  Resumo

139. Dimitriou I, Reckmann B, Nephuth O, et al. Single institution's experience in laparoscopic appendectomy as a suitable therapy for complicated appendicitis. Langenbecks Arch Surg. 2013 Jan;398(1):147-52. Resumo

140. Thomson JE, Kruger D, Jann-Kruger C, et al. Laparoscopic versus open surgery for complicated appendicitis: a randomized controlled trial to prove safety. Surg Endosc. 2015 Jul;29(7):2027-32. Resumo

141. Tuggle KR, Ortega G, Bolorunduro OB, et al. Laparoscopic versus open appendectomy in complicated appendicitis: a review of the NSQIP database. J Surg Res. 2010 Oct;163(2):225-8. Resumo

142. Athanasiou C, Lockwood S, Markides GA. Systematic review and meta-analysis of laparoscopic versus open appendicectomy in adults with complicated appendicitis: an update of the literature. World J Surg. 2017 Dec;41(12):3083-99. Resumo

143. Simillis C, Symeonides P, Shorthouse AJ, et al. A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon). Surgery. 2010 Jun;147(6):818-29. Resumo

144. Andersson RE, Petzold MG. Nonsurgical treatment of appendiceal abscess or phlegmon: a systematic review and meta-analysis. Ann Surg. 2007 Nov;246(5):741-8. Resumo

145. Horn CB, Coleoglou Centeno AA, Guerra JJ, et al. Drain failure in intra-abdominal abscesses associated with appendicitis. Surg Infect (Larchmt). 2018 Apr;19(3):321-5. Resumo

146. Gavriilidis P, de'Angelis N, Katsanos K, et al. Acute appendicectomy or conservative treatment for complicated appendicitis (phlegmon or abscess)? A systematic review by updated traditional and cumulative meta-analysis. J Clin Med Res. 2019 Jan;11(1):56-64. Resumo

147. Mentula P, Sammalkorpi H, Leppäniemi A. Laparoscopic surgery or conservative treatment for appendiceal abscess in adults? A randomized controlled trial. Ann Surg. 2015;262:237-42. Resumo

148. Mällinen J, Rautio T, Grönroos J, et al. Risk of appendiceal neoplasm in periappendicular abscess in patients treated with interval appendectomy vs follow-up with magnetic resonance imaging: 1-year outcomes of the Peri-Appendicitis Acuta randomized clinical trial. JAMA Surg. 2019 Mar 1;154(3):200-7.Texto completo  Resumo

149. Renteria O, Shahid Z, Huerta S. Outcomes of appendectomy in elderly veteran patients. Surgery. 2018 Sep;164(3):460-5. Resumo

150. Peltrini R, Cantoni V, Green R, et al. Risk of appendiceal neoplasm after interval appendectomy for complicated appendicitis: a systematic review and meta-analysis. Surgeon. 2021 Dec;19(6):e549-58. Resumo

151. Hayes D, Reiter S, Hagen E, et al. Is interval appendectomy really needed? A closer look at neoplasm rates in adult patients undergoing interval appendectomy after complicated appendicitis. Surg Endosc. 2021 Jul;35(7):3855-60. Resumo

152. Skendelas JP, Alemany VS, Au V, et al. Appendiceal adenocarcinoma found by surgery for acute appendicitis is associated with older age. BMC Surg. 2021 May 2;21(1):228.Texto completo  Resumo

153. Rushing A, Bugaev N, Jones C, et al. Management of acute appendicitis in adults: a practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2019 Jul;87(1):214-24.Texto completo  Resumo

154. Song CW, Kang JW, Kim JY. Different clinical features and lower scores in clinical scoring systems for appendicitis in preschool children: comparison with school age onset. Pediatr Gastroenterol Hepatol Nutr. 2018 Jan;21(1):51-8.Texto completo  Resumo

155. Stringer MD. Acute appendicitis. J Paediatr Child Health. 2017 Nov;53(11):1071-6. Resumo

156. Howell EC, Dubina ED, Lee SL. Perforation risk in pediatric appendicitis: assessment and management. Pediatric Health Med Ther. 2018 Oct 26;9:135-45.Texto completo  Resumo

157. Neogi S, Banerjee A, Panda SS, et al. Laparoscopic versus open appendicectomy for complicated appendicitis in children: a systematic review and meta-analysis. J Pediatr Surg. 2022 Mar;57(3):394-405. Resumo

158. Fugazzola P, Coccolini F, Tomasoni M, et al. Early appendectomy vs. conservative management in complicated acute appendicitis in children: a meta-analysis. J Pediatr Surg. 2019 Nov;54(11):2234-41. Resumo

159. Vaos G, Dimopoulou A, Gkioka E, et al. Immediate surgery or conservative treatment for complicated acute appendicitis in children? A meta-analysis. J Pediatr Surg. 2019 Jul;54(7):1365-71. Resumo

160. Wei HB, Huang JL, Zheng ZH, et al. Laparoscopic versus open appendectomy: a prospective randomized comparison. Surg Endosc. 2010 Feb;24(2):266-9. Resumo

161. Markar SR, Blackburn S, Cobb R, et al. Laparoscopic versus open appendectomy for complicated and uncomplicated appendicitis in children. J Gastrointest Surg. 2012 Oct;16(10):1993-2004. Resumo

162. Mason RJ. Surgery for appendicitis: is it necessary? Surg Infect (Larchmt). 2008 Aug;9(4):481-8. Resumo

163. Deakin DE, Ahmed I. Interval appendicectomy after resolution of adult inflammatory appendix mass - is it necessary? Surgeon. 2007;5:45-50. Resumo

164. Garba ES, Ahmed A. Management of appendiceal mass. Ann Afr Med. 2008 Dec;7(4):200-4. Resumo

165. Liberman MA, Greason KL, Frame S, et al. Single-dose cefotetan or cefoxitin versus multiple-dose cefoxitin as prophylaxis in patients undergoing appendectomy for acute nonperforated appendicitis. J Am Coll Surg. 1995 Jan;180(1):77-80. Resumo

166. Salazar MC, Canavan ME, Chilakamarry S, et al. Appendiceal cancer in the National Cancer Database: increasing frequency, decreasing age, and shifting histology. J Am Coll Surg. 2022 Jun 1;234(6):1082-9. Resumo

167. Casas MA, Dreifuss NH, Schlottmann F. High-volume center analysis and systematic review of stump appendicitis: solving the pending issue. Eur J Trauma Emerg Surg. 2022 Jun;48(3):1663-72. Resumo

168. Talan DA, Di Saverio S. Treatment of Acute Uncomplicated Appendicitis. N Engl J Med. 2021 Sep 16;385(12):1116-23. Resumo

Comorbidities Manager reference articles

169. Verbrugge FH, Grieten L, Mullens W. Management of the cardiorenal syndrome in decompensated heart failure. Cardiorenal Med. 2014 Dec;4(3-4):176-88Texto completo  Resumo

170. Davison SN. Clinical pharmacology considerations in pain management in patients with advanced kidney failure. Clin J Am Soc Nephrol. 2019 Jun 7;14(6):917-31Texto completo  Resumo

171. UK Kidney Association. Kidney Patient Safety Committee: safe prescribing of opiates in kidney disease. Nov 2020 [internet publication].Texto completo

172. National Institute for Health and Care Excellence. Acute kidney injury: prevention, detection and management. Oct 2024 [internet publication].Texto completo

173. McDonagh TA, Metra M, Adamo M, et al; ESC Scientific Document Group. 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021 Sep 21;42(36):3599-726Texto completo  Resumo

174. Global Initiative for Asthma. Global strategy for asthma management and prevention. 2024 [internet publication]Texto completo

175. Hogervorst VM, Buurman BM, De Jonghe A, et al. Emergency department management of older people living with frailty: a guide for emergency practitioners. Emerg Med J. 2021 Sep;38(9):724-9 Resumo

176. British Geriatric Society, Centre for Perioperative Care. Guideline for the care of people living with frailty undergoing elective and emergency surgery that encompasses the whole perioperative pathway. Sep 2021 [internet publication].Texto completo

177. NHS England. Toolkit for general practice in supporting older people living with frailty. March 2017 [internet publication]Texto completo

178. British Geriatrics Society (BGS), Getting It Right First Time (GIRFT). Six steps to better care for older people in acute hospitals. Jul 2023 [internet publication].Texto completo

179. Rockwood K; British Geriatrics Society. Silver book II: frailty. February 2021 [internet publication]Texto completo

180. Falk Erhag H, Guðnadóttir G, Alfredsson J, et al. The association between the clinical frailty scale and adverse health outcomes in older adults in acute clinical settings: a systematic review of the literature. Clin Interv Aging. 2023 Feb;18:249-61.Texto completo  Resumo

181. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2024 Apr;105(4s):S117-S314.Texto completo  Resumo

182. Conroy SP, Bardsley M, Smith P, et al. Comprehensive geriatric assessment for frail older people in acute hospitals: the HoW-CGA mixed-methods study. Health Services and Delivery Research. 2019 April:7(15)Texto completo

183. Quinn TJ, Mooijaart SP, Gallacher K, et al. Acute care assessment of older adults living with frailty. BMJ. 2019 Jan 31;364:l13 Resumo

184. Scottish Intercollegiate Guidelines Network. Risk reduction and management of delirium. Mar 2019 [internet publication].Texto completo

185. Nickel C, Arendts G, Lucke J, et al; British Geriatrics Society. Silver book II: geriatric syndromes. February 2021 [internet publication].Texto completo

186. National Institute for Health and Care Excellence. Fractures (non-complex): assessment and management. February 2016 [internet publication]Texto completo

187. National Institue for Health and Care Excellence. Palliative care for adults: strong opioids for pain relief. Aug 2016 [internet publication].Texto completo

188. Joint British Diabetes Societies for Inpatient Care. The management of diabetic ketoacidosis in adults. Mar 2023 [internet publication].Texto completo

189. Joint British Diabetes Societies for Inpatient Care. The management of the hyperosmolar hyperglycaemic state (HHS) in adults. Feb 2022 [internet publication].Texto completo

190. Chowdhury TA, Cheston H, Claydon A. Managing adults with diabetes in hospital during an acute illness. BMJ. 2017 Jun 22;357:j2551 Resumo

191. Joint British Diabetes Societies for Inpatient Care. Self-management of diabetes in hospital. Feb 2023 [internet publication].Texto completo

192. Joint British Diabetes Societies for Inpatient Care. Glycaemic management during enteral feeding for people with diabetes in hospital. Apr 2024 [internet publication].Texto completo

193. Joint British Diabetes Societies for Inpatient Care. The use of variable rate intravenous insulin infusion (VRIII) in medical inpatients. Oct 2014 [internet publication].Texto completo

194. Joint British Diabetes Societies for Inpatient Care. A good inpatient diabetes service. Jul 2019 [internet publication].Texto completo

195. Centre for Perioperative Care. Guideline for perioperative care for people with diabetes mellitus undergoing elective and emergency surgery. Oct 2023 [internet publication].Texto completo

196. Pasquel FJ, Lansang MC, Dhatariya K, et al. Management of diabetes and hyperglycaemia in the hospital. Lancet Diabetes Endocrinol. 2021 Mar;9(3):174-88Texto completo  Resumo

197. Medicines and Healthcare products Regulatory Agency. SGLT2 inhibitors: monitor ketones in blood during treatment interruption for surgical procedures or acute serious medical illness. March 2020 [internet publication]Texto completo

198. Peters AL, Buschur EO, Buse JB, et al. Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition. Diabetes Care. 2015 Jun 15;38(9):1687-93 Resumo

199. Umapathysivam MM, Gunton J, Stranks SN, et al. Euglycemic ketoacidosis in two patients without diabetes after introduction of sodium-glucose cotransporter 2 inhibitor for heart failure with reduced ejection fraction. Diabetes Care. 2024 Jan 1;47(1):140-3.Texto completo  Resumo

200. American Diabetes Association Professional Practice Committee. 16. Diabetes care in the hospital: standards of care in diabetes - 2024. Diabetes Care. 2024 Jan 1;47(suppl 1):S295-306.Texto completo  Resumo

201. Winstein CJ, Stein J, Arena R, et al. Guidelines for adult stroke rehabilitation and recovery: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016 May 4;47(6):e98-e169Texto completo  Resumo

202. Pendlebury ST, Klaus SP, Mather M, et al. Routine cognitive screening in older patients admitted to acute medicine: abbreviated mental test score (AMTS) and subjective memory complaint versus Montreal Cognitive Assessment and IQCODE. Age Ageing. 2015 Oct 13;44(6):1000-5Texto completo  Resumo

203. Hodkinson HM. Evaluation of a mental test score for assessment of mental impairment in the elderly. Age Ageing. 1972 Nov;1(4):233-8 Resumo

204. Emery A, Wells J, Klaus SP, et al. Underestimation of cognitive impairment in older inpatients by the Abbreviated Mental Test Score versus the Montreal Cognitive Assessment: cross-sectional observational study. Dement Geriatr Cogn Dis Extra. 2020 Sep-Dec;10(3):205-15.Texto completo  Resumo

205. Bellelli G, Morandi A, Davis DH, et al. Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people. Age Ageing. 2014 Mar 2;43(4):496-502.Texto completo  Resumo

206. National Institute for Health and Care Excellence. Delirium: prevention, diagnosis and management in hospital and long-term care. Jan 2023 [internet publication].Texto completo

207. Tieges Z, Maclullich AMJ, Anand A, et al. Diagnostic accuracy of the 4AT for delirium detection in older adults: systematic review and meta-analysis. Age Ageing. 2021 May 5;50(3):733-43.Texto completo  Resumo

208. Zhang XM, Jiao J, Xie XH, et al. The association between frailty and delirium among hospitalized patients: an updated meta-analysis. J Am Med Dir Assoc. 2021 Mar;22(3):527-34. Resumo

209. National Institute for Health and Care Excellence. Dementia: assessment, management and support for people living with dementia and their carers. Jun 2018 [internet publication].Texto completo

210. Fritz Z, Slowther AM, Perkins GD. Resuscitation policy should focus on the patient, not the decision. BMJ. 2017 Feb 28;356:j813Texto completo  Resumo

211. British Medical Association, the Resuscitation Council (UK) and the Royal College of Nursing. Decisions relating to cardiopulmonary resuscitation. 2016 [internet publication].Texto completo

212. The National Institute for Health and Care Excellence. Decision making and mental capacity. October 2018 [internet publication]Texto completo

213. Office of the Public Guardian. Mental Capacity Act: making decisions. Jun 2023 [internet publication]Texto completo

214. Social Care Institute for Excellence. Independent mental capacity advocate (IMCA). January 2010 [internet publication]Texto completo

215. Taylor DM, Barnes TRE, Young AH. The Maudsley prescribing guidelines in psychiatry. 14th edition. Chichester: Wiley-Blackwell; 2021

216. Roose SP, Rutherford BR. Selective serotonin reuptake inhibitors and operative bleeding risk: a review of the literature. J Clin Psychopharmacol. 2016 Dec;36(6):704-9 Resumo

217. White S, Griffiths R, Baxter M, et al. Guidelines for the peri-operative care of people with dementia: guidelines from the Association of Anaesthetists. Anaesthesia. 2019 Jan 11;74(3):357-72Texto completo  Resumo

218. Bishara D. Managing drugs with anticholinergic activity. Drug Ther Bull. 2023 Sep;61(9):135-9.Texto completo  Resumo

219. Lisibach A, Gallucci G, Benelli V, et al. Evaluation of the association of anticholinergic burden and delirium in older hospitalised patients: a cohort study comparing 19 anticholinergic burden scales. Br J Clin Pharmacol. 2022 Nov;88(11):4915-27.Texto completo  Resumo

220. Smith H, Fligelstone H. Reducing patient and planetary harms from high anticholinergic burden medication. BMJ. 2024 Jan 15;384:e075708.Texto completo  Resumo

221. UK Health Security Agency. Urinary tract infection: diagnostic tools for primary care. Jul 2025 [internet publication]Texto completo

222. Medicines and Healthcare products Regulatory Agency. Haloperidol (haldol): reminder of risks when used in elderly patients for the acute treatment of delirium. Dec 2021 [internet publication]Texto completo

223. Mühlbauer V, Möhler R, Dichter MN, et al. Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia. Cochrane Database Syst Rev. 2021 Dec 17;12(12):CD013304.Texto completo  Resumo

224. Yunusa I, Alsumali A, Garba AE, et al. Assessment of reported comparative effectiveness and safety of atypical antipsychotics in the treatment of behavioral and psychological symptoms of dementia: a network meta-analysis. JAMA Netw Open. 2019 Mar 1;2(3):e190828.Texto completo  Resumo

225. Van Leeuwen E, Petrovic M, van Driel ML, et al. Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia. Cochrane Database Syst Rev. 2018 Mar 30;3:CD007726.Texto completo  Resumo

226. National Institute for Health and Care Excellence. Type 1 diabetes in adults: diagnosis and management. Aug 2022 [internet publication].Texto completo

227. Rehman A, Setter SM, Vue MH. Drug-induced glucose alterations part 2: drug-Induced hyperglycemia. Diabetes Spect. 2011 Nov;24(4):234-8Texto completo

228. NHS Digital. National Diabetes Inpatient Audit (NaDIA) - 2019. Nov 2020 [internet publication]Texto completo

229. Joint British Diabetes Societies for Inpatient Care. The hospital management of hypoglycaemia in adults with diabetes mellitus. Jan 2023 [internet publication].Texto completo

230. Kerry C, Mitchell S, Sharma S, et al. Diurnal temporal patterns of hypoglycaemia in hospitalized people with diabetes may reveal potentially correctable factors. Diabet Med. 2013 Dec;30(12):1403-6 Resumo

231. Rajendran R, Kerry C, Rayman G, et al. Temporal patterns of hypoglycaemia and burden of sulfonylurea-related hypoglycaemia in UK hospitals: a retrospective multicentre audit of hospitalised patients with diabetes. BMJ Open. 2014 Jul 9;4(7):e005165Texto completo  Resumo

232. National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. October 2019 [internet publication]Texto completo

233. Rayman G, Vas PR, Baker N, et al. The Ipswich Touch Test: a simple and novel method to identify inpatients with diabetes at risk of foot ulceration. Diabetes Care. 2011 May 18;34(7):1517-8Texto completo  Resumo

234. British Thoracic Society; Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma: a national clinical guideline. Nov 2024 [internet publication]Texto completo

235. Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis. Chest. 2004 Jun;125(6):2309-21Texto completo  Resumo

236. Au DH, Curtis JR, Every NR, et al. Association between inhaled beta-agonists and the risk of unstable angina and myocardial infarction. Chest. 2002 Mar;121(3):846-51Texto completo  Resumo

237. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. 2025 [internet publication].Texto completo

238. Walters JA, Tan DJ, White CJ, et al. Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2018 Mar 19;3:CD006897Texto completo  Resumo

239. National Institute for Health and Care Excellence. Chronic obstructive pulmonary disease in over 16s: diagnosis and management. July 2019 [internet publication]Texto completo

240. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13 Resumo

241. Boden JM, Fergusson DM. Alcohol and depression. Addiction. 2011 May;106(5):906-14. Resumo

242. National Institute for Health and Care Excellence. Liaison psychiatry. In: Emergency acute medical care in over 16s: service delivery and organisation. March 2018 [internet publication]Texto completo

243. National Confidential Enquiry into Patient Outcome and Death (NCEPOD). Treat as one. Bridging the gap between mental and physical healthcare in general hospitals. 2017 [internet publication]Texto completo

244. DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000 Jul 24;160(14):2101-7 Resumo

245. Clarke DM, Currie KC. Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence. Med J Aust. 2009 Apr 6;190(S7):S54-60 Resumo

246. National Institute for Health and Care Excellence. Depression in adults with a chronic physical health problem: recognition and management. October 2009 [internet publication]Texto completo

247. Prina AM, Cosco TD, Dening T, et al. The association between depressive symptoms in the community, non-psychiatric hospital admission and hospital outcomes: a systematic review. J Psychosom Res. 2015 Jan;78(1):25-33Texto completo  Resumo

248. Archer G, Kuh D, Hotopf M, et al. Association between lifetime affective symptoms and premature mortality. JAMA Psychiatry. 2020 Aug 1;77(8):806-13Texto completo  Resumo

249. Machado MO, Veronese N, Sanches M, et al. The association of depression and all-cause and cause-specific mortality: an umbrella review of systematic reviews and meta-analyses. BMC Med. 2018 Jul 20;16(1):112Texto completo  Resumo

250. National Institute for Health and Care Excellence. Depression in adults: treatment and management. Jun 2022 [internet publication]Texto completo

251. Horowitz M, Taylor DM. The Maudsley deprescribing guidelines: antidepressants, benzodiazepines, gabapentinoids and Z-drugs. Chichester: Wiley-Blackwell; 2024.

252. Cleare A, Pariante CM, Young AH, et al. Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2008 British Association for Psychopharmacology guidelines. J Psychopharmacol. 2015 May 12;29(5):459-525Texto completo  Resumo

253. Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005 Mar 17;352(11):1112-20. Resumo

254. Buckley NA, Dawson AH, Isbister GK. Serotonin syndrome. BMJ. 2014 Feb 19;348:g1626 Resumo

255. Nochaiwong S, Ruengorn C, Awiphan R, et al. Use of serotonin reuptake inhibitor antidepressants and the risk of bleeding complications in patients on anticoagulant or antiplatelet agents: a systematic review and meta-analysis. Ann Med. 2022 Dec;54(1):80-97Texto completo  Resumo

256. Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther. 2008 Jan 1;27(1):31-40Texto completo  Resumo

257. Flowers L. Nicotine replacement therapy. Am J Psychiatry Resid. 2016 Jun;11(6)4-7Texto completo

258. Desai HD, Seabolt J, Jann MW. Smoking in patients receiving psychotropic medications: a pharmacokinetic perspective. CNS Drugs. 2001;15(6):469-94 Resumo

259. Oliveira P, Ribeiro J, Donato H, Madeira N. Smoking and antidepressants pharmacokinetics: a systematic review. Ann Gen Psychiatry. 2017;16:17Texto completo  Resumo

260. National Institute for Health and Care Excellence. Tobacco: preventing uptake, promoting quitting and treating dependence. Feb 2025 [internet publication].Texto completo

261. Theodoulou A, Chepkin SC, Ye W, et al. Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev. 2023 Jun 19;6(6):CD013308Texto completo  Resumo

262. Rigotti NA, Kruse GR, Livingstone-Banks J, et al. Treatment of tobacco smoking: a review. JAMA. 2022 Feb 8;327(6):566-77.Texto completo  Resumo

263. Agrawal S, Evison M, Ananth S, et al. Medical management of inpatients with tobacco dependency. Thorax. 2024 Mar 26;79(suppl 1):3-11.Texto completo  Resumo

264. Lindson N, Theodoulou A, Ordóñez-Mena JM, et al. Pharmacological and electronic cigarette interventions for smoking cessation in adults: component network meta-analyses. Cochrane Database Syst Rev. 2023 Sep 12;9(9):CD015226.Texto completo  Resumo

265. Thomas KH, Dalili MN, López-López JA, et al. Comparative clinical effectiveness and safety of tobacco cessation pharmacotherapies and electronic cigarettes: a systematic review and network meta-analysis of randomized controlled trials. Addiction. 2022 Apr;117(4):861-76.Texto completo  Resumo

266. Livingstone-Banks J, Fanshawe TR, Thomas KH, et al. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev. 2023 June 28;6(6):CD006103Texto completo

267. Streck JM, Rigotti NA, Livingstone-Banks J, et al. Interventions for smoking cessation in hospitalised patients. Cochrane Database Syst Rev. 2024 May 21;5(5):CD001837.Texto completo  Resumo

268. Livingstone-Banks J, Vidyasagaran AL, Croucher R, et al. Interventions for smokeless tobacco use cessation. Cochrane Database Syst Rev. 2025 Apr 15;4(4):CD015314.Texto completo  Resumo

269. Joint British Diabetes Societies for Inpatient Care. A good inpatient diabetes service. Jul 2019 [internet publication].Texto completo

270. Gracie TJ, Caufield-Noll C, Wang NY, et al. The association of preoperative frailty and postoperative delirium: a meta-analysis. Anesth Analg. 2021 Aug 1;133(2):314-23.Texto completo  Resumo

271. Liu CY, Gong N, Liu W. The association between preoperative frailty and postoperative delirium: a systematic review and meta-analysis. J Perianesth Nurs. 2022 Feb;37(1):53-62.e1. Resumo

272. Burton JK, Craig L, Yong SQ, et al. Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients. Cochrane Database Syst Rev. 2021 Nov 26;(11):CD013307.Texto completo  Resumo

273. Grau AJ, Urbanek C, Palm F. Common infections and the risk of stroke. Nat Rev Neurol. 2010 Nov 9;6(12):681-94 Resumo

274. Elkind MSV, Boehme AK, Smith CJ, et al. Infection as a stroke risk factor and determinant of outcome after stroke. Stroke. 2020 Oct;51(10):3156-68.Texto completo  Resumo

275. Eigenbrodt ML, Rose KM, Couper DJ, et al. Orthostatic hypotension as a risk factor for stroke: the atherosclerosis risk in communities (ARIC) study, 1987-1996. Stroke. 2000 Oct;31(10):2307-13 Resumo

276. Joint British Diabetes Societies for Inpatient Care. Inpatient care of the frail older adult with diabetes. Feb 2023 [internet publication].Texto completo

277. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001 Nov 8;345(19):1359-67Texto completo  Resumo

278. NICE-SUGAR Study Investigators, Finfer S, Chittock DR, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009 Mar 26;360(13):1283-97.Texto completo  Resumo

279. Marik PE, Preiser JC. Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest. 2010 Mar;137(3):544-51Texto completo  Resumo

280. TREND Diabetes. End of life guidance for diabetes care. November 2021 [internet publication]Texto completo

281. Freeman R, Wieling W, Axelrod FB, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011 Apr;21(2):69-72 Resumo

282. National Institute for Health and Care Excellence. Hypertension in adults. Nov 2023 [internet publication].Texto completo

283. Griffin M, Rao VS, Ivey-Miranda J, et al. Empagliflozin in heart failure: diuretic and cardiorenal effects. Circulation. 2020 Sep 15;142(11):1028-39.Texto completo  Resumo

284. National Institute for Health and Care Excellence. Intravenous fluid therapy in adults in hospital. Clinical guideline CG174. May 2017 [internet publication]Texto completo

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