Patients often present following routine screening with digital rectal examination (DRE) and prostate-specific antigen (PSA). Alternatively, patients may present with symptoms and signs of urological obstruction. A prostate biopsy (using transrectal ultrasound [TRUS]-guided needle biopsy or magnetic resonance imaging [MRI]-TRUS fusion-guided biopsy) confirms diagnosis and aids grading. Staging is determined using imaging studies and biopsies when indicated.

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