A diagnosis of nephrolithiasis may be suspected based on the clinical history, physical examination findings and laboratory test results, and is confirmed with imaging studies.
Obstructed renal and ureteric stones can cause renal colic: severe, acute flank pain that may radiate to the ipsilateral groin, commonly associated with nausea and vomiting. Rarely, this is accompanied by macroscopic haematuria. As stones pass and get lodged in the distal ureter or intramural tunnel, this can lead to bladder irritation manifested as urinary frequency or urgency. Ipsilateral testicular and groin pain may occur rarely in men with obstructive stones. However, in the absence of obstruction, calculi may be asymptomatic.
In patients with renal colic, costovertebral angle and ipsilateral flank tenderness may be pronounced. Signs of sepsis, including fever, tachycardia, and hypotension, might indicate an obstructing stone with infection, warranting urgent urology referral.
Initial laboratory tests in all patients with suspected nephrolithiasis are urinalysis, FBC, and serum chemistry to include electrolytes, serum urea/creatinine (to assess renal function), calcium, phosphorus, and uric acid. Urinalysis is helpful in confirming a diagnosis of renal stones as microscopic haematuria is present in the majority of patients. However, the absence of haematuria does not exclude nephrolithiasis. Presence of >5 to 10 WBCs per high-powered field in urine or pyuria could indicate presence of urinary tract infection or be secondary to inflammation. Urinary crystals of calcium oxalate, uric acid, or cystine may indicate the nature of the calculus, although only cystine crystals are pathognomonic for the underlying type of stones. A urine pH greater than 7 suggests presence of urea-splitting organisms, such as Proteus, Pseudomonas, or Klebsiella species, and struvite stones. A urine pH less than 5.5 suggests uric acid stones.
A raised WBC count may indicate infection (pyelonephritis or urinary tract infection). Hypercalcaemia may suggest hyperparathyroidism as an underlying aetiology; hyperuricaemia may indicate gout. In women of childbearing age, a pregnancy test should be done prior to imaging with ionising radiation and to rule out ectopic pregnancy as a cause of symptoms.
Twenty-four-hour urine sampling is not always necessary in a first-time stone former without significant risk for recurrence. However, it is indicated in recurrent stone formers, those with bilateral or multiple stones, history of inflammatory bowel disease, chronic diarrhoea, bowel surgery or malabsorption; those with primary hyperparathyroidism, gout or renal tubular acidosis, nephrocalcinosis or stones formed of cystine, uric acid, or calcium phosphate; in children; and in interested first-time stone-formers. Basic measurements should include volume, pH, creatinine, calcium, sodium, oxalate, uric acid, and citrate. Analysis of stone composition provides information on chemical composition and aetiology. Stones are analysed after they are extracted during surgery or when patients expel and collect them for analysis. A urine screen for cystine, if the diagnosis of cystinuria is not excluded by stone analysis, should be considered. Serum parathyroid hormone is only measured in cases of high or high-normal serum calcium results.
If there is suspicion for nephrolithiasis based on the history, physical examination, and laboratory tests, then imaging is indicated.
Non-contrast helical computed tomography (NCCT) scan is the preferred imaging modality due to its high sensitivity and specificity. Computed tomography (CT) accurately determines presence, size, and location of stones; if it is negative, nephrolithiasis can be ruled out with high likelihood. A low-dose non-contrast CT (<4 mSv) is preferred for patients with a body mass index (BMI) ≤30 kg/m², as this limits the potential radiation exposure while maintaining both sensitivity and specificity at 90% or higher. However, low-dose CT is not recommended for those with a BMI >30 kg/m², owing to lower sensitivity and specificity in these patients. Patients with indinavir and ritonavir stones from anti-HIV medication may have radiolucent stones on CT scan. However, this makes up only a tiny fraction of patients. CT scans are also used when patients with known stones have new onset of renal colic because stones commonly change location or new ones are formed. However, there is a risk of significant radiation exposure with repeated CT scans, and a physician should use his or her judgement.
Plain abdominal radiography (KUB) can determine whether stones are radiopaque and can be used to monitor disease activity. Calcium oxalate and calcium phosphate stones are radiopaque, whereas pure uric acid and indinavir stones are radiolucent and cystine stones are partially radiolucent. The KUB radiograph can suggest the fluoroscopic appearance of a stone, which determines whether it can be targeted with extracorporeal shock wave lithotripsy (ESWL).
Renal ultrasound can be used to diagnose renal stones, particularly in pregnancy or other situations where avoiding radiation exposure is advised, although it can be operator dependent and has low sensitivity for diagnosing mid and distal ureteric stones. The combination of renal ultrasonography with KUB has been proposed as a reasonable initial evaluation protocol when a CT scan cannot be performed or is unavailable. For a known stone-former who has previously had radiopaque stones, it has been suggested that a combination of renal ultrasonography and KUB are a viable option for follow-up imaging; sensitivities of 58% to 100% and specificities of 37% to 100% have been reported for this combination of modalities.
Renal ultrasound and CT have been investigated for their safety and efficacy as an initial diagnostic test for patients who present to the emergency department with suspected nephrolithiasis. The results of a large, multicentre study showed no significant difference in high-risk diagnoses, serious adverse events, subsequent emergency room visits, or hospitalisations in those undergoing CT or renal ultrasound in this setting. Another multicentre randomised trial found that of 1666 patients diagnosed with nephrolithiasis in the emergency department (following abdominal ultrasound or CT), the majority of patients (78%) ultimately had CT performed before elective intervention. Patients whose ultrasound was performed by an emergency department physician were 2.6 times more likely to undergo CT before intervention than those whose ultrasound was performed by a radiologist. Ultrasound as the initial imaging modality did not result in a significant delay to intervention.
An intravenous pyelogram (IVP) can provide both anatomical and functional information on stones and the urinary tract and, before NCCT, was the traditional imaging modality. However, IVP is now less commonly used due to the improved sensitivity of CT scans. Disadvantages include the need for intravenous contrast material, which may provoke an allergic response or renal failure, and the need for multiple delayed films in certain cases and concerns for radiation exposure.
Renal ultrasound is the first-line imaging modality for pregnant patients. For pregnant patients when renal ultrasound is non-diagnostic, transvaginal ultrasound can assist with diagnosis by determining if ureteral dilation extends beyond the pelvic brim; it can also diagnose stones in the distal ureter. Magnetic resonance imaging (MRI), which confers no radiation to the patient, is a second-line imaging modality because stones are not directly visible on MRI and only seen as a filling defect in the collecting system. Radiation doses of <50 mGy have not been associated with increased risk of fetal anomalies or loss; therefore, low-dose protocol CT (<4 mGy) can be used as a last-line option in pregnant women after the first trimester to aid in difficult-to-diagnose cases.
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