References
Key articles
Institute of Medicine of the National Academies. Beyond myalgic encephalomyelitis/chronic fatigue syndrome: redefining an illness. Feb 2015 [internet publication].Full text
National Institute for Health and Care Excellence. Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management. Oct 2021 [internet publication].Full text
Nacul L, Authier FJ, Scheibenbogen C, et al. European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): expert consensus on the diagnosis, service provision, and care of people with ME/CFS in Europe. Medicina (Kaunas). 2021 May 19;57(5):510.Full text Abstract
International Association for Chronic Fatigue Syndrome/Myalgic Encephalomeyelitis. Chronic fatigue syndrome/myalgic encephalomeyelitis: primer for clinical practitioners. 2014 [internet publication].Full text
Reference articles
1. Komaroff AL. Myalgic encephalomyelitis/chronic fatigue syndrome: a real illness. Ann Intern Med. 2015 Jun 16;162(12):871-2.Full text Abstract
2. World Health Organization. International classification of diseases 11th revision for mortality and morbidity statistics (ICD-11 MMS). Jan 2023 [internet publication].Full text
3. Fukuda K, Straus SE, Hickie I, et al. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med. 1994 Dec 15;121(12):953-9. Abstract
4. Carruthers BM, Jain AK, De Meirleir KL, et al. Myalgic encephalomyelitis/chronic fatigue syndrome: clinical working case definition, diagnostic and treatment protocols. J Chron Fatigue S. 2003 Dec;11(1):7-115.Full text
5. Jason LA, Evans M, Porter N, et al. The development of a revised Canadian myalgic encephalomyelitis chronic fatigue syndrome case definition. Am J Biochem Biotechnol. 2010;6(2):120-35.Full text
6. Institute of Medicine of the National Academies. Beyond myalgic encephalomyelitis/chronic fatigue syndrome: redefining an illness. Feb 2015 [internet publication].Full text
7. Jason LA, Brown A, Evans M, et al. Contrasting chronic fatigue syndrome versus myalgic encephalomyelitis/chronic fatigue syndrome. Fatigue. 2013 Jun 1;1(3):168-83.Full text Abstract
8. National Institute for Health and Care Excellence. Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management. Oct 2021 [internet publication].Full text
9. Jason LA, Evans M, So S, et al. Problems in defining post-exertional malaise. J Prev Interv Community. 2015;43(1):20-31.Full text Abstract
10. Nacul L, Authier FJ, Scheibenbogen C, et al. European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): expert consensus on the diagnosis, service provision, and care of people with ME/CFS in Europe. Medicina (Kaunas). 2021 May 19;57(5):510.Full text Abstract
11. Rowe PC, Underhill RA, Friedman KJ, et al. Myalgic encephalomyelitis/chronic fatigue syndrome diagnosis and management in young people: a primer. Front Pediatr. 2017 Jun 19;5:121.Full text Abstract
12. Sulheim D, Fagermoen E, Winger A, et al. Disease mechanisms and clonidine treatment in adolescent chronic fatigue syndrome: a combined cross-sectional and randomized clinical trial. JAMA Pediatr. 2014 Apr;168(4):351-60.Full text Abstract
13. Jason LA, Barker K, Brown A. Pediatric myalgic encephalomyelitis/chronic fatigue syndrome. Rev Health Care. 2012 Jan 1;3(4):257-70.Full text Abstract
14. Collin SM, Nuevo R, van de Putte EM, et al. Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME) is different in children compared to in adults: a study of UK and Dutch clinical cohorts. BMJ Open. 2015 Oct 28;5(10):e008830. [Erratum in: BMJ Open. 2019 Nov 20;9(11):e008830corr1.]Full text Abstract
15. Johnston S, Brenu EW, Staines D, et al. The prevalence of chronic fatigue syndrome/ myalgic encephalomyelitis: a meta-analysis. Clin Epidemiol. 2013;5:105-10.Full text Abstract
16. Nacul LC, Lacerda EM, Pheby D, et al. Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care. BMC Med. 2011 Jul 28;9:91.Full text Abstract
17. Estévez-López F, Mudie K, Wang-Steverding X, et al. Systematic review of the epidemiological burden of myalgic encephalomyelitis/chronic fatigue syndrome across europe: current evidence and EUROMENE research recommendations for epidemiology. J Clin Med. 2020 May;9(5):1557.Full text Abstract
18. Lim EJ, Ahn YC, Jang ES, et al. Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). J Transl Med. 2020 Feb 24;18(1):100.Full text Abstract
19. Jones JF, Nisenbaum R, Solomon L, et al. Chronic fatigue syndrome and other fatiguing illnesses in adolescents: a population based study. J Adolesc Health. 2004 Jul;35(1):34-40. Abstract
20. Rimes KA, Goodman R, Hotopf M, et al. Incidence, prognosis, and risk factors for fatigue and chronic fatigue syndrome in adolescents: a prospective community study. Pediatrics. 2007 Mar;119(3):e603-9. Abstract
21. Centers for Disease Control and Prevention. Myalgic encephalomyelitis/ chronic fatigue syndrome: epidemiology. Mar 2023 [internet publication].Full text
22. Jason LA, Richman JA, Rademaker AW, et al. A community-based study of chronic fatigue syndrome. Arch Intern Med. 1999 Oct 11;159(18):2129-37.Full text Abstract
23. International Association for Chronic Fatigue Syndrome/Myalgic Encephalomeyelitis. Chronic fatigue syndrome/myalgic encephalomeyelitis: primer for clinical practitioners. 2014 [internet publication].Full text
24. Bakken IJ, Tveito K, Gunnes N, et al. Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008-2012. BMC Med. 2014 Oct 1;12:167.Full text Abstract
25. Wessely S. The epidemiology of chronic fatigue syndrome. Epidemiol Rev. 1995;17(1):139-51. Abstract
26. Steele L, Dobbins JG, Fukuda K, et al. The epidemiology of chronic fatigue in San Francisco. Am J Med. 1998 Sep 28;105(3a):83S-90S. Abstract
27. Dinos S, Khoshaba B, Ashby D, et al. A systematic review of chronic fatigue, its syndromes and ethnicity: prevalence, severity, co-morbidity and coping. Int J Epidemiol. 2009 Dec;38(6):1554-70. Abstract
28. Bhui KS, Dinos S, Ashby D, et al. Chronic fatigue syndrome in an ethnically diverse population: the influence of psychosocial adversity and physical inactivity. BMC Med. 2011 Mar 21;9:26.Full text Abstract
29. Maes M, Twisk FN, Johnson C. Myalgic encephalomyelitis (ME), chronic fatigue syndrome (CFS), and chronic fatigue (CF) are distinguished accurately: results of supervised learning techniques applied on clinical and inflammatory data. Psychiatry Res. 2012 Dec 30;200(2-3):754-60. Abstract
30. Araja D, Berkis U, Lunga A, et al. Shadow burden of undiagnosed myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) on society: retrospective and prospective-in light of COVID-19. J Clin Med. 2021 Jul;10(14):3017.Full text Abstract
31. Capelli E, Zola R, Lorusso L, et al. Chronic fatigue syndrome/myalgic encephalomyelitis: an update. Int J Immunopathol Pharmacol. 2010 Oct-Dec;23(4):981-9. Abstract
32. Rasa S, Nora-Krukle Z, Henning N, et al. Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). J Transl Med. 2018 Oct 1;16(1):268.Full text Abstract
33. Miller RR, Uyaguari-Diaz M, McCabe MN, et al. Metagenomic investigation of plasma in individuals with ME/CFS highlights the importance of technical controls to elucidate contamination and batch effects. PLoS One. 2016 Nov 2;11(11):e0165691.Full text Abstract
34. White PD, Thomas JM, Amess J, et al. Incidence, risk and prognosis of acute and chronic fatigue syndromes and psychiatric disorders after glandular fever. Br J Psychiatry. 1998 Dec;173:475-81. Abstract
35. Buchwald DS, Rea TD, Katon WJ, et al. Acute infectious mononucleosis: characteristics of patients who report failure to recover. Am J Med. 2000 Nov;109(7):531-7. Abstract
36. Katz BZ, Shiraishi Y, Mears CJ, et al. Chronic fatigue syndrome after infectious mononucleosis in adolescents. Pediatrics. 2009 Jul;124(1):189-93.Full text Abstract
37. Jason LA, Cotler J, Islam MF, et al. Predictors for developing severe myalgic encephalomyelitis/chronic fatigue syndrome following infectious mononucleosis. J Rehabil Ther. 2022;4(1):1-5.Full text Abstract
38. Ayres JG, Flint N, Smith EG, et al. Post-infection fatigue syndrome following Q fever. QJM. 1998 Feb;91(2):105-23.Full text Abstract
39. Zhang L, Gough J, Christmas D, et al. Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis. J Clin Pathol. 2010 Feb;63(2):156-64.Full text Abstract
40. Attard L, Bonvicini F, Gelsomino F, et al. Paradoxical response to intravenous immunoglobulin in a case of Parvovirus B19-associated chronic fatigue syndrome. J Clin Virol. 2015 Jan;62:54-7. Abstract
41. Limonard GJ, Peters JB, Nabuurs-Franssen MH, et al. Detailed analysis of health status of Q fever patients 1 year after the first Dutch outbreak: a case-control study. QJM. 2010 Dec;103(12):953-8.Full text Abstract
42. Garcia MN, Hause AM, Walker CM, et al. Evaluation of prolonged fatigue post-West Nile virus infection and association of fatigue with elevated antiviral and proinflammatory cytokines. Viral Immunol. 2014 Sep;27(7):327-33.Full text Abstract
43. Chia J, Chia A, Voeller M, et al. Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence. J Clin Pathol. 2010 Feb;63(2):165-8. Abstract
44. Chia JK. The role of enterovirus in chronic fatigue syndrome. J Clin Pathol. 2005 Nov;58(11):1126-32.Full text Abstract
45. Chia JK, Chia AY. Chronic fatigue syndrome is associated with chronic enterovirus infection of the stomach. J Clin Pathol. 2008 Jan;61(1):43-8. Abstract
46. Tansey CM, Louie M, Loeb M, et al. One-year outcomes and health care utilization in survivors of severe acute respiratory syndrome. Arch Intern Med. 2007 Jun 25;167(12):1312-20.Full text Abstract
47. Lam MH, Wing YK, Yu MW, et al. Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors: long-term follow-up. Arch Intern Med. 2009 Dec 14;169(22):2142-7.Full text Abstract
48. Magnus P, Gunnes N, Tveito K, et al. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with pandemic influenza infection, but not with an adjuvanted pandemic influenza vaccine. Vaccine. 2015 Nov 17;33(46):6173-7. Abstract
49. Komaroff AL, Bateman L. Will COVID-19 lead to myalgic encephalomyelitis/chronic fatigue syndrome? Front Med (Lausanne). 2021 Jan 18;7:606824.Full text Abstract
50. Desai AD, Lavelle M, Boursiquot BC, et al. Long-term complications of COVID-19. Am J Physiol Cell Physiol. 2022 Jan 1;322(1):C1-11.Full text Abstract
51. Jason LA, Islam M, Conroy K, et al. COVID-19 symptoms over time: comparing long-haulers to ME/CFS. Fatigue. 2021;9(2):59-68.Full text Abstract
52. Wilson A, Hickie I, Lloyd A, et al. The treatment of chronic fatigue syndrome: science and speculation. Am J Med. 1994 Jun;96(6):544-50. Abstract
53. Kogelnik AM, Loomis K, Hoegh-Petersen M, et al. Use of valganciclovir in patients with elevated antibody titers against Human Herpesvirus-6 (HHV-6) and Epstein-Barr Virus (EBV) who were experiencing central nervous system dysfunction including long-standing fatigue. J Clin Virol. 2006 Dec;37(suppl 1):S33-8. Abstract
54. Montoya JG, Kogelnik AM, Bhangoo M, et al. Randomized clinical trial to evaluate the efficacy and safety of valganciclovir in a subset of patients with chronic fatigue syndrome. J Med Virol. 2013 Dec;85(12):2101-9.Full text Abstract
55. Walsh CM, Zainal NZ, Middleton SJ, et al. A family history study of chronic fatigue syndrome. Psychiatr Genet. 2001 Sep;11(3):123-8. Abstract
56. Schluederberg A, Straus SE, Peterson P, et al. NIH conference. Chronic fatigue syndrome research. Definition and medical outcome assessment. Ann Intern Med. 1992 Aug 15;117(4):325-31. Abstract
57. Montague TJ, Marrie TJ, Bewick DJ, et al. Cardiac effects of common viral illnesses. Chest. 1988 Nov;94(5):919-25. Abstract
58. Fluge Ø, Bruland O, Risa K, et al. Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome: a double-blind and placebo-controlled study. PLoS One. 2011;6(10):e26358.Full text Abstract
59. Fluge Ø, Mella O. Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series. BMC Neurol. 2009 Jul 1;9:28.Full text Abstract
60. Lyall M, Peakman M, Wessley S. A systematic review and critical evaluation of the immunology of chronic fatigue syndrome. J Psychosom Res. 2003 Aug;55(2):79-90. Abstract
61. Hornig M, Gottschalk G, Peterson DL, et al. Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome. Mol Psychiatry. 2016 Feb;21(2):261-9. Abstract
62. Fletcher MA, Zeng XR, Barnes Z, et al. Plasma cytokines in women with chronic fatigue syndrome. J Transl Med. 2009 Nov 12;7:96.Full text Abstract
63. Broderick G, Fuite J, Kreitz A, et al. A formal analysis of cytokine networks in chronic fatigue syndrome. Brain Behav Immun. 2010 Oct;24(7):1209-17.Full text Abstract
64. Nguyen T, Johnston S, Clarke L, et al. Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels. Clin Exp Immunol. 2017 Feb;187(2):284-93.Full text Abstract
65. Fletcher MA, Zeng XR, Maher K, et al. Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV/CD26. PLoS One. 2010 May 25;5(5):e10817.Full text Abstract
66. Curriu M, Carrillo J, Massanella M, et al. Screening NK-, B- and T-cell phenotype and function in patients suffering from chronic fatigue syndrome. J Transl Med. 2013 Mar 20;11:68.Full text Abstract
67. Brenu EW, van Driel ML, Staines DR, et al. Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis. J Transl Med. 2012 May 9;10:88.Full text Abstract
68. Li H, Yu X, Liles C, et al. Autoimmune basis for postural tachycardia syndrome. J Am Heart Assoc. 2014 Feb 26;3(1):e000755.Full text Abstract
69. Ruzieh M, Batizy L, Dasa O, et al. The role of autoantibodies in the syndromes of orthostatic intolerance: a systematic review. Scand Cardiovasc J. 2017 Oct;51(5):243-7. Abstract
70. White AT, Light AR, Hughen RW, et al. Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome. Psychophysiology. 2010 Jul 1;47(4):615-24.Full text Abstract
71. Brenu EW, Ashton KJ, Batovska J, et al. High-throughput sequencing of plasma microRNA in chronic fatigue syndrome/myalgic encephalomyelitis. PLoS One. 2014 Sep 19;9(9):e102783.Full text Abstract
72. de Vega WC, Vernon SD, McGowan PO. DNA methylation modifications associated with chronic fatigue syndrome. PLoS One. 2014 Aug 11;9(8):e104757.Full text Abstract
73. Carlo-Stella N, Bozzini S, De Silvestri A, et al. Molecular study of receptor for advanced glycation endproduct gene promoter and identification of specific HLA haplotypes possibly involved in chronic fatigue syndrome. Int J Immunopathol Pharmacol. 2009 Jul-Sep;22(3):745-54. Abstract
74. Cabanas H, Muraki K, Eaton N, et al. Loss of transient receptor potential melastatin 3 ion channel function in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients. Mol Med. 2018 Aug 14;24(1):44.Full text Abstract
75. Eaton-Fitch N, du Preez S, Cabanas H, et al. A systematic review of natural killer cells profile and cytotoxic function in myalgic encephalomyelitis/chronic fatigue syndrome. Syst Rev. 2019 Nov 14;8(1):279.Full text Abstract
76. Groven N, Fors EA, Reitan SK. Patients with fibromyalgia and chronic fatigue syndrome show increased hsCRP compared to healthy controls. Brain Behav Immun. 2019 Oct;81:172-7.Full text Abstract
77. Cockshell SJ, Mathias JL. Cognitive functioning in chronic fatigue syndrome: a meta-analysis. Psychol Med. 2010 Aug;40(8):1253-67. Abstract
78. Schwartz RB, Garada BM, Komaroff AL, et al. Detection of intracranial abnormalities in patients with chronic fatigue syndrome: comparison of MR imaging and SPECT. AJR Am J Roentgenol. 1994 Apr;162(4):935-41.Full text Abstract
79. Caseras X, Mataix-Cols D, Giampietro V, et al. Probing the working memory system in chronic fatigue syndrome: a functional magnetic resonance imaging study using the n-back task. Psychosom Med. 2006 Nov-Dec;68(6):947-55. Abstract
80. van der Schaaf ME, De Lange FP, Schmits IC, et al. Prefrontal structure varies as a function of pain symptoms in chronic fatigue syndrome. Biol Psychiatry. 2017 Feb 15;81(4):358-65. Abstract
81. Miller AH, Jones JF, Drake DF, et al. Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue. PLoS One. 2014 May 23;9(5):e98156.Full text Abstract
82. Kim BH, Namkoong K, Kim JJ, et al. Altered resting-state functional connectivity in women with chronic fatigue syndrome. Psychiatry Res. 2015 Dec 30;234(3):292-7. Abstract
83. Wortinger LA, Endestad T, Melinder AM, et al. Aberrant resting-state functional connectivity in the salience network of adolescent chronic fatigue syndrome. PLoS One. 2016 Jul 14;11(7):e0159351.Full text Abstract
84. Barnden LR, Crouch B, Kwiatek R, et al. Evidence in chronic fatigue syndrome for severity-dependent upregulation of prefrontal myelination that is independent of anxiety and depression. NMR Biomed. 2015 Mar;28(3):404-13.Full text Abstract
85. Shan ZY, Kwiatek R, Burnet R, et al. Progressive brain changes in patients with chronic fatigue syndrome: a longitudinal MRI study. J Magn Reson Imaging. 2016 Nov;44(5):1301-11.Full text Abstract
86. Barnden LR, Crouch B, Kwiatek R, et al. A brain MRI study of chronic fatigue syndrome: evidence of brainstem dysfunction and altered homeostasis. NMR Biomed. 2011 Dec;24(10):1302-12.Full text Abstract
87. Barnden LR, Kwiatek R, Crouch B, et al. Autonomic correlations with MRI are abnormal in the brainstem vasomotor centre in chronic fatigue syndrome. Neuroimage Clin. 2016 Mar 31;11:530-7.Full text Abstract
88. Nakatomi Y, Mizuno K, Ishii A, et al. Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an 11C-(R)-PK11195 PET study. J Nucl Med. 2014 Jun;55(6):945-50.Full text Abstract
89. Maksoud R, du Preez S, Eaton-Fitch N, et al. A systematic review of neurological impairments in myalgic encephalomyelitis/ chronic fatigue syndrome using neuroimaging techniques. PLoS One. 2020;15(4):e0232475.Full text Abstract
90. Kozlowska K, Walker P, McLean L, et al. Fear and the defense cascade: clinical implications and management. Harv Rev Psychiatry. 2015 Jul-Aug;23(4):263-87.Full text Abstract
91. Bracha HS. Freeze, flight, fight, fright, faint: adaptationist perspectives on the acute stress response spectrum. CNS Spectr. 2004 Sep;9(9):679-85. Abstract
92. Bracha HS. Human brain evolution and the "Neuroevolutionary Time-depth Principle:" Implications for the reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jul;30(5):827-53. Abstract
93. Carruthers BM, van de Sande MI, De Meirleir KL, et al. Myalgic encephalomyelitis: International Consensus Criteria. J Intern Med. 2011 Oct;270(4):327-38.Full text Abstract
94. Giloteaux L, Goodrich JK, Walters WA, et al. Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome. Microbiome. 2016 Jun 23;4(1):30.Full text Abstract
95. Shukla SK, Cook D, Meyer J, et al. Changes in gut and plasma microbiome following exercise challenge in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). PLoS One. 2015 Dec 18;10(12):e0145453.Full text Abstract
96. Du Preez S, Corbitt M, Cabanas H, et al. A systematic review of enteric dysbiosis in chronic fatigue syndrome/myalgic encephalomyelitis. Syst Rev. 2018 Dec 20;7(1):241.Full text Abstract
97. Fluge Ø, Mella O, Bruland O, et al. Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome. JCI Insight. 2016 Dec 22;1(21):e89376.Full text Abstract
98. Naviaux RK, Naviaux JC, Li K, et al. Metabolic features of chronic fatigue syndrome. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5472-80.Full text Abstract
99. Missailidis D, Annesley SJ, Fisher PR. Pathological mechanisms underlying myalgic encephalomyelitis/chronic fatigue syndrome. Diagnostics (Basel). 2019 Jul 20;9(3):80.Full text Abstract
100. Wang PY, Ma J, Kim YC, et al. WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome. Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2302738120. Abstract
101. Esfandyarpour R, Kashi A, Nemat-Gorgani M, et al. A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Proc Natl Acad Sci U S A. 2019 May 21;116(21):10250-7.Full text Abstract
102. Holden S, Maksoud R, Eaton-Fitch N, et al. A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease. J Transl Med. 2020 Jul 29;18(1):290.Full text Abstract
103. Acworth I, Nicholass J, Morgan B, et al. Effect of sustained exercise on concentrations of plasma aromatic and branched-chain amino acids and brain amines. Biochem Biophys Res Commun. 1986 May 29;137(1):149-53. Abstract
104. White PD, Goldsmith KA, Johnson AL, et al. Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Lancet. 2011 Mar 5;377(9768):823-36.Full text Abstract
105. Clark LV, White PD. The role of deconditioning and therapeutic exercise in chronic fatigue syndrome (CFS). J Ment Health. 2005;14(3):237-52.
106. Fulcher KY, White PD. Strength and physiological response to exercise in patients with chronic fatigue syndrome. J Neurol Neurosurg Psychiatry. 2000 Sep;69(3):302-7.Full text Abstract
107. Gutkin M, Stewart JM. Orthostatic circulatory disorders: from nosology to nuts and bolts. Am J Hypertens. 2016 Sep;29(9):1009-19.Full text Abstract
108. Parsaik A, Allison TG, Singer W, et al. Deconditioning in patients with orthostatic intolerance. Neurology. 2012 Oct 2;79(14):1435-9.Full text Abstract
109. Vermeulen RC, Vermeulen van Eck IW. Decreased oxygen extraction during cardiopulmonary exercise test in patients with chronic fatigue syndrome. J Transl Med. 2014 Jan 23;12:20. Abstract
110. Snell CR, Stevens SR, Davenport TE, et al. Discriminative validity of metabolic and workload measurements for identifying people with chronic fatigue syndrome. Phys Ther. 2013 Nov;93(11):1484-92.Full text Abstract
111. Keller BA, Pryor JL, Giloteaux L. Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO₂peak indicates functional impairment. J Transl Med. 2014 Apr 23;12:104.Full text Abstract
112. Nelson MJ, Bahl JS, Buckley JD, et al. Evidence of altered cardiac autonomic regulation in myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review and meta-analysis. Medicine (Baltimore). 2019 Oct;98(43):e17600.Full text Abstract
113. Weber KT, Janicki JS. Cardiopulmonary exercise testing for evaluation of chronic cardiac failure. Am J Cardiol. 1985 Jan 11;55(2):22A-31A. Abstract
114. White AT, Light AR, Hughen RW, et al. Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls. Psychosom Med. 2012 Jan;74(1):46-54.Full text Abstract
115. Light AR, Bateman L, Jo D, et al. Gene expression alterations at baseline and following moderate exercise in patients with chronic fatigue syndrome and fibromyalgia syndrome. J Intern Med. 2012 Jan;271(1):64-81.Full text Abstract
116. Iacob E, Light AR, Donaldson GW, et al. Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample. Arthritis Care Res (Hoboken). 2016 Jan;68(1):132-40.Full text Abstract
117. Light AR, White AT, Hughen RW, et al. Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects. J Pain. 2009 Oct;10(10):1099-112. Abstract
118. Light KC, Agarwal N, Iacob E, et al. Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome. Psychoneuroendocrinology. 2013 Dec;38(12):2983-95.Full text Abstract
119. Peckerman A, LaManca JJ, Dahl KA, et al. Abnormal impedance cardiography predicts symptom severity in chronic fatigue syndrome. Am J Med Sci. 2003 Aug;326(2):55-60. Abstract
120. Miwa K, Fujita M. Small heart with low cardiac output for orthostatic intolerance in patients with chronic fatigue syndrome. Clin Cardiol. 2011 Dec;34(12):782-6.Full text Abstract
121. Sheldon RS, Grubb BP 2nd, Olshansky B, et al. 2015 Heart Rhythm Society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Heart Rhythm. 2015 Jun;12(6):e41-63.Full text Abstract
122. Joseph P, Arevalo C, Oliveira RKF, et al. Insights from invasive cardiopulmonary exercise testing of patients with myalgic encephalomyelitis/chronic fatigue syndrome. Chest. 2021 Aug;160(2):642-51.Full text Abstract
123. Joseph P, Singh I, Oliveira R, et al. Exercise pathophysiology in myalgic encephalomyelitis/chronic fatigue syndrome and postacute sequelae of SARS-CoV-2: more in common than not? Chest. 2023 Sep;164(3):717-26.Full text Abstract
124. van Campen CLMC, Verheugt FWA, Rowe PC, et al. Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: a quantitative, controlled study using Doppler echography. Clin Neurophysiol Pract. 2020 Feb;5:50-8.Full text Abstract
125. van Campen CLMC, Rowe PC, Visser FC. Deconditioning does not explain orthostatic intolerance in ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome). J Transl Med. 2021 May 4;19(1):193.Full text Abstract
126. Campen CLMCV, Rowe PC, Visser FC. Orthostatic symptoms and reductions in cerebral blood flow in long-haul COVID-19 patients: similarities with myalgic encephalomyelitis/chronic fatigue syndrome. Medicina (Kaunas). 2021 Dec 24;58(1):28.Full text Abstract
127. Grayston R, Czanner G, Elhadd K, et al. A systematic review and meta-analysis of the prevalence of small fiber pathology in fibromyalgia: implications for a new paradigm in fibromyalgia etiopathogenesis. Semin Arthritis Rheum. 2019 Apr;48(5):933-40.Full text Abstract
128. Albrecht PJ, Hou Q, Argoff CE, et al. Excessive peptidergic sensory innervation of cutaneous arteriole-venule shunts (AVS) in the palmar glabrous skin of fibromyalgia patients: implications for widespread deep tissue pain and fatigue. Pain Med. 2013 Jun;14(6):895-915.Full text Abstract
129. Thomas N, Gurvich C, Huang K, et al. The underlying sex differences in neuroendocrine adaptations relevant to Myalgic Encephalomyelitis Chronic Fatigue Syndrome. Front Neuroendocrinol. 2022 Jul;66:100995. Abstract
130. Dibble JJ, McGrath SJ, Ponting CP. Genetic risk factors of ME/CFS: a critical review. Hum Mol Genet. 2020 Sep 30;29(r1):R117-24.Full text Abstract
131. Buchwald D, Herrell R, Ashton S, et al. A twin study of chronic fatigue. Psychosom Med. 2001 Nov-Dec;63(6):936-43. Abstract
132. Fuhrer R, Wessely S. The epidemiology of fatigue and depression: a French primary-care study. Psychol Med. 1995 Sep;25(5):895-905. Abstract
133. Harvey SB, Wadsworth M, Wessely S, et al. The relationship between prior psychiatric disorder and chronic fatigue: evidence from a national birth cohort study. Psychol Med. 2008 Jul;38(7):933-40.Full text Abstract
134. Pacey V, Tofts L, Adams RD, et al. Quality of life prediction in children with joint hypermobility syndrome. J Paediatr Child Health. 2015 Jul;51(7):689-95. Abstract
135. Nijs J, Aerts A, De Meirleir K. Generalized joint hypermobility is more common in chronic fatigue syndrome than in healthy control subjects. J Manipulative Physiol Ther. 2006 Jan;29(1):32-9. Abstract
136. Eccles JA, Owens AP, Mathias CJ, et al. Neurovisceral phenotypes in the expression of psychiatric symptoms. Front Neurosci. 2015 Feb 10;9:4.Full text Abstract
137. Rowe PC, Marden CL, Flaherty MA, et al. Impaired range of motion of limbs and spine in chronic fatigue syndrome. J Pediatr. 2014 Aug;165(2):360-6. Abstract
138. Brown AA, Jason LA. Validating a measure of myalgic encephalomyelitis/chronic fatigue syndrome symptomatology. Fatigue. 2014;2(3):132-52.Full text Abstract
139. Bell DS. The doctor’s guide to chronic fatigue syndrome: understanding, treating and living with CFIDS. Boston, MA: Da Capo Lifelong Books; 1995.
140. van't Leven M, Zielhuis GA, van der Meer JW, et al. Fatigue and chronic fatigue syndrome-like complaints in the general population. Eur J Public Health. 2010 Jun;20(3):251-7.Full text Abstract
141. Newton JL, Mabillard H, Scott A, et al. The Newcastle NHS Chronic Fatigue Syndrome Service: not all fatigue is the same. J R Coll Physicians Edinb. 2010 Dec;40(4):304-7. Abstract
142. Tiffany A, Vetter P, Mattia J, et al. Ebola virus disease complications as experienced by survivors in Sierra Leone. Clin Infect Dis. 2016 Jun 1;62(11):1360-6.Full text Abstract
143. Sharpe MC, Archard LC, Banatvala JE, et al. A report - chronic fatigue syndrome: guidelines for research. J R Soc Med. 1991 Feb;84(2):118-21.Full text Abstract
144. Reeves WC, Lloyd A, Vernon SD, et al; International Chronic Fatigue Syndrome Study Group. Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution. BMC Health Serv Res. 2003 Dec 31;3(1):25.Full text Abstract
145. Green CR, Cowan P, Elk R, et al. National Institutes of Health Pathways to Prevention workshop: advancing the research on myalgic encephalomyelitis/chronic fatigue syndrome. Ann Intern Med. 2015 Jun 16;162(12):860-5.Full text Abstract
146. Jason LA, Torres-Harding SR, Jurgens A, et al. Comparing the Fukuda et al. criteria and the Canadian case definition for chronic fatigue syndrome. J Chronic Fatigue Synd. 2004;12(1):37-52.
147. Morris G, Maes M. Case definitions and diagnostic criteria for myalgic encephalomyelitis and chronic fatigue syndrome: from clinical-consensus to evidence-based case definitions. Neuro Endocrinol Lett. 2013;34(3):185-99. Abstract
148. Bateman L, Bested AC, Bonilla HF, et al. Myalgic encephalomyelitis/chronic fatigue syndrome: essentials of diagnosis and management. Mayo Clin Proc. 2021 Nov;96(11):2861-78.Full text Abstract
149. Vallings R. The pocket guide to chronic fatigue syndrome/ME. Key facts and tips for improved health. 1st ed. Auckland, New Zealand: Calico Publishing Limited, 2017.
150. Alexander NB, Taffet GE, Horne FM, et al. Bedside-to-Bench conference: research agenda for idiopathic fatigue and aging. J Am Geriatr Soc. 2010 May;58(5):967-75.Full text Abstract
151. Chang CJ, Hung LY, Kogelnik AM, et al. A comprehensive examination of severely ill ME/CFS patients. Healthcare (Basel). 2021 Sep 29;9(10):1290.Full text Abstract
152. Hutchinson CV, Badham SP. Patterns of abnormal visual attention in myalgic encephalomyelitis. Optom Vis Sci. 2013 Jun;90(6):607-14. Abstract
153. Wolfe F, Clauw DJ, Fitzcharles MA, et al. Fibromyalgia criteria and severity scales for clinical and epidemiological studies: a modification of the ACR preliminary diagnostic criteria for fibromyalgia. J Rheumatol. 2011 Jun;38(6):1113-22. Abstract
154. Wolfe F, Clauw DJ, Fitzcharles MA, et al. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016 Dec;46(3):319-29. Abstract
155. Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia: report of the multicenter criteria committee. Arthritis Rheum. 1990 Feb;33(2):160-72. Abstract
156. Grubb BP. Postural tachycardia syndrome. Circulation. 2008 May 27;117(21):2814-7.Full text Abstract
157. Axe E, Satz P. Psychiatric correlates in chronic fatigue syndrome. Ann Epidemiol. 2000 Oct 1;10(7):458. Abstract
158. Konstantinov K, von Mikecz A, Buchwald D, et al. Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome. J Clin Invest. 1996 Oct 15;98(8):1888-96.Full text Abstract
159. Nishikai M. Antinuclear antibodies in patients with chronic fatigue syndrome [in Japanese]. Nihon Rinsho. 2007 Jun;65(6):1067-70. Abstract
160. Komaroff AL, Buchwald DS. Chronic fatigue syndrome: an update. Annu Rev Med. 1998;49:1-13. Abstract
161. Baraniuk JN, Clauw DJ, Gaumond E. Rhinitis symptoms in chronic fatigue syndrome. Ann Allergy Asthma Immunol. 1998 Oct;81(4):359-65. Abstract
162. Davenport TE, Lehnen M, Stevens SR, et al. Chronotropic intolerance: an overlooked determinant of symptoms and activity limitation in myalgic encephalomyelitis/chronic fatigue syndrome? Front Pediatr. 2019 Mar 22;7:82.Full text Abstract
163. Stevens S, Snell C, Stevens J, et al. Cardiopulmonary exercise test methodology for assessing exertion intolerance in myalgic encephalomyelitis/chronic fatigue syndrome. Front Pediatr. 2018 Sep 4;6:242.Full text Abstract
164. Loy BD, O'Connor PJ, Dishman RK. Effect of acute exercise on fatigue in people with ME/CFS/SEID: a meta-analysis. Med Sci Sports Exerc. 2016 Oct;48(10):2003-12.Full text Abstract
165. Thaweethai T, Jolley SE, Karlson EW, et al. Development of a definition of postacute sequelae of SARS-CoV-2 infection. JAMA. 2023 Jun 13;329(22):1934-46.Full text Abstract
166. Ravindran MK, Zheng Y, Timbol C, et al. Migraine headaches in chronic fatigue syndrome (CFS): comparison of two prospective cross-sectional studies. BMC Neurol. 2011 Mar 5;11:30.Full text Abstract
167. Miller AJ, Schubart JR, Sheehan T, et al. Arterial elasticity in Ehlers-Danlos syndromes. Genes (Basel). 2020 Jan 4;11(1):55.Full text Abstract
168. Hakim A, De Wandele I, O'Callaghan C, et al. Chronic fatigue in Ehlers-Danlos syndrome-hypermobile type. Am J Med Genet C Semin Med Genet. 2017 Mar;175(1):175-80. Abstract
169. Germain DP. Clinical and genetic features of vascular Ehlers-Danlos syndrome. Ann Vasc Surg. 2002 May;16(3):391-7. Abstract
170. Barron DF, Cohen BA, Geraghty MT, et al. Joint hypermobility is more common in children with chronic fatigue syndrome than in healthy controls. J Pediatr. 2002 Sep;141(3):421-5. Abstract
171. Longstreth GF, Thompson WG, Chey WD, et al. Functional bowel disorders. Gastroenterology. 2006 Apr;130(5):1480-91.Full text Abstract
172. Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol. 1997 Sep;32(9):920-4. Abstract
173. Goldstein AT, Pukall CF, Brown C, et al. Vulvodynia: assessment and treatment. J Sex Med. 2016 Apr;13(4):572-90. Abstract
174. Freeman R, Wieling W, Axelrod FB, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011 Apr;21(2):69-72. Abstract
175. McManimen SL, Devendorf AR, Brown AA, et al. Mortality in patients with myalgic encephalomyelitis and chronic fatigue syndrome. Fatigue. 2016;4(4):195-207.Full text Abstract
176. Nordin LE, Möller MC, Julin P, et al. Post mTBI fatigue is associated with abnormal brain functional connectivity. Sci Rep. 2016 Feb 16;6:21183.Full text Abstract
177. Vernooij MW, Ikram MA, Tanghe HL, et al. Incidental findings on brain MRI in the general population. N Engl J Med. 2007 Nov 1;357(18):1821-8.Full text Abstract
178. Centers for Disease Control and Prevention. Unexplained illness among Persian Gulf War veterans in an Air National Guard Unit: preliminary report -August 1990-March 1995. MMWR Morb Mortal Wkly Rep. 1995 Jun 16;44(23):443-7.Full text Abstract
179. Fukuda K, Nisenbaum R, Stewart G, et al. Chronic multisymptom illness affecting Air Force veterans of the Gulf War. JAMA. 1998 Sep 16;280(11):981-8. Abstract
180. Naviaux RK, Naviaux JC, Li K, et al. Metabolic features of Gulf War illness. PLoS One. 2019 Jul 26;14(7):e0219531.Full text Abstract
181. Washington SD, Rayhan RU, Garner R, et al. Exercise alters brain activation in Gulf War illness and myalgic encephalomyelitis/chronic fatigue syndrome. Brain Commun. 2020 Aug 10;2(2):fcaa070.Full text Abstract
182. Saligan LN, Olson K, Filler K, et al. The biology of cancer-related fatigue: a review of the literature. Support Care Cancer. 2015 Aug;23(8):2461-78.Full text Abstract
183. Centers for Disease Control and Prevention. Myalgic encephalomyelitis/chronic fatigue syndrome: symptoms and diagnosis of ME/CFS. Jul 2018 [internet publication].Full text
184. Smith ME, Haney E, McDonagh M, et al. Treatment of myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review for a National Institutes of Health Pathways to Prevention workshop. Ann Intern Med. 2015 Jun 16;162(12):841-50.Full text Abstract
185. White P, Abbey S, Angus B, et al. Anomalies in the review process and interpretation of the evidence in the NICE guideline for chronic fatigue syndrome and myalgic encephalomyelitis. J Neurol Neurosurg Psychiatry. 2023 Dec;94(12):1056-63. Abstract
186. Mallet M, King E, White PD. A UK based review of recommendations regarding the management of chronic fatigue syndrome. J Psychosom Res. 2016 Sep;88:33-5. Abstract
187. Strand EB, Nacul L, Mengshoel AM, et al. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): investigating care practices pointed out to disparities in diagnosis and treatment across European Union. PLoS One. 2019 Dec 5;14(12):e0225995.Full text Abstract
188. Larun L, Brurberg KG, Odgaard-Jensen J, et al. Exercise therapy for chronic fatigue syndrome. Cochrane Database Syst Rev. 2019 Oct 2;(10):CD003200.Full text Abstract
189. Geraghty K, Hann M, Kurtev S. Myalgic encephalomyelitis/chronic fatigue syndrome patients' reports of symptom changes following cognitive behavioural therapy, graded exercise therapy and pacing treatments: analysis of a primary survey compared with secondary surveys. J Health Psychol. 2019 Sep;24(10):1318-33. Abstract
190. Marks DF. Special issue on the PACE Trial. J Health Psychol. 2017 Aug;22(9):1103-5.Full text Abstract
191. Cochrane. News: publication of Cochrane review: 'Exercise therapy for chronic fatigue syndrome'. Oct 2019 [internet publication].Full text
192. Centers for Disease Control and Prevention. Myalgic encephalomyelitis/chronic fatigue syndrome: treatment of ME/CFS. Jan 2021 [internet publication].Full text
193. Centers for Disease Control and Prevention. Myalgic encephalomyelitis/chronic fatigue syndrome: treating the most disruptive symptoms first and preventing worsening of symptoms. Apr 2021 [internet publication].Full text
194. Friedberg F, Sunnquist M, Nacul L. Rethinking the standard of care for myalgic encephalomyelitis/chronic fatigue syndrome. J Gen Intern Med. 2020 Mar;35(3):906-9.Full text Abstract
195. Jason LA, Brown M, Brown A, et al. Energy conservation/envelope theory interventions to help patients with myalgic encephalomyelitis/chronic fatigue syndrome. Fatigue. 2013 Jan 14;1(1-2):27-42.Full text Abstract
196. O'Dowd H, Gladwell P, Rogers CA, et al Cognitive behavioural therapy in chronic fatigue syndrome: a randomised controlled trial of an outpatient group programme. Health Technol Assess. 2006 Oct;10(37):iii-iv, ix-x, 1-121. Abstract
197. Ingman T, Smakowski A, Goldsmith K, et al. A systematic literature review of randomized controlled trials evaluating prognosis following treatment for adults with chronic fatigue syndrome. Psychol Med. 2022 Oct;52(14):2917-29.Full text Abstract
198. Andersson G, Rozental A, Shafran R, et al. Long-term effects of internet-supported cognitive behaviour therapy. Expert Rev Neurother. 2018 Jan;18(1):21-8. Abstract
199. Geraghty KJ, Blease C. Cognitive behavioural therapy in the treatment of chronic fatigue syndrome: a narrative review on efficacy and informed consent. J Health Psychol. 2018 Jan;23(1):127-38. Abstract
200. Merkes M. Mindfulness-based stress reduction for people with chronic diseases. Aust J Prim Health. 2010;16(3):200-10. Abstract
201. Verspaandonk J, Coenders M, Bleijenberg G, et al. The role of the partner and relationship satisfaction on treatment outcome in patients with chronic fatigue syndrome. Psychol Med. 2015 Aug;45(11):2345-52. Abstract
202. Centers for Disease Control and Prevention. Myalgic encephalomyelitis/chronic fatigue syndrome: monitoring the use of all medicines and supplements. Jul 2018 [internet publication].Full text
203. Mayo Clinic. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). May 2023 [internet publication].Full text
204. Qaseem A, Kansagara D, Forciea MA, et al. Management of chronic insomnia disorder in adults: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2016 Jul 19;165(2):125-33.Full text Abstract
205. Welsch P, Üçeyler N, Klose P, et al. Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia. Cochrane Database Syst Rev. 2018 Feb 28;(2):CD010292.Full text Abstract
206. Walitt B, Urrútia G, Nishishinya MB, et al. Selective serotonin reuptake inhibitors for fibromyalgia syndrome. Cochrane Database Syst Rev. 2015 Jun 5;(6):CD011735.Full text Abstract
207. National Institute for Health and Care Excellence. Neuropathic pain in adults: pharmacological management in non-specialist settings. Sep 2020 [internet publication].Full text
208. Bou-Holaigah I, Rowe PC, Kan J, et al. The relationship between neurally mediated hypotension and the chronic fatigue syndrome. JAMA. 1995 Sep 27;274(12):961-7. Abstract
209. Joseph P, Pari R, Miller S, et al. Neurovascular dysregulation and acute exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome: a randomized, placebo-controlled trial of pyridostigmine. Chest. 2022 Nov;162(5):1116-26. Abstract
210. Campagnolo N, Johnston S, Collatz A, et al. Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review. J Hum Nutr Diet. 2017 Jun;30(3):247-59.Full text Abstract
211. Karyotaki E, Smit Y, de Beurs DP, et al. The long-term efficacy of acute-phase psychotherapy for depression: a meta-analysis of randomized trials. Depress Anxiety. 2016 May;33(5):370-83. Abstract
212. Health Quality Ontario. Psychotherapy for major depressive disorder and generalized anxiety disorder: a health technology assessment. Ont Health Technol Assess Ser. 2017 Nov 13;17(15):1-167.Full text Abstract
213. Roberts E, Wessely S, Chalder T, et al. Mortality of people with chronic fatigue syndrome: a retrospective cohort study in England and Wales from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Clinical Record Interactive Search (CRIS) Register. Lancet. 2016 Apr 16;387(10028):1638-43.Full text Abstract
214. Wearden AJ, Dunn G, Dowrick C, et al. Depressive symptoms and pragmatic rehabilitation for chronic fatigue syndrome. Br J Psychiatry. 2012 Sep;201(3):227-32. Abstract
215. Garg H, Douglas M, Turkington GD, et al. Recovery from refractory chronic fatigue syndrome with CBT and modafinil. BMJ Case Rep. 2021 Mar 22;14(3):e240283.Full text Abstract
216. Randall DC, Cafferty FH, Shneerson JM, et al. Chronic treatment with modafinil may not be beneficial in patients with chronic fatigue syndrome. J Psychopharmacol. 2005 Nov;19(6):647-60. Abstract
217. Pliszka AG. Modafinil: a review and its potential use in the treatment of long COVID fatigue and neurocognitive deficits. Am J Psychiatry Resid J. 2022 Jun 28;17(4):5-7.Full text
218. Meirleir KD, McGregor N. Canadian chronic fatigue syndrome guidelines. J Chronic Fatigue Syndrome. 2003;11(1).Full text
219. Blockmans D, Persoons P. Long-term methylphenidate intake in chronic fatigue syndrome. Acta Clin Belg. 2016 Dec;71(6):407-14. Abstract
220. Morillas-Arques P, Rodriguez-Lopez CM, Molina-Barea R, et al. Trazodone for the treatment of fibromyalgia: an open-label, 12-week study. BMC Musculoskelet Disord. 2010 Sep 10;11:204.Full text Abstract
221. Calandre EP, Morillas-Arques P, Molina-Barea R, et al. Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study. BMC Musculoskelet Disord. 2011 May 16;12:95.Full text Abstract
222. Clemons A, Vasiadi M, Kempuraj D, et al. Amitriptyline and prochlorperazine inhibit proinflammatory mediator release from human mast cells: possible relevance to chronic fatigue syndrome. J Clin Psychopharmacol. 2011 Jun;31(3):385-7.Full text Abstract
223. Tofferi JK, Jackson JL, O'Malley PG. Treatment of fibromyalgia with cyclobenzaprine: a meta-analysis. Arthritis Rheum. 2004 Feb 15;51(1):9-13.Full text Abstract
224. Collatz A, Johnston SC, Staines DR, et al. A systematic review of drug therapies for chronic fatigue syndrome/myalgic encephalomyelitis. Clin Ther. 2016 Jun;38(6):1263-71. Abstract
225. Kim DY, Lee JS, Park SY, et al. Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). J Transl Med. 2020 Jan 6;18(1):7.Full text Abstract
226. Bagnall AM, Whiting P, Richardson R, et al. Interventions for the treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis. Qual Saf Health Care. 2002 Sep;11(3):284-8.Full text Abstract
227. Abdulla NE, Ninan MJ, Markowitz AB. Rituximab: current status as therapy for malignant and benign hematologic disorders. BioDrugs. 2012 Apr 1;26(2):71-82. Abstract
228. Fluge Ø, Risa K, Lunde S, et al. B-lymphocyte depletion in myalgic encephalopathy/chronic fatigue syndrome: an open-label phase II study with rituximab maintenance treatment. PLoS One. 2015 Jul 1;10(7):e0129898.Full text Abstract
229. ME Association. Negative phase III clinical trial result from Norway for rituximab in ME/CFS. Nov 2017 [internet publication].Full text
230. Fluge Ø, Rekeland IG, Lien K, et al. B-Lymphocyte depletion in patients with myalgic encephalomyelitis/chronic fatigue syndrome: a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2019 May 7;170(9):585-93. Abstract
231. Crosby LD, Kalanidhi S, Bonilla A, et al. Off label use of aripiprazole shows promise as a treatment for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole. J Transl Med. 2021 Feb 3;19(1):50.Full text Abstract
232. Cash A, Kaufman DL. Oxaloacetate treatment for mental and physical fatigue in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long-COVID fatigue patients: a non-randomized controlled clinical trial. J Transl Med. 2022 Jun 28;20(1):295.Full text Abstract
233. Rekeland IG, Fosså A, Lande A, et al. Intravenous cyclophosphamide in myalgic encephalomyelitis/chronic fatigue syndrome. An open-label phase II study. Front Med (Lausanne). 2020 Apr 29;7:162.Full text Abstract
234. Kaiser JD. A prospective, proof-of-concept investigation of KPAX002 in chronic fatigue syndrome. Int J Clin Exp Med. 2015 Jul 15;8(7):11064-74.Full text Abstract
235. Mitchell W. Review of Ampligen clinical trials in chronic fatigue syndrome. J Clin Virol. 2006;37(suppl 1):S113.
236. Strayer DR, Carter WA, Brodsky I, et al. A controlled clinical trial with a specifically configured RNA drug, poly(I).poly(C12U), in chronic fatigue syndrome. Clin Infect Dis. 1994 Jan;18(suppl 1):S88-95. Abstract
237. Strayer DR, Carter WA, Stouch BC, et al. A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome. PLoS One. 2012;7(3):e31334.Full text Abstract
238. Mitchell WM. Efficacy of rintatolimod in the treatment of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Expert Rev Clin Pharmacol. 2016 Jun;9(6):755-70.Full text Abstract
239. Strayer DR, Young D, Mitchell WM. Effect of disease duration in a randomized phase III trial of rintatolimod, an immune modulator for myalgic encephalomyelitis/chronic fatigue syndrome. PLoS One. 2020 Oct 29;15(10):e0240403.Full text Abstract
240. Younger J, Parkitny L, McLain D. The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain. Clin Rheumatol. 2014 Apr;33(4):451-9.Full text Abstract
241. Younger J, Mackey S. Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study. Pain Med. 2009 May-Jun;10(4):663-72.Full text Abstract
242. Younger J, Noor N, McCue R, et al. Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels. Arthritis Rheum. 2013 Feb;65(2):529-38.Full text Abstract
243. Hall DL, Lattie EG, Milrad SF, et al. Telephone-administered versus live group cognitive behavioral stress management for adults with CFS. J Psychosom Res. 2017 Feb;93:41-7.Full text Abstract
244. Tirelli U, Lleshi A, Berretta M, et al. Treatment of 741 Italian patients with chronic fatigue syndrome. Eur Rev Med Pharmacol Sci. 2013 Nov;17(21):2847-52.Full text Abstract
245. Peterson PK, Shepard J, Macres M, et al. A controlled trial of intravenous immunoglobulin G in chronic fatigue syndrome. Am J Med. 1990 Nov;89(5):554-60. Abstract
246. Kerr JR, Cunniffe VS, Kelleher P, et al. Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome. Clin Infect Dis. 2003 May 1;36(9):e100-6.Full text Abstract
247. Rowe KS. Double-blind randomized controlled trial to assess the efficacy of intravenous gammaglobulin for the management of chronic fatigue syndrome in adolescents. J Psychiatr Res. 1997 Jan-Feb;31(1):133-47. Abstract
248. Fagermoen E, Sulheim D, Winger A, et al. Effects of low-dose clonidine on cardiovascular and autonomic variables in adolescents with chronic fatigue: a randomized controlled trial. BMC Pediatr. 2015 Sep 10;15:117.Full text Abstract
249. Hartz AJ, Bentler SE, Brake KA, et al. The effectiveness of citalopram for idiopathic chronic fatigue. J Clin Psychiatry. 2003 Aug;64(8):927-35. Abstract
250. Blockmans D, Persoons P, Van Houdenhove B, et al. Combination therapy with hydrocortisone and fludrocortisone does not improve symptoms in chronic fatigue syndrome: a randomized, placebo-controlled, double-blind, crossover study. Am J Med. 2003 Jun 15;114(9):736-41. Abstract
251. Cleare AJ, Miell J, Heap E, et al. Hypothalamo-pituitary-adrenal axis dysfunction in chronic fatigue syndrome, and the effects of low-dose hydrocortisone therapy. J Clin Endocrinol Metab. 2001 Aug;86(8):3545-54.Full text Abstract
252. Blockmans D, Persoons P, Van Houdenhove B, et al. Does methylphenidate reduce the symptoms of chronic fatigue syndrome? Am J Med. 2006 Feb;119(2):167.e23-30.Full text Abstract
253. van Heukelom RO, Prins JB, Smits MG, et al. Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion. Eur J Neurol. 2006 Jan;13(1):55-60. Abstract
254. Williams G, Waterhouse J, Mugarza J, et al. Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy. Eur J Clin Invest. 2002 Nov;32(11):831-7. Abstract
255. Blacker CV, Greenwood DT, Wesnes KA, et al. Effect of galantamine hydrobromide in chronic fatigue syndrome: a randomized controlled trial. JAMA. 2004 Sep 8;292(10):1195-204.Full text Abstract
256. Forsyth LM, Preuss HG, MacDowell AL, et al. Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome. Ann Allergy Asthma Immunol. 1999 Feb;82(2):185-91. Abstract
257. Castro-Marrero J, Cordero MD, Segundo MJ, et al. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome? Antioxid Redox Signal. 2015 Mar 10;22(8):679-85.Full text Abstract
258. Zachrisson O, Regland B, Jahreskog M, et al. Treatment with staphylococcus toxoid in fibromyalgia/chronic fatigue syndrome: a randomised controlled trial. Eur J Pain. 2002;6(6):455-66. Abstract
259. Roerink ME, Bredie SJH, Heijnen M, et al. Cytokine inhibition in patients with chronic fatigue syndrome: a randomized trial. Ann Intern Med. 2017 Apr 18;166(8):557-64. Abstract
260. Ostojic SM, Stojanovic M, Drid P, et al. Supplementation with guanidinoacetic acid in women with chronic fatigue syndrome. Nutrients. 2016 Jan 29;8(2):72.Full text Abstract
261. Park SB, Kim KN, Sung E, et al. Human placental extract as a subcutaneous injection is effective in chronic fatigue syndrome: a multi-center, double-blind, randomized, placebo-controlled study. Biol Pharm Bull. 2016 May 1;39(5):674-9.Full text Abstract
262. Henderson TA. Valacyclovir treatment of chronic fatigue in adolescents. Adv Mind Body Med. 2014;28:4-14. Abstract
263. Diaz-Mitoma F, Turgonyi E, Kumar A, et al. Clinical improvement in chronic fatigue syndrome is associated with enhanced natural killer cell-mediated cytotoxicity: the results of a pilot study with isoprinosine. J Chronic Fatigue Syndr 2003;11(2):71-95.
264. Yancey JR, Thomas SM. Chronic fatigue syndrome: diagnosis and treatment. Am Fam Physician. 2012 Oct 15;86(8):741-6.Full text Abstract
265. Burgess M, Andiappan M, Chalder T. Cognitive behaviour therapy for chronic fatigue syndrome in adults: face to face versus telephone treatment: a randomized controlled trial. Behav Cogn Psychother. 2012 Mar;40(2):175-91. Abstract
266. Tummers M, Knoop H, van Dam A, et al. Implementing a minimal intervention for chronic fatigue syndrome in a mental health centre: a randomized controlled trial. Psychol Med. 2012 Oct;42(10):2205-15. Abstract
267. Wearden AJ, Dowrick C, Chew-Graham C, et al. Nurse led, home based self help treatment for patients in primary care with chronic fatigue syndrome: randomised controlled trial. BMJ. 2010 Apr 23;340:c1777.Full text Abstract
268. Friedberg F, Napoli A, Coronel J, et al. Chronic fatigue self-management in primary care: a randomized trial. Psychosom Med. 2013 Sep;75(7):650-7.Full text Abstract
269. Maes M, Mihaylova I, Leunis JC. In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation. Neuro Endocrinol Lett. 2005 Dec;26(6):745-51. Abstract
270. Brouwers FM, Van Der Werf S, Bleijenberg G, et al. The effect of a polynutrient supplement on fatigue and physical activity of patients with chronic fatigue syndrome: a double-blind randomized controlled trial. QJM. 2002 Oct;95(10):677-83.Full text Abstract
271. Weatherley-Jones E, Nicholl JP, Thomas KJ, et al. A randomised, controlled, triple-blind trial of the efficacy of homeopathic treatment for chronic fatigue syndrome. J Psychosom Res. 2004 Feb;56(2):189-97. Abstract
272. Wang YY, Li XX, Liu JP, et al. Traditional Chinese medicine for chronic fatigue syndrome: a systematic review of randomized clinical trials. Complement Ther Med. 2014 Aug;22(4):826-33. Abstract
273. Oka T, Tanahashi T, Chijiwa T, et al. Isometric yoga improves the fatigue and pain of patients with chronic fatigue syndrome who are resistant to conventional therapy: a randomized, controlled trial. Biopsychosoc Med. 2014 Dec 11;8(1):27.Full text Abstract
274. The GK, Verkes RJ, Fekkes D, et al. Tryptophan depletion in chronic fatigue syndrome, a pilot cross-over study. BMC Res Notes. 2014 Sep 16;7:650.Full text Abstract
275. Ho RT, Chan JS, Wang CW, et al. A randomized controlled trial of qigong exercise on fatigue symptoms, functioning, and telomerase activity in persons with chronic fatigue or chronic fatigue syndrome. Ann Behav Med. 2012 Oct;44(2):160-70.Full text Abstract
276. Chan JS, Ho RT, Wang CW, et al. Effects of qigong exercise on fatigue, anxiety, and depressive symptoms of patients with chronic fatigue syndrome-like illness: a randomized controlled trial. Evid Based Complement Alternat Med. 2013;2013:485341.Full text Abstract
277. Alraek T, Lee MS, Choi TY, et al. Complementary and alternative medicine for patients with chronic fatigue syndrome: a systematic review. BMC Complement Altern Med. 2011 Oct 7;11:87.Full text Abstract
278. Vercoulen JH, Swanink CM, Fennis JF, et al. Prognosis in chronic fatigue syndrome: a prospective study of the natural course. J Neurol Neurosurg Psychiatry. 1996 May;60(5):489-94.Full text Abstract
279. Ray C, Jefferies S, Weir WR. Coping and other predictors of outcome in chronic fatigue syndrome: A 1-year follow-up. J Psychosom Res. 1997 Oct;43(4):405-15. Abstract
280. Bonner D, Ron M, Chalder T, et al. Chronic fatigue syndrome: a follow-up study. J Neurol Neurosurg Psychiatry. 1994 May;57(5):617-21.Full text Abstract
281. Nyland M, Naess H, Birkeland JS, et al. Longitudinal follow-up of employment status in patients with chronic fatigue syndrome after mononucleosis. BMJ Open. 2014 Nov 26;4(11):e005798.Full text Abstract
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