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Stomach cancer

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  • Overview
  • Theory
  • Diagnosis
  • Management
  • Follow up
  • Resources
Last reviewed: 21 Oct 2025
Last updated: 29 Jul 2025

Summary

Определение

Анамнез и осмотр

Ключевые диагностические факторы

  • abdominal pain
  • weight loss
  • lymphadenopathy
Полная информация

Другие диагностические факторы

  • age 50-70 years
  • male sex
  • smoking
  • family history
  • nausea
  • dysphagia
  • lower gastrointestinal bleeding
Полная информация

Факторы риска

  • pernicious anemia
  • Helicobacter pylori
  • N-nitroso compounds
  • diet low in fruits and vegetables
  • high-salt diet
  • smoking
  • family history
Полная информация

Диагностические исследования

Исследования, которые показаны в первую очередь

  • esophagogastroduodenoscopy with biopsy
  • CT of chest/abdomen/pelvis
  • CBC
  • comprehensive metabolic panel
  • H pylori testing/screening
  • molecular and pathological tests
Полная информация

Исследования, проведение которых нужно рассмотреть

  • endoscopic ultrasound
  • laparoscopy
  • PET/CT scan
  • liquid biopsy
Полная информация

Алгоритм лечения

Острый

localized: suitable for surgery

localized: not suitable for surgery

advanced and metastatic disease

Составители

Авторы

Ahmed Abdelhakeem, MD

Fellow Physician

Department of Hematology and Oncology

Mayo Clinic - Mayo Clinic Comprehensive Cancer Center

Jacksonville

FL

Раскрытие информации

AA declares that he has no competing interests.

Mariela Blum Murphy, MD

Associate Professor

Department of GI Medical Oncology

University of Texas

MD Anderson Cancer Center

Houston

TX

Раскрытие информации

MBM declares that she has no competing interests.

Выражение благодарностей

Dr Ahmed Abdelhakeem and Dr Mariela Blum Murphy would like to gratefully acknowledge Dr Valerie Reed and Dr Prajnan Das, previous contributors to this topic.

Раскрытие информации

VR and PD declare that they have no competing interests.

Рецензенты

Theodore Hong, MD

Director

Gastrointestinal Radiation Oncology

Massachusetts General Hospital Cancer Center

Boston

MA

Раскрытие информации

TH declares that he has no competing interests.

Andreas Leodolter, MD

Head of Department

Department of Gastroenterology

Sana Klinikum

Remscheid

Germany

Раскрытие информации

AL declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Список литературы

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Основные статьи

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: gastric cancer [internet publication].Полный текст

Lordick F, Carneiro F, Cascinu S, et al. Gastric cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol. 2022 Oct;33(10):1005-20.Полный текст  Аннотация

Songun I, Putter H, Kranenbarg EM, et al. Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial. Lancet Oncol. 2010 May;11(5):439-49. Аннотация

Smalley SR, Benedetti JK, Haller DG, et al. Updated analysis of SWOG-directed intergroup study 0116: a phase III trial of adjuvant radiochemotherapy versus observation after curative gastric cancer resection. J Clin Oncol. 2012 Jul 1;30(19):2327-33. Аннотация

Cunningham D, Allum WH, Stenning SP, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006 Jul 6;355(1):11-20.Полный текст  Аннотация

Bang YJ, Van CE, Feyereislova A, et al; ToGA Trial Investigators. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010 Aug 28;376(9742):687-97. Аннотация

Статьи, указанные как источники

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