Alcohol-use disorder

References

Key articles

American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed., (DSM-5). Washington, DC: American Psychiatric Publishing; 2013.

Lingford-Hughes AR, Welch S, Peter L, et al. BAP updated guidelines: evidence-based guidelines for the pharmacological management of substance abuse, harmful use, addiction and comorbidity: recommendations from BAP. J Psychopharmacol. 2012 Jul;26(7):899-952. Abstract

Swift R. Emerging approaches to managing alcohol dependence. Am J Health Syst Pharm. 2007 Mar 1;64(5 suppl 3):S12-22. Abstract

Anton RF, O'Malley SS, Ciraulo DA, et al. Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. JAMA. 2006 May 3;295(17):2003-17.Full text  Abstract

Reference articles

1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed., (DSM-5). Washington, DC: American Psychiatric Publishing; 2013.

2. Swift RM. Drug therapy for alcohol dependence. N Engl J Med. 1999 May 13;340(19):1482-90. Abstract

3. World Health Organization. International statistical classification of diseases and related health problems. 10th ed. Geneva, Switzerland: WHO; 2016.Full text

4. Rehm J, Room R, van den Brink W, et al. Alcohol use disorders in EU countries and Norway: an overview of the epidemiology. Eur Neuropsychopharmacol. 2005 Aug;15(4):377-88. Abstract

5. Soyka M, Kranzler HR, Hesselbrock V, et al. Guidelines for biological treatment of substance use and related disorders, part 1: Alcoholism, first revision. World J Biol Psychiatry. 2017 Mar;18(2):86-119.Full text  Abstract

6. Grant BF, Goldstein RB, Saha TD, et al. Epidemiology of DSM-5 alcohol use disorder: results from the national epidemiologic survey on alcohol and related conditions III. JAMA Psychiatry. 2015 Aug;72(8):757-66.Full text  Abstract

7. Grant BF, Dawson DA, Stinson FS, et al. The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002. Drug Alcohol Depend. 2004 Jun 11;74(3):223-34. Abstract

8. Fiellin DA, Reid MC, O'Connor PG. New therapies for alcohol problems. Am J Med. 2000 Feb 15;108(3):227-37. Abstract

9. Hasin DS, Tsai WY, Endicott J, et al. Five-year course of major depression: effects of comorbid alcoholism. J Affect Disord. 1996 Nov 4;41(1):63-70. Abstract

10. Addolorato G, Leggio L, Abenavoli L, et al. Neurobiochemical and clinical aspects of craving in alcohol addiction: a review. Addict Behav. 2005 Jul;30(6):1209-24. Abstract

11. McLellan AT, Lewis DC, O'Brien CP, et al. Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation. JAMA. 2000 Oct 4;284(13):1689-95. Abstract

12. Public Health England. Consumption of alcoholic beverages and risk of cancer: a statement from the Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC). January 2016 [internet publication].Full text

13. UK Chief Medical Officers. Alcohol consumption: advice on low risk drinking. August 2016 [internet publication].Full text

14. Koob G, Kreek MJ. Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry. 2007 Aug;164(8):1149-59.Full text  Abstract

15. Leggio L, Kenna GA, Swift RM. New developments for the pharmacological treatment of alcohol withdrawal syndrome: a focus on non-benzodiazepine GABAergic medications. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1106-17. Abstract

16. Malcolm RJ. GABA systems, benzodiazepines, and substance dependence. J Clin Psychiatry. 2003;64(suppl 3):36-40. Abstract

17. Gordis E. Alcohol research: at the cutting edge. Arch Gen Psychiatry. 1996 Mar;53(3):199-201. Abstract

18. Cloninger CR, Bohman M, Sigvardsson S. Inheritance of alcohol abuse: cross-fostering analysis of adopted men. Arch Gen Psychiatry. 1981 Aug;38(8):861-8. Abstract

19. Babor TF, Dolinsky ZS, Meyer RE, et al. Types of alcoholics: concurrent and predictive validity of some common classification schemes. Br J Addict. 1992 Oct;87(10):1415-31. Abstract

20. Leggio L, Addolorato G. Serotonin transporter (SERT) brain density and neurobiological cloninger subtypes model: a lesson by human autoradiography studies. Alcohol Alcohol. 2008 Mar-Apr;43(2):148-50. Abstract

21. Poikolainen K. Risk factors for alcohol dependence: a case-control study. Alcohol Alcohol. 2000 Mar-Apr;35(2):190-6. Abstract

22. Ward RJ, McPherson AJS, Chow C, et al. Identification and characterization of alcohol-induced flushing in Caucasian subjects. Alcohol Alcohol. 1994 Jul;29(4):433-8. Abstract

23. Schuckit MA, Hesselbrock V, Tipp J, et al. A comparison of DSM-III-R, DSM-IV and ICD-10 substance use disorders diagnoses in 1922 men and women subjects in the COGA study. Addiction. 1994 Dec;89(12):1629-38. Abstract

24. Svensson PA, Anveden Å, Romeo S, et al. Alcohol consumption and alcohol problems after bariatric surgery in the Swedish obese subjects study. Obesity (Silver Spring). 2013 Dec;21(12):2444-51.Full text  Abstract

25. Toomey TL, Wagenaar AC. Policy options for prevention: the case of alcohol. J Public Health Policy. 1999;20(2):192-213. Abstract

26. Anderson P, Chisholm D, Fuhr DC. Effectiveness and cost-effectiveness of policies and programmes to reduce the harm caused by alcohol. Lancet. 2009 Jun 27;373(9682):2234-46. Abstract

27. Smit E, Verdurmen J, Monshouwer K, et al. Family interventions and their effect on adolescent alcohol use in general populations; a meta-analysis of randomized controlled trials. Drug Alcohol Depend. 2008 Oct 1;97(3):195-206. Abstract

28. Donoghue K, Patton R, Phillips T, et al. The effectiveness of electronic screening and brief intervention for reducing levels of alcohol consumption: a systematic review and meta-analysis. J Med Internet Res. 2014 Jun 2;16(6):e142.Full text  Abstract

29. Kypri K, Langley JD, Saunders JB, et al. Randomized controlled trial of web-based alcohol screening and brief intervention in primary care. Arch Intern Med. 2008 Mar 10;168(5):530-6. Abstract

30. Désy PM, Howard PK, Perhats C, et al. Alcohol screening, brief intervention, and referral to treatment conducted by emergency nurses: an impact evaluation. J Emerg Nurs. 2010 Nov;36(6):538-45. Abstract

31. World Health Organization. Management of substance abuse: dependence syndrome. 2018 [internet publication].Full text

32. First MB, Spitzer RL, Gibbon M, et al. Structured clinical interview for DSM-IV axis I disorders, clinician version (SCID-CV). Washington, DC: American Psychiatric Press; 1996.Full text

33. Babor TF, Higgins-Biddle JC, Saunders JB, et al. The Alcohol Use Disorders Identification Test (AUDIT). Guidelines for use in primary care, second edition. Geneva: World Health Organization; 2001.Full text

34. Agabio R, Nioi M, Serra C, et al. Alcohol use disorders in primary care patients in Cagliari, Italy. Alcohol Alcohol. 2006 May-Jun;41(3):341-4.Full text  Abstract

35. Berner MM, Kriston L, Bentele M, et al. The alcohol use disorders identification test for detecting at-risk drinking: a systematic review and meta-analysis. J Stud Alcohol Drugs. 2007 May;68(3):461-73. Abstract

36. Grucza RA, Bierut LJ. Co-occurring risk factors for alcohol dependence and habitual smoking: update on findings from the Collaborative Study on the Genetics of Alcoholism. Alcohol Res Health. 2006;29(3):172-8. Abstract

37. Sullivan JT, Swift RM, Lewis DC. Benzodiazepines requirements during alcohol withdrawal syndrome: clinical implications of using standardized withdrawal scale. J Clin Psychopharmacol. 1991 Oct;11(5):291-5. Abstract

38. Swift RM. Direct measurement of alcohol and its metabolites. Addiction. 2003 Dec;98(suppl 2):73-80. Abstract

39. Bilban M, Vrhovec S, Karlovsek MZ. Blood biomarkers of alcohol abuse. Arh Hig Rada Toksikol. 2003 Dec;54(4):253-9. Abstract

40. SAMHSA. Lab tests for alcohol abuse: SAMHSA advisory. December 2006 [internet publication].Full text

41. Needle R, Brown P, Lavee Y, et al. Costs and consequences of drug use: a comparison of health care utilization and social-psychological consequences for clinical and non clinical adolescents and their families. Int J Addict. 1988 Nov;23(11):1125-43. Abstract

42. Chick J, Kemppainen E. Estimating alcohol consumption. Pancreatology. 2007;7(2-3):157-61. Abstract

43. Klatsky AL, Friedman GD, Armstrong MA. The relationships between alcoholic beverage use and other traits to blood pressure: a new Kaiser Permanente study. Circulation. 1986 Apr;73(4):628-36.Full text  Abstract

44. Addolorato G, Capristo E, Greco AV, et al. Influence of chronic alcohol abuse on body weight and energy metabolism: is excess ethanol consumption a risk factor for obesity or malnutrition? J Intern Med. 1998 Nov;244(5):387-95.Full text  Abstract

45. Addolorato G, Capristo E, Greco AV, et al. Three months of abstinence from alcohol normalizes energy expenditure and substrate oxidation in alcoholics: a longitudinal study. Am J Gastroenterol. 1998 Dec;93(12):2476-81. Abstract

46. Addolorato G, Leggio L, Ojetti V, et al. Effects of short-term moderate alcohol administration on oxidative stress and nutritional status in healthy males. Appetite. 2008 Jan;50(1):50-6. Abstract

47. Addolorato G, Capristo E, Leggio L, et al. Relationship between ghrelin levels, alcohol craving, and nutritional status in current alcoholic patients. Alcohol Clin Exp Res. 2006 Nov;30(11):1933-7. Abstract

48. Leggio L, Ferrulli A, Malandrino N, et al. Insulin but not insulin growth factor-1 correlates with craving in currently drinking alcohol-dependent patients.Alcohol Clin Exp Res. 2008 Mar;32(3):450-8. Abstract

49. Tilg H, Day CP. Management strategies in alcoholic liver disease. Nat Clin Pract Gastroenterol Hepatol. 2007 Jan;4(1):24-34. Abstract

50. Kostovic K, Lipozencic J. Skin diseases in alcoholics. Acta Dermatovenerol Croat. 2004;12(3):181-90. Abstract

51. Kranzler HR, Babor TF, Goldstein L, et al. Dental pathology and alcohol-related indicators in an outpatient clinic sample. Community Dent Oral Epidemiol. 1990 Aug;18(4):204-7. Abstract

52. Lingford-Hughes AR, Welch S, Peter L, et al. BAP updated guidelines: evidence-based guidelines for the pharmacological management of substance abuse, harmful use, addiction and comorbidity: recommendations from BAP. J Psychopharmacol. 2012 Jul;26(7):899-952. Abstract

53. Sullivan JT, Sykora K, Schneiderman J, et al. Assessment of alcohol withdrawal: the revised Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA-Ar). Br J Addict. 1989 Nov;84(11):1353-7. Abstract

54. Kosten TR, O'Connor PG. Management of drug and alcohol withdrawal. N Engl J Med. 2003 May 1;348(18):1786-95. Abstract

55. Baker AL, Kavanagh DJ, Kay-Lambkin FJ, et al. Randomized controlled trial of cognitive-behavioural therapy for coexisting depression and alcohol problems: short-term outcome. Addiction. 2010 Jan;105(1):87-99. Abstract

56. Álvarez-Bueno C, Rodríguez-Martín B, García-Ortiz L, et al. Effectiveness of brief interventions in primary health care settings to decrease alcohol consumption by adult non-dependent drinkers: a systematic review of systematic reviews. Prev Med. 2015 Jul;76(suppl):S33-8. Abstract

57. Cunningham RM, Chermack ST, Ehrlich PF, et al. Alcohol interventions among underage drinkers in the ED: a randomized controlled trial. Pediatrics. 2015 Oct;136(4):e783-93.Full text  Abstract

58. Kaner EF, Beyer FR, Muirhead C, et al. Effectiveness of brief alcohol interventions in primary care populations. Cochrane Database Syst Rev. 2018 Feb 24;(2):CD004148.Full text  Abstract

59. Bernstein J, Heeren T, Edward E, et al. A brief motivational interview in a pediatric emergency department, plus 10-day telephone follow-up, increases attempts to quit drinking among youth and young adults who screen positive for problematic drinking. Acad Emerg Med. 2010 Aug;17(8):890-902.Full text  Abstract

60. Kaner EF, Dickinson HO, Beyer F, et al. The effectiveness of brief alcohol interventions in primary care settings: a systematic review. Drug Alcohol Rev. 2009 May;28(3):301-23. Abstract

61. D'Onofrio G, Fiellin DA, Pantalon MV, et al. A brief intervention reduces hazardous and harmful drinking in emergency department patients. Ann Emerg Med. 2012 Aug;60(2):181-92.Full text  Abstract

62. Miller WR, Rollnick S. Motivational interviewing: preparing people to change addictive behavior. New York, NY: Guilford Press; 1991.

63. Field C, Walters S, Marti CN, et al. A multisite randomized controlled trial of brief intervention to reduce drinking in the trauma care setting: how brief is brief? Ann Surg. 2014 May;259(5):873-80.Full text  Abstract

64. Ait-Daoud N, Malcolm RJ Jr, Johnson BA. An overview of medications for the treatment of alcohol withdrawal and alcohol dependence with an emphasis on the use of older and newer anticonvulsants. Addict Behav. 2006 Sep;31(9):1628-49. Abstract

65. Powers MB, Vedel E, Emmelkamp PM. Behavioral couples therapy (BCT) for alcohol and drug use disorders: a meta-analysis. Clin Psychol Rev. 2008 Jul;28(6):952-62. Abstract

66. Swift R. Emerging approaches to managing alcohol dependence. Am J Health Syst Pharm. 2007 Mar 1;64(5 suppl 3):S12-22. Abstract

67. Agosti V, Nunes EV, O'Shea D. Do manualized psychosocial interventions help reduce relapse among alcohol-dependent adults treated with naltrexone or placebo? A meta-analysis. Am J Addict. 2012 Nov-Dec;21(6):501-7. Abstract

68. Kelly JF, Hoeppner B, Stout RL, et al. Determining the relative importance of the mechanisms of behavior change within Alcoholics Anonymous: a multiple mediator analysis. Addiction. 2012 Feb;107(2):289-99.Full text  Abstract

69. Saitz R, Cheng DM, Winter M, et al. Chronic care management for dependence on alcohol and other drugs: the AHEAD randomized trial. JAMA. 2013 Sep 18;310(11):1156-67.Full text  Abstract

70. Addolorato G, Abenavoli L, Leggio L, et al. How many cravings? Pharmacological aspects of craving treatment in alcohol addiction: a review. Neuropsychobiology. 2005;51(2):59-66. Abstract

71. Heilig M, Egli M. Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacol Ther. 2006 Sep;111(3):855-76. Abstract

72. Addolorato G, Armuzzi A, Gasbarrini G, et al. Pharmacological approaches to the management of alcohol addiction. Eur Rev Med Pharmacol Sci. 2002 Sep-Oct;6(5):89-97. Abstract

73. Williams SH. Medications for treating alcohol dependence. Am Fam Physician. 2005 Nov 1;72(9):1775-80.Full text  Abstract

74. Soyka M, Rösner S. Opioid antagonists for pharmacological treatment of alcohol dependence - a critical review. Curr Drug Abuse Rev. 2008 Nov;1(3):280-91. Abstract

75. Anton RF, O'Malley SS, Ciraulo DA, et al. Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. JAMA. 2006 May 3;295(17):2003-17.Full text  Abstract

76. Bogenschutz MP, Scott Tonigan J, Pettinati HM. Effects of alcoholism typology on response to naltrexone in the COMBINE study. Alcohol Clin Exp Res. 2009 Jan;33(1):10-8.Full text  Abstract

77. Anton RF, Oroszi G, O'Malley S, et al. An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry. 2008 Feb;65(2):135-44.Full text  Abstract

78. Ooteman W, Naassila M, Koeter MW, et al. Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators. Addict Biol. 2009 Jul;14(3):328-37. Abstract

79. Ray LA, Hutchison KE. Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study. Arch Gen Psychiatry. 2007 Sep;64(9):1069-77. Abstract

80. Gueorguieva R, Wu R, Pittman B, et al. New insights into the efficacy of naltrexone based on trajectory-based reanalyses of two negative clinical trials. Biol Psychiatry. 2007 Jun 1;61(11):1290-5.Full text  Abstract

81. Swift R, Oslin DW, Alexander M, et al. Adherence monitoring in naltrexone pharmacotherapy trials: a systematic review. J Stud Alcohol Drugs. 2011 Nov;72(6):1012-8. Abstract

82. National Institute for Health and Care Excellence. Alcohol-use disorders: diagnosis, assessment and management of harmful drinking and alcohol dependence. February 2011 [internet publication].Full text

83. Ciraulo DA, Dong Q, Silverman BL, et al. Early treatment response in alcohol dependence with extended-release naltrexone. J Clin Psychiatry. 2008 Feb;69(2):190-5. Abstract

84. Lucey MR, Silverman BL, Illeperuma A, et al. Hepatic safety of once-monthly injectable extended-release naltrexone administered to actively drinking alcoholics. Alcohol Clin Exp Res. 2008 Mar;32(3):498-504. Abstract

85. Pettinati HM, Silverman BL, Battisti JJ, et al. Efficacy of extended-release naltrexone in patients with relatively higher severity of alcohol dependence. Alcohol Clin Exp Res. 2011 Oct;35(10):1804-11. Abstract

86. Rösner S, Hackl-Herrwerth A, Leucht S, et al. Acamprosate for alcohol dependence. Cochrane Database Syst Rev. 2010 Sep 8;(9):CD004332.Full text  Abstract

87. Mason BJ, Lehert P. Acamprosate for alcohol dependence: a sex-specific meta-analysis based on individual patient data. Alcohol Clin Exp Res. 2012 Mar;36(3):497-508.Full text  Abstract

88. Mason BJ, Salvato FR, Williams LD, et al. A double-blind, placebo-controlled study of oral nalmefene for alcohol dependence. Arch Gen Psychiatry. 1999 Aug;56(8):719-24.Full text  Abstract

89. Palpacuer C, Laviolle B, Boussageon R, et al. Risks and benefits of nalmefene in the treatment of adult alcohol dependence: a systematic literature review and meta-analysis of published and unpublished double-blind randomized controlled trials. PLoS Med. 2015 Dec 22;12(12):e1001924.Full text  Abstract

90. Pettinati HM, Weiss RD, Miller, WR, et al. COMBINE monograph series, volume 2. Medical management treatment manual: a clinical research guide for medically trained clinicians providing pharmacotherapy as part of the treatment for alcohol dependence. Bethesda, MD: NIAAA; 2004.Full text

91. O'Malley SS, Carroll KM. Psychotherapeutic considerations in pharmacological trials: alcoholism, clinical and experimental research. Alcohol Clin Exp Res. 1996 Oct;20(7 suppl):17A-22A. Abstract

92. Pettinati HM, Volpicelli JR, Pierce JD, et al. Improving naltrexone response: an intervention for medical practitioners to enhance medication compliance in alcohol dependent patients. J Addict Dis. 2000;19(1):71-83. Abstract

93. Hobbs JD, Kushner MG, Lee SS, et al. Meta-analysis of supplemental treatment for depressive and anxiety disorders in patients being treated for alcohol dependence. Am J Addict. 2011 Jul-Aug;20(4):319-29.Full text  Abstract

94. Smith EJ, Lui S, Terplan M. Pharmacologic interventions for pregnant women enrolled in alcohol treatment. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD007361.Full text  Abstract

95. Tripodi SJ, Bender K, Litschge C, et al. Interventions for reducing adolescent alcohol abuse: a meta-analytic review. Arch Pediatr Adolesc Med. 2010 Jan;164(1):85-91.Full text  Abstract

96. Engle B, Macgowan MJ. A critical review of adolescent substance abuse group treatments. J Evid Based Soc Work. 2009 Jul;6(3):217-43. Abstract

97. Anderson P. Is it time to ban alcohol advertising? Clin Med (Lond). 2009 Apr;9(2):121-4. Abstract

98. Mayo-Smith MF. Pharmacological management of alcohol withdrawal: a meta-analysis and evidence-based practice guideline: American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal. JAMA. 1997 Jul 9;278(2):144-51. Abstract

99. Saitz R. Clinical practice: unhealthy alcohol use. N Engl J Med. 2005 Feb 10;352(6):596-607. Abstract

100. Agabio R. Thiamine administration in alcohol-dependent patients. Alcohol Alcohol. 2005 Mar-Apr;40(2):155-6. Abstract

101. Johnson BA, Ait-Daoud N, Bowden CL, et al. Oral topiramate for treatment of alcohol dependence: a randomised controlled trial. Lancet. 2003 May 17;361(9370):1677-85. Abstract

102. Johnson BA, Rosenthal N, Capece JA, et al. Topiramate for treating alcohol dependence: a randomized controlled trial. JAMA. 2007 Oct 10;298(14):1641-51.Full text  Abstract

103. Johnson BA, Rosenthal N, Capece JA, et al. Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial. Arch Intern Med. 2008 Jun 9;168(11):1188-99. Abstract

104. Shinn AK, Greenfield SF. Topiramate in the treatment of substance-related disorders: a critical review of the literature. J Clin Psychiatry. 2010 May;71(5):634-48.Full text  Abstract

105. Kenna GA, Lomastro TL, Schiesl A, et al. Review of topiramate: an antiepileptic for the treatment of alcohol dependence. Curr Drug Abuse Rev. 2009 May;2(2):135-42. Abstract

106. Arbaizar B, Diersen-Sotos T, Gómez-Acebo I, et al. Topiramate in the treatment of alcohol dependence: a meta-analysis. Actas Esp Psiquiatr. 2010 Jan-Feb;38(1):8-12.Full text  Abstract

107. Swift RM. Topiramate for the treatment of alcohol dependence: initiating abstinence. Lancet. 2003 May 17;361(9370):1666-7. Abstract

108. Kranzler HR, Covault J, Feinn R, et al. Topiramate treatment for heavy drinkers: moderation by a GRIK1 polymorphism. Am J Psychiatry. 2014 Apr;171(4):445-52.Full text  Abstract

109. Johnson BA, Roache JD, Javors MA, et al. Ondansetron for reduction of drinking among biologically predisposed alcoholic patients: a randomized controlled trial. JAMA. 2000 Aug 23-30;284(8):963-71.Full text  Abstract

110. Johnson BA, Ait-Daoud N, Seneviratne C, et al. Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking. Am J Psychiatry. 2011 Mar;168(3):265-75.Full text  Abstract

111. Pettinati HM, Volpicelli JR, Kranzler HR, et al. Sertraline treatment for alcohol dependence: interactive effects of medication and alcoholic subtype. Alcohol Clin Exp Res. 2000 Jul;24(7):1041-9. Abstract

112. Kranzler HR, Burleson JA, Brown J, et al. Fluoxetine treatment seems to reduce the beneficial effects of cognitive-behavioral therapy in type B alcoholics. Alcohol Clin Exp Res. 1996 Dec;20(9):1534-41. Abstract

113. Cornelius JR, Bukstein OG, Wood DS, et al. Double-blind placebo-controlled trial of fluoxetine in adolescents with comorbid major depression and an alcohol use disorder. Addict Behav. 2009 Oct;34(10):905-9.Full text  Abstract

114. Addolorato G, Leggio L, Abenavoli L, et al. Baclofen in the treatment of alcohol withdrawal syndrome: a comparative study vs diazepam. Am J Med. 2006 Mar;119(3):276.e13-8. Abstract

115. Addolorato G, Caputo F, Capristo E, et al. Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study. Alcohol Alcohol. 2002 Sep-Oct;37(5):504-8. Abstract

116. Addolorato G, Leggio L, Agabio R, et al. Baclofen: a new drug for the treatment of alcohol dependence. Int J Clin Pract. 2006 Aug;60(8):1003-8. Abstract

117. Addolorato G, Leggio L, Ferrulli A, et al. Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study. Lancet. 2007 Dec 8;370(9603):1915-22. Abstract

118. Muzyk AJ, Rivelli SK, Gagliardi JP. Defining the role of baclofen for the treatment of alcohol dependence: a systematic review of the evidence. CNS Drugs. 2012 Jan 1;26(1):69-78. Abstract

119. Pani PP, Trogu E, Pacini M, et al. Anticonvulsants for alcohol dependence. Cochrane Database Syst Rev. 2014 Feb 13;(2):CD008544.Full text  Abstract

120. Mason BJ, Quello S, Goodell V, et al. Gabapentin treatment for alcohol dependence: a randomized clinical trial. JAMA Intern Med. 2014 Jan;174(1):70-7.Full text  Abstract

121. Tait RJ, Christensen H. Internet-based interventions for young people with problematic substance use: a systematic review. Med J Aust. 2010 Jun 7;192(11 suppl):S15-21. Abstract

122. Carey KB, Scott-Sheldon LA, Elliott JC, et al. Computer-delivered interventions to reduce college student drinking: a meta-analysis. Addiction. 2009 Nov;104(11):1807-19.Full text  Abstract

123. Gainsbury S, Blaszczynski A. A systematic review of internet-based therapy for the treatment of addictions. Clin Psychol Rev. 2011 Apr;31(3):490-8. Abstract

124. Carey KB, Scott-Sheldon LA, Elliott JC, et al. Face-to-face versus computer-delivered alcohol interventions for college drinkers: a meta-analytic review, 1998 to 2010. Clin Psychol Rev. 2012 Dec;32(8):690-703.Full text  Abstract

125. Bingham CR, Barretto AI, Walton MA, et al. Efficacy of a web-based, tailored, alcohol prevention/intervention program for college students: initial findings. J Am Coll Health. 2010 Jan-Feb;58(4):349-56. Abstract

126. Carey KB, Carey MP, Henson JM, et al. Brief alcohol interventions for mandated college students: comparison of face-to-face counseling and computer-delivered interventions. Addiction. 2011 Mar;106(3):528-37.Full text  Abstract

127. Grant BF. Prevalence and correlates of alcohol use and DSM-IV alcohol dependence in the United States: results of the National Longitudinal Alcohol Epidemiological Survey. J Stud Alcohol. 1997 Sep;58(5):464-73. Abstract

128. Finney JW, Hahn AC, Moos RH. The effectiveness of inpatient and outpatient treatment for alcohol abuse: the need to focus on mediators and moderators of setting effects. Addiction. 1996 Dec;91(12):1773-96. Abstract

129. US Department of Health and Human Services. Tenth special report to the US Congress on alcohol and health. Bethesda, MD: NIAAA; 2000.Full text

130. Mayo-Smith MF, Beecher LH, Fischer TL, et al. Management of alcohol withdrawal delirium: an evidence-based practice guideline. Arch Intern Med. 2004 Jul 12;164(13):1405-12.Full text  Abstract

131. Rathlev NK, Ulrich AS, Delanty N, et al. Alcohol-related seizures. J Emerg Med. 2006 Aug;31(2):157-63. Abstract

132. Thomson AD. Mechanisms of vitamin deficiency in chronic alcohol misusers and development of the Wernicke-Korsakoff syndrome. Alcohol Alcohol Suppl. 2000 May-Jun;35(1):2-7. Abstract

133. Dwivedi M, Misra SP. Mallory-Weiss syndrome: clinical features and management. J Assoc Physicians India. 1999 Apr;47(4):397-9. Abstract

134. Zhang X, Li SY, Brown RA, et al. Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress. Alcohol. 2004 Apr;32(3):175-86. Abstract

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