Acute appendicitis

References

Key articles

Di Saverio S, Podda M, de Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020 Apr 15;15(1):27.Full text  Abstract

Gorter RR, Eker HH, Gorter-Stam MA, et al. Diagnosis and management of acute appendicitis: EAES consensus development conference 2015. Surg Endosc. 2016 Nov;30(11):4668-90.Full text  Abstract

Association of Surgeons of Great Britain and Ireland; Royal College of Surgeons of England. Commissioning guide: emergency general surgery (acute abdominal pain). April 2014 [internet publication].Full text

Reference articles

1. Fitz RH. Perforating inflammation of the vermiform appendix with special reference to its early diagnosis and treatment. Am J Med Sci. 1886;92:321-46.

2. Itskowitz MS, Jones SM. Appendicitis. Emerg Med. 2004;36:10-5.

3. Andersen B, Nielsen TF. Appendicitis in pregnancy: diagnosis, management and complications. Acta Obstet Gynecol Scand. 1999 Oct;78(9):758-62. Abstract

4. Di Saverio S, Podda M, de Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020 Apr 15;15(1):27.Full text  Abstract

5. Davenport M. Acute abdominal pain in children. BMJ. 1996 Feb 24;312(7029):498-501.Full text  Abstract

6. Benabbas R, Hanna M, Shah J, et al. Diagnostic accuracy of history, physical examination, laboratory tests, and point-of-care ultrasound for pediatric acute appendicitis in the emergency department: a systematic review and meta-analysis. Acad Emerg Med. 2017 May;24(5):523-51.Full text  Abstract

7. NHS Digital. Hospital admitted patient care activity 2019-20. September 2020 [internet publication].Full text

8. Owings MF, Kozak LJ. Ambulatory and inpatient procedures in the United States, 1996. Vital Health Stat 13. 1998;139:1-119.Full text  Abstract

9. O'Keefe SJ. The association between dietary fibre deficiency and high-income lifestyle-associated diseases: Burkitt's hypothesis revisited. Lancet Gastroenterol Hepatol. 2019 Dec;4(12):984-96.Full text  Abstract

10. Körner H, Söndenaa K, Söreide JA, et al. Incidence of nonperforated and perforated appendicitis: age-specific and sex-specific analysis. World J Surg. 1997 Mar-Apr;21(3):313-7. Abstract

11. Addiss DG, Shaffer N, Fowler BS, et al. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol. 1990 Nov;132(5):910-25. Abstract

12. Flum DR, Koepsell TD. The clinical and economic correlates of misdiagnosed appendicitis: nationwide analysis. Arch Surg. 2002 Jul;137(7):799-804.Full text  Abstract

13. Gorter RR, Eker HH, Gorter-Stam MA, et al. Diagnosis and management of acute appendicitis: EAES consensus development conference 2015. Surg Endosc. 2016 Nov;30(11):4668-90.Full text  Abstract

14. Di Sebastiano P, Fink T, di Mola FF, et al. Neuroimmune appendicitis. Lancet. 1999 Aug 7;354(9177):461-6. Abstract

15. Soffer D, Zait S, Klausner J, et al. Peritoneal cultures and antibiotic treatment in patients with perforated appendicitis. Eur J Surg. 2001 Mar;167(3):214-6. Abstract

16. Brunicardi FC, Andersen DK, Billiar TR, et al, eds. Schwartz's principles of surgery. 8th ed. New York, NY: McGraw-Hill; 2005.

17. Arnbjornsson E. Acute appendicitis and dietary fiber. Arch Surg. 1983 Jul;118(7):868-70. Abstract

18. Naaeder SB, Archampong EQ. Acute appendicitis and dietary fibre intake. West Afr J Med. 1998 Oct-Dec;17(4):264-7. Abstract

19. Barker DJ, Osmond C, Golding J, et al. Acute appendicitis and bathrooms in three samples of British children. Br Med J (Clin Res Ed). 1988 Apr 2;296(6627):956-8.Full text  Abstract

20. Huis in 't Veld JH. Gastrointestinal flora and health in man and animal [in Dutch]. Tijdschr Diergeneeskd. 1991 Mar 1;116(5):232-9. Abstract

21. Walker AR, Segal I. What causes appendicitis? J Clin Gastroenterol. 1990 Apr;12(2):127-9. Abstract

22. Montgomery SM, Pounder RE, Wakefield AJ. Smoking in adults and passive smoking in children are associated with acute appendicitis. Lancet. 1999 Jan 30;353(9150):379. Abstract

23. Howell JM, Eddy OL, Lukens TW, et al. Clinical policy: critical issues in the evaluation and management of emergency department patients with suspected appendicitis. Ann Emerg Med. 2010 Jan;55(1):71-116.Full text  Abstract

24. Snyder MJ, Guthrie M, Cagle S. Acute appendicitis: efficient diagnosis and management. Am Fam Physician. 2018 Jul 1;98(1):25-33.Full text  Abstract

25. Lewis SR, Mahony PJ, Simpson J. Appendicitis. BMJ. 2011 Oct 6;343:d5976. Abstract

26. National Institute for Health and Care Excellence. Sepsis: recognition, diagnosis and early management. September 2017 [internet publication].Full text

27. Association of Surgeons of Great Britain and Ireland; Royal College of Surgeons of England. Commissioning guide: emergency general surgery (acute abdominal pain). April 2014 [internet publication].Full text

28. Carstens AK, Fensby L, Penninga L. Nonoperative treatment of appendicitis during pregnancy in a remote area. AJP Rep. 2018 Jan;8(1):e37-8.Full text  Abstract

29. Humes DJ, Simpson J. Acute appendicitis. BMJ. 2006 Sep 9;333(7567):530-4.Full text  Abstract

30. Berry J, Malt RA. Appendicitis near its centenary. Ann Surg. 1984 Nov;200(5):567-75.Full text  Abstract

31. Bhangu A; RIFT Study Group on behalf of the West Midlands Research Collaborative. Evaluation of appendicitis risk prediction models in adults with suspected appendicitis. Br J Surg. 2020 Jan;107(1):73-86.Full text  Abstract

32. Lee SL, Walsh AJ, Ho HS. Computed tomography and ultrasonography do not improve and may delay the diagnosis and treatment of acute appendicitis. Arch Surg. 2001 May;136(5):556-62.Full text  Abstract

33. Makama JG, Kache SA, Ajah LJ, et al. Intestinal obstruction caused by appendicitis: a systematic review. J West Afr Coll Surg. 2017 Jul-Sep;7(3):94-115.Full text  Abstract

34. Ahmed KA, Hamdy AMF, Seifeldin MI, et al. Mechanical small bowel obstruction due to appendiceal tourniquet: a case report and review of literature. J Med Case Rep. 2019 Aug 8;13(1):208.Full text  Abstract

35. Brown JJ, Wilson C, Coleman S, Joypaul BV. Appendicitis in pregnancy: an ongoing diagnostic dilemma. Colorectal Dis. 2009 Feb;11(2):116-22. Abstract

36. Baird DLH, Simillis C, Kontovounisios C, et al. Acute appendicitis. BMJ. 2017 Apr 19;357:j1703. Abstract

37. Takada T, Nishiwaki H, Yamamoto Y, et al. The role of digital rectal examination for diagnosis of acute appendicitis: a systematic review and meta-analysis. PLoS One. 2015 Sep 2;10(9):e0136996.Full text  Abstract

38. Manterola C, Vial M, Moraga J, et al. Analgesia in patients with acute abdominal pain. Cochrane Database Syst Rev. 2011 Jan 19;(1):CD005660.Full text  Abstract

39. Green R, Bulloch B, Kabani A, et al. Early analgesia for children with acute abdominal pain. Pediatrics. 2005 Oct;116(4):978-83. Abstract

40. Chong CF, Adi MI, Thien A, et al. Development of the RIPASA score: a new appendicitis scoring system for the diagnosis of acute appendicitis. Singapore Med J. 2010 Mar;51(3):220-5.Full text  Abstract

41. de Castro SM, Ünlü C, Steller EP, et al. Evaluation of the appendicitis inflammatory response score for patients with acute appendicitis. World J Surg. 2012 Jul;36(7):1540-5.Full text  Abstract

42. Sammalkorpi HE, Mentula P, Savolainen H, et al. The introduction of Adult Appendicitis Score reduced negative appendectomy rate. Scand J Surg. 2017 Sep;106(3):196-201.Full text  Abstract

43. Tan WJ, Acharyya S, Goh YC, et al. Prospective comparison of the Alvarado score and CT scan in the evaluation of suspected appendicitis: a proposed algorithm to guide CT use. J Am Coll Surg. 2015 Feb;220(2):218-24.Full text  Abstract

44. Samuel M. Pediatric appendicitis score. J Pediatr Surg. 2002 Jun;37(6):877-81. Abstract

45. Kulik DM, Uleryk EM, Maguire JL. Does this child have appendicitis? A systematic review of clinical prediction rules for children with acute abdominal pain. J Clin Epidemiol. 2013 Jan;66(1):95-104.Full text  Abstract

46. Song CW, Kang JW, Kim JY. Different clinical features and lower scores in clinical scoring systems for appendicitis in preschool children: comparison with school age onset. Pediatr Gastroenterol Hepatol Nutr. 2018 Jan;21(1):51-8.Full text  Abstract

47. Chung PHY, Dai K, Yang Z, et al. Validity of Alvarado Score in predicting disease severity and postoperative complication in pediatric acute appendicitis. World J Pediatr Surg. 2019 Feb 12;2:e000003.Full text

48. Macco S, Vrouenraets BC, de Castro SM. Evaluation of scoring systems in predicting acute appendicitis in children. Surgery. 2016 Dec;160(6):1599-604. Abstract

49. Benito J, Fernandez S, Gendive M, et al. A new clinical score to identify children at low risk for appendicitis. Am J Emerg Med. 2020 Mar;38(3):554-61. Abstract

50. van Tol RR, Breukink SO, Lahaye MJ, et al. Inclusion of C-reactive protein and white blood cell count in diagnostic workup of patients with clinically suspected appendicitis stratifies for imaging. J Med Diagn Meth 2016;5:2.Full text

51. Andersson RE. Meta-analysis of the clinical and laboratory diagnosis of acute appendicitis. Br J Surg. 2004 Jan;91(1):28-37. Abstract

52. Bendeck SE, Nino-Murcia M, Berry GJ, et al. Imaging for suspected appendicitis: negative appendectomy and perforation rates. Radiology. 2002 Oct;225(1):131-6.Full text  Abstract

53. Bachur RG, Callahan MJ, Monuteaux MC, et al. Integration of ultrasound findings and a clinical score in the diagnostic evaluation of pediatric appendicitis. J Pediatr. 2015 May;166(5):1134-9. Abstract

54. Dahabreh IJ, Adam GP, Halladay CW, et al. Diagnosis of right lower quadrant pain and suspected acute appendicitis. In: Agency for Healthcare Research and Quality (US). AHRQ Comparative effectiveness reviews report no. 15(16)-EHC025-EF. 2015. Rockville, MD: Agency for Healthcare Research and Quality (US).Full text  Abstract

55. Puylaert JB. Imaging and intervention in patients with acute right lower quadrant disease. Baillieres Clin Baillieres Clin Gastroenterol. 1995 Mar;9(1):37-51. Abstract

56. Basaran A, Basaran M. Diagnosis of acute appendicitis during pregnancy: a systematic review. Obstet Gynecol Surv. 2009 Jul;64(7):481-8. Abstract

57. Choi D, Park H, Lee YR, et al. The most useful finding for the diagnosing acute appendicitis on contrast-enhanced helical CT. Acta Radiol. 2003 Nov;44(6):574-82. Abstract

58. Terasawa T, Blackmore CC, Bent S, et al. Systematic review: computed tomography and ultrasonography to detect acute appendicitis in adults and adolescents. Ann Intern Med. 2004 Oct 5;141(7):537-46. Abstract

59. Rud B, Vejborg TS, Rappeport ED, et al. Computed tomography for diagnosis of acute appendicitis in adults. Cochrane Database Syst Rev. 2019 Nov 19;2019(11):CD009977.Full text  Abstract

60. Hlibczuk V, Dattaro JA, Jin Z, et al. Diagnostic accuracy of noncontrast computed tomography for appendicitis in adults: a systematic review. Ann Emerg Med. 2010 Jan;55(1):51-9. Abstract

61. Wei B, Qi CL, Chen TF, et al. Laparoscopic versus open appendectomy for acute appendicitis: a metaanalysis. Surg Endosc. 2011 Apr;25(4):1199-208. Abstract

62. Anderson BA, Salem L, Flum DR. A systematic review of whether oral contrast is necessary for the computed tomography diagnosis of appendicitis in adults. Am J Surg. 2005 Sep;190(3):474-8. Abstract

63. Yamamoto M, Ando T, Kanai S, et al. Abnormal urinalysis in acute appendicitis. Hinyokika Kiyo. 1985 Oct;31(10):1723-5.Full text  Abstract

64. Gray J, Wardrope J, Fothergill DJ. 7 Abdominal pain, abdominal pain in women, complications of pregnancy and labour. Emerg Med J. 2004 Sep;21(5):606-13.Full text  Abstract

65. Sabiston D. The biliary system. In: Sabiston D, Lyerly HK, eds. Textbook of surgery: the biological basis of modern surgical practice. 15th ed. Philadelphia, PA: W.B. Saunders Company; 1997:1127.

66. Vincelette J, Schirm J, Bogard M, et al. Multicenter evaluation of the fully automated COBAS AMPLICATOR PCR test for detection of Chlamydia trachomatis in urogenital specimens. J Clin Microbiol. 1999 Jan;37(1):74-80.Full text  Abstract

67. Lobo DN, Awad S. Should chloride-rich crystalloids remain the mainstay of fluid resuscitation to prevent 'pre-renal' acute kidney injury? Kidney Int. 2014 Dec;86(6):1096-105.Full text  Abstract

68. National Institute for Health and Care Excellence. Intravenous fluid therapy in adults in hospital. May 2017 [internet publication].Full text

69. NHS England. Sepsis guidance implementation advice for adults. September 2017 [internet publication].Full text

70. Royal College of Physicians. National early warning score (NEWS) 2: standardising the assessment of acute-illness severity in the NHS. December 2017 [internet publication].Full text

71. Nutbeam T, Daniels R; The UK Sepsis Trust. Professional resources: clinical [internet publication].Full text

72. Bion J, Barton G, Boyle A, et al. Academy of Medical Royal Colleges statement on the initial antimicrobial treatment ofsepsis. Academy of Medical Royal Colleges. May 2022 [internet publication].Full text

73. Andersen BR, Kallehave FL, Andersen HK. Antibiotics versus placebo for prevention of postoperative infection after appendicectomy. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD001439.Full text  Abstract

74. Weston P, Moroz P. Appendicitis in pregnancy: how to manage and whether to deliver. Obstet Gynecol. 2015 Apr;17(2):105-10.Full text

75. United Kingdom National Surgical Research Collaborative; Bhangu A. Safety of short, in-hospital delays before surgery for acute appendicitis: multicentre cohort study, systematic review, and meta-analysis. Ann Surg. 2014 May;259(5):894-903. Abstract

76. Salminen P, Paajanen H, Rautio T, et al. Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial. JAMA. 2015 Jun 16;313(23):2340-8. Abstract

77. Bhangu A, Søreide K, Di Saverio S, et al. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet. 2015 Sep 26;386(10000):1278-87. Abstract

78. Flum DR. Clinical practice: a cute appendicitis – appendectomy or the "antibiotics first" strategy. N Engl J Med. 2015 May 14;372(20):1937-43. Abstract

79. Mahida JB, Lodwick DL, Nacion KM, et al. High failure rate of nonoperative management of acute appendicitis with an appendicolith in children. J Pediatr Surg. 2016 Jun;51(6):908-11. Abstract

80. Ventham NT, Dungworth JC, Benzoni C. Transition towards laparoscopic appendicectomy at a UK center over a 7-year period. Surg Laparosc Endosc Percutan Tech. 2015 Feb;25(1):59-63. Abstract

81. Markar SR, Penna M, Harris A. Laparoscopic approach to appendectomy reduces the incidence of short- and long-term post-operative bowel obstruction: systematic review and pooled analysis. J Gastrointest Surg. 2014 Sep;18(9):1683-92. Abstract

82. Webster J, Osborne S, Rickard CM, et al. Clinically-indicated replacement versus routine replacement of peripheral venous catheters. Cochrane Database Syst Rev. 2019 Jan 23;(1):CD007798.Full text  Abstract

83. Kasatpibal N, Nørgaard M, Sørensen HT, et al. Risk of surgical site infection and efficacy of antibiotic prophylaxis: a cohort study of appendectomy patients in Thailand. BMC Infect Dis. 2006 Jul 12;6:111.Full text  Abstract

84. Daskalakis K, Juhlin C, Påhlman L. The use of pre- or postoperative antibiotics in surgery for appendicitis: a systematic review. Scand J Surg. 2014 Mar;103(1):14-20.Full text  Abstract

85. Mui LM, Ng CS, Wong SK, et al. Optimum duration of prophylactic antibiotics in acute non-perforated appendicitis. ANZ J Surg. 2005 Jun;75(6):425-8. Abstract

86. Pinto DJ, Sanderson PJ. Rational use of antibiotic therapy after appendicectomy. Br Med J. 1980 Feb 2;280(6210):275-7.Full text  Abstract

87. Ambrose NS, Donovan IA, Wise R, et al. Metronidazole and ticarcillin in the prevention of sepsis after appendicectomy. Am J Surg. 1983 Sep;146(3):346-8. Abstract

88. Coakley BA, Sussman ES, Wolfson TS, et al. Postoperative antibiotics correlate with worse outcomes after appendectomy for nonperforated appendicitis. J Am Coll Surg. 2011 Dec;213(6):778-83. Abstract

89. van Rossem CC, Schreinemacher MH, Treskes K, et al. Duration of antibiotic treatment after appendicectomy for acute complicated appendicitis. Br J Surg. 2014 May;101(6):715-9. Abstract

90. Liu Z, Zhang P, Ma Y, et al. Laparoscopy or not: a meta-analysis of the surgical effects of laparoscopic versus open appendicectomy. Surg Laparosc Endosc Percutan Tech. 2010 Dec;20(6):362-70. Abstract

91. Jaschinski T, Mosch CG, Eikermann M, et al. Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev. 2018 Nov 28;(11):CD001546.Full text  Abstract

92. Kraemer M, Ohmann C, Leppert R, et al. Macroscopic assessment of the appendix at diagnostic laparoscopy is reliable. Surg Endosc. 2000 Jul;14(7):625-33. Abstract

93. van den Broek WT, Bijnen AB, de Ruiter P, et al. A normal appendix found during diagnostic laparoscopy should not be removed. Br J Surg. 2001 Feb;88(2):251-4. Abstract

94. Jaschinski T, Mosch C, Eikermann M, et al. Laparoscopic versus open appendectomy in patients with suspected appendicitis: a systematic review of meta-analyses of randomised controlled trials. BMC Gastroenterol. 2015 Apr 15;15:48.Full text  Abstract

95. Lee SH, Lee JY, Choi YY, et al. Laparoscopic appendectomy versus open appendectomy for suspected appendicitis during pregnancy: a systematic review and updated meta-analysis. BMC Surg. 2019 Apr 25;19(1):41.Full text  Abstract

96. Wang YC, Yang HR, Chung PK, et al. Laparoscopic appendectomy in the elderly. Surg Endosc. 2006 Jun;20(6):887-9. Abstract

97. Kim MJ, Fleming FJ, Gunzler DD, et al. Laparoscopic appendectomy is safe and efficacious for the elderly: an analysis using the National Surgical Quality Improvement Project database. Surg Endosc. 2011 Jun;25(6):1802-7. Abstract

98. Yeh CC, Wu SC, Liao CC, et al. Laparoscopic appendectomy for acute appendicitis is more favorable for patients with comorbidities, the elderly, and those with complicated appendicitis: a nationwide population-based study. Surg Endosc. 2011 Sep;25(9):2932-42. Abstract

99. Masoomi H, Mills S, Dolich MO, et al. Does laparoscopic appendectomy impart an advantage over open appendectomy in elderly patients? World J Surg. 2012 Jul;36(7):1534-9. Abstract

100. Southgate E, Vousden N, Karthikesalingam A, et al. Laparoscopic vs open appendectomy in older patients. Arch Surg. 2012 Jun;147(6):557-62.Full text  Abstract

101. Busch M, Gutzwiller FS, Aellig S, et al. In-hospital delay increases the risk of perforation in adults with appendicitis. World J Surg. 2011 Jul;35(7):1626-33. Abstract

102. Teo AT, Lefter LP, Zarrouk AJ, et al. Institutional review of patients presenting with suspected appendicitis. ANZ J Surg. 2015 Jun;85(6):420-4. Abstract

103. Stahlfeld K, Hower J, Homitsky S, et al. Is acute appendicitis a surgical emergency? Am Surg. 2007 Jun;73(6):626-9. Abstract

104. Livingston EH, Woodward WA, Sarosi GA, et al. Disconnect between incidence of nonperforated and perforated appendicitis: implications for pathophysiology and management. Ann Surg. 2007 Jun;245(6):886-92.Full text  Abstract

105. CODA Collaborative; Flum DR, Davidson GH, Monsell SE, et al. A randomized trial comparing antibiotics with appendectomy for appendicitis. N Engl J Med. 2020 Nov 12;383(20):1907-19.Full text  Abstract

106. Supreme Court (UK). Judgment: Montgomery (appellant) v Lanarkshire Health Board (respondent) (Scotland). March 2015 [internet publication].Full text

107. Andersson RE. The natural history and traditional management of appendicitis revisited: spontaneous resolution and predominance of prehospital perforations imply that a correct diagnosis is more important than an early diagnosis. World J Surg. 2007 Jan;31(1):86-92. Abstract

108. Go DY, Boo YJ, Lee JS, et al. Transumbilical laparoscopic-assisted appendectomy is a useful surgical option for pediatric uncomplicated appendicitis: a comparison with conventional 3-port laparoscopic appendectomy. Ann Surg Treat Res. 2016 Aug;91(2):80-4.Full text  Abstract

109. Andersson RE, Hugander A, Ravn H, et al. Repeated clinical and laboratory examinations in patients with an equivocal diagnosis of appendicitis. World J Surg. 2000 Apr;24(4):479-85. Abstract

110. Salminen P, Tuominen R, Paajanen H, et al. Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial. JAMA. 2018 Sep 25;320(12):1259-65.Full text  Abstract

111. Zhang S, Du T, Jiang X, et al. Laparoscopic appendectomy in children with perforated appendicitis: a meta-analysis. Surg Laparosc Endosc Percutan Tech. 2017 Aug;27(4):262-6. Abstract

112. Yu MC, Feng YJ, Wang W, et al. Is laparoscopic appendectomy feasible for complicated appendicitis? A systematic review and meta-analysis. Int J Surg. 2017 Apr;40:187-97.Full text  Abstract

113. Low ZX, Bonney GK, So JBY, et al. Laparoscopic versus open appendectomy in pediatric patients with complicated appendicitis: a meta-analysis. Surg Endosc. 2019 Dec;33(12):4066-77. Abstract

114. Temple CL, Shirley AH, Temple WJ. The natural history of appendicitis in adults: a prospective study. Ann Surg. 1995 Mar;221(3):278-81.Full text  Abstract

115. Franz MG, Norman J, Fabri PJ. Increased morbidity of appendicitis with advancing age. Am Surg. 1995 Jan;61(1):40-4. Abstract

116. Teixeira PG, Sivrikoz E, Inaba K, et al. Appendectomy timing: waiting until the next morning increases the risk of surgical site infections. Ann Surg. 2012 Sep;256(3):538-43. Abstract

117. Dimitriou I, Reckmann B, Nephuth O, et al. Single institution's experience in laparoscopic appendectomy as a suitable therapy for complicated appendicitis. Langenbecks Arch Surg. 2013 Jan;398(1):147-52. Abstract

118. Thomson JE, Kruger D, Jann-Kruger C, et al. Laparoscopic versus open surgery for complicated appendicitis: a randomized controlled trial to prove safety. Surg Endosc. 2015 Jul;29(7):2027-32. Abstract

119. Tuggle KR, Ortega G, Bolorunduro OB, et al. Laparoscopic versus open appendectomy in complicated appendicitis: a review of the NSQIP database. J Surg Res. 2010 Oct;163(2):225-8. Abstract

120. Athanasiou C, Lockwood S, Markides GA. Systematic review and meta-analysis of laparoscopic versus open appendicectomy in adults with complicated appendicitis: an update of the literature. World J Surg. 2017 Dec;41(12):3083-99. Abstract

121. Simillis C, Symeonides P, Shorthouse AJ, et al. A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon). Surgery. 2010 Jun;147(6):818-29. Abstract

122. Andersson RE, Petzold MG. Nonsurgical treatment of appendiceal abscess or phlegmon: a systematic review and meta-analysis. Ann Surg. 2007 Nov;246(5):741-8. Abstract

123. Horn CB, Coleoglou Centeno AA, Guerra JJ, et al. Drain failure in intra-abdominal abscesses associated with appendicitis. Surg Infect (Larchmt). 2018 Apr;19(3):321-5. Abstract

124. Gavriilidis P, de'Angelis N, Katsanos K, et al. Acute appendicectomy or conservative treatment for complicated appendicitis (phlegmon or abscess)? A systematic review by updated traditional and cumulative meta-analysis. J Clin Med Res. 2019 Jan;11(1):56-64. Abstract

125. Mentula P, Sammalkorpi H, Leppäniemi A. Laparoscopic surgery or conservative treatment for appendiceal abscess in adults? A randomized controlled trial. Ann Surg. 2015;262:237-42. Abstract

126. Mällinen J, Rautio T, Grönroos J, et al. Risk of appendiceal neoplasm in periappendicular abscess in patients treated with interval appendectomy vs follow-up with magnetic resonance imaging: 1-year outcomes of the Peri-Appendicitis Acuta randomized clinical trial. JAMA Surg. 2019 Mar 1;154(3):200-7.Full text  Abstract

127. Renteria O, Shahid Z, Huerta S. Outcomes of appendectomy in elderly veteran patients. Surgery. 2018 Sep;164(3):460-5.Full text  Abstract

128. Rushing A, Bugaev N, Jones C, et al. Management of acute appendicitis in adults: a practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2019 Jul;87(1):214-24. Abstract

129. Song CW, Kang JW, Kim JY. Different clinical features and lower scores in clinical scoring systems for appendicitis in preschool children: comparison with school age onset. Pediatr Gastroenterol Hepatol Nutr. 2018 Jan;21(1):51-8.Full text  Abstract

130. Stringer MD. Acute appendicitis. J Paediatr Child Health. 2017 Nov;53(11):1071-6. Abstract

131. Howell EC, Dubina ED, Lee SL. Perforation risk in pediatric appendicitis: assessment and management. Pediatric Health Med Ther. 2018 Oct 26;9:135-45.Full text  Abstract

132. Fugazzola P, Coccolini F, Tomasoni M, et al. Early appendectomy vs. conservative management in complicated acute appendicitis in children: a meta-analysis. J Pediatr Surg. 2019 Nov;54(11):2234-41. Abstract

133. Vaos G, Dimopoulou A, Gkioka E, et al. Immediate surgery or conservative treatment for complicated acute appendicitis in children? A meta-analysis. J Pediatr Surg. 2019 Jul;54(7):1365-71. Abstract

134. Verbrugge FH, Grieten L, Mullens W. Management of the cardiorenal syndrome in decompensated heart failure. Cardiorenal Med. 2014 Dec;4(3-4):176-88Full text  Abstract

135. National Institute for Health and Care Excellence. Acute kidney injury: prevention, detection and management. December 2019 [internet publication]Full text

136. Hsu CY, Ordoñez JD, Chertow GM, et al. The risk of acute renal failure in patients with chronic kidney disease. Kidney Int. 2008 Apr 2;74(1):101-7Full text  Abstract

137. Davison SN. Clinical pharmacology considerations in pain management in patients with advanced kidney failure. Clin J Am Soc Nephrol. 2019 Jun 7;14(6):917-31Full text  Abstract

138. Global Initiative for Asthma. Global strategy for asthma management and prevention. 2022 [internet publication]Full text

139. Pendlebury ST, Klaus SP, Mather M, et al. Routine cognitive screening in older patients admitted to acute medicine: abbreviated mental test score (AMTS) and subjective memory complaint versus Montreal Cognitive Assessment and IQCODE. Age Ageing. 2015 Oct 13;44(6):1000-5Full text  Abstract

140. Hodkinson HM. Evaluation of a mental test score for assessment of mental impairment in the elderly. Age Ageing. 1972 Nov;1(4):233-8 Abstract

141. National Institute for Health and Care Excellence. Delirium: diagnosis, prevention and management. March 2019 [internet publication]Full text

142. National Institute for Health and Care Excellence. Dementia: assessment, management and support for people living with dementia and their carers. June 2018 [internet publication]Full text

143. Scottish Intercollegiate Guidelines Network. Risk reduction and management of delirium. March 2019 [internet publication]Full text

144. Nova Scotia Health Authority. This is not my Mom. 2012 [internet publication]Full text

145. Inouye SK, Schlesinger MJ, Lydon TJ. Delirium: a symptom of how hospital care is failing older persons and a window to improve quality of hospital care. Am J Med. 1999 May;106(5):565-73 Abstract

146. Bellelli G, Morandi A, Davis DH, et al. Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people. Age Ageing. 2014 Mar 2;43(4):496-502Full text  Abstract

147. MacLullich AM, Shenkin SD, Goodacre S, et al. The 4 'A's test for detecting delirium in acute medical patients: a diagnostic accuracy study. Health Technol Assess. 2019 Aug;23(40):1-194Full text  Abstract

148. White S, Griffiths R, Baxter M, et al. Guidelines for the peri-operative care of people with dementia: guidelines from the Association of Anaesthetists. Anaesthesia. 2019 Jan 11;74(3):357-72Full text  Abstract

149. Siddiqi N, Harrison JK, Clegg A, et al. Interventions for preventing delirium in hospitalised non-ICU patients. Cochrane Database Syst Rev. 2016 Mar 11;3:CD005563Full text  Abstract

150. Martinez F, Tobar C, Hill N. Preventing delirium: should non-pharmacological, multicomponent interventions be used? A systematic review and meta-analysis of the literature. Age Ageing. 2014 Nov 25;44(2):196-204Full text  Abstract

151. Public Health England. Urinary tract infection: diagnostic tools for primary care. October 2020 [internet publication]Full text

152. Medicines and Healthcare products Regulatory Agency. Haloperidol (haldol): reminder of risks when used in elderly patients for the acute treatment of delirium. 2021 [internet publication]Full text

153. Ma H, Huang Y, Cong Z, et al. The efficacy and safety of atypical antipsychotics for the treatment of dementia: a meta-analysis of randomized placebo-controlled trials. J Alzheimers Dis. 2014;42(3):915-37 Abstract

154. Huybrechts KF, Gerhard T, Crystal S, et al. Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study. BMJ. 2012 Feb 23;344:e977Full text  Abstract

155. Van Leeuwen E, Petrovic M, van Driel ML, et al. Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia. Cochrane Database Syst Rev. 2018 Mar 30;3:CD007726Full text  Abstract

156. Grau AJ, Urbanek C, Palm F. Common infections and the risk of stroke. Nat Rev Neurol. 2010 Nov 9;6(12):681-94 Abstract

157. Eigenbrodt ML, Rose KM, Couper DJ, et al. Orthostatic hypotension as a risk factor for stroke: the atherosclerosis risk in communities (ARIC) study, 1987-1996. Stroke. 2000 Oct;31(10):2307-13Full text  Abstract

158. Winstein CJ, Stein J, Arena R, et al. Guidelines for adult stroke rehabilitation and recovery: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016 May 4;47(6):e98-e169Full text  Abstract

159. Fritz Z, Slowther AM, Perkins GD. Resuscitation policy should focus on the patient, not the decision. BMJ. 2017 Feb 28;356:j813Full text  Abstract

160. The National Institute for Health and Care Excellence. Decision making and mental capacity. October 2018 [internet publication]Full text

161. Department of Health. Mental Capacity Act 2005 [internet publication]Full text

162. Social Care Institute for Excellence. Independent mental capacity advocate (IMCA). 2011 [internet publication]Full text

163. Cleare A, Pariante CM, Young AH, et al. Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines. J Psychopharmacol. 2015 May 12;29(5):459-525Full text  Abstract

164. National Institute for Health and Care Excellence. Depression in adults with a chronic physical health problem: recognition and management. October 2009 [internet publication]Full text

165. Taylor DM, Barnes TRE, Young AH. The Maudsley prescribing guidelines in psychiatry. 14th edition. Chichester: Wiley-Blackwell; 2021

166. Flowers L. Nicotine replacement therapy. Am J Psychiatry Resid. 2016 Jun;11(6)4-7Full text

167. Desai HD, Seabolt J, Jann MW. Smoking in patients receiving psychotropic medications: a pharmacokinetic perspective. CNS Drugs. 2001;15(6):469-94

168. Oliveira P, Ribeiro J, Donato H, Madeira N. Smoking and antidepressants pharmacokinetics: a systematic review. Ann Gen Psychiatry. 2017;16:17Full text  Abstract

169. National Centre for Smoking Cessation and Training. Smoking cessation and mental health. 2014 [internet publication]Full text

170. Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005 Mar 17;352(11):1112-20 Abstract

171. Auerbach AD, Vittinghoff E, Maselli J, et al. Perioperative use of selective serotonin reuptake inhibitors and risks for adverse outcomes of surgery. JAMA Intern Med. 2013 Jun 24;173(12):1075-81Full text  Abstract

172. Chowdhury TA, Cheston H, Claydon A. Managing adults with diabetes in hospital during an acute illness. BMJ. 2017 Jun 22;357:j2551 Abstract

173. Joint British Diabetes Societies for inpatient care. Self-management of diabetes in hospital. August 2021 [internet publication]Full text

174. Joint British Diabetes Societies for inpatient care. Glycaemic management during the inpatient enteral feeding of stroke patients with diabetes. November 2019 [internet publication]Full text

175. Joint British Diabetes Societies for inpatient care. The use of variable rate intravenous insulin infusion (VRIII) in medical inpatients. October 2014 [internet publication]Full text

176. Joint British Diabetes Societies for inpatient care. A good inpatient diabetes service. July 2019 [internet publication]Full text

177. Centre for Perioperative Care. Guideline for perioperative care for people with diabetes mellitus undergoing elective and emergency surgery. March 2021 [internet publication]Full text

178. Pasquel FJ, Lansang MC, Dhatariya K, et al. Management of diabetes and hyperglycaemia in the hospital. Lancet Diabetes Endocrinol. 2021 Mar;9(3):174-88Full text  Abstract

179. Medicines and Healthcare products Regulatory Agency. SGLT2 inhibitors: monitor ketones in blood during treatment interruption for surgical procedures or acute serious medical illness. March 2020 [internet publication]Full text

180. Peters AL, Buschur EO, Buse JB, et al. Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition. Diabetes Care. 2015 Jun 15;38(9):1687-93 Abstract

181. Joint British Diabetes Societies for inpatient care. The management of diabetic ketoacidosis in adults. June 2021 [internet publication]Full text

182. Joint British Diabetes Societies for inpatient care. The management of the hyperosmolar hyperglycaemic state (HHS) in adults. February 2022 [internet publication]Full text

183. American Diabetes Association. 16. Diabetes care in the hospital: standards of medical care in diabetes - 2022. Diabetes Care. 2022 Jan 1;45(suppl 1):S244-S253.Full text  Abstract

184. Joint British Diabetes Societies for inpatient care. A good inpatient diabetes service. July 2019 [internet publication]Full text

185. National Institute for Health and Care Excellence. Type 1 diabetes in adults: diagnosis and management. March 2022 [internet publication]Full text

186. Joint British Diabetes Societies for inpatient care. Inpatient care of the frail older adult with diabetes. 2019 [internet publication]Full text

187. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001 Nov 8;345(19):1359-67Full text  Abstract

188. NICE-SUGAR Study Investigators; Finfer S, Chittock DR, Su SY, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009 Mar 26;360(13):1283-97.Full text  Abstract

189. Marik PE, Preiser JC. Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest. 2010 Mar;137(3):544-51Full text  Abstract

190. Rehman A, Setter SM, Vue MH. Drug-induced glucose alterations part 2: drug-Induced hyperglycemia. Diabetes Spect. 2011 Nov;24(4):234-8Full text

191. NHS Digital. National Diabetes Inpatient Audit (NaDIA) - 2019. Nov 2020 [internet publication]Full text

192. Joint British Diabetes Societies for inpatient care. The hospital management of hypoglycaemia in adults with diabetes mellitus. March 2022 [internet publication]Full text

193. TREND Diabetes. End of life guidance for diabetes care. November 2021 [internet publication]Full text

194. British Thoracic Society; Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma: a national clinical guideline. July 2019 [internet publication].Full text

195. Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis. Chest. 2004 Jun;125(6):2309-21Full text  Abstract

196. Au DH, Curtis JR, Every NR, et al. Association between inhaled beta-agonists and the risk of unstable angina and myocardial infarction. Chest. 2002 Mar;121(3):846-51Full text  Abstract

197. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. 2020 [internet publication]Full text

198. Walters JA, Tan DJ, White CJ, et al. Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2018 Mar 19;3:CD006897Full text  Abstract

199. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13 Abstract

200. Boden JM, Fergusson DM. Alcohol and depression. Addiction. 2011 Mar 7;106(5):906-14Full text  Abstract

201. National Institute for Health and Care Excellence. Liaison psychiatry. In: Emergency acute medical care in over 16s: service delivery and organisation. March 2018 [internet publication]Full text

202. National Confidential Enquiry into Patient Outcome and Death (NCEPOD). Treat as one. Bridging the gap between mental and physical healthcare in general hospitals. 2017 [internet publication]Full text

203. DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000 Jul 24;160(14):2101-7 Abstract

204. Clarke DM, Currie KC. Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence. Med J Aust. 2009 Apr 6;190(7 suppl):S54-60 Abstract

205. Prina AM, Cosco TD, Dening T, et al. The association between depressive symptoms in the community, non-psychiatric hospital admission and hospital outcomes: a systematic review. J Psychosom Res. 2014 Nov 8;78(1):25-33Full text  Abstract

206. World Health Organization. Excess mortality in persons with severe mental disorders. 2016 [internet publication]Full text

207. National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. October 2019 [internet publication]Full text

208. Rayman G, Vas PR, Baker N, et al. The Ipswich Touch Test: a simple and novel method to identify inpatients with diabetes at risk of foot ulceration. Diabetes Care. 2011 May 18;34(7):1517-8Full text  Abstract

209. National Institute for Health and Care Excellence. Tobacco: preventing uptake, promoting quitting and treating dependence. Nov 2021 [internet publication]Full text

210. Freeman R, Wieling W, Axelrod FB, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011 Apr;21(2):69-72 Abstract

211. National Institute for Health and Care Excellence. Intravenous fluid therapy in adults in hospital. Clinical guideline CG174. May 2017 [internet publication]Full text

212. Wei HB, Huang JL, Zheng ZH, et al. Laparoscopic versus open appendectomy: a prospective randomized comparison. Surg Endosc. 2010 Feb;24(2):266-9. Abstract

213. Markar SR, Blackburn S, Cobb R, et al. Laparoscopic versus open appendectomy for complicated and uncomplicated appendicitis in children. J Gastrointest Surg. 2012 Oct;16(10):1993-2004. Abstract

214. Mason RJ. Surgery for appendicitis: is it necessary? Surg Infect (Larchmt). 2008 Aug;9(4):481-8. Abstract

215. Deakin DE, Ahmed I. Interval appendicectomy after resolution of adult inflammatory appendix mass - is it necessary? Surgeon. 2007;5:45-50. Abstract

216. Garba ES, Ahmed A. Management of appendiceal mass. Ann Afr Med. 2008 Dec;7(4):200-4.Full text  Abstract

217. Liberman MA, Greason KL, Frame S, et al. Single-dose cefotetan or cefoxitin versus multiple-dose cefoxitin as prophylaxis in patients undergoing appendectomy for acute nonperforated appendicitis. J Am Coll Surg. 1995 Jan;180(1):77-80. Abstract

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