Last reviewed: 6 Nov 2021
Last updated: 13 Oct 2021

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • pelvic mass
  • ascites
  • pleural effusion

Other diagnostic factors

  • gastrointestinal symptoms
  • urinary urgency or frequency
  • symptom duration >3 months
  • abdominal distension
  • pelvic/abdominal pain or pressure

Risk factors

  • BRCA1 mutation
  • BRCA2 mutation
  • increasing age
  • family history of ovarian cancer
  • family history of breast cancer
  • never used combined oral contraceptives
  • Lynch syndrome
  • nulliparity
  • obesity
  • hormone therapy
  • endometriosis

Diagnostic investigations

Treatment algorithm

Contributors

Authors

Sareena Singh, MD

Gynecologic Oncologist

Aultman Medical Group

Northeast Ohio Medical University

Canton

OH

Disclosures

SS declares that she has no competing interests.

Acknowledgements

Dr Sareena Singh would like to gratefully acknowledge Dr Justin C. Chura and Dr Allison E. Axtell, previous contributors to this topic.

Disclosures

JCC and AEA declare that they have no competing interests.

Peer reviewers

Michael P. Hopkins, MD, MEd

Chairman

Obstetrics and Gynecology

Northeast Ohio Universities of Medicine (NEOMED)

Rootstown

OH

Disclosures

MPH declares that he has no competing interests.

Ritu Salani, MD

Gynecologic Oncology Fellow

Johns Hopkins Medical Institutions

Baltimore

MD

Disclosures

RS declares that she has no competing interests.

Susan A. Davidson, MD

Associate Professor

Chief, Gynecologic Oncology

Department of Obstetrics & Gynecology (UCD)

University of Colorado Cancer Center

Aurora

CO

Disclosures

SAD declares that she has no competing interests.

Khadra Galaal, MBChB, MPH, MRCOG

Consultant Gynaecological Oncologist

Northern Gynaecological Oncology Centre

Queen Elizabeth Hospital

Gateshead

UK

Disclosures

KG is co-author of a systematic review of follow-up strategies after primary treatment in ovarian cancer. This is not referenced in this topic.

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