Summary
Definition
History and exam
Key diagnostic factors
- presence of risk factors
- elevated prostate-specific antigen (PSA)
Other diagnostic factors
- abnormal digital rectal examination (DRE)
- nocturia
- urinary frequency
- urinary hesitancy
- dysuria
- haematuria
- weight loss/anorexia
- lethargy
- bone pain
- palpable lymph nodes
Risk factors
- age >50 years
- black ethnicity
- Northwest European, Caribbean, Australian, New Zealand, North American, and Southern African populations
- positive family history/genetic factors
- high levels of dietary fat
Diagnostic investigations
1st investigations to order
- serum prostate-specific antigen (PSA)
- testosterone
- LFTs
- FBC
- renal function
- prostate biopsy
Investigations to consider
- bone scan
- plain radiographs
- pelvic CT scan
- pelvic MRI/endorectal MRI
Emerging tests
- genetic biomarkers
- 18F-sodium fluoride PET/CT and 11C-choline PET/CT
- prostate cancer antigen 3 (PCA3) assay
- TMPRSS2-ERG gene fusions
- prostate health index (PHI)
- 4Kscore test
Treatment algorithm
Contributors
Authors
Radiation Oncologist
Department of Radiation Oncology
Virginia Commonwealth University
Richmond
VA
Disclosures
TJW declares that he is the principal investigator of an R-21 NIH research grant investigating the tumour-mediated immune responses in African-American men with prostate cancer.
Professor Emeritus
Department of Radiation Oncology
Virginia Commonwealth University
Richmond
VA
Disclosures
MSA declares that he has no competing interests.
Peer reviewers
Clinical Oncology Registrar
St Luke's Cancer Centre
Royal Surrey Hospital
Guildford
Surrey
UK
Disclosures
EA has received consultation fees from the following organisations: Blue Cross/Blue Shield Association, Sanofi-Aventis, Ferring Pharmaceuticals, Pfizer Corporation, American Urological Association, National Institutes of Health, Accreditation Council for Graduate Medical Education, Royal Hallamshire Hospital, Hartford County Medical Association. EA owns shares in Pfizer Pharmaceuticals, Johnson and Johnson, and General Electric Corporation.
Medical Director
UConn Medical Group
University of Connecticut Health Center
Farmington
CT
Disclosures
PA declares that he has no competing interests.
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