PCT is the most common of the porphyrias. It is most common in middle-aged men and in women associated with use of oestrogen. Incidence of PCT has not been accurately determined and differs by geographical area, probably reflecting geographical variations in the prevalence of susceptibility factors. Prevalence in the US has been estimated to be 1 in 25,000, and yearly incidence in the UK has been estimated at 2 to 5 per million.
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