Last reviewed:September 2019
Last updated:September  2019

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • rash
  • mucosal involvement
  • Nikolsky's sign
  • blisters

Risk factors

  • anticonvulsant medicines
  • recent infection
  • recent antibiotic use
  • other medicines
  • systemic lupus erythematosus
  • AIDS
  • radiotherapy
  • bone marrow transplantation
  • human leukocyte antigen and genetic predisposition
  • smallpox vaccination

Diagnostic investigations

1st investigations to order

  • skin biopsy
  • blood cultures
  • FBC
  • glucose
  • magnesium
  • phosphate
  • urea
  • bicarbonate
  • LFTs
  • arterial blood gases and saturation of oxygen
Full details

Investigations to consider

  • serum electrolytes
  • serum creatinine
  • direct immunofluorescence
Full details

Treatment algorithm

Contributors

Adjunct Research Faculty

Arizona Burn Center

Maricopa Integrated Health Systems

Phoenix

AZ

Disclosures

AK-V performs occasional manuscript reviews on various topics for Research Square, Inc. in the US for which she receives a nominal monetary fee.

Peer reviewersVIEW ALL

Director Burn Unit

Department of Surgery

University of Iowa Hospitals

Iowa City

IA

Disclosures

BAL declares that she has no competing interests.

Assistant Chief of Burns

Shriners Hospital

UC Davis

Sacramento

CA

Disclosures

TP declares that she has no competing interests.

Consultant Dermatologist

Department of Dermatology

West Suffolk Hospital

Bury St. Edmunds

UK

Disclosures

VG declares that he has no competing interests.

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