Approach

Presumptive diagnosis of squamous cell carcinoma (SCC) of the skin is usually based on a thorough history and clinical findings; however, skin biopsy confirms the diagnosis.

Patients with SCC of the skin often present with multiple actinic keratoses (AK). These are skin-coloured, yellowish, or erythematous, ill-defined, irregularly shaped, small, scaly macules or plaques localised to sun-exposed areas of the body that have the potential to progress into SCC. Vigilance and a low threshold for investigation are important in achieving early diagnosis and a successful outcome.

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