Resumo
Definição
História e exame físico
Principais fatores diagnósticos
- diarrhoea
- flushing
Outros fatores diagnósticos
- palpitations
- abdominal cramps
- telangiectasia
- signs of right heart failure
- cardiac murmurs
- hepatomegaly
- wheeze
- pellagra
- abdominal masses
Fatores de risco
- genetic multiple endocrine neoplasia type 1 (MEN-1) syndrome
Investigações diagnósticas
Primeiras investigações a serem solicitadas
- serum chromogranin A/B
- urinary 5-hydroxyindoleacetic acid
- metabolic panel
- liver function tests
- full blood count
Investigações a serem consideradas
- CT chest, abdomen, and pelvis with dual-phase liver
- bronchoscopy
- endoscopy
- somatostatin receptor scintigraphy ± somatostatin single photon emission CT (SPECT)
- iodine I-123 meta-iodobenzylguanidine (MIBG) scintigraphy
- histology
- somatostatin receptor positron emission tomography (SSTR-PET) or fludeoxyglucose F-18 (FDG)
Algoritmo de tratamento
localised disease
metastatic disease
Colaboradores
Autores
Rajaventhan Srirajaskanthan, BSc (Hons), MD (Res), FRCP
Consultant Gastroenterologist
Neuroendocrine Tumour Unit
Kings College Hospital
London
UK
Declarações
RS has received research grants from Novartis and Ipsen, and has attended advisory boards for Novartis, Ipsen and ITM.
Martyn Caplin, BSc, DM, FRCP
Professor
Consultant in Hepatobiliary and Gastroenterology
Neuroendocrine Tumour Unit
Royal Free Hospital
London
UK
Declarações
MC is on the advisory boards for Novartis, Ipsen, Lexicon, and Pfizer; he has also received speaker honoraria from them.
Revisores
Wail Malaty, MD
Clinical Professor
Department of Family Medicine
University of North Carolina
Chapel Hill
Assistant Program Director
MAHEC Rural Family Medicine Residency
Hendersonville
NC
Declarações
WM declares that he has no competing interests.
Rajesh K. Garg, MD
Instructor in Medicine
Brigham and Women's Hospital
Division of Endocrinology
Diabetes and Hypertension
Boston
MA
Declarações
RKG declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
Referências
Principais artigos
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors [internet publicaton].Texto completo
North American Neuroendocrine Tumor Society. NANETS guidelines. 2022 [internet publication].Texto completo
Artigos de referência
Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
Diagnósticos diferenciais
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Mais Diagnósticos diferenciaisDiretrizes
- NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors
- European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma
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